Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples
Weidele, Kathrin; Stojanović, Nataša; Feliciello, Giancarlo; Markiewicz, Aleksandra; Scheitler, Sebastian; Alberter, Barbara; Renner, Philipp; Haferkamp, Sebastian; Klein, Christoph A.; Polzer, Bernhard
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2018Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer
Hoffmann, Martin; Pasch, Sophie; Schamberger, Thomas; Maneck, Matthias; Möhlendick, Birte; Schumacher, Sarah; Brockhoff, Gero; Knoefel, Wolfram Trudo; Izbicki, Jakob; Polzer, Bernhard; Stoecklein, Nikolas H.; Klein, Christoph A.
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2018Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
Werner-Klein, Melanie; Scheitler, Sebastian; Hoffmann, Martin; Hodak, Isabelle; Dietz, Klaus; Lehnert, Petra; Naimer, Veronika; Polzer, Bernhard; Treitschke, Steffi; Werno, Christian; Markiewicz, Aleksandra; Weidele, Kathrin; Czyz, Zbigniew; Hohenleutner, Ulrich; Hafner, Christian; Haferkamp, Sebastian; Berneburg, Mark; Rümmele, Petra; Ulmer, Anja; Klein, Christoph A.
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2018Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: The potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment
Lüke, Florian; Blazquez, Raquel; Yamaci, Rezan Fahrioglu; Lu, Xin; Pregler, Benedikt; Hannus, Stefan; Menhart, Karin; Hellwig, Dirk; Wester, Hans-Jürgen; Kropf, Saskia; Heudobler, Daniel; Grosse, Jirka; Moosbauer, Jutta; Hutterer, Markus; Hau, Peter; Riemenschneider, Markus J.; Bayerlová, Michaela; Bleckmann, Annalen; Polzer, Bernhard; Beißbarth, Tim; Klein, Christoph A.; Pukrop, Tobias
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2018Modulation of tumor-microenvironmental factors and cancer growth in co-cultures of fresh human lung tissue and patient-derived cancer cells
Konzok, Sebastian; Dehmel, Susann; Werno, Christian; Braubach, Peter; Warnecke, Gregor; Zardo, Patrick; Jonigk, Danny; Pfennig, Olaf; Fieguth, Hans-Gerd; Polzer, Bernhard; Weidele, Kathrin; Klein, Christoph A.; Braun, Armin; Sewald, Katherina
Abstract
2018The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival
Ulmer, Anja; Dietz, Klaus; Werner-Klein, Melanie; Hafner, Hans-Martin; Schulz, Claudia; Renner, Philipp; Weber, Florian; Breuninger, Helmut; Röcken, Martin; Garbe, Claus; Fierlbeck, Gerhard; Klein, Christoph A.
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2018Single cell polarity in liquid phase facilitates tumour metastasis
Lorentzen, Anna; Becker, Paul F.; Kosla, Jan; Saini, Massimo; Weidele, Kathrin; Ronchi, Paolo; Klein, Corinna; Wolf, Monika J.; Geist, Felix; Seubert, Bastian; Ringelhan, Marc; Mihic-Probst, Daniela; Esser, Knud; Roblek, Marko; Kuehne, Felix; Bianco, Gaia; O'Connor, Tracy; Müller, Quentin; Schuck, Kathleen; Lange, Sebastian; Hartmann, Daniel; Spaich, Saskia; Gross, Olaf; Utikal, Jochen; Haferkamp, Sebastian; Sprick, Martin R.; Damle-Vartak, Amruta; Hapfelmeier, Alexander; Hüser, Norbert; Protzer, Ulrike; Trumpp, Andreas; Saur, Dieter; Vartak, Nachiket; Klein, Christoph A.; Polzer, Bernhard; Borsig, Lubor; Heikenwalder, Mathias
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2016Early dissemination seeds metastasis in breast cancer
Hosseini, Hedayatollah; Obradović, Milan M.S.; Hoffmann, Martin; Harper, Kathryn L.; Sosa, Maria Soledad; Werner-Klein, Melanie; Nanduri, Lahiri Kanth; Werno, Christian; Ehrl, Carolin; Maneck, Matthias; Patwary, Nina; Haunschild, Gundula; Gužvić, Miodrag; Reimelt, Christian; Grauvogl, Michael; Eichner, Norbert; Weber, Florian; Hartkopf, Andreas D.; Taran, Florin-Andrei; Brucker, Sara Y.; Fehm, Tanja; Rack, Brigitte; Buchholz, Stefan; Spang, Rainer; Meister, Gunter; Aguirre-Ghiso, Julio A.; Klein, Christoph A.
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2016Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Harper, Kathryn L.; Sosa, Maria Soledad; Entenberg, David; Hosseini, Hedayatollah; Cheung, Julie F.; Nobre, Rita; Avivar-Valderas, Alvaro; Nagi, Chandandaneep; Girnius, Nomeda; Davis, Roger J.; Farias, Eduardo F.; Condeelis, John; Klein, Christoph A.; Aguirre-Ghiso, Julio A.
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2016Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes
Suzuki, Toru; Asami, Maki; Hoffmann, Martin; Lu, Xin; Guzvic, Miodrag; Klein, Christoph A.; Perry, Anthony C.F.
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2016Single-cell analysis of CTCs with diagnostic precision: Opportunities and challenges for personalized medicine. Review
Alberter, Barbara; Klein, Christoph A.; Polzer, Bernhard
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2015Deterministic whole-genome amplification of single cells
Czyz, Zbigniew Tadeusz; Klein, Christoph A.
Aufsatz in Buch
2015Method and kit for determining the genome integrity and/or the quality of a library of DNA-sequences otained by deterministic restriction site whole genome amplification
Klein, Christoph Andreas; Polzer, Bernhard Michael; Manaresi, Nicolo
Patent
2014Analysis of nucleic acids in single cells
Kirsch, Stefan; Polzer, Bernhard; Klein, Christoph A.
Aufsatz in Buch
2014Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes
Guzvic, Miodrag; Braun, Bernhard; Ganzer, Roman; Burger, Maximilian; Nerlich, Michael; Winkler, Sebastian; Werner-Klein, Melanie; Czyz, Zbigniew T.; Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2014Entwicklung eines Assays zu Qualitätskontrolle von Whole Transcriptome Amplifications
Ganser, Iris
: Klein, Christoph A. (Betreuer)
Bachelor Thesis
2014Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer
Neves, Rui P.L.; Raba, Katharina; Schmidt, Oliver; Honisch, Ellen; Meier-Stiegen, Franziska; Behrens, Bianca; Möhlendick, Birte; Fehm, Tanja; Neubauer, Hans; Klein, Christoph A.; Polzer, Bernhard; Sproll, Christoph; Fischer, Johannes C.; Niederacher, Dieter; Stoecklein, Nikolas H.
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2014Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients
Werner-Klein, Melanie; Proske, Judith; Werno, Christian; Schneider, Katharina; Hofmann, Hans-Stefan; Rack, Brigitte; Buchholz, Stefan; Ganzer, Roman; Blana, Andreas; Seelbach-Göbel, Birgit; Nitsche, Ulrich; Männel, Daniela N.; Klein, Christoph A.
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2014Molecular profiling of single circulating tumor cells with diagnostic intention
Polzer, Bernhard; Medoro, Gianni; Pasch, Sophie; Fontana, Francesca; Zorzino, Laura; Pestka, Aurelia; Andergassen, Ulrich; Meier-Stiegen, Franziska; Czyz, Zbigniew T.; Alberter, Barbara; Treitschke, Steffi; Schamberger, Thomas; Sergio, Maximilian; Bregola, Giulia; Doffini, Anna; Gianni, Stefano; Calanca, Alex; Signorini, Giulio; Bolognesi, Chiara; Hartmann, Arndt; Fasching, Peter A.; Sandri, Maria T.; Rack, Brigitte; Fehm, Tanja; Giorgini, Guiseppe; Manaresi, Nicolò; Klein, Christoph A.
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2014Reliable single cell array CGH for clinical samples
Czyz, Zbigniew T.; Hoffmann, Martin; Schlimok, Günter; Polzer, Bernhard; Klein, Christoph A.
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2014Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres
Wang, Jianwei; Lu, Xin; Sakk, Vadim; Klein, Christoph A.; Rudolph, Karl Lenhard
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2013Metastasis awakening: The challenges of targeting minimal residual cancer
Polzer, Bernhard; Klein, Christoph A.
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2013Molecular profiling of single Sca-1(+)/CD34(+,-) cells - the putative murine lung stem cells
Hittinger, Markus; Czyz, Zbigniew T.; Huesemann, Yves; Maneck, Matthias; Botteron, Cathrine; Kaeufl, Stephanie; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz