Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples
Weidele, Kathrin; Stojanović, Nataša; Feliciello, Giancarlo; Markiewicz, Aleksandra; Scheitler, Sebastian; Alberter, Barbara; Renner, Philipp; Haferkamp, Sebastian; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz
2019Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification
Durst, F.C.; Grujovic, A.; Ganser, I.; Hoffmann, M.; Ugocsai, P.; Klein, C.A.; Czyz, Z.T.
Zeitschriftenaufsatz
2019Therapy resistance beyond cellular dormancy
Werner-Klein, M.; Klein, C.A.
Zeitschriftenaufsatz
2018Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer
Hoffmann, Martin; Pasch, Sophie; Schamberger, Thomas; Maneck, Matthias; Möhlendick, Birte; Schumacher, Sarah; Brockhoff, Gero; Knoefel, Wolfram Trudo; Izbicki, Jakob; Polzer, Bernhard; Stoecklein, Nikolas H.; Klein, Christoph A.
Zeitschriftenaufsatz
2018Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma
Werner-Klein, Melanie; Scheitler, Sebastian; Hoffmann, Martin; Hodak, Isabelle; Dietz, Klaus; Lehnert, Petra; Naimer, Veronika; Polzer, Bernhard; Treitschke, Steffi; Werno, Christian; Markiewicz, Aleksandra; Weidele, Kathrin; Czyz, Zbigniew; Hohenleutner, Ulrich; Hafner, Christian; Haferkamp, Sebastian; Berneburg, Mark; Rümmele, Petra; Ulmer, Anja; Klein, Christoph A.
Zeitschriftenaufsatz
2018Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: The potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment
Lüke, Florian; Blazquez, Raquel; Yamaci, Rezan Fahrioglu; Lu, Xin; Pregler, Benedikt; Hannus, Stefan; Menhart, Karin; Hellwig, Dirk; Wester, Hans-Jürgen; Kropf, Saskia; Heudobler, Daniel; Grosse, Jirka; Moosbauer, Jutta; Hutterer, Markus; Hau, Peter; Riemenschneider, Markus J.; Bayerlová, Michaela; Bleckmann, Annalen; Polzer, Bernhard; Beißbarth, Tim; Klein, Christoph A.; Pukrop, Tobias
Zeitschriftenaufsatz
2018Modulation of tumor-microenvironmental factors and cancer growth in co-cultures of fresh human lung tissue and patient-derived cancer cells
Konzok, Sebastian; Dehmel, Susann; Werno, Christian; Braubach, Peter; Warnecke, Gregor; Zardo, Patrick; Jonigk, Danny; Pfennig, Olaf; Fieguth, Hans-Gerd; Polzer, Bernhard; Weidele, Kathrin; Klein, Christoph A.; Braun, Armin; Sewald, Katherina
Abstract
2018The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival
Ulmer, Anja; Dietz, Klaus; Werner-Klein, Melanie; Hafner, Hans-Martin; Schulz, Claudia; Renner, Philipp; Weber, Florian; Breuninger, Helmut; Röcken, Martin; Garbe, Claus; Fierlbeck, Gerhard; Klein, Christoph A.
Zeitschriftenaufsatz
2018Single cell polarity in liquid phase facilitates tumour metastasis
Lorentzen, Anna; Becker, Paul F.; Kosla, Jan; Saini, Massimo; Weidele, Kathrin; Ronchi, Paolo; Klein, Corinna; Wolf, Monika J.; Geist, Felix; Seubert, Bastian; Ringelhan, Marc; Mihic-Probst, Daniela; Esser, Knud; Roblek, Marko; Kuehne, Felix; Bianco, Gaia; O'Connor, Tracy; Müller, Quentin; Schuck, Kathleen; Lange, Sebastian; Hartmann, Daniel; Spaich, Saskia; Gross, Olaf; Utikal, Jochen; Haferkamp, Sebastian; Sprick, Martin R.; Damle-Vartak, Amruta; Hapfelmeier, Alexander; Hüser, Norbert; Protzer, Ulrike; Trumpp, Andreas; Saur, Dieter; Vartak, Nachiket; Klein, Christoph A.; Polzer, Bernhard; Borsig, Lubor; Heikenwalder, Mathias
Zeitschriftenaufsatz
2018The WASCAL hydrometeorological observatory in the Sudan savanna of Burkina Faso and Ghana
Bliefernicht, J.; Berger, S.; Salack, S.; Guug, S.; Hingerl, L.; Heinzeller, D.; Mauder, M.; Steinbrecher, R.; Steup, G.; Bossa, A.Y.; Waongo, M.; Quansah, E.; Balogun, A.A.; Yira, Y.; Arnault, J.; Wagner, Sven; Klein, C.; Gessner, U.; Knauer, K.; Straub, A.; Schönrock, R.; Kunkel, R.; Okogbue, E.C.; Rogmann, A.; Neidl, F.; Jahn, C.; Diekkrüger, B.; Aduna, A.; Barry, B.; Kunstmann, H.
Zeitschriftenaufsatz
2017Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma
Schumacher, S.; Bartenhagen, C.; Hoffmann, M.; Will, D.; Fischer, J.C.; Baldus, S.E.; Vay, C.; Fluegen, G.; Dizdar, L.; Vallböhmer, D.; Klein, C.A.; Knoefel, W.T.; Stoecklein, N.H.; Möhlendick, B.
Zeitschriftenaufsatz
2016Adaptive Software für sicherheitskritische Funktionen in Batterie-elektrischen Fahrzeugen
Rosenthal, Thorsten; Feismann, Timo; Schleiß, Philipp; Weiß, Gereon; Klein, Cornel
Konferenzbeitrag
2016Early dissemination seeds metastasis in breast cancer
Hosseini, Hedayatollah; Obradović, Milan M.S.; Hoffmann, Martin; Harper, Kathryn L.; Sosa, Maria Soledad; Werner-Klein, Melanie; Nanduri, Lahiri Kanth; Werno, Christian; Ehrl, Carolin; Maneck, Matthias; Patwary, Nina; Haunschild, Gundula; Gužvić, Miodrag; Reimelt, Christian; Grauvogl, Michael; Eichner, Norbert; Weber, Florian; Hartkopf, Andreas D.; Taran, Florin-Andrei; Brucker, Sara Y.; Fehm, Tanja; Rack, Brigitte; Buchholz, Stefan; Spang, Rainer; Meister, Gunter; Aguirre-Ghiso, Julio A.; Klein, Christoph A.
Zeitschriftenaufsatz
2016Fail-operational in-vehicle E/E-architectures - dependable basis for automated driving
Weiß, Gereon; Klein, Cornel
Vortrag
2016Mechanism of early dissemination and metastasis in Her2+ mammary cancer
Harper, Kathryn L.; Sosa, Maria Soledad; Entenberg, David; Hosseini, Hedayatollah; Cheung, Julie F.; Nobre, Rita; Avivar-Valderas, Alvaro; Nagi, Chandandaneep; Girnius, Nomeda; Davis, Roger J.; Farias, Eduardo F.; Condeelis, John; Klein, Christoph A.; Aguirre-Ghiso, Julio A.
Zeitschriftenaufsatz
2016Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes
Suzuki, Toru; Asami, Maki; Hoffmann, Martin; Lu, Xin; Guzvic, Miodrag; Klein, Christoph A.; Perry, Anthony C.F.
Zeitschriftenaufsatz
2016Single-cell analysis of CTCs with diagnostic precision: Opportunities and challenges for personalized medicine. Review
Alberter, Barbara; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz
2016Towards prevention of metastatic prostate cancer
Gužvić, M.; Klein, C.A.
Zeitschriftenaufsatz
2015Deterministic whole-genome amplification of single cells
Czyz, Zbigniew Tadeusz; Klein, Christoph A.
Aufsatz in Buch
2015The genetic heterogeneity of circulating tumor cells: a longitudinal study in breast cancer patients
Terracciano, M.; Buson, G.; Forcato, C.; Luca, F. de; Galardi, F.; Sero, V.; Pestrin, M.; Gabellini, S.; Koestler, C.; Czyz, Z.T.; Bregola, G.; Tononi, P.; Bolognesi, C.; Fontana, F.; Medoro, G.; Polzer, B.; Leo, A. di; Klein, C.A.; Manaresi, N.
Abstract
2015Identification and molecular characterization of different subpopulations of EpCAM-positive single disseminated cancer cells in prostate cancer
Polzer, B.; Guzvic, M.; Ganzer, R.; Weckermann, D.; Braun, B.; Appel, I.; Obradovic, M.; Huppert, V.; Klein, C.A.
Abstract
2015Longitudinal genetic characterization of circulating tumor cells in metastatic breast cancer patients
Sero, V.; Luca, F. de; Doffini, A.; Galardi, F.; Pestrin, M.; Czyz, Z.T.; Buson, G.; Bregola, G.; Bolognesi, C.; Fontana, F.; Medoro, G.; Polzer, B.; Leo, A. di; Klein, C.A.; Manaresi, N.
Abstract
2015Method and kit for determining the genome integrity and/or the quality of a library of DNA-sequences otained by deterministic restriction site whole genome amplification
Klein, Christoph Andreas; Polzer, Bernhard Michael; Manaresi, Nicolo
Patent
2015Molecular characterization of early disseminating cancer cells in non-small cell lung cancer
Yamaci, R.F.; Elsner, F.; Sziklavari, Z.; Potzger, T.; Hofmann, H.S.; Klein, C.
Abstract
2015Molecular mechanisms of early cancer cell dissemination in breast cancer
Hosseini, H.; Carolin, E.L.; Nanduri, L.K.; Werno, C.; Maneck, M.; Husemann, Y.; Klein, C.A.
Abstract
2015Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Guzvic, M.; Braun, B.; Ganzer, R.; Burger, M.; Nerlich, M.; Winkler, S.; Werner-Klein, M.; Czyz, Z.T.; Polzer, B.; Klein, C.A.
Abstract
2014Analysis of nucleic acids in single cells
Kirsch, Stefan; Polzer, Bernhard; Klein, Christoph A.
Aufsatz in Buch
2014Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes
Guzvic, Miodrag; Braun, Bernhard; Ganzer, Roman; Burger, Maximilian; Nerlich, Michael; Winkler, Sebastian; Werner-Klein, Melanie; Czyz, Zbigniew T.; Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2014Entwicklung eines Assays zu Qualitätskontrolle von Whole Transcriptome Amplifications
Ganser, Iris
: Klein, Christoph A. (Betreuer)
Bachelor Thesis
2014Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer
Neves, Rui P.L.; Raba, Katharina; Schmidt, Oliver; Honisch, Ellen; Meier-Stiegen, Franziska; Behrens, Bianca; Möhlendick, Birte; Fehm, Tanja; Neubauer, Hans; Klein, Christoph A.; Polzer, Bernhard; Sproll, Christoph; Fischer, Johannes C.; Niederacher, Dieter; Stoecklein, Nikolas H.
Zeitschriftenaufsatz
2014Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients
Werner-Klein, Melanie; Proske, Judith; Werno, Christian; Schneider, Katharina; Hofmann, Hans-Stefan; Rack, Brigitte; Buchholz, Stefan; Ganzer, Roman; Blana, Andreas; Seelbach-Göbel, Birgit; Nitsche, Ulrich; Männel, Daniela N.; Klein, Christoph A.
Zeitschriftenaufsatz
2014Molecular profiling of single circulating tumor cells with diagnostic intention
Polzer, Bernhard; Medoro, Gianni; Pasch, Sophie; Fontana, Francesca; Zorzino, Laura; Pestka, Aurelia; Andergassen, Ulrich; Meier-Stiegen, Franziska; Czyz, Zbigniew T.; Alberter, Barbara; Treitschke, Steffi; Schamberger, Thomas; Sergio, Maximilian; Bregola, Giulia; Doffini, Anna; Gianni, Stefano; Calanca, Alex; Signorini, Giulio; Bolognesi, Chiara; Hartmann, Arndt; Fasching, Peter A.; Sandri, Maria T.; Rack, Brigitte; Fehm, Tanja; Giorgini, Guiseppe; Manaresi, Nicolò; Klein, Christoph A.
Zeitschriftenaufsatz
2014Quantitative measurement of melanoma spread in sentinel lymph nodes and survival
Ulmer, A.; Dietz, K.; Hodak, I.; Polzer, B.; Scheitler, S.; Yildiz, M.; Czyz, Z.; Lehnert, P.; Fehm, T.; Hafner, C.; Schanz, S.; Röcken, M.; Garbe, C.; Breuninger, H.; Fierlbeck, G.; Klein, C.A.
Zeitschriftenaufsatz
2014Reliable single cell array CGH for clinical samples
Czyz, Zbigniew T.; Hoffmann, Martin; Schlimok, Günter; Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2014Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres
Wang, Jianwei; Lu, Xin; Sakk, Vadim; Klein, Christoph A.; Rudolph, Karl Lenhard
Zeitschriftenaufsatz
2013Implantable silicone electrode for measurement of muscle activity: Results of first in vivo evaluation
Lewis, S.; Hahn, M.; Klein, C.; Russold, M.F.; Ruff, R.; Hoffmann, K.P.; Unger, E.; Lanmüller, H.; Aszmann, O.; Dietl, H.; Kaniusas, E.
Zeitschriftenaufsatz, Konferenzbeitrag
2013Interface engineering for the TaN/Ta barrier film deposition process to control Ta-crystal growth
Gerlich, L.; Ohsiek, S.; Klein, C.; Geiß, M.; Friedemann, M.; Kücher, P.; Schmeißer, D.
Zeitschriftenaufsatz
2013Metastasis awakening: The challenges of targeting minimal residual cancer
Polzer, Bernhard; Klein, Christoph A.
Zeitschriftenaufsatz
2013Molecular profiling of single Sca-1(+)/CD34(+,-) cells - the putative murine lung stem cells
Hittinger, Markus; Czyz, Zbigniew T.; Huesemann, Yves; Maneck, Matthias; Botteron, Cathrine; Kaeufl, Stephanie; Klein, Christoph A.; Polzer, Bernhard
Zeitschriftenaufsatz
2013Selection and adaptation during metastatic cancer progression
Klein, C.A.
Zeitschriftenaufsatz
2012Feasibility study of optical/e-beam complementary lithography
Hohle, Christoph; Choi, Kang-Hoon; Freitag, Martin; Gutsch, Manuela; Rudolph, Matthias; Thrun, Xaver; Jaschinsky, Philipp; Kahlenberg, Frank; Klein, Christof; Klikovits, Jan
Konferenzbeitrag
2012Physical characterization of PECVD and PEALD Ru(-C) films and comparison with PVD ruthenium film properties
Wojcik, H.; Junige, M.; Bartha, W.; Albert, M.; Neumann, V.; Merkel, U.; Peeva, A.; Gluch, J.; Menzel, S.; Munnik, F.; Liske, R.; Utess, D.; Richter, I.; Klein, C.; Engelmann, H.J.; Ho, P.; Hossbach, C.; Wenzel, C.
Zeitschriftenaufsatz
2012Sequence error storms and the landscape of mutations in cancer
Kirsch, S.; Klein, C.A.
Zeitschriftenaufsatz
2012Umsetzung und Erprobung von aktiven Lagern im Fahrwerksbereich
Atzrodt, Heiko; Drögemüller, Tobias; Klein, Christoph
Konferenzbeitrag
2011Information extraction from text for improving research on small molecules and histone modifications
Klein, Corinna
Dissertation
2011Investigation of the analysis parameters and background subtraction for high-k materials with atom probe tomography
Mutas, S.; Klein, C.; Gerstl, S.S.A.
Konferenzbeitrag, Zeitschriftenaufsatz
2011NM-series of representative manufactured nanomaterials. NM-300 Silver. Characterisation, stability, homogeneity
Klein, C.L.; Comero, S.; Stahlmecke, B.; Romazanov, J.; Kuhlbusch, T.A.; Doren, E. van; Temmerman, P.-J. de; Mast, J.; Wick, P.; Krug, H.; Locoro, G.; Hund-Rinke, K.; Kördel, W.; Friedrichs, S.; Maier, G.; Werner, J.; Linsinger, T.; Gawlik, B.M.
Aufsatz in Buch
2011Sol-Gel-Verfahren für die Herstellung von ZrO2-Schichten
Klein, C.
Dissertation
2011Ultrathin TaN/Ta barrier modifications to fullfill next technology node requirements
Gerlich, L.; Ohsiek, S.; Klein, C.; Geiß, M.; Friedemann, M.; Kücher, P.; Schmeißer, D.
Konferenzbeitrag
2010Investigation of the analysis parameters and background substraction for high-k materials with Atom Probe Tomography
Mutas, S.; Klein, C.; Gerstl, S.S.
Abstract
2010Physical and electrical properties of MOCVD and ALD deposited HfZrO4 gate dielectrics for 32nm CMOS high performance logic SOI technologies
Kelwing, T.; Mutas, S.; Trentzsch, M.; Naumann, A.; Trui, B.; Herrmann, L.; Graetsch, F.; Klein, C.; Wilde, L.; Ohsiek, S.; Weisheit, M.; Peeva, A.; Richter, I.; Prinz, H.; Wuerfel, A.; Carter, R.; Stephan, R.; Kücher, P.; Hansch, W.
Konferenzbeitrag
2009Charged particle multi-beam lithography evaluations for sub-16nm hp mask node fabrication and wafer direct write
Platzgummer, E.; Klein, C.; Joechl, P.; Loeschner, H.; Witt, M.; Pilz, W.; Butschke, J.; Jurisch, M.; Letzkus, F.; Sailer, H.; Irmscher, M.
Konferenzbeitrag
2009A framework for numerical modeling and simulation of shunt damping technology
Kurch, M.; Klein, C.; Mayer, D.
Konferenzbeitrag
2009Investigation of boron delta-layers in silicon measured by atom probe tomography (APT)
Klein, C.; Mutas, S.; Würfel, A.; Zschech, E.
Konferenzbeitrag, Zeitschriftenaufsatz
2009Investigations of field-evaporated end forms in voltage- and laser-pulsed atom probe tomography
Shariq, A.; Mutas, S.; Wedderhoff, K.; Klein, C.; Hortenbach, H.; Teichert, S.; Kücher, P.; Gerstl, S.S.A.
Konferenzbeitrag, Zeitschriftenaufsatz
2009PML2: The maskless multibeam solution for the 22nm node and beyond
Klein, C.; Platzgummer, E.; Klikovits, J.; Piller, W.; Loeschner, H.; Bejdak, T.; Dolezel, P.; Kolarik, V.; Klingler, W.; Letzkus, F.; Butschke, J.; Irmscher, M.; Witt, M.; Pilz, W.; Jaschinsky, P.; Thrum, F.; Hohle, C.; Kretz, J.; Nogatch, J.T.; Zepka, A.
Konferenzbeitrag
2009The reference-matrix concept applied to chemical testing of soils
Kördel, W.; Peijnenburg, W.; Klein, C.L.; Kuhnt, G.; Bussian, B.M.; Gawlik, B.M.
Zeitschriftenaufsatz
2008MAGIC: A european program to push the insertion of maskless lithography
Pain, L.; Icard, B.; Tedesco, S.; Kampherbeck, B.; Gross, G.; Klein, C.; Loeschner, H.; Platzgummer, E.; Morgan, R.; Manakli, S.; Kretz, J.; Holhe, C.; Choi, K.-H.; Thrum, F.; Kassel, E.; Pilz, W.; Keil, K.; Butschke, J.; Irmscher, M.; Letzkus, F.; Hudek, P.; Paraskevopoulos, A.; Ramm, P.; Weber, J.
Konferenzbeitrag
2008Projection maskless lithography (PML2)
Klein, C.; Platzgummer, E.; Loeschner, H.; Gross, G.; Dolezel, P.; Tmej, M.; Kolarik, V.; Klingler, W.; Letzkus, F.; Butschke, J.; Irmscher, M.; Witt, M.; Pilz, W.
Konferenzbeitrag
2007Dermal fibroblasts induce maturation of dendritic cells
Saalbach, A.; Klein, C.; Sleemann, J.; Sack, U.; Kauer, F.; Gebhardt, C.; Averbeck, M.; Anderegg, U.; Simon, J.C.
Zeitschriftenaufsatz
2006An approach to reduce cost and size of active mounts for automobile applications
Thomaier, M.; Mayer, D.; Melz, T.; Herold, S.; Atzrodt, H.; Klein, C.
Konferenzbeitrag
2006Vorrichtung und Verfahren zur Schwingungstilgung einer mechanischen Struktur
Hanselka, H.; Klein, C.; Mayer, D.; Melz, T.
Patent
2004Programmable networks for IP service deployment
: Galis, Alex (Ed.); Denazis, Spyros (Ed.); Brou, Célestin (Ed.); Klein, Cornel (Ed.)
Buch
2004Softwareentwicklung für EMUS-Frontend
Klein, C.
Diplomarbeit
2000A Flexible IP Active Networks Architecture
Galis, A.; Plattner, B.; Smith, J.M.; Denazis, S.; Moeller, E.; Guo, H.; Klein, C.; Serrat, J.; Laarhuis, J.; Karetsos, G.T.; Todd, C.
Konferenzbeitrag