Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
1991Coenzyme-independent enzymatic synthesis of alpha,alpha-trehalose
Schick, I.; Fleckenstein, J.; Kulbe, K.-D.; Weber, H.
Aufsatz in Buch
1991Cofactor regeneration in continuous enzymatic synthesis
Kulbe, K.-D.
Aufsatz in Buch
1991Development of an extraction scheme and a cellular testing system for screening of immune modulating and antitumoral carbohydrate derivatives from microorganisms and plants
Müller-Kehrmann, H.; Otto, M.K.; Kulbe, K.-D.
Aufsatz in Buch
1991Enzymatic synthesis of polyhydroxy alcohols by new NAD-P-H-dependent microbial enzymes
Haug, I.; Lutz, S.; Scholze, H.A.; Stolz, P.; Wiesner, W.; Heinzler, A.; Kulbe, K.-D.
Aufsatz in Buch
1991New bacteria and enzymes for degradation and modification of natural and low molecular weight heparins
Bohn, J.R.; Otto, M.K.; Kulbe, K.-D.
Aufsatz in Buch
1991Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3.
Kulbe, K.-D.; Mörsberger, F.-M.; Müller, R.; Otto, M.K.
Zeitschriftenaufsatz
1990Aspects of enzymatic dehalogenation of 2-halocarbonic acids with regard to biotechnical application
Kulbe, K.-D.; Mörsberger, F.-M.; Otto, M.
Konferenzbeitrag
1990Bacterial enzymes in halogenation processes
Kulbe, K.-D.; Otto, M.K.; Wiesner, W.
Aufsatz in Buch
1990Cell culture and biotechniques at the Fraunhofer-Institute for surface technology and biochemical engineering
Wissler, J.H.; Chmiel, H.; Graeve, T.; Kulbe, K.-D.
Konferenzbeitrag
1990Continuous coenzyme dependent stereoselective synthesis of sulcatol by alcohol dehydrogenase.
Röthig, T.R.; Bückmann, F.; Carrea, G.; Kulbe, K.-D.
Zeitschriftenaufsatz
1990A continuous enzyme membrane reactor retaining the native nicotinamide cofactor NAD-H.
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Aufsatz in Buch
1990Enzymatic synthesis of L-ascorbic acid 3. L-galactono-Gamma-lactone oxidase from yeasts
Haller, C.-P.; Kulbe, K.-D.; Otto, M.
Konferenzbeitrag
1990Hemocyanin from cell cultures of the sea snail. Megathura crenulata
Graeve, T.; Wirth, U.; Schopf, B.; Schandar, M.; Kulbe, K.-D.
Konferenzbeitrag
1990In vitro assays for testing the influence of biologically active substances on bone formation
Baur, M.; Becker, A.G.; Graeve, T.; Kramer, R.; Kulbe, K.-D.
Konferenzbeitrag
1990Modeling of kinetics of alcohol dehydrogenase from Thermoanaerobium brockii with continuous cofactor regeneration
Röthig, T.R.; Schmidt, K.; Chmiel, H.; Kulbe, K.-D.
Konferenzbeitrag
1990NAD-P-H-dependent reduction of aldehyde sugars and aromatic aldehydes by unspecific aldose reductases from yeasts
Kulbe, K.-D.; Scholze, H.
Konferenzbeitrag
1990Simulation and optimization of biochemical production processes
Decker, E.; Röthig, T.R.; Schmidt, K.; Chmiel, H.; Kulbe, K.-D.
Konferenzbeitrag
1990Simultaneous synthesis of sorbitol and gluconic acid by glucose-fructose-oxidoreductase
Haug, I.; Heinzler, A.; Kulbe, K.-D.
Konferenzbeitrag
1990Umwandlung nachwachsender Rohstoffe. Enzymtechnologische Prozesse ermöglichen eine umweltfreundliche Gewinnung höherwertiger Produkte
Schmidt, K.; Chmiel, H.; Kulbe, K.-D.
Zeitschriftenaufsatz
1989Charged membrane enzyme reactors for continuous regeneration of native coenzymes. I. Processing techniques for NAD(P) regeneration and retention in aqueous systems
Schmidt, K.; Chmiel, H.; Heinzler, A.; Kulbe, K.-D.
Konferenzbeitrag
1989Charged membrane enzyme reactors for continuous regeneration of native coenzymes. II. Synthesis of hydrophobic compounds with NADP(H) dependent dehydrogenases
Röthig, T.R.; Schmidt, K.; Hasenfratz, H.; Chmiel, H.; Kulbe, K.-D.
Konferenzbeitrag
1989Coenzyme-dependent carbohydrate conversions with industrial potential.
Chmiel, H.; Kulbe, K.-D.
Aufsatz in Buch
1989Continuous bromination of barbituric acid by chlorperoxidase from pseudomonas pyrrocinia
Wiesner, W.; Otto, M.K.; Kulbe, K.-D.
Konferenzbeitrag
1989Hirudin from cell cultures of the leech Hirudo medicinalis
Graeve, T.; Schopf, B.; Chmiel, H.; Kulbe, K.-D.
Konferenzbeitrag
1989Simultaneous conversion of glucose/fructose mixtures in a membrane reactor.
Chmiel, H.; Gottlob, A.; Howaldt, M.; Kulbe, K.-D.
Aufsatz in Buch
1989Technische Biochemie
Kulbe, K.-D.
Zeitschriftenaufsatz
1988Bacterial enzymes in halogenation processes
Wiesner, W.; Otto, M.K.; Kulbe, K.-D.
Konferenzbeitrag
1988Cofactor-dependent enzymatic synthesis of mannitol, gluconic acid, and ascorbic acid. I. NADP-dependent microbial mannitol- and hexonate-dehydrogenase - molecular and kinetic properties.
Heinzler, A.; Knopki-Fobo, G.; Kulbe, K.-D.; Müller, R.
Konferenzbeitrag
1988Cofactor-dependent enzymatic synthesis of mannitol, gluconic acid, and ascorbic acid. II. FAD-dependent microbial glucose- and aldono-gamma-lactone oxidases - isolation, stabilization and cofactor regeneration.
Haller, C.P.; Schädel, A.; Kulbe, K.-D.
Konferenzbeitrag
1988Cofactor-dependent enzymatic synthesis of mannitol, gluconic acid, and ascorbic acid. III. Membranes for coenzyme retention and product recovery.
Schmidt, K.; Röthig, T.R.; Muth, W.; Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1988Continuous enzyme membrane reactors retaining the native nicotinamide cofactors.
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1988Effect of phenolic compounds on cellulose degradation by some white rot basidiomycetes
Müller, H.W.; Kulbe, K.-D.; Trösch, W.
Zeitschriftenaufsatz
1988Enzymatic process for vitamin C-synthesis. 1. D-galacturonic acid from pectin.
Gudernatsch, W.; Heinzler, A.; Knopki-Fobo, G.; Kulbe, K.-D.
Konferenzbeitrag
1988Enzymatic transformation of carbohydrates by continous redox and phosphate transfer processes.
Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1988Enzymtechnologie und nachwachsende Rohstoffe
Kulbe, K.-D.
Zeitschriftenaufsatz
1988In-vitro-Testung osteogener Substanzen
Kramer, R.; Schopf, B.; Kulbe, K.-D.
Zeitschriftenaufsatz
1988Simplified detection of biological dehalogenation with a halide sensor
Otto, M.K.; Mörseberger, F.; Müller, R.; Schenk, T.; Thiele, J.; Kulbe, K.-D.
Konferenzbeitrag
1988Survival of porcine islets of Langerhans after freezing with different cooling rates and cryoprotective agents.
Schilling, G.; Kulbe, K.-D.
Konferenzbeitrag
1987Coenzyme-dependent carbohydrate conversions with industrial potential
Chmiel, H.; Kulbe, K.-D.
Konferenzbeitrag
1987Coenzyme-dependent enzymatic synthesis of fine chemicals. Enzymatic synthesis of L-ascorbic acid via uronic acids. 2. L-hexonate dehydrogenase from yeasts
Knopki-Fobo, G.; Kulbe, K.-D.
Konferenzbeitrag
1987Coenzyme-depenent enzymatic synthesis of fine chemicals. Optimization of enzyme reactors with an external filtration unit
Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1987Conjugated NAD+-dependent dehydrogenases for the continuous production of mannitol and gluconic acid from glucose-fructose mixtures in a membrane reactor
Howaldt, M.; Kulbe, K.-D.; Schwab, U.
Aufsatz in Buch
1987Continuous hydrogen and phosphate transfer reactions in enzyme catalyzed carbohydrate conversion processes
Kulbe, K.-D.
Konferenzbeitrag
1987Continuous synthesis of fine chemicals by cofactor dependent enzymes with simultaneous cofactor regeneration
Haller, C.P.; Hasenfratz, H.; Schädel, A.; Weber, H.; Gudernatsch, W.; Heinzler, A.; Howaldt, M.; Knopki-Fobo, G.; Kulbe, K.-D.
Aufsatz in Buch
1987Coupled enzyme systems with conjugated coenzyme regeneration in membrane reactors with an external filtration unit
Chmiel, H.; Gottlob, A.; Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1987D-Galacturonic acid and oligogalacturonic acid by enzymatic pectin degradation, chromatography, and membrane reactor integrated electrodialysis
Gudernatsch, W.; Heinzler, A.; Knopki-Fobo, G.; Kulbe, K.-D.
Konferenzbeitrag
1987Einfluß der Tiefkühlkonservierung auf die Isolierung und Funktionsfähigkeit von Langerhans'schen Inseln
Lutz, G.; Kulbe, K.-D.
Konferenzbeitrag
1987Einfluß der Tiefkühlkonservierung auf die Isolierung und Funktionsfähigkeit von Langerhans'schen Inseln
Lutz, G.; Kulbe, K.-D.
Zeitschriftenaufsatz
1987Der Einfluß fischölreicher Diät auf den Fettstoffwechsel bei chronischen Hämodialysepatienten
Schmitt, Y.; Fuchs, G.; Kulbe, K.-D.; Schneider, H.
Zeitschriftenaufsatz
1987Enzymatic synthesis of L-ascorbic acid via D-uronic acids. Membrane-reactor integrated recovery of D-galacturonic acid from pectin hydrolysates.
Heinzler, A.; Knopki-Fobo, G.; Kulbe, K.-D.
Konferenzbeitrag
1987Enzyme-catalyzed production of mannitol and gluconic acid.
Gudernatsch, W.; Kulbe, K.-D.; Schwab, U.
Aufsatz in Buch
1987Heparin-abbauende Enzyme aus Mikroorganismen
Otto, M.K.; Kimmerle, I.; Hartmann, H.; Weber, H.; Kulbe, K.-D.
Konferenzbeitrag
1987Heparin-degrading enzymes - screening, selection and mutation of new microorganisms
Kimmerle, I.; Hartmann, H.; Otto, M.K.; Weber, H.; Kulbe, K.-D.
Konferenzbeitrag
1987Immobilized artificial electron acceptors to improve the long-term performance of oxidase-catalyzed reactions
Schädel, A.; Kulbe, K.-D.
Konferenzbeitrag
1987Microbial enzymes for the production of low molecular weight heparins with different biological activity
Kimmerle, I.; Hartmann, H.; Otto, M.K.; Weber, H.; Kulbe, K.-D.
Konferenzbeitrag
1987Minimizing enzyme requirement by choice of appropriate reactor type.
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Aufsatz in Buch
1987NADPH-dependent oxido-reductases for the synthesis of fine chemicals
Bückmann, A.F.; Carrea, G.; Kulbe, K.-D.
Konferenzbeitrag
1987Optimization of performance of an enzyme membrane reactor - computer simulation and experimental results.
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1987Optimization of reactor performance for coenzyme dependent enzyme reactions - computer simulation and experiments.
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1987Simplified detection of biological halogenation and dehalogenation with a halide sensor
Otto, M.K.; Müller, R.; Chmiel, H.; Kulbe, K.-D.
Konferenzbeitrag
1987Vereinfachte Messung biologischer Halogenisierungsreaktionen mit einem Halogenidsensor
Otto, M.K.; Müller, R.; Schenk, T.; Thiele, J.; Kulbe, K.-D.
Konferenzbeitrag
1986Anwendung von Membranverfahren bei der simultanen Herstellung von Mannitol und Gluconsaeure aus Saccharose durch konjugierte NAD hoch plus-abhaengige Dehydrogenasen
Howaldt, M.; Kimmerle, K.; Kulbe, K.-D.; Schwab, U.
Aufsatz in Buch
1986Bioartificial pancreas based on cryopreserved islets of Langerhans
Lutz, G.; Kulbe, K.-D.
Zeitschriftenaufsatz
1986Choice of reactor to minimize enzyme requirement - 1. Mathematical model for one-substrate Michaelis-Menten type kinetics in continuous reactors
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Zeitschriftenaufsatz
1986Continuous enzymatic conversion of glucose-fructose mixtures into gluconic acid and sorbitol or mannitol within a hollow fiber membrane reactor
Kulbe, K.-D.; Schwab, U.; Gudernatsch, W.; Hasenfratz, H.; Howaldt, M.; Kimmerle, K.; Otto, M.K.
Aufsatz in Buch
1986Enzyme-catalyzed production of mannitol and gluconic acid. Product recovery by various procedures
Gudernatsch, W.; Kulbe, K.-D.; Schwab, U.
Konferenzbeitrag
1986In vitro and in vivo studies with a non-aluminium phosphate binding compound
Schneider, H.-W.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Zeitschriftenaufsatz
1986Minimizing enzyme requirements by choice of appropriate reactor type. Computer simulation and experimental results
Chmiel, H.; Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1986Rhesus monkey C 3 monoclonal antibodies for testing hemocompatibility of membrane materials
Wild, T.; Kulbe, K.-D.
Zeitschriftenaufsatz
1986Simultaneous enzymatic synthesis of mannitol -Sorbitol- and gluconic acid in a membrane reactor. I. Enzymes
Kulbe, K.-D.; Schwab, U.
Konferenzbeitrag
1986Simultaneous enzymatic synthesis of mannitol -Sorbitol- and gluconic acid in a membrane reactor. III. Membrane reactor development
Howaldt, M.; Kulbe, K.-D.
Konferenzbeitrag
1986Simultaneous enzymatic synthesis of mannitov -Sorbitol- and gluconic acid in a membrane reactor. II. Coenzyme derivatives and product recovery
Hasenfratz, H.; Schwab, U.; Gudernatsch, W.; Kulbe, K.-D.
Konferenzbeitrag
1985Alternative concept and procedure for enzymatic inactivation of heparin
Metzger, I.; Kulbe, K.-D.; Weber, H.
Konferenzbeitrag
1985Aluminium-free oral phosphate binder
Schneider, H.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Zeitschriftenaufsatz
1985Conjugated NAD+-dependent dehydrogenases for the continous production of mannitol and gluconic acid from glucose-fructose mixtures in membrane reactor
Howaldt, M.; Kulbe, K.-D.; Schwab, U.
Konferenzbeitrag
1985Konjugierte und intrasequentielle Cofaktor-Regenerierung als alternative Konzepte für die ökonomische Durchführung enzymkatalisierter Redoxreaktionen
Knopki-Fobo, G.; Kulbe, K.-D.; Schwab, U.
Konferenzbeitrag
1984Aluminium-free intestinal phosphate binding
Schneider, H.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Zeitschriftenaufsatz
1984Aluminium-free oral phosphate binder
Schneider, H.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Aufsatz in Buch
1984Aluminium-free oral phosphate binder
Schneider, H.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Zeitschriftenaufsatz
1984Analysis of coupled thermal and osmotic phenomena in the cryopreservation of living tissue
Diller, K.R.; Kulbe, K.-D.
Konferenzbeitrag
1984Biological pretreatment of wheat straw for biogas production
Mueller, W.; Kulbe, K.-D.; Troesch, W.
Aufsatz in Buch
1984Cryopreservation of pig islets of Langerhans - Effects of cooling rates and different Cryoprotectants
Lutz, G.; Diller, K.R.; Kulbe, K.-D.
Aufsatz in Buch
1984Economic coenzyme regeneration by conjugated enzyme reactions generating two requested products simultaneously. Gluconic acid and polyhydroxy alcohols from glucose-fructose mixtures
Kulbe, K.-D.; Schwab, U.
Aufsatz in Buch
1984Enzymatische Synthese von L-Ascorbinsäure -Vitamin C-
Kulbe, K.-D.
Aufsatz in Buch
1984Enzymreaktoren in der Medizinischen Verfahrenstechnik und Lebensmitteltechnologie
Chmiel, H.; Kulbe, K.-D.
Aufsatz in Buch
1984GC- and HPLC-analysis of volatile fatty acids and alcohols in a two-stage anaerobic fermentation process
Hasenfratz, H.; Kulbe, K.-D.; Troesch, W.
Aufsatz in Buch
1984The macroscopic solidification process during the freezing of biological specimens with cryoprotective additives
Diller, K.R.; Lutz, G.; Kulbe, K.-D.
Aufsatz in Buch
1984Microbial acetate conversion to methane - Kinetics, yields and pathways in a two step digestion process
Chmiel, H.; Kulbe, K.-D.; Troesch, W.; Weber, H.
Zeitschriftenaufsatz
1984Natural polymers for phosphate binding in uremic patients
Schneider, H.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Aufsatz in Buch
1983High effective aluminium free intestinal phosphate binder. In vitro and in vivo studies
Schneider, H.; Kulbe, K.-D.; Streicher, E.; Weber, H.
Aufsatz in Buch
19823-phosphoglycerate kinase form bovine liver and yeast
Kulbe, K.-D.; Bojanovski, M.
Aufsatz in Buch
19823-Phosphoglycerate kinase, bovine liver and yeast
Bojanovski, M.; Kulbe, K.-D.
Aufsatz in Buch
1982Displacement of Toxins from their Protein complexes by specific interacting substances
Hasenfratz, H.; Chmiel, H.; Kern, P.; Kulbe, K.-D.
Konferenzbeitrag
1982Immobilization of heparin on cellulosic membranes to improve their biocompatibility
Hasenfratz, H.; Knaup, G.; Kulbe, K.-D.
Zeitschriftenaufsatz
1982Improvement of the blood compatibility of cellulosic membranes through the immobilization of Heparin
Hasenfratz, H.; Knaup, G.; Kulbe, K.-D.
Aufsatz in Buch
1982Simultaneous purification of D-glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase and phosphoglycerate mutase from liver and muscle, pig
Foellmer, H.; Fuchs, K.; Kulbe, K.-D.
Aufsatz in Buch
1982Simultaneous purification of glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and phosphoglycerate mutase from pig liver and muscle
Foellmer, H.; Fuchs, J.; Kulbe, K.-D.
Aufsatz in Buch
1981Heparin fixation into cellulosic membranes to improve their antithrombogenicity
Hasenfratz, H.; Knaup, G.; Kulbe, K.-D.
Zeitschriftenaufsatz
1981The influence in plasma seperation modules of pressure and flow conditions on the filtration properties and cell deposition
Chmiel, H.; Kulbe, K.-D.; Stroh, N.; Troesch, W.
Zeitschriftenaufsatz
1981Measurement of biological heparin activities on heparinized cellulosic membranes
Hasenfratz, H.; Knaup, G.; Kulbe, K.-D.
Konferenzbeitrag
1981New techniques for simultaneous purification of consecutive enzymes from the same cell extract
Schmidt, H.; Kaiser, A.; Kulbe, K.-D.
Konferenzbeitrag
1981Plasma seperation modules - the influence of pressure, flow conditions and membrane surface composition on the filtration properties and cell deposition
Walitza, E.; Chmiel, H.; Kulbe, K.-D.; Stroh, N.; Troesch, W.
Zeitschriftenaufsatz
1981An urease based adsorptive hemofiltrate regeneration system
Hasenfratz, H.; Kulbe, K.-D.
Konferenzbeitrag
1981An urease based adsorptive hemofiltrate regeneration system
Hasenfratz, H.; Kulbe, K.-D.
Zeitschriftenaufsatz
1981Verfahren zur Regeneration von Haemofiltrat
Hasenfratz, H.; Kulbe, K.-D.
Zeitschriftenaufsatz