Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Challenges of screening applications for early detection of cancer using liquid biopsy
Kermani, B.G.; Huecker, S.; Kirsch, S.; Polzer, B.
Abstract
2019In Vivo Detection of Circulating Tumor Cells in High-Risk Non-Metastatic Prostate Cancer Patients Undergoing Radiotherapy
Chen, S.; Tauber, G.; Langsenlehner, T.; Schmölzer, L.M.; Pötscher, M.; Riethdorf, S.; Kuske, A.; Leitinger, G.; Kashofer, K.; Czyż, Z.T.; Polzer, B.; Pantel, K.; Sedlmayr, P.; Kroneis, T.; El-Heliebi, A.
Zeitschriftenaufsatz
2019Interleukin 6 transsignaling is a candidate mechanism to drive progression of human DCCs during periods of clinical latency
Werner-Klein, M.; Grujovic, A.; Obradovic, M.; Hoffmann, M.; Lu, X.; Kirsch, S.; Treitschke, S.; Köstler, C.; Weidele, K.; Irlbeck, C.; Botteron, C.; Werno, C.; Polzer, B.; Guzvic, M.; Buchholz, S.; Rümmele, P.; Heine, N.; Rose-John, S.; Klein, C.A.
Abstract
2019Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples
Weidele, Kathrin; Stojanović, Nataša; Feliciello, Giancarlo; Markiewicz, Aleksandra; Scheitler, Sebastian; Alberter, Barbara; Renner, Philipp; Haferkamp, Sebastian; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz
2019A novel workflow for isolation and multi-omic profiling of DCCs derived from cerebrospinal fluid of patients with pediatric brain cancer
Czyz, Z.T.; Feliciello, G.; Guzvic, M.; Schamberger, T.; Grunewald, S.; Corbacioglu, S.; Riemenschneider, M.J.; Polzer, B.; Klein, C.A.
Abstract
2019Semi-automated detection, isolation and molecular analysis of single disseminated melanoma cells from lymph nodes
Alberter, B.; Scheitler, S.; Feliciello, G.; Ferrarini, A.; Werner-Klein, M.; Haferkamp, S.; Klein, C.A.; Polzer, B.
Abstract
2018Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer
Hoffmann, Martin; Pasch, Sophie; Schamberger, Thomas; Maneck, Matthias; Möhlendick, Birte; Schumacher, Sarah; Brockhoff, Gero; Knoefel, Wolfram Trudo; Izbicki, Jakob; Polzer, Bernhard; Stoecklein, Nikolas H.; Klein, Christoph A.
Zeitschriftenaufsatz
2018Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
Werner-Klein, Melanie; Scheitler, Sebastian; Hoffmann, Martin; Hodak, Isabelle; Dietz, Klaus; Lehnert, Petra; Naimer, Veronika; Polzer, Bernhard; Treitschke, Steffi; Werno, Christian; Markiewicz, Aleksandra; Weidele, Kathrin; Czyz, Zbigniew; Hohenleutner, Ulrich; Hafner, Christian; Haferkamp, Sebastian; Berneburg, Mark; Rümmele, Petra; Ulmer, Anja; Klein, Christoph A.
Zeitschriftenaufsatz
2018Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: The potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment
Lüke, Florian; Blazquez, Raquel; Yamaci, Rezan Fahrioglu; Lu, Xin; Pregler, Benedikt; Hannus, Stefan; Menhart, Karin; Hellwig, Dirk; Wester, Hans-Jürgen; Kropf, Saskia; Heudobler, Daniel; Grosse, Jirka; Moosbauer, Jutta; Hutterer, Markus; Hau, Peter; Riemenschneider, Markus J.; Bayerlová, Michaela; Bleckmann, Annalen; Polzer, Bernhard; Beißbarth, Tim; Klein, Christoph A.; Pukrop, Tobias
Zeitschriftenaufsatz
2018Modulation of tumor-microenvironmental factors and cancer growth in co-cultures of fresh human lung tissue and patient-derived cancer cells
Konzok, Sebastian; Dehmel, Susann; Werno, Christian; Braubach, Peter; Warnecke, Gregor; Zardo, Patrick; Jonigk, Danny; Pfennig, Olaf; Fieguth, Hans-Gerd; Polzer, Bernhard; Weidele, Kathrin; Klein, Christoph A.; Braun, Armin; Sewald, Katherina
Abstract
2018Single cell polarity in liquid phase facilitates tumour metastasis
Lorentzen, Anna; Becker, Paul F.; Kosla, Jan; Saini, Massimo; Weidele, Kathrin; Ronchi, Paolo; Klein, Corinna; Wolf, Monika J.; Geist, Felix; Seubert, Bastian; Ringelhan, Marc; Mihic-Probst, Daniela; Esser, Knud; Roblek, Marko; Kuehne, Felix; Bianco, Gaia; O'Connor, Tracy; Müller, Quentin; Schuck, Kathleen; Lange, Sebastian; Hartmann, Daniel; Spaich, Saskia; Gross, Olaf; Utikal, Jochen; Haferkamp, Sebastian; Sprick, Martin R.; Damle-Vartak, Amruta; Hapfelmeier, Alexander; Hüser, Norbert; Protzer, Ulrike; Trumpp, Andreas; Saur, Dieter; Vartak, Nachiket; Klein, Christoph A.; Polzer, Bernhard; Borsig, Lubor; Heikenwalder, Mathias
Zeitschriftenaufsatz
2018Target cell pre-enrichment and whole genome amplification for single cell downstream characterization
Chen, Shukun; El-Heliebi, Amin; Schmid, Julia; Kashofer, Karl; Czyz, Zbigniew T.; Polzer, Bernhard Michael; Pantel, Klaus; Kroneis, Thomas; Sedlmayr, Peter
Zeitschriftenaufsatz
2017Catch and release: Rare cell analysis from a functionalised medical wire
Chen, Shukun; El-Heliebi, Amin; Tauber, Gerlinde; Langsenlehner, Tanja; Pötscher, Michaela; Kashofer, Karl; Czyz, Zbigniew T.; Polzer, Bernhard; Riethdorf, Sabine; Kuske, Andra; Leitinger, Gerd; Pantel, Klaus; Kroneis, Thomas; Sedlmayr, Peter
Zeitschriftenaufsatz
2017HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category
Holzschuh, M.-A.; Czyz, Z.; Hauke, S.; Inwald, E.C.; Polzer, B.; Brockhoff, G.
Zeitschriftenaufsatz
2016Characterization of rare, dormant, and therapy-resistant cells in acute lymphoblastic leukemia
Ebinger, S.; Özdemir, E.Z.; Ziegenhain, C.; Tiedt, S.; Castro Alves, C.; Grunert, M.; Dworzak, M.; Lutz, C.; Turati, V.A.; Enver, T.; Horny, H.-P.; Sotlar, K.; Parekh, S.; Spiekermann, K.; Hiddemann, W.; Schepers, A.; Polzer, B.; Kirsch, S.; Hoffmann, M.; Knapp, B.; Hasenauer, J.; Pfeifer, H.; Panzer-Grümayer, R.; Enard, W.; Gires, O.; Jeremias, I.
Zeitschriftenaufsatz
2016Low primary intra-tumoural heterogeneity versus high genomic disparity between primary and distant sites in NSCLC
Polzer, B.; Wendler, N.; Fahrioglu-Yamaci, R.; Elsner, F.; Cucuruz, B.; Lindner, M.; Hofmann, H.S.; Passlick, B.; Klein, C.A.
Abstract
2016Micro-fluidic enrichment of circulating or disseminated cancer cells from blood or lymph nodes independent of surface marker expression
Stojanovic, N.; Weidele, K.; Scheitler, S.; Alberter, B.; Raab, M.; Markiewicz, A.; Haferkamp, S.; Klein, C.A.; Polzer, B.
Abstract
2016Single-cell analysis of CTCs with diagnostic precision: Opportunities and challenges for personalized medicine. Review
Alberter, Barbara; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz
2015The genetic heterogeneity of circulating tumor cells: a longitudinal study in breast cancer patients
Terracciano, M.; Buson, G.; Forcato, C.; Luca, F. de; Galardi, F.; Sero, V.; Pestrin, M.; Gabellini, S.; Koestler, C.; Czyz, Z.T.; Bregola, G.; Tononi, P.; Bolognesi, C.; Fontana, F.; Medoro, G.; Polzer, B.; Leo, A. di; Klein, C.A.; Manaresi, N.
Abstract
2015Identification and molecular characterization of different subpopulations of EpCAM-positive single disseminated cancer cells in prostate cancer
Polzer, B.; Guzvic, M.; Ganzer, R.; Weckermann, D.; Braun, B.; Appel, I.; Obradovic, M.; Huppert, V.; Klein, C.A.
Abstract
2015Laser microdissection of FFPE tissue areas and subsequent whole genome amplification by Ampli1™
Czyz, Zbigniew Tadeusz; Stoecklein, Nikolas H.; Polzer, Bernhard
Aufsatz in Buch
2015Longitudinal genetic characterization of circulating tumor cells in metastatic breast cancer patients
Sero, V.; Luca, F. de; Doffini, A.; Galardi, F.; Pestrin, M.; Czyz, Z.T.; Buson, G.; Bregola, G.; Bolognesi, C.; Fontana, F.; Medoro, G.; Polzer, B.; Leo, A. di; Klein, C.A.; Manaresi, N.
Abstract
2015Method and kit for determining the genome integrity and/or the quality of a library of DNA-sequences otained by deterministic restriction site whole genome amplification
Klein, Christoph Andreas; Polzer, Bernhard Michael; Manaresi, Nicolo
Patent
2015Personalisierte Tumortherapie
Alberter, B.; Polzer, B.
Zeitschriftenaufsatz
2015Principles of whole-genome amplification
Czyz, Zbigniew Tadeusz; Kirsch, Stefan; Polzer, Bernhard
Aufsatz in Buch
2015Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Guzvic, M.; Braun, B.; Ganzer, R.; Burger, M.; Nerlich, M.; Winkler, S.; Werner-Klein, M.; Czyz, Z.T.; Polzer, B.; Klein, C.A.
Abstract
2014Analysis of nucleic acids in single cells
Kirsch, Stefan; Polzer, Bernhard; Klein, Christoph A.
Aufsatz in Buch
2014Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes
Guzvic, Miodrag; Braun, Bernhard; Ganzer, Roman; Burger, Maximilian; Nerlich, Michael; Winkler, Sebastian; Werner-Klein, Melanie; Czyz, Zbigniew T.; Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2014Einzelzell Heterogenität von Melanomsphären generiert aus disseminierten Tumorzellen
Sadlers, Sabine Jennifer
: Rosenau, Frank (Gutachter); Polzer, Bernhard (Gutachter); Hennes, Kilian (Zweitprüfer)
Master Thesis
2014Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer
Neves, Rui P.L.; Raba, Katharina; Schmidt, Oliver; Honisch, Ellen; Meier-Stiegen, Franziska; Behrens, Bianca; Möhlendick, Birte; Fehm, Tanja; Neubauer, Hans; Klein, Christoph A.; Polzer, Bernhard; Sproll, Christoph; Fischer, Johannes C.; Niederacher, Dieter; Stoecklein, Nikolas H.
Zeitschriftenaufsatz
2014Molecular profiling of single circulating tumor cells with diagnostic intention
Polzer, Bernhard; Medoro, Gianni; Pasch, Sophie; Fontana, Francesca; Zorzino, Laura; Pestka, Aurelia; Andergassen, Ulrich; Meier-Stiegen, Franziska; Czyz, Zbigniew T.; Alberter, Barbara; Treitschke, Steffi; Schamberger, Thomas; Sergio, Maximilian; Bregola, Giulia; Doffini, Anna; Gianni, Stefano; Calanca, Alex; Signorini, Giulio; Bolognesi, Chiara; Hartmann, Arndt; Fasching, Peter A.; Sandri, Maria T.; Rack, Brigitte; Fehm, Tanja; Giorgini, Guiseppe; Manaresi, Nicolò; Klein, Christoph A.
Zeitschriftenaufsatz
2014Quantitative measurement of melanoma spread in sentinel lymph nodes and survival
Ulmer, A.; Dietz, K.; Hodak, I.; Polzer, B.; Scheitler, S.; Yildiz, M.; Czyz, Z.; Lehnert, P.; Fehm, T.; Hafner, C.; Schanz, S.; Röcken, M.; Garbe, C.; Breuninger, H.; Fierlbeck, G.; Klein, C.A.
Zeitschriftenaufsatz
2014Reliable single cell array CGH for clinical samples
Czyz, Zbigniew T.; Hoffmann, Martin; Schlimok, Günter; Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2013Metastasis awakening: The challenges of targeting minimal residual cancer
Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2013Molecular profiling of single Sca-1(+)/CD34(+,-) cells - the putative murine lung stem cells
Hittinger, Markus; Czyz, Zbigniew T.; Huesemann, Yves; Maneck, Matthias; Botteron, Cathrine; Kaeufl, Stephanie; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz