Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease
Moreno-Cinos, C.; Sassetti, E.; Salado, I.G.; Witt, G.; Benramdane, S.; Reinhardt, L.; Cruz, C.D.; Joossens, J.; Veken, P. Van der; Brötz-Oesterhe, H.; Tammela, P.; Winterhalter, M.; Gribbon, P.; Windshügel, B.; Augustyns, K.
Zeitschriftenaufsatz
2019Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Ehrnhoefer, D.E.; Skotte, N.H.; Reinshagen, J.; Qiu, X.; Windshügel, B.; Jaishankar, P.; Ladha, S.; Petina, O.; Khankischpur, M.; Nguyen, Y.T.N.; Caron, N.S.; Razeto, A.; Meyer zu Rheda, M.; Deng, Y.; Huynh, K.T.; Wittig, I.; Gribbon, P.; Renslo, A.R.; Geffken, D.; Gul, S.; Hayden, M.R.
Zeitschriftenaufsatz
2019Discovery pipelines for marine resources: An ocean of opportunity for biotechnology?
Smith, D.; Buddie, A.G.; Goss, R.J.M.; Overmann, J.; Lepleux, C.; Brönstrup, M.; Kloareg, B.; Meiners, T.; Brennecke, P.; Ianora, A.; Bouget, F.-Y.; Gribbon, P.; Pina, M.
Zeitschriftenaufsatz
2019EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
Brennecke, P.; Rasina, D.; Aubi, O.; Herzog, K.; Landskron, J.; Cautain, B.; Vicente, F.; Quintana, J.; Mestres, J.; Stechmann, B.; Ellinger, B.; Brea, J.; Kolanowski, J.L.; Pilarski, R.; Orzaez, M.; Pineda-Lucena, A.; Laraia, L.; Nami, F.; Zielenkiewicz, P.; Paruch, K.; Hansen, E.; Kries, J.P. von; Neuenschwander, M.; Specker, E.; Bartunek, P.; Simova, S.; Lesnikowski, Z.; Krauss, S.; Lehtio, L.; Bilitewski, U.; Bronstrup, M.; Tasken, K.; Jirgensons, A.; Lickert, H.; Clausen, M.H.; Andersen, J.H.; Vicent, M.J.; Genilloud, O.; Martinez, A.; Nazare, M.; Fecke, W.; Gribbon, P.
Zeitschriftenaufsatz
2019High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor
Heine, P.; Witt, G.; Gilardi, A.; Gribbon, P.; Kummer, L.; Plückthun, A.
Zeitschriftenaufsatz
2019Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli ClpP inhibitors
Sassetti, E.; Durante Cruz, C.; Tammela, P.; Winterhalter, M.; Augustyns, K.; Gribbon, P.; Windshügel, B.
Zeitschriftenaufsatz
2018The European Marine Biological Research Infrastructure Cluster: An Alliance of European Research Infrastructures to Promote the Blue Bioeconomy
Piña, M.; Colas, P.; Cancio, I.; Audic, A.; Bosser, L.; Canario, A.; Gribbon, P.; Johnston, I.A.; Kervella, A.E.; Kooistra, W.H.C.F.; Merciecca, M.; Magoulas, A.; Nardello, I.; Smith, D.; Pade, N.; Robinson, D.; Schön, A.; Schultz, F.; Kloareg, B.
Aufsatz in Buch
2018In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
Witte, W.E.A. de; Versfelt, J.W.; Kuzikov, M.; Rolland, S.; Georgi, V.; Gribbon, P.; Gul, S.; Huntjens, D.; Graaf, P.H. van der; Danhof, M.; Fernández‐Montalván, A.; Witt, G.; Lange, E.C.M. de
Zeitschriftenaufsatz
2018Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets
Lempiäinen, H.; Brænne, I.; Michoel, T.; Tragante, V.; Vilne, B.; Webb, T.R.; Kyriakou, T.; Eichner, J.; Zeng, L.; Willenborg, C.; Franzen, O.; Ruusalepp, A.; Goel, A.; Laan, S.W. van der; Biegert, C.; Hamby, S.; Talukdar, H.A.; Foroughi Asl, H.; Dichgans, M.; Dreker, T.; Graettinger, M.; Gribbon, P.; Kessler, T.; Malik, R.; Prestel, M.; Stiller, B.; Schofield, C.; Pasterkamp, G.; Watkins, H.; Samani, N.J.; Wittenberger, T.; Erdmann, J.; Schunkert, H.; Asselbergs, F.W.; Björkegren, J.L.M.
Zeitschriftenaufsatz
2017Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt
Gilardi, A.; Bhamidimarri, S.P.; Brönstrup, M.; Bilitewski, U.; Marreddy, R.K.R.; Pos, K.M.; Benier, L.; Gribbon, P.; Winterhalter, M.; Windshügel, B.
Zeitschriftenaufsatz
2017Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production
Kebede, B.; Wrigley, S.K.; Prashar, A.; Rahlff, J.; Wolf, M.; Reinshagen, J.; Gribbon, P.; Imhoff, J.F.; Silber, J.; Labes, A.; Ellinger, B.
Zeitschriftenaufsatz
2017Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
Linciano, P.; Dawson, A.; Pöhner, I.; Costa, D.M.; Sá, M.S.; Cordeiro-da-Silva, A.; Luciani, R.; Gul, S.; Witt, G.; Ellinger, B.; Kuzikov, M.; Gribbon, P.; Reinshagen, J.; Wolf, M.; Behrens, B.; Hannaert, V.; Michels, P.A.M.; Nerini, E.; Pozzi, C.; Pisa, F. di; Landi, G.; Santarem, N.; Ferrari, S.; Saxena, P.; Lazzari, S.; Cannazza, G.; Freitas-Junior, L.H.; Moraes, C.B.; Pascoalino, B.S.; Alcântara, L.M.; Bertolacini, C.P.; Fontana, V.; Wittig, U.; Müller, W.; Wade, R.C.; Hunter, W.N.; Mangani, S.; Costantino, L.; Costi, M.P.
Zeitschriftenaufsatz
2017A high-content small molecule screen identifies novel inducers of definitive endoderm
Korostylev, A.; Mahaddalkar, P.U.; Keminer, O.; Hadian, K.; Schorpp, K.; Gribbon, P.; Lickert, H.
Zeitschriftenaufsatz
2017A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor
Nilam, M.; Gribbon, P.; Reinshagen, J.; Cordts, K.; Schwedhelm, E.; Nau, W.M.; Hennig, A.
Zeitschriftenaufsatz
2017Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Borsari, C.; Santarem, N.; Torrado, J.; Olías, A.I.; Corral, M.J.; Baptista, C.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Witt, G.; Gribbon, P.; Reinshagen, J.; Linciano, P.; Tait, A.; Costantino, L.; Freitas-Junior, L.H.; Moraes, C.B.; Bruno dos Santos, P.; Alcântara, L.M.; Franco, C.H.; Bertolacini, C.D.; Fontana, V.; Tejera Nevado, P.; Clos, J.; Alunda, J.M.; Cordeiro-da-Silva, A.; Ferrari, S.; Costi, M.P.
Zeitschriftenaufsatz
2017Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience
Sousa, P.A. de; Steeg, R.; Wachter, E.; Bruce, K.; King, J.; Hoeve, M.; Khadun, S.; McConnachie, G.; Holder, J.; Kurtz, A.; Seltmann, S.; Dewender, J.; Reimann, S.; Stacey, G.; O'Shea, O.; Chapman, C.; Healy, L.; Zimmermann, H.; Bolton, B.; Rawat, T.; Atkin, I.; Veiga, A.; Kuebler, B.; Serano, B.M.; Saric, T.; Hescheler, J.; Brüstle, O.; Peitz, M.; Thiele, C.; Geijsen, N.; Holst, B.; Clausen, C.; Lako, M.; Armstrong, L.; Gupta, S.K.; Kvist, A.J.; Hicks, R.; Jonebring, A.; Brolen, G.; Ebneth, A.; Cabrera-Socorro, A.; Foerch, P.; Geraerts, M.; Stummann, T.C.; Harmon, S.; George, C.; Streeter, I.; Clarke, L.; Parkinson, H.; Harrison, P.W.; Faulconbridge, A.; Cherubin, L.; Burdett, T.; Trigueros, C.; Patel, M.J.; Lucas, C.; Hardy, B.; Predan, R.; Dokler, J.; Brajnik, M.; Keminer, O.; Pless, O.; Gribbon, P.; Claussen, C.; Ringwald, A.; Kreisel, B.; Courtney, A.; Allsopp, T.E.
Zeitschriftenaufsatz
2017The target residence time of antihistamines determines their antagonism of the G protein-coupled histamine H1 receptor
Bosma, R.; Witt, G.; Vaas, L.A.I.; Josimovic, I.; Gribbon, P.; Vischer, H.F.; Gul, S.; Leurs, R.
Zeitschriftenaufsatz
2016Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase
Klingler, F.-M.; Wolf, M.; Wittmann, S.; Gribbon, P.; Proschak, E.
Zeitschriftenaufsatz
2016DropTech® - a hanging drop based automated stem cell technology platform for production and testing
Meiser, I.; Stracke, F.; Gentile, L.; Neubauer, J.C.; Gorjup, E.; Koutsouraki, E.; Gardner, J.; Sousa, P. de; Keminer, O.; Claussen, C.; Gribbon, P.; Pless, O.; Zimmermann, H.
Poster
2016Electronic laboratory notebooks in a public-private partnership
Vaas, L.A.I.; Witt, G.; Windshügel, B.; Bosin, A.; Serra, G.; Bruengger, A.; Winterhalter, M.; Gribbon, P.; Levy-Petelinkar, C.J.; Kohler, M.
Zeitschriftenaufsatz
2016Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
Borsari, C.; Lucian, R.; Pozz, C.; Poehner, I.; Henrich, S.; Trande, M.; Cordeiro-Da-silva, A.; Santarem, N.; Baptista, C.; Tait, A.; Di Pisa, F.; Iacono, L.D.; Landi, G.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Reinshagen, J.; Witt, G.; Gribbon, P.; Kohler, M.; Keminer, O.; Behrens, B.; Costantino, L.; Nevado, P.T.; Bifeld, E.; Eick, J.; Clos, J.; Torrado, J.; Jiménez-Antón, M.D.; Corral, M.J.; Alunda, J.Ma.; Pellati, F.; Wade, R.C.; Ferrari, S.; Mangani, S.; Costi, M.P.
Zeitschriftenaufsatz
2016Risk mitigation in academic drug discovery
Ellinger, B.; Gribbon, P.
Zeitschriftenaufsatz
2016Towards a hit for every target. Editorial
Rees, S.; Gribbon, P.; Birmingham, K.; Janzen, W.P.; Pairaudeau, G.
Zeitschriftenaufsatz
2015Stem cell reprogramming
Brändl, B.; Schneider, S.A.; Loring, J.F.; Hardy, J.; Gribbon, P.; Müller, F.J.
Zeitschriftenaufsatz
2014A Phenotypic Screening Approach to Identify Anticancer Compounds Derived from Marine Fungi
Ellinger, B.; Silber, J.; Prashar, A.; Landskron, J.; Weber, J.; Rehermann, S.; Müller, F.J.; Smith, S.; Wrigley, S.; Taskén, K.; Gribbon, P.; Labes, A.; Imhoff, J.F.
Zeitschriftenaufsatz