Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021Predicting the environmental emissions arising from conventional and nanotechnology-related pharmaceutical drug products
Jung, F.; Thurn, M.; Krollik, K.; Gao, G.F.; Hering, I.; Eilebrecht, E.; Emara, Y.; Weiler, M.; Günday-Türeli, N.; Türeli, E.; Parnham, M.J.; Wacker, M.G.
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2020Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms
Maculins, T.; Garcia-Pardo, J.; Skenderovic, A.; Gebel, J.; Putyrski, M.; Vorobyov, A.; Busse, P.; Varga, G.; Kuzikov, M.; Zaliani, A.; Rahighi, S.; Schaeffer, V.; Parnham, M.J.; Sidhu, S.S.; Ernst, A.; Dötsch, V.; Akutsu, M.; Dikic, I.
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2020Exploring CYP2J2: Lipid mediators, inhibitors and therapeutic implications
Sisignano, M.; Steinhilber, D.; Parnham, M.J.; Geisslinger, G.
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2020Impact of hyperhomocysteinemia and different dietary interventions on cognitive performance in a knock-in mouse model for alzheimer's disease
Nieraad, H.; de Bruin, N.; Arne, O.; Hofmann, M.C.J.; Schmidt, M.; Saito, T.; Saido, T.C.; Gurke, R.; Schmidt, D.; Till, U.; Parnham, M.J.; Geisslinger, G.
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2020In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
Blum, L.; Gul, S.; Ulshöfer, T.; Henke, M.; Krieg, R.; Berneburg, I.; Thomas, D.; Trautmann, S.; Kurz, J.; Geyer, J.; Geisslinger, G.; Becker, K.; Parnham, M.J.; Schiffmann, S.
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2020Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages
Ebert, R.; Cumbana, R.; Lehmann, C.; Kutzner, L.; Toewe, A.; Ferreirós, N.; Parnham, M.J.; Schebb, N.H.; Steinhilber, D.; Kahnt, A.S.
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2020Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells
Blum, L.; Geisslinger, G.; Parnham, M.J.; Grünweller, A.; Schiffmann, S.
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2020A sensitive in vitro performance assay reveals the in vivo drug release mechanisms of long-acting medroxyprogesterone acetate microparticles
Gao, G.F.; Thurn, M.; Wendt, B.; Parnham, M.J.; Wacker, M.G.
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2020Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach
Ingelfinger, R.; Henke, M.; Roser, L.; Ulshöfer, T.; Calchera, A.; Singh, G.; Parnham, M.J.; Geisslinger, G.; Fürst, R.; Schmitt, I.; Schiffmann, S.
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20194 Ds in health research - working together toward rapid precision medicine
Niederberger, E.; Parnham, M.J.; Maas, J.; Geisslinger, G.
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2019Ceramides as Novel Disease Biomarkers
Kurz, J.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
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2019Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells
Trümper, V.; Knethen, A. von; Preuß, A.; Ermilov, E.; Hackbarth, S.; Kuchler, L.; Gunne, S.; Schäfer, A.; Bornhütter, T.; Vereb, G.; Ujlaky-Nagy, L.; Brüne, B.; Röder, B.; Schindler, M.; Parnham, M.J.; Knape, T.
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2019IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells
Han, Y.; Mora, J.; Huard, A.; Silva, P. da; Wiechmann, S.; Putyrski, M.; Schuster, C.; Elwakeel, E.; Lang, G.; Scholz, A.; Scholz, T.; Schmid, T.; Bruin, N. de; Billuart, P.; Sala, C.; Burkhardt, H.; Parnham, M.J.; Ernst, A.; Brüne, B.; Weigert, A.
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2019Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab
Mojtahed Poor, S.; Ulshöfer, T.; Gabriel, L.A.; Henke, M.; Köhm, M.; Behrens, F.; Geisslinger, G.; Parnham, M.J.; Burkhardt, H.; Schiffmann, S.
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2019Implantable wireless biometric animal telemetry system: a powerful tool to improve translational sepsis research
Knape, T.; Wilken-Schmitz, A.; Schneider, A.K.; Arne, O.; Schmidt, M.; Götze, L.; Hofmann, M.C.J.; Bruin, N.M.W.J. de; Gerdes, C.; Glenschek-Sieberth, M.; Schmidt, M.V.; Remie, R.; Brill, B.; Parnham, M.J.; Knethen, A. von
Abstract
2019Maintaining hepatic PD-L1 expression improves sepsis survival in a murine polymicrobial sepsis model by tolerizing CTL
Knethen, A. von; Schäfer, A.; Kuchler, L.; Knape, T.; Christen, U.; Hintermann, E.; Fisslthaler, B.; Schröder, K.; Brandes, R.P.; Genz, B.; Abshagen, K.; Pützer, B.M.; Sha, L.K.; Weigert, A.; Syed, S.N.; Schulz, M.; Shah, A.M.; Ernst, A.; Putyrski, M.; Finkelmeier, F.; Pesic, M.; Greten, F.; Hoghardt, M.; Kempf, V.A.J.; Gunne, S.; Parnham, M.J.; Brüne, B.
Abstract
2019Novel Approaches to Persistent Pain Therapy
Sisignano, M.; Parnham, M.J.; Geisslinger, G.
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2019Potential biomarkers for persistent and neuropathic pain therapy
Sisignano, M.; Lötsch, J.; Parnham, M.J.; Geisslinger, G.
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2019Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001
Nothnagel, L.; Jung, F.; Rossmanith, T.; Thurn, M.; Ashtikar, M.; Geisslinger, G.; Parnham, M.J.; Wacker, M.G.
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2019Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy
Feczkó, T.; Piiper, A.; Ansar, S.; Blixt, F.W.; Ashtikar, M.; Schiffmann, S.; Ulshöfer, T.; Parnham, M.J.; Harel, Y.; Israel, L.L.; Lellouche, J.-P.; Wacker, M.G.
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2019Structure optimization of a new class of PPARγ antagonists
Hernandez-Olmos, V.; Knape, T.; Heering, J.; Knethen, A. von; Kilu, W.; Kaiser, A.; Wurglics, M.; Helmstadter, M.; Merk, D.; Schubert-Zsilavecz, M.; Parnham, M.J.; Steinhilber, D.; Proschak, E.
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2019Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis
Knethen, A. von; Schäfer, A.; Kuchler, L.; Knape, T.; Christen, U.; Hintermann, E.; Fißlthaler, B.; Schröder, K.; Brandes, R.P.; Genz, B.; Abshagen, K.; Pützer, B.M.; Sha, L.K.; Weigert, A.; Syed, S.N.; Schulz, M.; Shah, A.M.; Ernst, A.; Putyrski, M.; Finkelmeier, F.; Pesic, M.; Greten, F.; Hogardt, M.; Kempf, V.A.J.; Gunne, S.; Parnham, M.J.; Brüne, B.
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2018Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression
Blum, L.; Tafferner, N.; Spring, I.; Kurz, J.; deBruin, N.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
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2018Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase
Roos, J.; Peters, M.; Maucher, I.V.; Kühn, B.; Fettel, J.; Hellmuth, N.; Brat, C.; Sommer, B.; Urbschat, A.; Piesche, M.; Vogel, A.; Proschak, E.; Blöcher, R.; Buscató, E.; Häfner, A.-K.; Matrone, C.; Werz, O.; Heidler, J.; Wittig, I.; Angioni, C.; Geisslinger, G.; Parnham, M.J.; Zacharowski, K.; Steinhilber, D.; Maier, T.J.
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2018Immunomodulation by antibiotics
Blum, L.; Schiffmann, S.; Parnham, M.J.
Aufsatz in Buch
2018An in vitro test system for compounds that modulate human inflammatory macrophage polarization
Shiratori, H.; Feinweber, C.; Luckhardt, S.; Wallner, N.; Geisslinger, G.; Weigert, A.; Parnham, M.J.
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2018A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes
Kringel, D.; Lippmann, C.; Parnham, M.J.; Kalso, E.; Ultsch, A.; Lötsch, J.
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2018Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains
Bruin, N. de; Ferreirós, N.; Schmidt, M.; Hofmann, M.; Angioni, C.; Geisslinger, G.; Parnham, M.J.
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2018Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation
Hofmann, M.C.J.; Schmidt, M.; Arne, O.; Geisslinger, G.; Parnham, M.J.; Bruin, N.M.W.J. de
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2018The relevance of ceramides and their synthesizing enzymes for multiple sclerosis
Kurz, J.; Brunkhorst, R.; Foerch, C.; Blum, L.; Henke, M.; Gabriel, L.; Ulshöfer, T.; Ferreiros, N.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
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2017Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis
Netzer, C.; Knape, T.; Kuchler, L.; Weigert, A.; Zacharowski, K.; Pfeilschifter, W.; Sempowski, G.; Parnham, M.J.; Brüne, B.; Knethen, A. von
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2017Drugging the pain epigenome
Niederberger, E.; Resch, E.; Parnham, M.J.; Geisslinger, G.
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2017Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis
Schmitz, K.; Brunkhorst, R.; Bruin, N. de; Mayer, C.A.; Häussler, A.; Ferreiros, N.; Schiffmann, S.; Parnham, M.J.; Tunaru, S.; Chun, J.; Offermanns, S.; Foerch, C.; Scholich, K.; Vogt, J.; Wicker, S.; Lötsch, J.; Geisslinger, G.; Tegeder, I.
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2017Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
Maucher, I.V.; Rühl, M.; Kretschmer, S.B.M.; Hofmann, B.; Kühn, B.; Fettel, J.; Vogel, A.; Flügel, K.-T.; Manolikakes, G.; Hellmuth, N.; Häfner, A.-K.; Golghalyani, V.; Ball, A.K.; Piesche, M.; Matrone, C.; Geisslinger, G.; Parnham, M.J.; Karas, M.; Steinhilber, D.; Roos, J.; Maier, T.J.
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2017Nrf2, the master regulator of anti-oxidative responses
Vomund, S.; Schäfer, A.; Parnham, M.J.; Brüne, B.; Knethen, A. von
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2017PPARgamma as a putative stress marker in T cells following kidney transplantation
Aghajaanpour, R.; Brenneis, M.; Köhler, N.; Knape, T.; Büttner, S.; Kuchler, L.; Parnham, M.J.; Bruene, B.; Hauser, I.A.; Knethen, A. von
Abstract
2017Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications
Parnham, M.J.
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2017R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4
Wobst, I.; Ebert, L.; Birod, K.; Wegner, M.-S.; Hoffmann, M.; Thomas, D.; Angioni, C.; Parnham, M.J.; Steinhilber, D.; Tegeder, I.; Geisslinger, G.; Grösch, S.
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2017THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro
Shiratori, H.; Feinweber, C.; Luckhardt, S.; Linke, B.; Resch, E.; Geisslinger, G.; Weigert, A.; Parnham, M.J.
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2016Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE
Tafferner, N.; Barthelmes, J.; Eberle, M.; Ulshöfer, T.; Henke, M.; deBruin, N.; Mayer, C.A.; Foerch, C.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
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2016Drug repurposing for the development of novel analgesics
Sisignano, M.; Parnham, M.J.; Geisslinger, G.
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2016The enigma of ceramide synthase regulation in mammalian cells
Wegner, M.-S.; Schiffmann, S.; Parnham, M.J.; Geisslinger, G.; Grösch, S.
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2016High-throughput analysis of global DNA methylation using methyl-sensitive digestion
Shiratori, H.; Feinweber, C.; Knothe, C.; Lötsch, J.; Thomas, D.; Geisslinger, G.; Parnham, M.J.; Resch, E.
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2016Induction of experimental autoimmune encephalomyelitis in mice and evaluation of the disease-dependent distribution of immune cells in various tissues
Barthelmes, J.; Tafferner, N.; Kurz, J.; de Bruin, N.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
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2016Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis
Bruin, N.M.W.J. de; Schmitz, K.; Schiffrnann, S.; Tafferner, N.; Schmidt, M.; Jordan, H.; Häußler, A.; Tegeder, I.; Geisslinger, G.; Parnham, M.J.
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2016Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques
Beyer, S.; Xie, L.; Schmidt, M.; De Bruin, N.; Ashtikar, M.; Rüschenbaum, S.; Lange, C.M.; Vogel, V.; Mäntele, W.; Parnham, M.J.; Wacker, M.G.
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2016Pparγ Expression in T Cells as a Prognostic Marker of Sepsis
Brenneis, M.; Aghajaanpour, R.; Knape, T.; Sha, L.K.; Neb, H.; Meybohm, P.; Zacharowski, K.; Hauser, I.A.; Buttner, S.; Parnham, M.J.; Brune, B.; Knethen, A. von
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2016Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors
Roos, J.; Grösch, S.; Werz, O.; Schröder, P.; Ziegler, S.; Fulda, S.; Paulus, P.; Urbschat, A.; Kühn, B.; Maucher, I.; Fettel, J.; Vorup-Jensen, T.; Piesche, M.; Matrone, C.; Steinhilber, D.; Parnham, M.J.; Maier, T.J.
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2016Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain
Sisignano, M.; Angioni, C.; Park, C.-K.; Santos, S.M.D.; Jordan, H.; Kuzikov, M.; Liu, D.; Zinn, S.; Hohman, S.W.; Schreiber, Y.; Zimmer, B.; Schmidt, M.; Lu, R.; Suo, J.; Zhang, D.-D.; Schäfer, S.M.G.; Hofmann, M.; Yekkirala, A.S.; De Bruin, N.; Parnham, M.J.; Woolf, C.J.; Ji, R.-R.; Scholich, K.; Geisslinger, G.
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2015Anti-inflammatory macrolides to manage chronic neutrophilic inflammation
Burnet, M.; Guse, J.-H.; Gutke, H.-J.; Guillot, L.; Laufer, S.; Hahn, U.; Seed, M.P.; Valleo, E.; Eggers, M.; McKenzie, D.; Albrecht, W.; Parnham, M.J.
Aufsatz in Buch
2015Different pathophysiological relevance of branched fatty acid metabolism in mice and men: alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis
Mayer, C.A.; Tafferner, N.; Barthelmes, J.; Eberle, M.; Ferreiros, N.; Ulshöfer, T.; Henke, M.; Bruin, N. de; Geisslinger, G.; Foerch, C.; Parnham, M.J.; Schiffmann, S.
Abstract
2015Identification and characterisation of a prototype for a new class of competitive PPAR gamma antagonists
Knape, T.; Flesch, D.; Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Labocha, S.; Ferreirós, N.; Schmid, T.; Wurglics, M.; Schubert-Zsilavecz, M.; Proschak, E.; Brüne, B.; Parnham, M.J.; Knethen, A. von
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2015Inverted perceptual judgment of nociceptive stimuli at threshold level following inconsistent cues
Walter, C.; Dimova, V.; Bu, J.; Parnham, M.J.; Oertel, B.G.; Lötsch, J.
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2015Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein
Lehmann, C.; Homann, J.; Ball, A.-K.; Blöcher, R.; Kleinschmidt, T.K.; Basavarajappa, D.; Angioni, C.; Ferreirós, N.; Häfner, A.-K.; Radmark, O.; Proschak, E.; Haeggström, J.Z.; Geisslinger, G.; Parnham, M.J.; Steinhilber, D.; Kahnt, A.S.
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2015MTTB: A new pharmacological concept for sepsis
Knape, T.; Flesch, D.; Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Nova, N.V.; Labocha, S.; Ferreiros, N.; Schmid, T.; Wacker, M.; Wurglics, M.; Zsilavecz, S.; Proschak, E.; Brune, B.; Parnham, M.J.; Knethen, A. von
Abstract
2015Nanocarriers for photodynamic therapy - rational formulation design and medium-scale manufacture
Villa Nova, M.; Janas, C.; Schmidt, M.; Ulshoefer, T.; Gräfe, S.; Schiffmann, S.; Bruin, N. de; Wiehe, A.; Albrecht, V.; Parnham, M.J.; Bruschi, M.L.; Wacker, M.G.
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2015PPAR(3) expression in human T cells may serve as a new prognostic marker for sepsis outcome
Brenneis, M.; Aghajaanpour, R.; Knape, T.; Hauser, I.A.; Büttner, S.; Neb, H.; Meybohm, P.; Zacharowski, K.; Parnham, M.J.; Brüne, B.; Knethen, A.
Abstract
2014Azithromycin: Mechanisms of action and their relevance for clinical applications
Parnham, M.J.; Haber, V.E.; Giamarellos-Bourboulis, E.J.; Perletti, G.; Verleden, G.M.; Vos, R.
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2014Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators
Homann, J.; Lehmann, C.; Kahnt, A.S.; Steinhilber, D.; Parnham, M.J.; Geisslinger, G.; Ferreirós, N.
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2014R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice
Schmitz, K.; Bruin, N. de; Bishay, P.; Männich, J.; Häussler, A.; Altmann, C.; Ferreirós, N.; Lötsch, J.; Ultsch, A.; Parnham, M.J.; Geisslinger, G.; Tegeder, I.
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2014Role of alpha-metylacyl-CoA racemase in immune cells during the development of experimental autoimmune encephalomyelitis
Tafferner, N.; Männich, J.; Eberle, M.; Ferreiros, N.; Debruin, N.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
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2014Treatment with FTY-720 reverses social recognition deficits without affecting clinical scores or impaired motor performance in EAE in SJL mice
Bruin, N.M.W.J. de; Schmitz, K.; Tegeder, I.; Talmon, S.; Jordan, H.; Schmidt, M.; Haeussler, A.; Geisslinger, G.; Parnham, M.J.
Abstract
2013Common non-epigenetic drugs as epigenetic modulators
Lötsch, J.; Schneider, G.; Reker, D.; Parnham, M.J.; Schneider, P.; Geisslinger, G.; Doehring, A.
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2013The early research and development of ebselen
Parnham, M.J.; Sies, H.
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2013Journal status and new developments
Parnham, M.J.; Battista, J.A. di
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2013Pharmacokinetics of non-intravenous formulations of fentanyl
Lötsch, J.; Walter, C.; Parnham, M.J.; Oertel, B.G.; Geisslinger, G.
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