Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020Behandlung von Immunerkrankungen durch die antikörpervermittelte Neutralisierung spezifischer Darmbakterien
Oelkrug, Christopher; Wagner, Daniel-Christoph; Braun, Armin; Hesse, Christina
Patent
2019Cigarette smoke induced pathophysiological changes in the extracellular matrix but not inflammation as early events in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Warnecke, G.; Zardo, P.; Fieguth, H.-G.; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2019Enhanced tissue damage following H1N1 infection in human precision-cut lung slices (PCLS)
Danov, Olga; Martin, Gaël; Greif, A.; Bailly, B.; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Itzstein, M. von; Sewald, Katherina; Wronski, Sabine; Braun, Armin
Abstract
2019Hazard characterisation of acrylates by in vitro and ex vivo models - an update of the ExITox project
Schramm, Sinja-Fee; Wehr, Matthias; Danov, Olga; Obernolte, Helena; Knebel, Jan; Koschmann, J.; Meckbach, C.; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Hansen, Tanja; Braun, Armin; Sewald, Katherina; Escher, Sylvia E.
Abstract
2019Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo
Danov, Olga; Laßwitz, Lisa; Obernolte, Helena; Hesse, Christina; Braun, Armin; Wronski, Sabine; Sewald, Katherina
Zeitschriftenaufsatz
2018Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Konzok, Sebastian; Obernolte, Helena; Dehmel, Susann; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Zardo, Patrick; Warnecke, Gregor; Martin, Christian; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2018Bronchobini® Ingredients (BRO) prevent rhinovirus infection in viable mouse lung tissue
Sewald, Katherina; Hirth, Natalie; Warnecke, Jürgen; Danov, Olga; Obernolte, Helena; Braun, Armin; Wronski, Sabine
Abstract
2018Characterization of human precision cut liver slices by various viability andfunctional parameters during 24 hour culture
Elenschneider, Leroy; Knebel, Jan; Braun, Armin; Fangmann, J.; Hansen, Tanja
Abstract
2018Clinically validated markers of the extracellular matrix remodelling are altered by potential anti-fibrotic compounds in a human lung fibrosis ex vivo model
Leeming, Diana Julie; Sand, Jannie M.B.; Hesse, Christina; Konzok, Sebastian; Sewald, Katherina; Rønnow, Sarah; Braun, Armin; Karsdal, Morten A.; Brockbank, Sarah; Cruwys, Simon
Abstract
2018Common marmosets (Callithrix jacchus) can exhibit features of asthma
Curths, Christoph
: Braun, Armin; Pabst, Reinhard; Bleich, André
Dissertation
2018Comparison of IP-10 production induced by ex-vivo stimulation with Respiratory Syncytial Virus (RSV) and the TLR3 agonist Poly I: C in human and non-human primate lung tissues
Twisterling, Elaine S.; Dahlmann, Franziska; Dehmel, Susann; Wronski, Sabine; Braubach, Peter; Jonigk, Danny; Warnecke, G.; Krüger, M.; Zardo, P.; Sewald, Katherina; Braun, Armin
Abstract
2018A computational framework for complex disease stratification from multiple large-scale datasets
Meulder, Bertrand de; Lefaudeux, Diane; Bansal, Aruna T.; Mazein, Alexander; Chaiboonchoe, Amphun; Ahmed, Hassan; Balaur, Irina; Saqi, Mansoor; Pellet, Johann; Ballereau, Stephane; Lemonnier, Nathanaël; Sun, Kai; Pandis, Ioannis; Yang, Xian; Batuwitage, Manohara; Kretsos, Kosmas; Eyll, Jonathan van; Bedding, Alun; Davison, Timothy; Dodson, Paul; Larminie, Christopher; Postle, Anthony; Corfield, Julie; Djukanović, Ratko; Chung, Kian Fan; Adcock, Ian M.; Guo, Yi-Ke; Sterk, Peter J.; Manta, Alexander; Rowe, Anthony; Baribaud, Frédéric; Auffray, Charles; Badorrek, Philipp; Faulenbach, Cornelia; Braun, Armin; Hohlfeld, Jens; Krug, Norbert
Zeitschriftenaufsatz
2018Early biomarkers indicating COPD can be induced by whole cigarette smoke in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Zardo, Patrick; Fieguth, Hans-Gerd; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2018Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin
Müller, Laura; Murgia, Xabier; Siebenburger, Lorenz; Börger, Carsten; Schwarzkopf, Konrad; Sewald, Katherina; Häussler, Susanne; Braun, Armin; Lehr, Claus-Michael; Hittinger, Marius; Wronski, Sabine
Zeitschriftenaufsatz
2018Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs
Danov, Olga; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Seehase, Sophie; Dehmel, Susann; Braubach, Peter; Fieguth, Hans-Gerd; Matschiner, Gabriele; Fitzgerald, Mary; Jonigk, Danny; Knauf, Sascha; Pfennig, Olaf; Warnecke, Gregor; Wichmann, Judy; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2018Human teratoma-derived hematopoiesis is a highly polyclonal process supported by human umbilical vein endothelial cells
Philipp, Friederike; Selich, Anton; Rothe, Michael; Hoffmann, Dirk; Rittinghausen, Susanne; Morgan, Michael A.; Klatt, Denise; Glage, Silke; Lienenklaus, Stefan; Neuhaus, Vanessa; Sewald, Katherina; Braun, Armin; Schambach, Axel
Zeitschriftenaufsatz
2018An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages
Beneke, Valerie; Küster, Fennja; Neehus, Anna-Lena; Hesse, Christina; Lopez-Rodriguez, Elena; Haake, Kathrin; Rafiei Hashtchin, Anna; Schott, Juliane Wilhelmine; Walter, Dorothee; Braun, Armin; Wolkers, Willem F.; Ackermann, Mania; Lachmann, Nico
Zeitschriftenaufsatz
2018Importance of the IL-1 axis in haemophilus influenzae-stimulated M1 macrophages driving transepithelial signaling
Mang, Samuel; Braun, Armin; Pairet, Nicolas; Lamb, David J.
Zeitschriftenaufsatz
2018Induction of innate immune response in fresh human lung tissue ex vivo following P. aeruginosa infection
Müller, Laura; Kraemer, Nadine; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Pfennig, Olaf; Bersch, Claus; Braun, Armin; Sewald, Katherina; Wronski, Sabine
Abstract
2018Inflammatory exacerbation and inadequate interferone response to RV1b infection in HDM-sensitized lung tissue
Danov, Olga; Laßwitz, Lisa; Obernolte, Helena; Hesse, Christina; Braun, Armin; Wronski, Sabine; Sewald, Katherina
Abstract
2018Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients
Tschernig, Thomas; Pabst, Reinhard; Prenzler, Frauke; Rittinghausen, Susanne; Braun, Armin; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2018Mechanism of NK1-mediated bronchoconstriction in passively sensitized human lung tissue
Dehmel, Susann; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Reamon-Buettner, Stella Marie; Jonigk, Danny; Pfennig, Olaf; Braubach, Peter; Warnecke, Gregor; Fieguth, Hans-Gerd; Sewald, Katherina; Braun, Armin
Abstract
2018Die Milztyrosinkinase SYK reguliert die pulmonale Vasokonstriktion
Tabeling, Christoph; Herbert, Julia; Boiarina, Ekaterina; Hocke, Andreas C.; Sewald, Katherina; Lamb, David J.; Wollin, Stefan Lutz; Fehrenbach, Heinz; Kuebler, Wolfgang M.; Braun, Armin; Suttorp, Norbert W.; Weissmann, Norbert; Witzenrath, Martin
Abstract
2018Modulation of tumor-microenvironmental factors and cancer growth in co-cultures of fresh human lung tissue and patient-derived cancer cells
Konzok, Sebastian; Dehmel, Susann; Werno, Christian; Braubach, Peter; Warnecke, Gregor; Zardo, Patrick; Jonigk, Danny; Pfennig, Olaf; Fieguth, Hans-Gerd; Polzer, Bernhard; Weidele, Kathrin; Klein, Christoph A.; Braun, Armin; Sewald, Katherina
Abstract
2018Polyclonal development of hematopoiesis in teratomas generated with human induced pluripotent stem cells
Philipp, Friederike; Selich, Anton; Rothe, Michael; Hoffmann, Dirk; Rittinghausen, Susanne; Sewald, Katherina; Braun, Armin; Schambach, Axel
Zeitschriftenaufsatz, Konferenzbeitrag
2018Studies towards development of drugs targeting aspergillus fumigatus
Seegers, Carla
: Routier, Françoise (Betreuer); Braun, Armin (Betreuer)
Master Thesis
2018Syk expression and function in the pulmonary vasculature
Tabeling, Christoph; Herbert, Julia; Boiarina, Ekaterina; Hocke, Andreas C.; Sewald, Katherina; Lamb, David J.; Wollin, Stefan Lutz; Fehrenbach, Heinz; Kuebler, Wolfgang M.; Braun, Armin; Suttorp, Norbert W.; Weissmann, Norbert; Witzenrath, Martin
Abstract
2018TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1
Zmora, Pawel; Hoffmann, Markus; Kollmus, Heike; Moldenhauer, Anna-Sophie; Danov, Olga; Braun, Armin; Winkler, Michael; Schughart, Klaus; Pöhlmann, Stefan
Zeitschriftenaufsatz
2018Transcriptomic analyses reveal anti-viral responses of epithelial cells and multiple immune cell types in HRV infected human lung tissue
Obernolte, Helena; Braubach, Peter; Jonigk, Danny; Beinke, Soren; Belyaev, Nikolai N.; Lennon, Mark; Warnecke, Gregor; Fieguth, Hans-Gerd; Hessel, Edith M.; Braun, Armin; Sewald, Katherina; Wronski, Sabine; Twisterling, Serrao E.
Abstract
2017Evaluation of a human in vitro hepatocyte-NPC co-culture model for the prediction of idiosyncratic drug-induced liver injury: A pilot study
Granitzny, Anne; Knebel, Jan; Müller, Meike; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Zeitschriftenaufsatz
2017Evaluation of inflammatory and immune responses in long-term cultured human precision-cut lung slices
Temann, Angela; Golovina, Tatiana; Neuhaus, Vanessa; Thompson, Carolann; Chichester, Jessica A.; Braun, Armin; Yusibov, Vidadi
Zeitschriftenaufsatz, Konferenzbeitrag
2017Human effector memory T helper cells engage with mouse macrophages and cause Graft-versus-Host-like pathology in skin of humanized mice used in a nonclinical immunization study
Sundarasetty, Balasai; Volk, Valery; Theobald, Sebastian J.; Rittinghausen, Susanne; Schaudien, Dirk; Neuhaus, Vanessa; Figueiredo, Constanca; Schneider, Andreas; Gerasch, Laura; Mucci, Adele; Moritz, Thomas; Kaisenberg, Constantin von; Spineli, Loukia M.; Sewald, Katherina; Braun, Armin; Weigt, Henning; Ganser, Arnold; Stripecke, Renata
Zeitschriftenaufsatz
2017Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy
Veres, Tibor Z.; Kopcsányi, Támas; Tirri, Marko; Braun, Armin; Miyasaka, Masayuki; Germain, Ronald N.; Jalkanen, Sirpa; Salmi, Marko
Zeitschriftenaufsatz
2017Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound
Granitzny, Anne; Knebel, Jan; Schaudien, Dirk; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Zeitschriftenaufsatz
2017Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
Zmora, Pawel; Molau-Blazejewska, Paulina; Bertram, Stephanie; Walendy-Gnirß, Kerstin; Nehlmeier, Inga; Hartleib, Anika; Moldenhauer, Anna-Sophie; Konzok, Sebastian; Dehmel, Susann; Sewald, Katherina; Brinkmann, Constantin; Curths, Christoph; Knauf, Sascha; Gruber, Jens; Mätz-Rensing, Kerstin; Dahlmann, Franziska; Braun, Armin; Pöhlmann, Stefan
Zeitschriftenaufsatz
2017Pseudomonas aeruginosa induziert eine angeborene Immunantwort in frischem Lungengewebe ex vivo
Kraemer, Nadine
: Braun, Armin (1. Prüfer); Häußler, Susanne (2. Prüfer); Wronski, Sabine (Betr.); Müller, Laura (Betr.)
Master Thesis
2016BI 1002494, a novel potent and selective oral spleen tyrosine kinase inhibitor, displays differential potency in human basophils and B cells
Lamb, David J.; Wollin, Stefan Lutz; Schnapp, Andreas; Bischoff, Daniel; Erb, Klaus J.; Bouyssou, Thierry; Guilliard, Bernd; Strasser, Christine; Wex, Eva; Blum, Sylvia; Thaler, Eva; Nickel, Helga; Radmacher, Oliver; Haas, Hannah; Swantek, Jennifer L.; Souza, Don; Canfield, Melissa; White, Della; Panzenbeck, Mark; Kashem, Mohammed A.; Sanville-Ross, Mary; Kono, Takeshi; Sewald, Katherina; Braun, Armin; Obernolte, Helena; Danov, Olga; Schaenzle, Gerhard; Rast, Georg; Maier, Gerd-Michael; Hoffmann, Matthias
Zeitschriftenaufsatz
2016Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture
Tran, Doan Duy Hai; Koch, Alexandra; Saran, Shashank; Armbrecht, Marcel; Ewald, Florian; Koch, Martina; Wahlicht, Tom; Wirth, Dagmar; Braun, Armin; Nashan, Bjorn; Gaestel, Matthias; Tamura, Teruko
Zeitschriftenaufsatz
2016Morphology and staining behavior of neutrophilic and eosinophilic granulocytes of the common marmoset (Callithrix jacchus)
Bleyer, Martina; Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Bauer, Natali; Moritz, Andreas; Braun, Armin; Knauf, Sascha; Kaup, Franz-Josef; Gruber-Dujardin, Eva
Zeitschriftenaufsatz
2016Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity
Hess, A.; Wang-Lauenstein, Lan; Braun, Armin; Kolle, S.N.; Landsiedel, Robert; Liebsch, M.; Ma-Hock, Lan; Pirow, R.; Schneider, X.; Steinfath, M.; Vogel, S.; Martin, C.; Sewald, Katherina
Zeitschriftenaufsatz
2016Steroid treatment reduces allergic airway inflammation and does not alter the increased numbers of dendritic cells and calcitonin gene-related peptide-expressing neurons in airway sensory ganglia
Le, Duc Dung; Funck, Ulrike; Wronski, Sabine; Heck, Sebastian; Tschernig, Thomas; Bischoff, Markus; Sester, Martina; Herr, Christian; Bals, Robert; Welte, Tobias; Braun, Armin; Dinh, Quoc Thai
Zeitschriftenaufsatz
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Comparison of fibrotic and emphysematous alterations in the lungs of bleomycin-treated rats and hamsters
Hoymann, Heinz-G.; Schaudien, Dirk; Hansen, Tanja; Müller, Meike; Braun, Armin
Abstract
2015Development of a human organotypic tumor invasion model of cancer cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS)
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Eosinophils of the marmoset monkey (callithrix jacchus)
Gruber-Dujardin, E.; Curths, Christoph; Bleyer, Martina; Taubert, S.; Bauer, N.; Moritz, A.; Dahlmann, Franziska; Braun, Armin; Knauf, Sascha; Kaup, Franz Josef
Abstract
2015House-dust-mite induced features of asthma in marmoset monkeys
Curths, Christoph; Dahlmann, Franziska; Wichmann, Judy; Becker, Tamara; Knauf, Y.; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Abstract
2015Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Niedrig dosierte inhalative Endotoxin Provokation bei gesunden Probanden als Modell in der klinischen Atemwegsforschung
Janssen, Ole
: Hohlfeld, Jens M. (Betreuer); Braun, Armin (Referent); Dittrich, Anna-Maria (Korreferent)
Dissertation
2015A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Peripheral sensory nerves stimulation lead to bronchoconstriction-augment in passive sensitized human precision-cut lung slices and is histamine 1 receptor dependent
Jiménez Delgado, Sharon Melissa; Schindler, Susann; Sewald, Katherina; Braun, Armin
Abstract
2015Precision-cut lung slices as an alternative model for repeated-dose inhalation toxicity
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Syliva; Braun, Armin; Sewald, Katherina
Abstract
2015Risk assessment of inhalable read-across chemicals with different mode of action showed great differences in cytotoxicity in rat and human precision-cut lung slices
Danov, Olga; Schröder, Katrin; Braubach, Peter; Jonigk, D.; Warnecke, G.; Braun, Armin; Escher, Syliva; Sewald, Katherina
Abstract
2015The serotonin receptor 5-HT7R regulates the morphology and migratory properties of dendritic cells
Holst, Katrin; Guseva, Daria; Schindler, Susann; Sixt, Michael; Braun, Armin; Chopra, Himpriya; Pabst, Oliver; Ponimaskin, Evgeni
Zeitschriftenaufsatz
2015Species comparison of rat and human precision-cut lung slices as an alternative in risk assessment based on read-across approach
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Bersch, Claus; Braubach, Peter; Jonigk, Danny; Pfennig, Olaf; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015TRPA1 agonists modulate the trachealis muscle tone via two independent mechanisms
Haider, Georg; Lee, Jae Hwa; Wiegand, Silke; Spies, Emma; Hoymann, Heinz-Gerd; Kummer, Wolfgang; Braun, Armin; Nassenstein, Christina
Abstract
2014Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets (Callithrix jacchus)
Curths, Christoph; Wichmann, Judy; Dunker, Sarah; Windt, Horst; Hoymann, Heinz-Gerd; Lauenstein, Hans D.; Hohlfeld, Jens M.; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Zeitschriftenaufsatz
2014Allergische Atemwegsentzündung induziert eine Zunahme von Dendritischen Zellen in den Atemwegsganglien der Maus
Le, Duc Dung; Rochlitzer, Sabine; Heck, Sebastian; Bals, Robert; Braun, Armin; Welte, Tobias; Dinh, Quoc Thai
Abstract
2014Alternative model for repeated dose inhalation toxicity using precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Sylvia; Schaudien, Dirk; Braun, Armin; Sewald, Katherina
Abstract
2014Biological impact of modified inhalable carbon black nanoparticles assessed in cell and tissue culture models
Danov, Olga; Kopf, Johannes; Ströbele, M.; Bockhorn, H.; Fehrenbach, H.; Braun, Armin; Sewald, Katherina; Hansen, Tanja
Abstract
2014Biomarker for eosinophil and T-cell recruitment induced by interleukin-13 as a therapeutic target for allergic asthma tested in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, H.; Pfennig, Olaf; Förster, C.; Hohlbaum, A.; Audoly, L.; Braun, Armin; Sewald, Katherina
Abstract
2014Biotechnologie statt Tierversuche
Braun, Armin
Zeitschriftenaufsatz
2014Characterization of ex vivo immunostimulated dendritic cells in murine lung tissue
Brandstetter, Ronja Lorena
: Braun, Armin (Gutachter); Schwinzer, Reinhard (Gutachter)
Master Thesis
2014Characterization of IL-13- and allergen-induced airway hyperreactivity in precision-cut lung slices of different species
Drake, Helena
: Förster, Irmgard (Supervisor); Burgdorf, Sven (Supervisor); Sewald, Katherina (Advisor); Braun, Armin (Advisor)
Master Thesis
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Otmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Zeitschriftenaufsatz
2014Ex vivo models for asthma, COPD and lung injury in precision cut lung slices (PCLS)
Sewald, Katherina; Braun, Armin
Abstract
2014Frühe Phase der Allergen-induzierten Atemwegsreaktion beim Weißbüschelaffen nach passiver Sensibilisierung von Lungengewebe mit humanem Blutplasma
Wichmann, Judy; Jiménez Delgado, Sharon Melissa; Curths, Christoph; Becker, Tamara; Kaup, Franz Josef; Braun, Armin; Sewald, Katherina; Knauf, Sascha
Abstract
2014A human in vitro allergy model showing allergen specific immune responses using house dust mite or grass pollen allergen
Müller, Meike; Schaumann, Frank; Braun, Armin
Abstract
2014Human organotypic cancer model
Konzok, Sebastian; Schindler, Susann; Braun, Armin; Sewald, Katherina
Abstract
2014IL-13 induced asthma model in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, H.; Seehase, Sophie; Hohlbaum, A.M.; Bersch, C.; Jonigk, D.; Warnecke, G.; Braun, Armin; Sewald, Katherina
Abstract
2014Interleukin-13 as a therapeutic target for allergic asthma tested in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Pfennig, Olaf; Forster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Braun, Armin; Sewald, Katherina
Abstract
2014Invasion, proliferation and influence of cancer cell line MDA-MB-231 on organotypic tissue using Precision Cut Lung Slices (PCLS)
Konzok, Sebastian
: Braun, Armin (Supervisor); Tamura-Niemann, Teruko (Supervisor)
Master Thesis
2014Invasive but repetitive lung function measurements in a rodent model of pulmonary fibrosis
Hoymann, Heinz-Gerd; Ernst, Heinrich; Creutzenberg, Otto H.; Schaudien, Dirk; Müller, Meike; Knudsen, Lars; Braun, Armin
Abstract
2014Kinetikanalysen des Aktivierungszustandes von ex vivo stimulierten dendritischen Zellen im murinen PCLS Modell
Baron, Lena
: Braun, Armin (1. Gutachter); Schwinzer, Reinhard (2. Gutachter)
Master Thesis
2014Lung function assessment in nonhuman primate models of obstructive pulmonary diseases
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz-Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Lung function assessment in the common marmoset (Callithrix jacchus) for the evaluation of translational nonhuman primate models of lung inflammation
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Lung tissue culture model for assessment of cytotoxicity and inflammation induced by inhalable carbon black nanoparticles
Braun, Armin; Danov, Olga; Kopf, Johannes Claudius; Ströbele, Michael; Hansen, Tanja; Fehrenbach, Heinz; Sewald, Katherina
Abstract
2014A model of neuronal hyperreactivity in passive sensitized human organotypic tissue
Schindler, Susann; Jiménez Delgado, Sharon Melissa; Braun, Armin
Abstract
2014Murine precision-cut liver slices (PCLS): A new tool for studying tumor microenvironments and cell signaling ex vivo
Koch, Alexandra; Saran, Shashank; Tran, Doan Duy Hai; Klebba-Färber, Sabine; Thiesler, Hauke; Sewald, Katherina; Schindler, Susann; Braun, Armin; Klopfleisch, Robert; Tamura, Teruko
Zeitschriftenaufsatz
2014Neuronale Plastizität in NGF-transgenen Mäusen bei allergischen Atemwegentzündungen
Dinh, Quoc Thai; Quarcoo, David; Braun, Armin; Welte, Tobias; Bals, Robert; Fischer, A.
Abstract
2014A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung
Neuhaus, Vanessa; Chichester, Jessica A.; Ebensen, Thomas; Schwarz, Katharina; Cartman, Caitlin E.; Shoji, Yoko; Guzman, Carlos A.; Yusibov, Vidadi; Sewald, Katherina; Braun, Armin
Zeitschriftenaufsatz
2014New treatment strategies for respiratory diseases: Ex vivo and in vivo evaluation of pharmacological immunomodulations using a nanoparticle-based drug delivery system
Neuhaus, Vanessa
: Braun, Armin (Supervisor); Dittrich, Anna-Maria (Cosupervisor); Müller-Goymann, Christel (Cosupervisor)
Dissertation
2014No exacerbation but impaired anti-viral mechanisms in a rhinovirus-chronic allergic asthma mouse model
Rochlitzer, Sabine; Hoymann, Heinz-Gerd; Müller, Meike; Braun, Armin
Zeitschriftenaufsatz
2014Passively sensitized precision-cut lung slices from marmoset monkeys as a preclinical assay to test novel IgE inhibitors
Wichmann, Judy; Jiménez Delgado, Sharon Melissa; Curths, Christoph; Becker, Tamara; Eggel, Alexander; Kaup, Franz-Josef; Braun, Armin; Sewald, Katherina; Knauf, Sascha
Abstract
2014Pre-validation of the ex vivo model precision-cut lung slices (PCLS) for prediction of acute inhalation toxicity
Sewald, Katherina; Lauenstein, Lan; Schneider, X.; Pirow, R.; Steinfath, M.; Ma-Hock, L.; Liebsch, M.; Landsiedel, R.; Braun, Armin; Martin, C.
Abstract
2014Precision-cut lung slices as alternative to mimic inflammation, lung injury and bronchoconstriction after short and long-term maintenance in culture
Neuhaus, Vanessa; Schaudien, Dirk; Sewald, Katherina; Braun, Armin
Abstract
2014Prevalidation of the ex vivo model PCLS for the prediction of acute inhalation toxicity
Sewald, Katherina; Hess, A.; Lauenstein, Lan; Schneider, X.; Vogel, S.; Steinfath, M.; Pirow, R.; Liebsch, M.; Kolle, S.; Ma-Hock, L.; Landsiedel, R.; Martin, C.; Braun, Armin
Abstract
2014Rhinovirus infection in human and mouse precision cut lung slices
Rochlitzer, Sabine; Müller, Meike; Sewald, Katherina; Braun, Armin
Abstract
2014Species comparison of interleukin-13 induced airway hyperreactivity in precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, Helena; Schindler, Susann; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz, Konferenzbeitrag
2014Toxicity testing of sildenafil base-loaded liposomes in in vitro and ex vivo models for pulmonary application
Paranjpe, Mukta; Neuhaus, Vanessa; Braun, Armin; Müller-Goymann, Christel C.
Zeitschriftenaufsatz
2014Use of rat precision-cut lung slices for long-term functional evaluation
Neuhaus, Vanessa; Braun, Armin; Sewald, Katherina
Abstract
2014Veränderung von MHC-II positiven Zellen der Atemwegsganglien bei chronischem Hausstaubmilben-Mausmodell und HRV1B Infektion
Funck, Ulrike; Le, Duc Dung; Rochlitzer, Sabine; Heck, Sebastian; Bals, Robert; Braun, Armin; Welte, Tobias; Dinh, Quoc Thai
Abstract
2013Aeroallergen challenge promotes dendritic cell proliferation in the airways
Veres, Tibor Z.; Voedisch, Sabrina; Spies, Emma; Valtonen, Joona; Prenzler, Frauke; Braun, Armin
Zeitschriftenaufsatz
2013Anti-inflammatory and immunomodulatory properties of alpha1-antitrypsin without inhibition of elastase
Jonigk, Danny; Al-Omari, Mariam; Maegel, Lavinia; Müller, Meike; Izykowski, Nicole; Hong, Jaewoo; Hong, Kwangwon; Kim, Soo-Hyun; Dorsch, Martina; Mahadeva, Riva; Laenger, Florian; Kreipe, Hans; Braun, Armin; Shahaf, Galit; Lewis, Eli C.; Welte, Tobias; Dinarello, Charles A.; Janciauskiene, Sabina
Zeitschriftenaufsatz
2013Assessment of immunotoxicity using precision-cut tissue slices
Sewald, Katherina; Braun, Armin
Zeitschriftenaufsatz
2013Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice
Hox, Valérie; Vanoirbeek, Jeron A.; Alpizar, Yeranddy Aguiar; Voedisch, Sabrina; Callebaut, Ina; Bobic, Sonja; Sharify, Ali; Vooght, Vanessa de; Gerven, Laura van; Devos, Fien; Liston, Adrian; Voets, Thomas; Vennekens, Rudi; Bullens, Dominique M.A.; Vries, Annick de; Hoet, Peter; Braun, Armin; Ceuppens, Jan L.; Talavera, Karel; Nemery, Benoit; Hellings, Peter W.
Zeitschriftenaufsatz
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2013Effects of carbon black nanoparticles on human pulmonary cell lines and precision cut lung slices
Hansen, Tanja; Kopf, Johannes Claudius; Danov, Olga; Ströbele, M.; Braun, Armin; Sewald, Katherina; Steinberg, P.; Fehrenbach, H.
Zeitschriftenaufsatz, Konferenzbeitrag
2013Effects of dipeptidyl peptidase-4 inhibition in an animal model of experimental asthma: A matter of dose, route, and time
Stephan, Michael; Suhling, Hendrik; Schade, Jutta; Wittlake, Mareike; Tasic, Tihana; Klemann, Christian; Pabst, Reinhard; Jurawitz, Marie-Charlot; Raber, Kerstin A.; Hoymann, Heinz G.; Braun, Armin; Glaab, Thomas; Hoffmann, Torsten; Schmiedl, Andreas; Hoersten, S. von
Zeitschriftenaufsatz
2013Expression of VPAC1 in a murine model of allergic asthma
Lauenstein, Hans D.; Quarcoo, David; Welte, Tobias; Braun, Armin; Groneberg, David A.
Zeitschriftenaufsatz
2013Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique
Neuhaus, Vanessa; Schwarz, Katharina; Klee, Anna; Seehase, Sophie; Förster, Christine; Pfennig, Olaf; Jonigk, Danny; Fieguth, Hans-Gerd; Koch, Wolfgang; Warnecke, Gregor; Yusibov, Vidadi; Sewald, Katherina; Braun, Armin
Zeitschriftenaufsatz
2013IL-13-induced cytokine release and hyperresponsiveness in precision cut lung slices of different species - characterization of a model potentially suitable for translational research of asthma cellular events
Jiménez Delgado, Sharon Melissa; Danov, Olga; Braun, Armin; Pfenning, Olaf; Förster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Hohlfeld, Jens; Sewald, Katherina
Zeitschriftenaufsatz, Konferenzbeitrag
2013IL-13-induced inflammation and hyperreagibility in precision-cut lung slices of different species
Jiménez Delgado, Sharon Melissa
: Braun, Armin (Supervisor); Schuberth, Hans-Joachim (Supervisor)
Master Thesis
2013In vitro and ex vivo toxicity screening for predicting toxicological effects of synthetic carbon black nanoparticles in humans
Hansen, Tanja; Kopf, Johannes; Danov, Olga; Ströbele, Michael; Braun, Armin; Sewald, Katherina; Bockhorn, H.; Fehrenbach, Heinz
Zeitschriftenaufsatz, Konferenzbeitrag
2013Invasive lung function measurement in common marmosets (Callithrix jacchus)
Wichmann, Judy; Curths, Christoph; Dunker, Sarah; Windt, Horst; Hoymann, Heinz Gerd; Lauenstein, Hans Dieter; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Zeitschriftenaufsatz, Konferenzbeitrag
2013Pre-validation of the ex vivo model precision cut lung slices (PCLuS) for the prediction of respiratory toxicology
Hess, A.; Lauenstein, Lan; Schneider, X.; Vogel, S.; Ma-Hock, L.; Kolle, S.; Martin, C.; Pirow, R.; Steinfath, M.; Liebsch, M.; Landsiedel, R.; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz, Konferenzbeitrag
2013Prevalidation of the ex vivo model precision cut lung slices (PCLS) for the prediction of respiratory toxicology
Sewald, Katherina; Lauenstein, Lan; Vogel, S.; Hess, A.; Schneider, X.; Martin, C.; Pirow, R.; Liebsch, M.; Landsiedel, R.; Braun, Armin
Zeitschriftenaufsatz, Konferenzbeitrag
2013Severity of allergic airway disease due to house dust mite allergen is not increased after clinical recovery of lung infection with chlamydia pneumoniae in mice
Dutow, Pavel; Lingner, Sandra; Laudeley, Robert; Glage, Silke; Hoymann, Heinz-Gerd; Dittrich, Anna-Maria; Fehlhaber, Beate; Müller, Meike; Braun, Armin; Klos, Andreas
Zeitschriftenaufsatz
2013A translational non-human primate model for human asthma in the common marmoset (Callithrix Jacchus)
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens M.; Sewald, Katherina; Windt, Horst; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Zeitschriftenaufsatz, Konferenzbeitrag
2013Ein translationales LPS-Modell zur präklinischen Testung anti-inflammatorischer Substanzen im Weißbüschelaffen (Callithrix jacchus)
Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz Josef; Schlumbohm, Christina; Fuchs, E.; Lauenstein, Hans Dieter; Sewald, Katherina; Hohlfeld, Jens M.; Braun, Armin; Knauf, Sascha
Zeitschriftenaufsatz, Konferenzbeitrag
2013Ein translationales Tiermodel für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Braun, Armin; Knauf, Sascha
Zeitschriftenaufsatz, Konferenzbeitrag
2013Ein translationales Tiermodell für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Becker, T.; Kaup, Franz Josef; Schlumbohm, Christina; Sewald, Katherina; Hohlfeld, Jens M.; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Zeitschriftenaufsatz, Konferenzbeitrag
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2012Assessment of lung toxicity induced by chemical allergens in human precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Prenzler, Frauke; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Abstract
2012Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function
Langer, Marybeth; Duggan, Elizabeth S.; Booth, John L.; Patel, Vineet I.; Zander, Ryan A.; Silasi-Mansat, Robert; Ramani, Vijay; Veres, Tibor Z.; Prenzler, Frauke; Sewald, Katherina; Williams, Daniel M.; Coggeshall, Kenneth M.; Awasthi, Shanjana; Lupu, Florea; Burian, Dennis; Ballard, Jimmy D.; Braun, Armin; Metcalf, Jordan P.
Zeitschriftenaufsatz
2012Bacterial infection triggers exacerbation of established pulmonary fibrosis in mice: Impact on lung protective immunity
Ueberberg, Bianca; Janze, Ann-Kathrin; Steinwede, Kathrin; Maus, Regina; Magel, Lavinia; Hoymann, Heinz-Gerd; Braun, Armin; Langer, Florian; Jonigk, Danny; Kolb, Martin; Gauldie, Jack; Welte, Tobias; Maus, Ulrich A.
Abstract
2012Cathepsin G and neutrophil elastase contribute to lung protective immunity against mycobacterial infections in mice
Steinwede, Kathrin; Maus, Regina; Bohling, Jennifer; Voedisch, Sabrina; Braun, Armin; Ochs, Matthias; Schmiedl, Andreas; Walter, Kerstin; Bange, Franz; Welte, Tobias; Ehlers, Stefan; Maus, Ulrich A.
Abstract
2012Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice
Steinwede, Kathrin; Maus, Regina; Bohling, Jennifer; Voedisch, Sabrina; Braun, Armin; Ochs, Matthias; Schmiedl, Andreas; Länger, Florian; Gauthier, Francis; Roes, Jürgen; Welte, Tobias; Bange, Franz C.; Niederweis, Michael; Bühling, Frank; Maus, Ulrich A.
Zeitschriftenaufsatz
2012Effect of Tiotropium on in vivo and ex vivo lung function in a rat model of bronchoconstriction
Seehase, Sophie; Köhncke, Sarah-Philine; Hoymann, Heinz-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2012Ex vivo lung culture models of marmoset monkeys and humans for anti-inflammatory drug testing
Seehase, Sophie; Neuhaus, Vanessa; Kaup, Franz-Josef; Pfennig, O.; Förster, Christine; Hohlfeld, Jens Michael; Knauf, Sascha; Braun, Armin; Sewald, Katherina
Abstract
2012Human alveolar epithelial barrier function is impaired by bacillus anthracis lethal toxin
Langer, Marybeth; Booth, John L.; Patel, Vineet I.; Duggan, Elizabeth S.; Braun, Armin; Ramani, Vijay; Awasthi, Shanjana; Silasi-Mansat, Robert; Lupu, Florea; Coggeshall, Kenneth M.; Metcalf, Jordan P.
Abstract
2012Immunotoxic characterization of a nanoparticle-based inhalable influenza vaccine in murine and human precision cut lung slices
Neuhaus, Vanessa; Schwarz, Katharina; Koch, Wolfgang; Sewald, Katherina; Yusibov, V.; Braun, Armin
Abstract
2012Marmoset monkeys as a preclinical model in respiratory research
Seehase, Sophie
: Kaup, Franz-Josef (1. Gutachter); Zimmermann, Elke (2. Gutachterin); Braun, Armin (Wiss. Betreuung)
Dissertation
2012Neuro-immune interaction in allergic airway inflammation: Expression and function of dendritic cells in sensory airway ganglia neurons
Le, Dung D.; Rochlitzer, Sabine; Funck, Ulrke; Suhling, Hendrik; Braun, Armin; Welte, Tobias; Din, Quoc Thai
Abstract
2012Neuropeptides influence airway dendritic cell behavior
Braun, Armin; Spies, Emma; Rochlitzer, Sabine; Voedisch, Sabrina
Abstract
2012A new model for testing human specific anti-inflammatory drugs: LPS-induced lung inflammation in the common marmoset
Knauf, Sascha; Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz-Josef; Schlumbohm, Christina; Fuchs, Eberhard; Lauenstein, Hand D.; Sewald, Katherina; Hohlfeld, Jens Michael; Braun, Armin
Abstract
2012The respiratory tract
Braun, Armin; Ernst, Heinrich; Schaudien, Dirk; Hoymann, Heinz-Gerd; Rittinghausen, Susanne
Aufsatz in Buch
2012Rhinovirus application on the background of allergic airway inflammation in a chronic house dust mite model
Rochlitzer, Sabine; Hoymann, Heinz-Gerd; Müller, Meike; Braun, Armin
Abstract
2012Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Schleh, Carsten; Rothen-Rutishauser, Barbara M.; Blank, Fabian; Lauenstein, Hans D.; Nassimi, Matthias; Krug, Norbert; Braun, Armin; Erpenbeck, Veit; Gehr, Peter; Hohlfeld, Jens M.
Zeitschriftenaufsatz
2011Characterization of local respiratory irritation and inflammation after acute exposure to biological and chemical substances in PCLS
Switalla, S.
: Steinhagen, D. (Referent); Braun, Armin (Korreferent); Bicker, Gerd (Korreferent)
Dissertation
2011Mechanisms of bronchoconstriction in precision-cut lung slices of non-human primates are comparable to human
Seehase, Sophie; Schlepütz, M.; Switalla, Simone; Fuchs, E.; Kaup, F.-J.; Ressmeyer, A.R.; Uhlig, S.; Lauenstein, Hans-Dieter; Braun, Armin; Martin, C.; Sewald, Katherina
Konferenzbeitrag, Zeitschriftenaufsatz
2011Neuronale Kontrolle bei chronisch entzündlichen und obstruktiven Lungenerkrankungen wie Asthma bronchiale und COPD
Dinh, Q.T.; Suhling, H.; Fischer, A.; Braun, Armin; Welte, Tobias
Zeitschriftenaufsatz
2011The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function
Rochlitzer, Sabine; Veres, Tibor Z.; Kühne, Kathleen; Prenzler, Frauke; Pilzner, Carolin; Knothe, Saskia; Winkler, Carla; Lauenstein, Hans-Dieter; Willart, M.; Hammad, H.; Müller, Meike; Krug, Norbert; Lambrecht, Bart N.; Braun, Armin
Zeitschriftenaufsatz
2011PCLS: From learning about 'in vivo' to reduction and replacement
Sewald, Katherina; Braun, Armin
Aufsatz in Buch
2011The phosphodiesterase-4-inhibitor Roflumilast reduces LPS-induced lung inflammation in common marmoset monkeys
Seehase, Sophie; Switalla, Simone; Prenzler, Frauke; Fuchs, E.; Schlumbohm, C.; Kaup, F.-J.; Sewald, Katherina; Lauenstein, Hans-Dieter; Braun, Armin
Konferenzbeitrag, Zeitschriftenaufsatz
2011Spatiotemporal and functional behavior of airway dendritic cells visualized by two-photon microscopy
Veres, Tibor Z.; Voedisch, Sabrina; Spies, Emma; Tschernig, Thomas; Braun, Armin
Zeitschriftenaufsatz