Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis
Prasse, Antje; Binder, Harald; Schupp, Jonas C.; Kayser, Gian; Bargagli, Elena; Jäger, Benedikt; Hess, Moritz; Rittinghausen, Susanne; Vuga, Louis; Lynn, Heather; Violette, Shelia; Jung, Birgit; Quast, Karsten; Vanaudenaerde, Bart; Xu, Yan; Hohlfeld, Jens M.; Krug, Norbert; Herazo-Maya, Jose D.; Rottoli, Paola; Wuyts, Wim A.; Kaminski, Naftali
Zeitschriftenaufsatz
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
Zeitschriftenaufsatz
2019Identification and prospective stability of electronic nose (eNose) - derived inflammatory phenotypes in patients with severe asthma
Brinkman, P.; Wagener, A.H.; Hekking, P.-P.; Bansal, A.T.; Zee, A.-H. Maitland-van der; Wang, Y.; Weda, H.; Knobel, H.H.; Vink, T.J.; Rattray, N.J.; D'Amico, A.; Pennazza, G.; Santonico, M.; Lefaudeux, D.; Meulder, B. de; Auffray, C.; Bakke, P.S.; Caruso, M.; Chanez, P.; Chung, K.F.; Corfield, J.; Dahlén, S.-E.; Djukanovic, R.; Geiser, T.; Horvath, I.; Krug, Norbert; Musial, J.; Sun, K.; Riley, J.H.; Shaw, D.E.; Sandström, T.; Sousa, A.R.; Montuschi, P.; Fowler, S.J.; Sterk, P.J.
Zeitschriftenaufsatz
2019Interferon Response Genes in Nasal Epithelium to Rhinovirus16 Challenge in Asthma Patients Links to Viral Clearance and Common Cold Scores
Ravi, A.; Chang, M.; Pol, M.A. van de; Yang, S.; Aliprantis, Antonios; Thornton, Bob; Hohlfeld, Jens M.; Sterk, Peter J.; Krug, Norbert; Lutter, René
Abstract
2019Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma
Tariq, K.; Schofield, James P.R.; Nicholas, Ben; Burg, Dominic; Brandsma, Joost; Bansal, Aruna T.; Wilson, Susan J.; Lutter, René; Fowler, Stephen J.; Bakke, Per; Caruso, Massimo; Dahlén, Barbro; Horvath, Ildiko; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandstrom, Thomas; Geiser, Thomas; Pandis, Ioannis; Sousa, Ana R.; Adcock, Ian M.; Shaw, Dominick E.; Auffray, Charles; Howarth, Peter H.; Sterk, Peter J.; Chung, Kian Fan; Skipp, Paul J.; Dimitrov, Borislav; Djukanovic, Ratko
Zeitschriftenaufsatz
2018A computational framework for complex disease stratification from multiple large-scale datasets
Meulder, Bertrand de; Lefaudeux, Diane; Bansal, Aruna T.; Mazein, Alexander; Chaiboonchoe, Amphun; Ahmed, Hassan; Balaur, Irina; Saqi, Mansoor; Pellet, Johann; Ballereau, Stephane; Lemonnier, Nathanaël; Sun, Kai; Pandis, Ioannis; Yang, Xian; Batuwitage, Manohara; Kretsos, Kosmas; Eyll, Jonathan van; Bedding, Alun; Davison, Timothy; Dodson, Paul; Larminie, Christopher; Postle, Anthony; Corfield, Julie; Djukanović, Ratko; Chung, Kian Fan; Adcock, Ian M.; Guo, Yi-Ke; Sterk, Peter J.; Manta, Alexander; Rowe, Anthony; Baribaud, Frédéric; Auffray, Charles; Badorrek, Philipp; Faulenbach, Cornelia; Braun, Armin; Hohlfeld, Jens; Krug, Norbert
Zeitschriftenaufsatz
2018Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort
Emma, Rosalia; Bansal, Aruna T.; Kolmert, Johan; Wheelock, Craig E.; Dahlén, Sven-Erik; Loza, Matthew J.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Dahlén, Barbro; Bakke, Per S.; Chanez, Pascal; Fowler, Stephen J.; Horvath, Ildiko; Montuschi, Paolo; Krug, Norbert; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Fleming, Louise J.; Djukanovic, Ratko; Howarth, Peter H.; Singer, Florian; Sousa, Ana R.; Sterk, Peter J.; Corfield, Julie; Pandis, Ioannis; Chung, Kian F.; Adcock, Ian M.; Lutter, René; Fabbella, Lorena; Caruso, Massimo
Zeitschriftenaufsatz
2018Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome
Burg, Dominic; Schofield, James P.R.; Brandsma, Joost; Staykova, Doroteya; Folisi, Caterina; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horvath, Ildiko; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian F.; Sterk, Peter J.; Djukanovic, Ratko; Skipp, Paul J.
Zeitschriftenaufsatz
2018Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers
Brandsma, Joost; Goss, Victoria M.; Yang, Xian; Bakke, Per S.; Caruso, Massimo; Chanez, Pascal; Dahlén, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Chung, Kian Fan; Singer, Florian; Fleming, Louise J.; Sousa, Ana R.; Pandis, Ioannis; Bansal, Aruna T.; Sterk, Peter J.; Djukanović, Ratko; Postle, Anthony D.
Zeitschriftenaufsatz
2018Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort
Alahmadi, Fahad; Simpson, Andrew; Gomez, Christina; Wheelock, Craig; Shaw, Dominick E.; Fleming, Louise; Roberts, Graham; Riley, John; Bates, Stewart; Sousa, Ana R.; Knowles, Richard; Bansal, Aruna T.; Corfield, Julie; Pandis, Ioannis; Sun, Kai; Bakke, Per; Caruso, Massimo; Chanez, Pascal; Dahlen, Babro; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sandstrom, Thomas; Singer, Florian; Wagers, Scott; Adcock, Ian M.; Djukanović, Ratko; Chung, Kian Fan; Sterk, Peter J.; Dahlén, Sven-Erik; Fowler, Stephen J.
Abstract
2018Periostin expression in the U-BIOPRED severe asthma bronchoscopy cohort
Wilson, Susan Jane; Faruqi, Ali; Ward, Jonathan A.; Norman, Jenny; Sousa, Ana R.; Corfield, Julie; Sterk, Peter J.; Chung, Fan; Djukanović, Ratko; Dahlén, Barbro; Chanez, Pascal; Shaw, Dominick E.; Krug, Norbert; Sandstrom, Thomas; Howarth, Peter; Holweg, Cecile
Abstract
2018Rhinovirus challenge in asthmatics and healthy volunteers to evaluate the safety and appropriate dose of a GMP human rhinovirus 16 preparation for challenge studies in mild-moderate asthmatics taking ICS
Krug, Norbert; Hohlfeld, Jens M.; Aliprantis, Antonios; Carayannopoulos, Leonidas; Bautmans, An; Robberechts, Martine; Lepeleire, Inge de; Ziehr, Holger; Singh, Dave; Diamant, Zuzana; Yang, Shan; Fitch, Neil; Thornton, Bob; Sterk, Peter J.; Lutter, René
Abstract
2018Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: An exploratory analysis
Takahashi, Kentaro; Pavlidis, Stelios; Ng Kee Kwong, Francois; Hoda, Uruj; Rossios, Christos; Sun, Kai; Loza, Matthew; Baribaud, Fred; Chanez, Pascal; Fowler, Steve J.; Horvath, Ildiko; Montuschi, Paolo; Singer, Florian; Musial, Jacek; Dahlén, Barbro; Dahlén, Sven-Erik; Krug, Norbert; Sandström, Thomas; Shaw, Dominick E.; Lutter, René; Bakke, Per; Fleming, Louise J.; Howarth, Peter H.; Caruso, Massimo; Sousa, Ana R.; Corfield, Julie; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Djukanovic, Ratko; Sterk, Peter J.; Guo, Yike; Adcock, Ian M.; Chung, Kian Fan
Zeitschriftenaufsatz
2018Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA
Schofield, James P.R.; Bigler, Jeanette; Boedigheimer, Michael; Affleck, Karen; Taylor, Adam; Pavlidis, Stelios; Riley, John H.; Strazzeri, Fabio; Roberts, Graham; Brandsma, Joost; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Per, Bakke; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horváth, Ildikó; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandstrom, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Knowles, Richard; Fitch, Neil; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian Fan; Sterk, Peter J.; Skipp, Paul; Djukanović, Ratko
Abstract
2018U-BIOPRED accessible handprint: Combining omics platforms to identify stable asthma subphenotypes
Meulder, Bertrand de; Yen, Romain Tching Chi; Li, Chuan-Xing; Wheelock, Asa; Chung, Kian Fan; Adcock, Ian M.; Djukanović, Ratko; Wagers, Scott; Riley, John; Erpenbeck, Veit J.; Bakke, Per; Caruso, Massimo; Chanez, Pascal; Dahlén, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Shaw, Dominic; Singer, Florian; Pandis, Ioannis; Bansal, Aruna T.; Sterk, Peter J.; Baribaud, Frédéric; Auffray, Charles
Abstract
2017Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure
Badorrek, Philipp; Müller, Meike; Koch, Wolfgang; Hohlfeld, Jens M.; Krug, Norbert
Zeitschriftenaufsatz
2017A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED
Kuo, C.H.S.; Pavlidis, S.; Loza, M.; Baribaud, F.; Rowe, A.; Pandis, I.; Hoda, U.; Rossios, C.; Souse, A.; Wilson, S.J.; Howarth, P.; Dahlen, B.; Dahlen, S.E.; Chanez, P.; Shaw, D.; Krug, Norbert; Sandström, T.; Meulder, B. de; Lefaudeux, D.; Fowler, S.; Fleming, L.; Corfield, J.; Auffray, C.; Sterk, P.J.; Djukanovic, R.; Guo, Y.K.; Adcock, I.M.; Chung, K.F.
Zeitschriftenaufsatz
2016Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber
Lüer, Katrin; Biller, Heike; Casper, Anja; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, A.; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2016Severe asthma exists despite suppressed tissue inflammation: Findings of the U-BIOPRED study
Wilson, Susan J.; Ward, Jonathan A.; Sousa, Ana R.; Corfield, Julie; Bansal, Aruna T.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Loza, Matthew J.; Baribaud, Frédéric; Fitch, Neil; Sterk, Peter J.; Chung, Kian Fan; Gibeon, David; Sun, Kai; Guo, Yi-Ke; Adcock, Ian M.; Djukanovic, Ratko; Dahlén, Barbro; Chanez, Pascal; Shaw, Dominick E.; Krug, Norbert; Hohlfeld, Jens; Sandström, Thomas; Howarth, Peter H.
Zeitschriftenaufsatz
2015Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
Krug, Norbert; Hohlfeld, Jens Michael; Kirsten, Anne-Marie; Kornmann, Oliver; Beeh, Kai-Michael; Kappeler, Dominik; Korn, Stephanie; Ignatenko, Stanislav; Timmer, Wolfgang; Rogon, Cordelia; Zeitvogel, Jana; Zhang, Nan; Bille, Joachim; Homburg, Ursula; Turowska, Agnieszka; Bachert, Claus; Werfel, Thomas; Buhl, Roland; Renz, Jonas; Garn, Holger; Renz, Harald
Zeitschriftenaufsatz
2015Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Shaw, Dominick E.; Sousa, Ana R.; Fowler, Stephen J.; Fleming, Louise J.; Roberts, Graham; Corfield, Julie; Pandis, Ioannis; Bansal, Aruna T.; Bel, Elisabeth H.; Auffray, Charles; Compton, Chris H.; Bisgaard, Hans; Bucchioni, Enrica; Caruso, Massimo; Chanez, Pascal; Dahlén, Barbro; Dahlén, Sven-Erik; Dyson, Kerry; Frey, Urs; Geiser, Thomas; Gerhardsson de Verdier, Maria; Gibeon, David; Guo, Yi-Ke; Hashimoto, Simone; Hedlin, Gunilla; Jeyasingham, Elizabeth; Hekking, Pieter-Paul W.; Higenbottam, Tim; Horváth, Ildikó; Knox, Alan J.; Krug, Norbert; Erpenbeck, Veit J.; Larsson, Lars X.; Lazarinis, Nikos; Matthews, John G.; Middelveld, Roelinde; Montuschi, Paolo; Musial, Jacek; Myles, David; Pahus, Laurie; Sandström, Thomas; Seibold, Wolfgang; Singer, Florian; Strandberg, Karin; Vestbo, Jorgen; Vissing, Nadja; Garnier, Christophe von; Adcock, Ian M.; Wagers, Scott; Rowe, Anthony; Howarth, Peter; Wagener, Ariane H.; Djukanovic, Ratko; Sterk, Peter J.; Chung, Kian Fan
Zeitschriftenaufsatz
2015Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis
Badorrek, Philipp; Hohlfeld, Jens M.; Krug, Norbert; Joshi, Abhijeet; Raut, Atul
Zeitschriftenaufsatz
2015Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Schaumann, Frank; Müller, Meike; Scholl, Dorothea; Hidi, R.; McLeod, Alison; Krug, Norbert; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2015Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: A proof of concept study
Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Winkler, Carla; Faulenbach, Cornelia; Jakob, Peter; Schaumann, Frank; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Zeitschriftenaufsatz
2015Pharmacological MRI (phMRI) of the human central nervous system
Lanfermann, Heinrich; Schindler, Chris; Jordan, Jens; Krug, Norbert; Raab, Peter
Zeitschriftenaufsatz
2015Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
Homburg, Ursula; Renz, Harald; Timmer, Wolfgang; Hohlfeld, Jens M.; Seitz, Friedeborg; Lüer, Katrin; Mayer, Alexandra; Wacker, Anja; Schmidt, Oliver; Kuhlmann, Jens; Turowska, Agnieszka; Roller, Julia; Kutz, Klaus; Schlüter, Gerhard; Krug, Norbert; Garn, Holger
Zeitschriftenaufsatz
2014Cell counting in human endobronchial biopsies - disagreement of 2D versus 3D morphometry
Bratu, Vlad A.; Erpenbeck, Veit J.; Fehrenbach, Antonia; Rausch, Tanja; Rittinghausen, Susanne; Krug, Norbert; Hohlfeld, Jens M.; Fehrenbach, Heinz
Zeitschriftenaufsatz
2014Dose-range finding of natural birch pollen exposure in patients with seasonal allergic rhinitis in the Fraunhofer Environmental Challenge Chamber
Lüer, Katrin; Windt, Horst; Schwarz, Katharina; Badorrek, Philipp; Sebastian, Ramona; Haefner, Dietrich; Koch, Wolfgang; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014The effect of controlled exposure to grass pollen in an environmental challenge chamber on dermal symptoms in patients with atopic dermatitis
Heratizadeh, Annice; Badorrek, Philipp; Niebuhr, Margarete; Erpenbeck, Veit Johannes; Lösche, C.; Krug, Norbert; Hohlfeld, Jens Michael; Werfel, Thomas
Abstract
2014Effect of sample processing on the analysis of IL4, IL5, and IL13 in sputum supernatants
Holz, Olaf; Müller, Meike; Ignatenko, Stanislav; Kappeler, Dominik; Buhl, Roland; Beeh, Kai-Michael; Kornmann, Oliver; Kirsten, Anne; Homburg, Ursula; Garn, Holger; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Otmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Zeitschriftenaufsatz
2014Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis
Krug, Norbert; Gupta, Abhy; Badorrek, Philipp; Koennen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M.; Wood, Chester
Zeitschriftenaufsatz
2014Omalizumab in patients with allergic (IgE-mediated) asthma and IgE/bodyweight combinations above those in the initially approved dosing table
Kornmann, Oliver; Watz, Henrik; Fuhr, Rainard; Krug, Norbert; Erpenbeck, Veit J.; Kaiser, Guenther
Zeitschriftenaufsatz
2014Phase-contrast MRI for detection of mild systemic hemodynamic response after segmental allergen challenge in asthmatic patients
Hinrichs, Jan; Schaumann, Frank; Renne, Julius; Schönfeld, Christian; Faulenbach, Cornelia; Winkler, Carla; Gutberlet, Marcel; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Zeitschriftenaufsatz
2014Prevalence and phenotypic characteristics of severe adult-onset asthma in the U-Biopred cohort
Hekking, Pieter-Paul; Wagener, Ariane H.; Sousa, Ana R.; Fowler, Stephen J.; Bakke, Per; Frey, Urs; Krug, Norbert; Hashimoto, Simone; Woodcock, Ashley; Chanez, Pascal; Montuschi, Paolo; Bisgaard, Hans; Corfield, Julie; Howarth, Peter H.; Djukanovic, Ratko; Chung, Kian Fan; Fleming, Louise; Riley, John; Jeyasingham, Elisabeth; Fichtner, Klaus; Rowe, Anthony; Roberts, Graham; Singer, Florian; Geiser, Thomas; Horvath, Ildiko; Riccardo, Polosa; Vissing, Nadja H.; Dahlen, Babro; Musial, Jacek; Murray, Clare S.; Myles, David; Compton, Chris; Higenbottam, Tim W.; Vestbo, J.; Pahus, Laurie; Larsson, Lars; Sandstrom, Thomas; Shaw, Dominic; Wagers, Scott S.; Sterk, Peter J.; Bansal, Aruna T.; Bel, Elisabeth
Abstract
2014Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging
Vogel-Claussen, Jens; Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Schaumann, Frank; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens Michael
Zeitschriftenaufsatz
2014Severe asthma patients on oral corticosteroid therapy as a distinct phenotype: The european U-BIOPRED cohort
Chung, Kian F.; Gibeon, David; Sousa, Ana R.; Corfield, Julie; Shaw, Dominick E.; Fowler, Stephen J.; Fleming, Louise J.; Riley, John; Jeyasingham, Elisabeth; Rowe, Anthony; Fichtner, Klaus; Roberts, Graham; Bakke, Per; Garnier, Christophe von; Horvath, Ildiko; Riccardo, Polosa; Krug, Norbert; Dahlen, Barbaro; Musial, Jacek; Pahus, Laurie; Myles, David; Compton, Chris; Higenbottam, Tim W.; Montuschi, Paolo; Larsson, Lars; Sandstrom, Thomas; Wagers, Scott S.; Howarth, Peter H.; Bel, Elisabeth; Bansal, Aruna T.; Djukanovic, Ratko; Sterk, Peter J.
Abstract
2013Associated factors with persistent airflow limitation in asthma in U-BIOPRED
Wagener, A.H.; Gibeon, D.; Yang, X.; Sousa, A.R.; Corfield, J.; Shaw, D.E.; Fowler, S.; Flemming, L.J.; Riley, J.; Jeyasingham, E.; Rowe, A.; Fichtner, K.; Robberts, G.; Bakke, P.; Singer, T.; Geiser, T.; Frey, U.; Horvarth, I.; Polosa, R.; Bonnelykke, K.; Krug, Norbert; Middelveld, R.; Dahlen, S.-E.; Dahlen, B.; Hedlin, G.; Hashimoto, S.; Nordlund, B.; Musial, J.; Woodcock, A.; Murray, C.S.; Pahus, L.; Chanez, P.; Myles, D.; Compton, C.; Higenbottam, T.W.; Montuschi, P.; Vestbo, J.; Larsson, L.; Sandstrom, T.; Bisgaard, H.; Wagers, S.S.; Howarth, P.H.; Bel, E.H.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.
Zeitschriftenaufsatz, Konferenzbeitrag
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2013Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
Janssen, Ole; Schaumann, Frank; Holz, Olaf; Lavae-Mokhtari, Bianca; Welker, Lutz; Winkler, Carla; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2013Safety profile and pharmacokinetics of an inhaled GATA-3-specific DNAzyme in a phase Ib study in patients with stable allergic asthma
Hohlfeld, Jens; Lüer, Katrin; Krug, Norbert; Turowska, Agnieszka; Renz, Harald; Garn, Holger; Homburg, Ursula
Zeitschriftenaufsatz, Konferenzbeitrag
2013U-BIOPRED asthma cohort: Inflammatory markers and corticosteroid use
Gibeon, D.; Wagener, A.H.; Yang, X.; Sousa, A.R.; Corfield, J.; Shaw, D.E.; Fowler, S.; Flemming, L.J.; Jeyasingham, E.; Rowe, A.; Fichtner, K.; Robberts, G.; Bakke, P.; Singer, T.; Geiser, T.; Frey, U.; Horvarth, I.; Polosa, R.; Bonnelykke, K.; Krug, Norbert; Middelveld, R.; Dahlen, S.-E.; Dahlen, B.; Hedlin, G.; Hashimoto, S.; Nordlund, B.; Musial, J.; Woodcock, A.; Murray, C.S.; Pahus, L.; Myles, D.; Compton, C.; Higenbottam, T.W.; Montuschi, P.; Vestbo, J.; Larsson, L.; Sandstrom, T.; Bisgaard, H.; Wagers, S.S.; Howarth, P.H.; Bel, E.H.; Djukanovic, R.; Sterk, P.J.; Chung, K.F.
Zeitschriftenaufsatz, Konferenzbeitrag
2012Acute ozone induced airway inflammation does not effect resting human sympathetic nerve traffic
Tank, J.; Biller, Heike; Heusser, K.; Holz, Olaf; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, Wolfgang; Krug, Norbert; Jordan, J.; Hohlfeld, Jens
Zeitschriftenaufsatz, Konferenzbeitrag
2012Die Bedeutung von Pollen und Starch Granules bei der Allergie der Atemwege
Emmert, Lorenz Samy
: Krug, Norbert (Doktorvater)
Dissertation
2012CRTH2 antagonist, BI 671800 (BI), reduces nasal symptoms and inhibits nasal cytokines and eosinophils in SAR patients exposed to grass pollen in an environmental challenge chamber (ECC)
Krug, Norbert; Gupta, A.; Badorrek, Philipp; Müller, Meike; Casper, Anja; Pivovarova, A.; Hilbert, J.; Koenen, R.; Hohlfeld, Jens M.; Wood, C.
Abstract
2012Depletion of neutrophils from induced sputum using a novel bead and sieve-separation system
Holz, Olaf; Schaumann, Frank; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Krug, Norbert; Heinrich, J.M.; Hohlfeld, Jens M.
Abstract
2012Experience with an allergen challenge chamber for clinical trials in allergic rhinitis
Krug, Norbert; Badorrek, Phillipp; Hohlfeld, Jens Michael
Zeitschriftenaufsatz, Konferenzbeitrag
2012Low-dose endotoxin inhalation in healthy volunteers: A challenge model for early clinical drug development of novel anti-inflammatory compounds
Schaumann, Frank; Holz, Olaf; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Abstract
2012Pollen starch granules in bronchial inflammation
Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert
Zeitschriftenaufsatz
2012Reproducibility of serum biomarkers and relationship to airway inflammation following LPS challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Faulenbach, Cornelia; Müller, Meike; Krug, Norbert; McLeod, Alison; Hohlfeld, Jens M.
Abstract
2012Safety and efficacy of house dust mite allergen challenge in patients with allergic rhinitis using a novel technique for inhalation studies in the Fraunhofer environmental challenge chamber
Lueer, Katrin; Biller, Heike; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, Armin; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Abstract
2012Semi-quantitative assessment of localized pulmonary inflammation by magnetic resonance imaging in patients with mild allergic asthma following segmental allergen challenge
Vogel-Claussen, Jens; Schaumann, Frank; Renne, Julius; Hinrichs, Jan; Schoenfeld, Christian; Gutberlet, Marcel; Hüper, Klaudia; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.
Abstract
2012Stable inflammatory phenotype in smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Krug, Norbert; Ernst, Peter; Lahu, Gezim; Hohlfeld, Jens M.
Abstract
2012Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Schleh, Carsten; Rothen-Rutishauser, Barbara M.; Blank, Fabian; Lauenstein, Hans D.; Nassimi, Matthias; Krug, Norbert; Braun, Armin; Erpenbeck, Veit; Gehr, Peter; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2011Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael
Zeitschriftenaufsatz
2011Breath profiles by electronic nose correlate with systemic markers but not ozone response
Biller, Heike; Holz, Olaf; Windt, Horst; Koch, Wolfgang; Müller, Meike; Jörres, Rudolf A.; Krug, Norbert; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2011The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function
Rochlitzer, Sabine; Veres, Tibor Z.; Kühne, Kathleen; Prenzler, Frauke; Pilzner, Carolin; Knothe, Saskia; Winkler, Carla; Lauenstein, Hans-Dieter; Willart, M.; Hammad, H.; Müller, Meike; Krug, Norbert; Lambrecht, Bart N.; Braun, Armin
Zeitschriftenaufsatz