Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Cigarette smoke induced pathophysiological changes in the extracellular matrix but not inflammation as early events in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Warnecke, G.; Zardo, P.; Fieguth, H.-G.; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2019Enhanced tissue damage following H1N1 infection in human precision-cut lung slices (PCLS)
Danov, Olga; Martin, Gaël; Greif, A.; Bailly, B.; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Itzstein, M. von; Sewald, Katherina; Wronski, Sabine; Braun, Armin
Abstract
2019Hazard characterisation of acrylates by in vitro and ex vivo models - an update of the ExITox project
Schramm, Sinja-Fee; Wehr, Matthias; Danov, Olga; Obernolte, Helena; Knebel, Jan; Koschmann, J.; Meckbach, C.; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Hansen, Tanja; Braun, Armin; Sewald, Katherina; Escher, Sylvia E.
Abstract
2018Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Konzok, Sebastian; Obernolte, Helena; Dehmel, Susann; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Zardo, Patrick; Warnecke, Gregor; Martin, Christian; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2018Early biomarkers indicating COPD can be induced by whole cigarette smoke in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Zardo, Patrick; Fieguth, Hans-Gerd; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2018Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs
Danov, Olga; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Seehase, Sophie; Dehmel, Susann; Braubach, Peter; Fieguth, Hans-Gerd; Matschiner, Gabriele; Fitzgerald, Mary; Jonigk, Danny; Knauf, Sascha; Pfennig, Olaf; Warnecke, Gregor; Wichmann, Judy; Braun, Armin; Sewald, Katherina
Zeitschriftenaufsatz
2018Induction of innate immune response in fresh human lung tissue ex vivo following P. aeruginosa infection
Müller, Laura; Kraemer, Nadine; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Pfennig, Olaf; Bersch, Claus; Braun, Armin; Sewald, Katherina; Wronski, Sabine
Abstract
2018Mechanism of NK1-mediated bronchoconstriction in passively sensitized human lung tissue
Dehmel, Susann; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Reamon-Buettner, Stella Marie; Jonigk, Danny; Pfennig, Olaf; Braubach, Peter; Warnecke, Gregor; Fieguth, Hans-Gerd; Sewald, Katherina; Braun, Armin
Abstract
2018Modulation of tumor-microenvironmental factors and cancer growth in co-cultures of fresh human lung tissue and patient-derived cancer cells
Konzok, Sebastian; Dehmel, Susann; Werno, Christian; Braubach, Peter; Warnecke, Gregor; Zardo, Patrick; Jonigk, Danny; Pfennig, Olaf; Fieguth, Hans-Gerd; Polzer, Bernhard; Weidele, Kathrin; Klein, Christoph A.; Braun, Armin; Sewald, Katherina
Abstract
2018Transcriptomic analyses reveal anti-viral responses of epithelial cells and multiple immune cell types in HRV infected human lung tissue
Obernolte, Helena; Braubach, Peter; Jonigk, Danny; Beinke, Soren; Belyaev, Nikolai N.; Lennon, Mark; Warnecke, Gregor; Fieguth, Hans-Gerd; Hessel, Edith M.; Braun, Armin; Sewald, Katherina; Wronski, Sabine; Twisterling, Serrao E.
Abstract
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Development of a human organotypic tumor invasion model of cancer cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS)
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Risk assessment of inhalable read-across chemicals with different mode of action showed great differences in cytotoxicity in rat and human precision-cut lung slices
Danov, Olga; Schröder, Katrin; Braubach, Peter; Jonigk, D.; Warnecke, G.; Braun, Armin; Escher, Syliva; Sewald, Katherina
Abstract
2015Species comparison of rat and human precision-cut lung slices as an alternative in risk assessment based on read-across approach
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Bersch, Claus; Braubach, Peter; Jonigk, Danny; Pfennig, Olaf; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract