Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Hazard characterisation of acrylates by in vitro and ex vivo models - an update of the ExITox project
Schramm, Sinja-Fee; Wehr, Matthias; Danov, Olga; Obernolte, Helena; Knebel, Jan; Koschmann, J.; Meckbach, C.; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Hansen, Tanja; Braun, Armin; Sewald, Katherina; Escher, Sylvia E.
Abstract
2019Messung der Permeabilitätskoeffizienten bei dem inhalierbaren Antibiotikum Ciprofloxacin HCl Monohydrat
Sonnenschein, Nico
: Walker, Gottfrid (1. Prüfer); Hansen, Tanja (2. Prüfer)
Master Thesis
2019A read-across study on diketones
Kühne, Britta; Ritter, Detlef; Knebel, Jan; Boei, J.; Vrieling, H.; Hiemstra, P.; Escher, Sylvia E.; Hansen, Tanja
Abstract
2018Acute inhalation toxicity in vitro and ex vivo test battery prior to regulatory OECD 403 studies
Schwarz, Katharina; Hansen, Tanja; Ritter, Detlef; Walter, Dorothee; Knebel, Jan
Abstract
2018Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II
Schwotzer, Daniela; Niehof, Monika; Schaudien, Dirk; Kock, Heiko; Hansen, Tanja; Dasenbrock, Clemens; Creutzenberg, Otto H.
Zeitschriftenaufsatz
2018Characterization of human precision cut liver slices by various viability andfunctional parameters during 24 hour culture
Elenschneider, Leroy; Knebel, Jan; Braun, Armin; Fangmann, J.; Hansen, Tanja
Abstract
2018A combination of in-vitro and ex-vivo test models as an upstream alternative to regulatory OECD 403 animal studies
Walter, Dorothee; Ritter, Detlef; Knebel, Jan; Schwarz, Katharina; Hansen, Tanja
Abstract
2018Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system
Knebel, Jan W.; Ritter, Detlef; Niehof, Monika; Hansen, Tanja; Strandh, M.; Falciani, C.; Flores, M.; Welscher, Y. te; Nostrum, C. van; Gracia, R.; Marradi, M.; Loinaz, I.
Abstract
2018Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process
Ritter, Detlef; Bitsch, Annette; Elend, Manfred; Schuchardt, Sven; Hansen, Tanja; Brodbeck, Carsten; Knebel, Jan; Fuchs, Anne; Gronewold, Claas; Fautz, Rolf
Zeitschriftenaufsatz
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2018Low dose carbon black nanoparticle exposure does not aggravate allergic airway inflammation in mice irrespective of the presence of surface polycyclic aromatic hydrocarbons
Lindner, Karina; Webering, Sina; Ströbele, Michael; Bockhorn, Henning; Hansen, Tanja; König, Peter; Fehrenbach, Heinz
Zeitschriftenaufsatz
2018Optimized protocol for the biocompatibility testing of compression stockings and similar products with close skin contact in vitro
Wiegand, Cornelia; Hansen, Tanja; Köhnlein, Johanna; Exner, Ines; Damisch-Pohl, Marlen; Schott, Peter; Krühner-Wiesenberger, Ulrike; Hipler, Uta-Christina; Pohlen, Ernst
Zeitschriftenaufsatz
2017Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons
Lindner, Karina; Ströbele, Michael; Schlick, Sandra; Webering, Sina; Jenckel, André; Kopf, Johannes; Danov, Olga; Sewald, Katherina; Buj, Christian; Creutzenberg, Otto; Tillmann, Thomas; Pohlmann, Gerhard; Ernst, Heinrich; Ziemann, Christina; Hüttmann, Gereon; Heine, Holger; Bockhorn, Henning; Hansen, Tanja; König, Peter
Zeitschriftenaufsatz
2017Evaluation of a human in vitro hepatocyte-NPC co-culture model for the prediction of idiosyncratic drug-induced liver injury: A pilot study
Granitzny, Anne; Knebel, Jan; Müller, Meike; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Zeitschriftenaufsatz
2017Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound
Granitzny, Anne; Knebel, Jan; Schaudien, Dirk; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Zeitschriftenaufsatz
2017RNA isolation from precision-cut lung slices (PCLS) from different species
Niehof, Monika; Hildebrandt, Tobias; Danov, Olga; Arndt, Kirsten; Koschmann, Jeannette; Dahlmann, Franziska; Hansen, Tanja; Sewald, Katherina
Zeitschriftenaufsatz
2016Method for identification of low soluble, biopersistent susts (GBS) - comparison of intratracheal installation and subacute inhalation
Creutzenberg, Otto H.; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Knebel, Jan
Abstract
2016Toxicity of CeO2 nanoparticles estimated in a 90-day nose-only inhalation study
Schwotzer, Daniela; Niehof, Monika; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Ernst, Heinrich; Creutzenberg, Otto H.
Abstract
2015Comparison of fibrotic and emphysematous alterations in the lungs of bleomycin-treated rats and hamsters
Hoymann, Heinz-G.; Schaudien, Dirk; Hansen, Tanja; Müller, Meike; Braun, Armin
Abstract
2015Development of a co-culture model for the prediction of idiosyncratic drug-induced liver injury
Granitzny, Anne; Hansen, Tanja; Knebel, Jan W.; Dasenbrock, Clemens; Steinberg, Pablo
Abstract
2015Development of hematological and immunological characteristics in neonatal rats
Sewald, Katherina; Müller, Meike; Buschmann, Jochen; Hansen, Tanja; Lewin, Geertje
Zeitschriftenaufsatz, Konferenzbeitrag
2015In vitro toxicity testing of two multi-walled carbon nanotubes determined for the purpose of targeted drug delivery
Requardt, Hendrik; Hansen, Tanja; Eisenbarth, E.; Hampel, S.; Dasenbrock, Clemens
Abstract
2015Inhalation toxicity of carbon black depends on surface coating with polycyclic aromatic hydrocarbons
Hansen, Tanja; König, P.; Creutzenberg, Otto H.; Weinhold, K.; Schlick, S.; Tillmann, Thomas; Pohlmann, Gerhard; Kolling, Angelika; Ziemann, Christina; Kopf, Johannes; Ströbele, Michael; Bockhorn, H.; Danov, Olga; Sewald, Katherina; Müller, B.; Fehrenbach, Heinz
Abstract
2015Method for identification of low soluble, biopersistent dusts (GBS) at workplaces
Creutzenberg, Otto H.; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas
Abstract
2015An overview of the InhalT-90 project - a 90-day inhalation toxicity study with CeO2 nanoparticles
Schwotzer, Daniela; Hansen, Tanja; Niehof, Monika; Creutzenberg, Otto
Abstract
2015The Silicoat project: In vitro and in vivo toxicity screening of quartz varieties from ceramics industry and approaches for an effective quartz surface coating
Creutzenberg, Otto H.; Reamon-Buettner, Stella Marie; Tillmann, Thomas; Hansen, Tanja; Garcia, M.J.; Monfort, Eliseo; Bonvicini, Giuliana; Escrig, Alberto; Ziemann, Christina
Abstract
2014Biological impact of modified inhalable carbon black nanoparticles assessed in cell and tissue culture models
Danov, Olga; Kopf, Johannes; Ströbele, M.; Bockhorn, H.; Fehrenbach, H.; Braun, Armin; Sewald, Katherina; Hansen, Tanja
Abstract
2014CEFIC-LRI N1 Project: Inhalation toxicity of a synthetic amorphous silica (SAS) in rats
Creutzenberg, Otto H.; Pohlmann, Gerhard; Hansen, Tanja; Schuchardt, Sven; Ernst, Heinrich; Tillmann, Thomas; Schaudien, Dirk
Abstract
2014Cytochrome P450 monooxygenases expression in human bronchial epithelial calu-3 cells under different culture conditions
Hansen, Tanja; Niehof, Monika; Knebel, Jan
Abstract
2014Establishment of pathway-specific gene expression analysis using the example of the paraquat action on human lung epithelial cells
Niehof, Monika; Augustin, Christian; Hansen, Tanja
Zeitschriftenaufsatz, Konferenzbeitrag
2014Lung tissue culture model for assessment of cytotoxicity and inflammation induced by inhalable carbon black nanoparticles
Braun, Armin; Danov, Olga; Kopf, Johannes Claudius; Ströbele, Michael; Hansen, Tanja; Fehrenbach, Heinz; Sewald, Katherina
Abstract
2014Optimizing gene-expression analysis for induced sputum
Holz, Olaf; Hansen, Tanja; Homburg, Ursula; Garn, Holger; Hohlfeld, Jens Michael; Niehof, Monika
Abstract
2014The SILICOAT project: In vitro and in vivo toxicity screening of quartz varieties from traditional ceramics industry and approaches for an effective quartz surface coating
Ziemann, Christina; Reamon-Buettner, Stella Marie; Tillmann, Thomas; Hansen, Tanja; Ibañez, Maria Jesus; Monfort, Eliseo; Bonvicini, Giuliana; Escrig, Alberto; Creutzenberg, Otto H.
Zeitschriftenaufsatz, Konferenzbeitrag
2014Toxic effects of various modifications of a nanoparticle following inhalation
Creutzenberg, Otto; Voss, Jens-Uwe; Mangelsdorf, Inge; Tillmann, Thomas; Pohlmann, Gerhard; Hansen, Tanja; Kock, Heiko; Schaudien, Dirk
Zeitschriftenaufsatz, Konferenzbeitrag
2014Toxikologische Untersuchungen von Multiwalled Carbon Nanotubes, mit und ohne Eisenkatalysator, für den Einsatz in der targeted Drug Delivery, durchgeführt an humanen Lungenepithelzellen und Hepatozyten
Requardt, Hendrik
: Eisenbarth, Eva (Erstprüferin); Hennes, Kilian (Zweitprüfer); Dasenbrock, Clemens (Betreuer); Hansen, Tanja (Betreuerin)
Master Thesis
2014Untersuchungen zum Wirkmechanismus von nanostrukturiertem Carbon Black mit unterschiedlicher Oberflächenbeschaffenheit
Tautenhahn, Sven
: Scharfenberg, Klaus (1. Gutachter); Hansen, Tanja (2. Gutachter); Niehof, Monika (Wiss. Betreuung)
Bachelor Thesis
2013CarbonBlack: A joint research project to establish a test system for predicting human-toxicological effects of synthetic carbon black nanoparticles
Fehrenbach, Heinz; Müller, B.; König, P.; Hansen, Tanja; Bockhorn, H.
Zeitschriftenaufsatz, Konferenzbeitrag
2013Cytochrome P450 monooxygenases expression in human epithelial lung cell lines
Niehof, Monika; Hansen, Tanja
Zeitschriftenaufsatz, Konferenzbeitrag
2013Effects of carbon black nanoparticles on human pulmonary cell lines and precision cut lung slices
Hansen, Tanja; Kopf, Johannes Claudius; Danov, Olga; Ströbele, M.; Braun, Armin; Sewald, Katherina; Steinberg, P.; Fehrenbach, H.
Zeitschriftenaufsatz, Konferenzbeitrag
2013In vitro and ex vivo toxicity screening for predicting toxicological effects of synthetic carbon black nanoparticles in humans
Hansen, Tanja; Kopf, Johannes; Danov, Olga; Ströbele, Michael; Braun, Armin; Sewald, Katherina; Bockhorn, H.; Fehrenbach, Heinz
Zeitschriftenaufsatz, Konferenzbeitrag
2013Pulmonary toxicity of printer toner following inhalation and intratracheal instillation
Morimoto, Yasuo; Oyabu, Takako; Horie, Masanori; Kambara, Tatsunori; Izumi, Hiroto; Kuroda, Etsushi; Creuzenberg, Otto; Bellmann, Bernd; Pohlmann, Gerhard; Schuhardt, Sven; Hansen, Tanja; Ernst, Heinrich
Zeitschriftenaufsatz
2013Relative oral bioavailability of glycidol from glycidyl fatty acid esters in rats
Appel, Klaus E.; Abraham, Klaus; Berger-Preiss, Edith; Hansen, Tanja; Apel, Elisabeth; Schuchardt, Sven; Vogt, Carla; Bakhiya, Nadiya; Creutzenberg, Otto; Lampen, Alfonso
Zeitschriftenaufsatz
2013Studies on the mode of action of Multi-Walled Carbon Nanotubes onto human bronchial epithelial cells
Walter, Dorothee; Niehof, Monika; Hackbarth, Anja; Hansen, Tanja
Abstract
2013Untersuchungen zum Wirkmechanismus von Multi-Walled Carbon Nanotubes an Bronchialepithelzellen
Walter, Dorothee
: Steinberg, Pablo (Erstprüfer); Hansen, Tanja (Zweitprüfer); Niehof, Monika (Betreuer)
Master Thesis
2012Subacute and subchronic inhalation toxicity and dermal absorption of the nanoscaled zinc oxide Z-COTE HP1 in the rat
Creutzenberg, Otto H.; Ziemann, Christina; Hansen, Tanja; Ernst, Heinrich; Schaudien, Dirk; Schuchardt, Sven; Wiench, Karin; Bellmann, Bernd
Zeitschriftenaufsatz