Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator
Hartmann, M.; Bibli, S.-I.; Tews, D.; Ni, X.; Kircher, T.; Kramer, J.S.; Kilu, W.; Heering, J.; Hernandez-Olmos, V.; Weizel, L.; Scriba, G.K.E.; Krait, S.; Knapp, S.; Chaikuad, A.; Merk, D.; Fleming, I.; Fischer-Posovszky, P.; Proschak, E.
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2021Demonstrating Ligandability of the LC3A and LC3B Adapter Interface
Hartmann, M.; Huber, J.; Kramer, J.S.; Heering, J.; Pietsch, L.; Stark, H.; Odadzic, D.; Bischoff, I.; Fürst, R.; Schröder, M.; Akutsu, M.; Chaikuad, A.; Dötsch, V.; Knapp, S.; Biondi, R.M.; Rogov, V.V.; Proschak, E.
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2021Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions
Willems, S.; Gellrich, L.; Chaikuad, A.; Kluge, S.; Werz, O.; Heering, J.; Knapp, S.; Lorkowski, S.; Schubert-Zsilavecz, M.; Merk, D.
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2021Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms
Willems, S.; Ohrndorf, J.; Kilu, W.; Heering, J.; Merk, D.
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2020Chemical starting matter for HNF4α ligand discovery and chemogenomics
Meijer, I.; Willems, S.; Ni, X.; Heering, J.; Chaikuad, A.; Merk, D.
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2020Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms
Chaikuad, A.; Pollinger, J.; Rühl, M.; Ni, X.; Kilu, W.; Heering, J.; Merk, D.
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2020Design, Synthesis, and Structure - Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
Hiesinger, K.; Kramer, J.S.; Beyer, S.; Eckes, T.; Brunst, S.; Flauaus, C.; Wittmann, S.K.; Weizel, L.; Kaiser, A.; Kretschmer, S.B.M.; George, S.; Angioni, C.; Heering, J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Schmidtko, A.; Pogoryelov, D.; Pfeilschifter, J.; Hofmann, B.; Steinhilber, D.; Schwalm, S.; Proschak, E.
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2020The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells
Pflüger-Müller, B.; Oo, J.A.; Heering, J.; Warwick, T.; Proschak, E.; Günther, S.; Looso, M.; Rezende, F.; Fork, C.; Geisslinger, G.; Thomas, D.; Gurke, R.; Steinhilber, D.; Schulz, M.; Leisegang, M.S.; Brandes, R.P.
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2020First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters
Hernandez-Olmos, V.; Heering, J.; Planz, V.; Liu, T.; Kaps, A.; Rajkumar, R.; Gramzow, M.; Kaiser, A.; Schubert-Zsilavecz, M.; Parnham, M.J.; Windbergs, M.; Steinhilber, D.; Proschak, E.
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2020l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC are Potent Activators of PPARγ
Gellrich, L.; Heitel, P.; Heering, J.; Kilu, W.; Pollinger, J.; Goebel, T.; Kahnt, A.; Arifi, S.; Pogoda, W.; Paulke, A.; Steinhilber, D.; Proschak, E.; Wurglics, M.; Schubert-Zsilavecz, M.; Chaikuad, A.; Knapp, S.; Bischoff, I.; Fürst, R.; Merk, D.
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2020The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs
Willems, S.; Kilu, W.; Ni, X.; Chaikuad, A.; Knapp, S.; Heering, J.; Merk, D.
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2020Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)
Hinnah, K.; Willems, S.; Morstein, J.; Heering, J.; Hartrampf, F.W.W.; Broichhagen, J.; Leippe, P.; Merk, D.; Trauner, D.
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2020A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode
Hanke, T.; Cheung, S.-Y.; Kilu, W.; Heering, J.; Ni, X.; Planz, V.; Schierle, S.; Faudone, G.; Friedrich, M.; Wanior, M.; Werz, O.; Windbergs, M.; Proschak, E.; Schubert-Zsilavecz, M.; Chaikuad, A.; Knapp, S.; Merk, D.
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2020Systematic Assessment of Fragment Identification for Multitarget Drug Design
Brunst, S.; Kramer, J.S.; Kilu, W.; Heering, J.; Pollinger, J.; Hiesinger, K.; George, S.; Steinhilber, D.; Merk, D.; Proschak, E.
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2019Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype
Heitel, P.; Gellrich, L.; Kalinowsky, L.; Heering, J.; Kaiser, A.; Ohrndorf, J.; Proschak, E.; Merk, D.
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2019Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain
Kramer, JS.; Woltersdorf, S.; Duflot, T.; Hiesinger, K.; Lillich, FF.; Knoll, F.; Wittmann, SK.; Klingler, FM.; Brunst, S.; Chaikuad, A.; Morisseau, C.; Hammock, BD.; Buccellati, C.; Sala, A.; Rovati, GE.; Leuillier, M.; Fraineau, S.; Rondeaux, J.; Hernandez-Olmos, V.; Heering, J.; Merk, D.; Pogoryelov, D.; Steinhilber, D.; Knapp, S.; Bellien, J.; Proschak, E.
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2019Hybrid reporter gene assays: Versatile in vitro tools to characterize nuclear receptor modulators
Heering, J.; Merk, D.
Aufsatz in Buch
2019Structure optimization of a new class of PPARγ antagonists
Hernandez-Olmos, V.; Knape, T.; Heering, J.; Knethen, A. von; Kilu, W.; Kaiser, A.; Wurglics, M.; Helmstadter, M.; Merk, D.; Schubert-Zsilavecz, M.; Parnham, M.J.; Steinhilber, D.; Proschak, E.
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2019Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation
Pollinger, J.; Gellrich, L.; Schierle, S.; Kilu, W.; Schmidt, J.; Kalinowsky, L.; Ohrndorf, J.; Kaiser, A.; Heering, J.; Proschak, E.; Merk, D.
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2019Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
Göbel, T.; Diehl, O.; Heering, J.; Merk, D.; Angioni, C.; Wittmann, S.K.; Buscato, E. la; Kottke, R.; Weizel, L.; Schader, T.; Maier, T.J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Steinhilber, D.; Proschak, E.; Kahnt, A.S.
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2018A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity
Kramer, J.; Désor, V.; Brunst, S.; Wittmann, S.K.; Lausen, J.; Heering, J.; Proschak, A.; Proschak, E.
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2018Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
Heitel, P.; Gellrich, L.; Heering, J.; Goebel, T.; Kahnt, A.; Proschak, E.; Schubert-Zsilavecz, M.; Merk, D.
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2018Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
Heitel, P.; Gellrich, L.; Heering, J.; Goebel, T.; Kahnt, A.; Proschak, E.; Schubert-Zsilavecz, M.; Merk, D.
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2017A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter nonalcoholic steatohepatitis
Schmidt, J.; Rotter, M.; Weiser, T.; Wittmann, S.; Weizel, L.; Kaiser, A.; Heering, J.; Goebel, T.; Angioni, C.; Wurglics, M.; Paulke, A.; Geisslinger, G.; Kahnt, A.; Steinhilber, D.; Proschak, E.; Merk, D.
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2017Nonacidic Farnesoid X Receptor Modulators
Flesch, D.; Cheung, S.Y.; Schmidt, J.; Gabler, M.; Heitel, P.; Kramer, J.; Kaiser, A.; Hartmann, M.; Lindner, M.; Lüddens-Dämgen, K.; Heering, J.; Lamers, C.; Lüddens, H.; Wurglics, M.; Proschak, E.; Schubert-Zsilavecz, M.; Merk, D.
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2016N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators
Blöcher, R.; Lamers, C.; Wittmann, S.K.; Merk, D.; Hartmann, M.; Weizel, L.; Diehl, O.; Brüggerhoff, A.; Boss, M.; Kaiser, A.; Schader, T.; Gobel, T.; Grundmann, M.; Angioni, C.; Heering, J.; Geisslinger, G.; Wurglics, M.; Kostenis, E.; Brüne, B.; Steinhilber, D.; Schubert-Zsilavecz, M.; Kahnt, A.S.; Proschak, E.
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2016Thermodynamic properties of leukotriene A4 hydrolase inhibitors
Wittmann, S.K.; Kalinowsky, L.; Kramer, J.S.; Bloecher, R.; Knapp, S.; Steinhilber, D.; Pogoryelov, D.; Proschak, E.; Heering, J.
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2012Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer
Heering, J.; Weis, N.; Holeiter, M.; Neugart, F.; Staebler, A.; Fehm, T.N.; Bischoff, A.; Schiller, J.; Duss, S.; Schmid, S.; Korte, T.; Herrmann, A.; Olayioye, M.A.
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