Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2016Epigenetic silencing of the lung tumor suppressor cell adhesion molecule 1
Borlak, J.; Buettner, S.M.R.
Abstract
2014Isolation and cultivation of metabolically competent alveolar epithelial cells from A/J mice
Hansen, T.; Chougule, A.; Borlak, J.
Zeitschriftenaufsatz
2013Improving the diagnosis and management of neuroendocrine tumors
Giandomenico, V.; Modlin, I.M.; Ponten, F.; Nilsson, M.; Landegrend, U.; Bergqvist, J.; Khan, M.S.; Millar, R.P.; Langström, B.; Borlak, J.; Eriksson, B.; Nielsen, B.; Baltzer, L.; Waterton, J.C.; Ahlström, H.; Öberg, K.
Zeitschriftenaufsatz
2013Spontane Nebenwirkungsmeldungen zu Analgetika - Relevanz für Risikobewertung?
Borlak, J.
Zeitschriftenaufsatz
2013Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease
Reamon-Büttner, Stella Marie; Sattleger, Evelyn; Ciribilli, Yari; Inga, Alberto; Wessel, Armin; Borlak, Jürgen
Zeitschriftenaufsatz
2012Combined micro-PET/micro-CT imaging of lung tumours in SPC-raf and SPC-myc transgenic mice
Rodt, T.; Luepke, M.; Boehm, C.; Hueper, K.; Halter, R.; Glage, S.; Hoy, L.; Wacker, F.; Borlak, J.; Falck, C. von
Zeitschriftenaufsatz
2012Dissecting epigenetic silencing complexity in the mouse lung cancer suppressor gene cadm1
Reamon-Büttner, Stella Marie; Borlak, Jürgen
Zeitschriftenaufsatz
2012Lung tumour growth kinetics in SPC-c-Raf-1-BB transgenic mice assessed by longitudinal in-vivo micro-CT quantification
Rodt, Thomas; Falck, Christian von; Dettmer, Sabine; Hueper, Katja; Halter, Roman; Hoy, Ludwig; Luepke, Matthias; Borlak, Jürgen; Wacker, Frank
Zeitschriftenaufsatz
2012MYC-regulated genes involved in liver cell dysplasia identified in a transgenic model of liver cancer
Hunecke, D.; Spanel, R.; Langer, F.; Nam, S.W.; Borlak, J.
Zeitschriftenaufsatz
2012PET/CT imaging of c-Myc transgenic mice identifies the genotoxic N-Nitroso-Diethylamine as carcinogen in a Short-Term cancer bioassay
Hueper, K.; Elalfy, M.; Laenger, F.; Halter, R.; Rodt, T.; Galanski, M.; Borlak, J.
Zeitschriftenaufsatz
2011Advanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancer
Stegmaier, P.; Voss, N.; Meier, T.; Kel, A.; Wingender, E.; Borlak, J.
Zeitschriftenaufsatz
2011Cancer proteomics of mouse serum and liver tissue samples to discover candidate biomarkers for hepatocellular carcinoma (HCC) in c-Myc transgenic mice
Ritorto, Maria Stella
: Borlak, Jürgen (Referent); Alves, Juergen (Korreferent)
Dissertation
2011Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies
Ritorto, M.S.; Borlak, J.
Zeitschriftenaufsatz
2011Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous adr reporting
Anderson, N.; Borlak, J.
Zeitschriftenaufsatz
2011Development of MALDI-TOF mass spectrometry based methods for the identification and molecular characterization of proteins, phosphoproteins and DNA adducts
Garaguso, Ignazio
: Borlak, Jürgen (Referent); Pich, Andreas (Korreferent)
Dissertation
2011A high resolution genome-wide scan of HNF4alpha recognition sites infers a regulatory gene network in colon cancer
Weltmeier, F.; Borlak, J.
Zeitschriftenaufsatz
2011HNF4alpha dysfunction as a molecular rational for cyclosporine induced hypertension
Niehof, M.; Borlak, J.
Zeitschriftenaufsatz
2011Pathology of flupirtine-induced liver injury: A histological and clinical study of six cases
Puls, F.; Agne, C.; Klein, F.; Koch, M.; Rifai, K.; Manns, M.P.; Borlak, J.; Kreipe, H.H.
Zeitschriftenaufsatz
2011Phantom and cadaver measurements of dose and dose distribution in micro-CT of the chest in mice
Rodt, Thomas; Luepke, Matthias; Boehm, Claudia; Falck, Christian von; Stamm, Georg; Borlak, Jürgen; Seifert, Hermann; Galanski, Michael
Zeitschriftenaufsatz
2011Produktion, Aufreinigung und Validierung eines monoklonalen anti-EpCAM-Antikörpers
Neß, Melanie
: Pfitzner, Reinhard (Betreuer); Borlak, Jürgen (Betreuer)
Bachelor Thesis
2010Commentary on "Investigations of somatic NKX2-5 mutations in congenital heart disease (CHD)"
Reamon-Buettner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2010Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration
Fritzinger, D.C.; Dean, R.; Meschter, C.; Wong, K.; Halter, R.; Borlak, J.; John, W.D.; Vogel, C.-W.
Konferenzbeitrag
2010Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels
Zwadlo, C.; Borlak, J.
Zeitschriftenaufsatz
2010Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells
Lehner, F.; Kulik, U.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2010Mapping of liver-enriched transcription factors in the human intestine
Lehner, F.; Kulik, U.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2010Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease
Thum, T.; Batkai, S.; Malinski, P.G.; Becker, T.; Mevius, I.; Klempnauer, J.; Meyer, H.H.; Frölich, J.C.; Borlak, J.; Tsikas, D.
Zeitschriftenaufsatz
2010Method for the rapid detection and molecular characterization of DNA alkylating agents by MALDI-TOF mass spectrometry
Garaguso, I.; Halter, R.; Krzeminski, J.; Amin, S.; Borlak, J.
Zeitschriftenaufsatz
2010Micro-computed tomography of pulmonary fibrosis in mice induced by adenoviral gene transfer of biologically active transforming growth factor-beta 1
Rodt, T.; Falck, C. von; Dettmer, S.; Halter, R.; Maus, R.; Ask, K.; Kolb, M.; Gauldie, J.; Länger, F.; Hoy, L.; Welte, T.; Galanski, M.; Maus, U.A.; Borlak, J.
Zeitschriftenaufsatz
2010Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers
Krüwel, T.; Schenone, S.; Radi, M.; Maga, G.; Rohrbeck, A.; Botta, M.; Borlak, J.
Zeitschriftenaufsatz
2010NKX2-5: An update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD)
Reamon-Büttner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2010A safety and tolerability study of differently-charged nanoparticles for local pulmonary drug delivery
Harush-Frenkel, O.; Bivas-Benita, M.; Nassar, T.; Springer, C.; Sherman, Y.; Avital, A.; Altschuler, Y.; Borlak, J.; Benita, S.
Zeitschriftenaufsatz
2010Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20
Riva, E.; Comi, D.; Borrelli, S.; Colombo, F.; Danieli, B.; Borlak, J.; Evensen, L.; Lorens, J.B.; Fontana, G.; Gia, O.M.; Via, L.D.; Passarella, D.
Zeitschriftenaufsatz
2010Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates
Passarella, D.; Peretto, B.; Blasco y Yepes, R.; Cappelletti, G.; Cartelli, D.; Ronchi, C.; Snaith, J.; Fontana, G.; Danieli, B.; Borlak, J.
Zeitschriftenaufsatz
2010Toxicogenomics applied to In Vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens
Rohrbeck, A.; Salinas, G.; Maaser, K.; Linge, J.; Salovaara, S.; Corvi, R.; Borlak, J.
Zeitschriftenaufsatz
2009A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice
Chatterji, B.; Borlak, J.
Zeitschriftenaufsatz
20093.3 Trovafloxacin: A case study of idiosyncratic or iatrogenic liver toxicity - molecular mechanisms and lessons for pharmacotoxicity
Borlak, J.
Zeitschriftenaufsatz
2009Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures
Kosacka, J.; Gericke, M.; Nowicki, M.; Kacza, J.; Borlak, J.; Spanel-Borowski, K.
Zeitschriftenaufsatz
2009Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1
Rohrbeck, A.; Borlak, J.
Zeitschriftenaufsatz
2009Charakterisierung experimenteller c-ABL/c-Src duale Kinase Hemmstoffe in der Therapie des nicht-kleinzelligen Adenokarzinoms der Lunge
Krüwel, T.
: Kalesse, M.; Borlak, J.
Master Thesis
2009Combined microPET/CT for imaging of hepatocellular carcinoma in mice
Falck, C. von; Rodt, T.; Halter, R.; Spanel, R.; Galanski, M.; Borlak, J.
Zeitschriftenaufsatz
2009Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures
Nowicki, M.; Kosacka, J.; Spanel-Borowski, K.; Borlak, J.
Zeitschriftenaufsatz
2009Epigenetics - A perspective in toxicogenomics
Borlak, J.
Abstract
2009Expression of HNF4alpha in the human and rat choroid plexus - implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier
Niehof, M.; Borlak, J.
Zeitschriftenaufsatz
2009A functional genetic study identifies HAND1 mutations in septation defects of the human heart
Reamon-Buettner, S.M.; Ciribilli, Y.; Traverso, I.; Kuhls, B.; Inga, A.; Borlak, J.
Zeitschriftenaufsatz
2009HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus
Borlak, J.; Niehof, M.
Zeitschriftenaufsatz
2009In vivo microCT quantification of lung tumor growth in SPC-raf transgenic mice
Rodt, T.; Falck, C. von; Halter, R.; Ringe, K.; Shin, H.O.; Galanski, M.; Borlak, J.
Zeitschriftenaufsatz
2009Molecular characterization of lung dysplasia induced by c-Raf-1
Rohrbeck, A.; Müller, V.S.; Borlak, J.
Zeitschriftenaufsatz
2009The risk of exaggerated risk aversion - a life and death struggle for molecular imaging
Langström, B.; Grahnen, A.; Honore, P.H.; Borlak, J.; Bergstrom, M.; Nielsen, B.; Vanderheyden, J.; Watanabe, Y.; Josephsson, R.; Hoilund-Carlsen, P.F.; Schwaiger, M.; Larson, S.M.; Goldenberg, D.M.; Melzer, A.; Engler, H.; Hicks, R.; Sundin, A.; Seppänen, M.; Hedenstierna, G.; Nordberg, A.; Brooks, D.
Zeitschriftenaufsatz
2009Serumproteomik zur Identifizierung tumorspezifischer Biomarker des nicht-kleinzelligen Bronchialkarzinoms
Chatterji, B.G.
: Borlak, J.; Kalesse, M.
Dissertation
2009Synthesis and biological evaluation of epothilone A dimeric compounds
Passarella, D.; Comi, D.; Cappelletti, G.; Cartelli, D.; Gertsch, J.; Quesada, A.R.; Borlak, J.; Altmann, K.-H.
Zeitschriftenaufsatz
2009Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety
Anderson, N.; Meier, T.; Borlak, J.
Zeitschriftenaufsatz
2009An update on the mouse liver proteome
Gazzana, G.; Borlak, J.
Zeitschriftenaufsatz
2008Absorption and transport of dietary lipid
Welch, V.A.; Borlak, J.T.
Aufsatz in Buch
2008Charakterisierung experimenteller c-Acl/c-Src dualer Kinase Hemmstoffe in der Therapie des nicht kleinzelligen Lungenkarzinoms
Sundermann, U.
: Pfitzner, R. (Prüfer); Borlak, J. (Prüfer)
Diplomarbeit
2008Clinical versatility of porcine hepatocytes in the light of interspecies differences in cytochrome P450 regulation and expression
Kleine, M.; Schrem, H.; Borlak, J.; Klempnauer, J.
Zeitschriftenaufsatz
2008Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation
Borlak, J.; Jenke, H.S.
Zeitschriftenaufsatz
2008Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2008Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors
Reamon-Büttner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2008EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4 alpha splice variants in hepatocellular carcinomas
Niehof, M.; Borlak, J.
Zeitschriftenaufsatz
2008Gender-incompatible liver transplantation is not a risk factor for patient survival
Lehner, F.; Becker, T.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2008Genome wide prediction of HNF4 alpha functional binding sites by the use of local and global sequence context
Kel, A.E.; Niehof, M.; Matys, V.; Zemlin, R.; Borlak, J.
Zeitschriftenaufsatz
2008A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators
Maaser, K.; Borlak, J.
Zeitschriftenaufsatz
2008Graft rejection: Pharmacogenetic analysis or drug anamnesis
Pham, V.V.; Stichtenoth, D.O.; Borlak, J.
Zeitschriftenaufsatz
2008HNF4 alpha and the Ca-Channel TRPC1 are novel disease candidate genes in diabetic nephropathy
Niehof, M.; Borlak, J.
Zeitschriftenaufsatz
2008Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper
Beineke, A; Markus, S.; Borlak, J.; Thum, T.; Baumgärtner, W.
Zeitschriftenaufsatz
2008Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III
Passarella, D.; Giardini, A.; Peretto, B.; Fontana, G.; Sacchetti, A.; Silvani, A.; Ronchi, C.; Cappelletti, G.; Cartelli, D.; Borlak, J.; Danieli, B.
Zeitschriftenaufsatz
2008A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts
Reamon-Büttner, S.M.; Ciribilli, Y.; Inga, A.; Borlak, J.
Zeitschriftenaufsatz
2008Lox-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor OCT-1 in human coronary arterial endothelium
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2008Mapping of the serum proteome of hepatocellular carcinoma induced by targeted overexpression of epidermal growth factor to liver cells of transgenic mice
Gazzana, G.; Borlak, J.
Zeitschriftenaufsatz
2008Matrix layer sample preparation
Garaguso, I.; Borlak, J.
Zeitschriftenaufsatz
2008Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
Anderson, N.; Borlak, J.
Zeitschriftenaufsatz
2008Morphologische und funktionelle Leberbildgebung in der Maus
Falck, C. von; Rodt, T.; Halter, R.; Galanski, M.; Borlak, J.
Zeitschriftenaufsatz
2008Multimodality in vivo imaging
Borlak, J.; Falck, C. von; Rodt, T.; Galanski, M.; Scholler, P.; Laström, B.
Zeitschriftenaufsatz
2008The next innovation cycle in toxicogenomics
Reamon-Büttner, S.M.; Mutschler, V.; Borlak, J.
Zeitschriftenaufsatz, Konferenzbeitrag
2008Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury
Lamle, J.; Marhenke, S.; Borlak, J.; Wasielewski, R. von; Eriksson, C.J.P.; Geffers, R.; Manns, M.P.; Yamamoto, M.; Vogel, A.
Zeitschriftenaufsatz
2008Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics
Schuchardt, S.; Borlak, J.
Zeitschriftenaufsatz
2008A simple and reliable protocol for mouse serum proteome profiling studies by use of two-dimensional electrophoresis and MALDI TOF/TOF mass spectrometry
Ritorto, M.S.; Borlak, J.
Zeitschriftenaufsatz
2008Topoisomerase II inhibition involves characteristic chromosomal expression patterns
Reymann, S.; Borlak, J.
Zeitschriftenaufsatz
2008Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network
Reymann, S.; Borlak, J.
Zeitschriftenaufsatz
2008Untersuchungen zur Regulation von leberspezifischen Transkriptionsfaktoren im humanen colorectalen Carcinom
Kulik, U.
: Borlak, J.
Dissertation
2007Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone mediated increase of insulin-like growth factor-1
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Galuppo, P.; Jakob, M.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Zeitschriftenaufsatz
2007Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
Thum, T.; Hoeber, S.; Klink, I.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2007Doppelt transgenes nicht menschliches Saeugetier
Borlak, J.; Halter, R.
Patent
2007The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells
Hansen, T.; Seidel, A.; Borlak, J.
Zeitschriftenaufsatz
2007The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases
Lehner, F.; Kulik, U.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2007Importance of DNA-adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes
Halter, R.; Hansen, T.; Seidel, A.; Ziemann, C.; Borlak, J.
Zeitschriftenaufsatz
2007Improved method for proteome mapping of the liver by 2-DE MALDI-TOF MS
Gazzana, G.; Borlak, J.
Zeitschriftenaufsatz
2007Leberspezifische Transkriptionsfaktoren und deren Bedeutung in kolorektalen Lebermetastasen
Lehner, F.; Klempnauer, J.; Borlak, J.
Konferenzbeitrag
2007Mechanisms of toxic liver injury
Anderson, N.; Borlak, J.
Aufsatz in Buch
2007MicroRNAs in the human heart
Thum, T.; Galuppo, P.; Wolf, C.; Fiedler, J.; Kneitz, S.; Laake, L.W. van; Doevendans, P.A.; Mummery, C.L.; Borlak, J.; Haverich, A.; Gross, C.; Engelhardt, S.; Ertl, G.; Bauersachs, J.
Zeitschriftenaufsatz
2007Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD)
Reamon-Buettner, S.M.; Cho, S.H.; Borlak, J.
Zeitschriftenaufsatz
2007The myelin-associated glycoprotein inhibitor BENZ induces outgrowth and survival of rat dorsal root ganglion cell cultures
Nowicki, M.; Kosacka, J.; Brossmer, R.; Spanel-Borowski, K.; Borlak, J.
Zeitschriftenaufsatz
2007Neue Biomarker für Leberkrebs
Ritorto, M.S.; Chatterji, B.; Borlak, J.
Zeitschriftenaufsatz
2007A new paradigm in toxicology and teratology: Altering gene activity in the absence of DNA sequence variation
Reamon-Buettner, S.M.; Borlak, J.
Zeitschriftenaufsatz, Konferenzbeitrag
2007No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy
Nowicki, M.; Zabirnyk, O.; Duerrschmidt, N.; Borlak, J.; Spanel-Borowski, K.
Zeitschriftenaufsatz
2007Serum proteomics of lung adenocarcinomas induced by targeted overexpression of c-raf in alveolar epithelium identifies candidate biomarkers
Chatterji, B.; Borlak, J.
Zeitschriftenaufsatz
2007Transcriptomics does not show adverse effects of beta-carotene in A/J mice exposed to smoke for 2 weeks
Kuntz, E.; Borlak, J.; Riss, G.; Aebischer, C.P.; Bachmann, H.; Seifert, N.; Hunziker, P.B.; Sölle, D.; Hunziker, W.; Goralczyk, R.; Wertz, K.
Zeitschriftenaufsatz
2007Verfahren zur Erkennung, Markierung und Behandlung von epithelialen Lungentumorzellen sowie Mittel zur Durchfuehrung des Verfahrens
Borlak, J.; Salinas-Riester, G.
Patent
2006Aberrant lipid metabolism in human diseases - the role of the lectin-like oxidised LDL-receptor (LOX-1) in endothelial dysfunction
Borlak, J.; Spanel-Borowski, K.
Abstract
2006Acetylsalicylic acid (aspirin) reduces endothelial cell senescence
Scalera, F.; Borlak, J.; Schubert, B.; Martens-Lobenhoffer, J.; Thum, T.; Frolich, J.C.; Bode-Boger, S.M.
Abstract
2006Adipocyte-derived angiopoietin-1 supports neurite outgrowth and synaptogenesis of sensory neurons
Kosacka, J.; Nowicki, M.; Kacza, J.; Borlak, J.; Engele, J.; Spanel-Borowski, K.
Zeitschriftenaufsatz
2006Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone-mediated increase of insulin-like growth factor-1
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2006Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone-mediated increase of insulin-like growth factor-1
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2006The age-related disturbance of endothelial progenitor cells is corrected through growth hormone medicated increase of the insulin like growth factor-1.
Thum, T.; Hoeber, S.; Froese, S.; Ivonne, K.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2006Bridging the gap between anatomy and molecular genetics for an improved understanding of congenital heart disease
Reamon-Buettner, S.M.; Spanel-Borowski, K.; Borlak, J.
Zeitschriftenaufsatz
2006Drug-induced phospholipidosis
Anderson, N.; Borlak, J.
Zeitschriftenaufsatz
2006Expression of a cyclin E1 isoform in mice is correlated with the quiescent cell cycle status of hepatocytes in vivo
Zschemisch, N.H.; Liedtke, C.; Dierssen, U.; Nevzorova, Y.A.; Wustefeld, T.; Borlak, J.; Manns, M.P.; Trautwein, C.
Zeitschriftenaufsatz
2006Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
Thum, T.; Erpenbeck, V.J.; Moeller, J.; Hohlfeld, J.M.; Krug, N.; Borlak, J.
Zeitschriftenaufsatz
2006HEY2 mutations in malformed hearts
Reamon-Buettner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2006Is lipotoxicity an oxymoron?
Spener, F.; Zechner, R.; Borlak, J.
Zeitschriftenaufsatz
2006The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression
Gebel, S.; Gerstmayer, B.; Kuhl, P.; Borlak, J.; Meurrens, K.; Müller, T.
Zeitschriftenaufsatz
2006Lectin-like oxidized low-density lipoprotein receptor-1-mediated autophagy in human granulosa cells as an alternative of programmed cell death
Duerrschmidt, N.; Zabirnyk, O.; Nowicki, M.; Ricken, A.; Hmeidan, F.A.; Blumenauer, V.; Borlak, J.; Spanel-Borowski, K.
Zeitschriftenaufsatz
2006N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients
Borlak, J.; Reamon-Büttner, S.
Zeitschriftenaufsatz
2006N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease
Borlak, J.; Reamon-Büttner, S.M.
Zeitschriftenaufsatz
2006N-Glucuronidation of the antiepileptic drug retigabine: Results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II
Borlak, J.; Gasparic, A.; Locher, M.; Schupke, H.; Hermann, R.
Zeitschriftenaufsatz
2006Nifedipine represses ion channels, transporters and Ca(2+)-binding proteins in hearts of spontaneously hypertensive rats
Zwadlo, C.; Borlak, J.
Zeitschriftenaufsatz
2006Onkoproteomics von Lungentumoren
Chatterji, B.; Ritorto, M.S.; Garaguso, I.; Belau, E.; Gazzana, G.; Borlak, J.
Zeitschriftenaufsatz
2006Physiological incompatibilities of porcine hepatocytes for clinical liver support
Schrem, H.; Kleine, M.; Borlak, J.; Klempnauer, J.
Zeitschriftenaufsatz
2006Primary rat alveolar epithelial cells for use in biotransformation and toxicity studies
Hansen, T.; Blickwede, M.; Borlak, J.
Zeitschriftenaufsatz
2006The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine
Hermann, R.; Borlak, J.; Munzel, U.; Niebch, G.; Fuhr, U.; Maus, J.E.K.; Erb, K.
Zeitschriftenaufsatz
2006Somatic mutations in cardiac malformations
Reamon-Büttner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2006Statins delay endothelial cell senescence
Scalera, F.; Borlak, J.; Schubert, B.; Martens-Lobenhoffer, J.; Thum, T.; Frölich, J.C.; Bode-Boger, S.M.
Abstract
2006Towards a lung adenocarcinoma proteome map: Studies with SP-C/c-raf transgenic mice
Rütters, H.; Zürbig, P.; Halter, R.; Borlak, J.
Zeitschriftenaufsatz
2006Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes
Reymann, S.; Borlak, J.
Zeitschriftenaufsatz
2006Use of novel HNFAalpha target genes and their gene products
Borlak, J.; Niehof, M.
Patent
2006Vitamin E in heart transplantation
Schulte, I.; Bektas, H.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2005Application of kernel method to reveal subtypes of TF binding motifs
Kel, A.; Tikunov, Y.; Voss, N.; Borlak, J.; Wingender, E.
Konferenzbeitrag
2005Carcinogenicity of polycyclic aromatic hydrocarbons
Straif, K.; Baan, R.; Grosse, Y.; Secretan, B.; Ghissassi, F. el; Cogliano, V.; Borlak, J.
Zeitschriftenaufsatz
2005Chromatin immunoprecipitation-based identification of gene regulatory networks
Niehof, M.; Borlak, J.
Aufsatz in Buch
2005Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB
Gerhard, R.; Tatge, H.; Genth, H.; Thum, T.; Borlak, J.; Fritz, G.; Just, I.
Zeitschriftenaufsatz
2005Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection
Jacobs, T.; Andra, J.; Gaworski, I.; Graefe, S.; Mellenthin, K.; Kromer, M.; Halter, R.; Borlak, J.; Clos, J.
Zeitschriftenaufsatz
2005Databases and tools for in silico analysis of regulation of gene expression
Kel, A.; Kel-Margoulis, O.; Borlak, J.; Tchehekmenev, D.; Wingender, E.
Aufsatz in Buch
2005Disease-associated changes in the expression of ion channels, ion receptors, ion exchangers and Ca(2+)-handling proteins in heart hypertrophy
Zwadlo, C.; Borlak, J.
Zeitschriftenaufsatz
2005Epidermal growth factor-induced hepatocellular carcinoma: Gene expression profiles in precursor lesions, early stage and solitary tumours
Borlak, J.; Meier, T.; Halter, R.; Spanel, R.; Spanel-Borowski, K.
Zeitschriftenaufsatz
2005Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system
Inga, A.; Reamon-Büttner, S.M.; Borlak, J.; Resnick, M.A.
Zeitschriftenaufsatz
2005GATA4 zinc finger mutations as a molecular rationale for septation defects of the human heart
Reamon-Buettner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2005Genetic analysis of cardiac-specific transcription factors reveals novel insights into molecular causes of congenital heart disease
Reamon-Buettner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2005Giving new life to archival DNA to understand mechanisms leading to congenital heart disease
Reamon-Buettner, S.; Borlak, J.
Zeitschriftenaufsatz
2005Handbook of toxicogenomics
: Borlak, J.
Buch
2005Identification and quantification of metabolites of arachidonic acid from cultures of endothelial cells by HPLC-MS2
Zelinski, V.; Borlak, J.
Zeitschriftenaufsatz
2005In vivo chip cloning of novel HNF4a gene targets
Borlak, J.; Zemlin, R.; Niehof, M.
Zeitschriftenaufsatz
2005Introduction
Borlak, J.
Aufsatz in Buch
2005Isolation and characterization of metabolically competent pulmonary epithelial cells from pig lung tissue
Blickwede, M.; Borlak, J.
Zeitschriftenaufsatz
2005A map of the rat liver proteome
Gazzana, G.; Borlak, J.
Zeitschriftenaufsatz
2005Metabolism of verapamil in cultures of rat alveolar epithelial cells and pharmacokinetics after administration by intravenous and inhalation routes
Borlak, J.; Blickwede, M.; Hansen, T.; Koch, W.; Walles, M.; Levsen, K.
Zeitschriftenaufsatz
2005Molekulare Medizin - Chance für die Arbeitsmedizin
Borlak, J.
Zeitschriftenaufsatz
2005PCR-Reaktionsgemisch fuer Fluoreszenz-basierende Genexpressions- und Genmutationsanalysen
Borlak, J.; Thum, T.
Patent
2005Regulatory networks of liver enriched transcription factors in liver biology and disease
Borlak, J.; Klempnauer, J.; Schrem, H.
Aufsatz in Buch
2005RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain
Niehof, M.; Borlak, J.
Zeitschriftenaufsatz
2005A shift in paradigm
Borlak, J.
Aufsatz in Buch
2005Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element
Liedtke, C.; Zschemisch, N.H.; Cohrs, A.; Roskams, T.; Borlak, J.; Manns, M.P.; Trautwein, C.
Zeitschriftenaufsatz
2005Toxicogenomics applied to cardiovascular toxicity
Thum, T.; Borlak, J.
Aufsatz in Buch
2005Toxicogenomics applied to teratogenicity studies
Hewitt, P.G.; Kramer, P.-J.; Borlak, J.
Aufsatz in Buch
2004An "omics" approach to study lung carcinogenesis
Borlak, J.; Meier, T.; Rütters, H.; Zürbig, P.; Halter, R.
Konferenzbeitrag
2004Androgen metabolism in thymus of fetal and adult rats
Borlak, J.; Schulte, I.; Thum, T.
Zeitschriftenaufsatz
2004Breakdown of transcription factor crosstalk in congenital heart disease
Borlak, J.; Reamon-Büttner, S.M.
Abstract
2004Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence
Scalera, F.; Borlak, J.; Beckmann, B.; Martens-Lobenhoffer, J.; Thum, T.; Tager, M.; Bode-Böger, S.M.
Zeitschriftenaufsatz
2004Expression of basolateral and canalicular transporters in rat liver and cultures of primary hepatocytes
Borlak, J.; Klutcka, T.
Zeitschriftenaufsatz
2004Genetic analysis of cardiac-specific transcription factors reveals insight into congenital heart disease
Reamon-Büttner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2004Liver-enriched transcription factors in liver function and development
Schrem, H.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2004Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2004Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2004Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography-mass spectrometry
Mullet, W.M.; Walles, M.; Levsen, K.; Borlak, J.; Pawliszyn, J.
Zeitschriftenaufsatz
2004The myosin ATPase inhibitor 2,3-butanedione monoxime dictates transcriptional activation of ion channels and Ca(2+)-handling proteins
Borlak, J.; Zwadlo, C.
Zeitschriftenaufsatz
2004A novel computational approach for the prediction of networked transcription factors of aryl hydrocarbon-receptor-regulated genes
Kel, A.; Reymann, S.; Matys, V.; Nettesheim, P.; Wingender, E.; Borlak, J.
Zeitschriftenaufsatz
2004Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations
Reamon-Büttner, S.M.; Hecker, H.; Spanel-Borowski, K.; Craatz, S.; Kuenzel, E.; Borlak, J.
Zeitschriftenaufsatz
2004Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure
Jetter, A.; Kinzig-Schippers, M.; Illauer, M.; Hermann, R.; Erb, K.; Borlak, J.; Wolf, H.; Smith, G.; Cascorbi, I.; Sörgel, F.; Fuhr, U.
Zeitschriftenaufsatz
2004Silencing of caspase-8 in murine hepatocellular carcinoma is correlated with CPG methylation of an essential caspase-8 promoter element
Liedtke, C.; Zschemisch, N.H.; Cohrs, A.; Borlak, J.; Manns, M.P.; Trautwein, C.
Konferenzbeitrag, Zeitschriftenaufsatz
2004Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease
Reamon-Büttner, S.M.; Borlak, J.
Zeitschriftenaufsatz
2004TBX5 mutations in non-Holt-Oram syndrome (HOS) malformed heart
Reamon-Büttner, S.M.; Borlak, J.
Abstract
2004Verbesserte Arzneitherapie
Borlak, J.
Aufsatz in Buch
2003Altered protein/DNA interactions of liver-enriched transcription factors as predictors for toxicity - implications for toxicogenomic research
Borlak, J.; Sowa, A.; Niehof, M.
Zeitschriftenaufsatz
2003Aspirin reduces endothelial-cell senescence
Scalera, F.; Thum, T.; Borlak, J.; Schubert, B.; Frolich, J.C.; Bode-Boger, S.M.
Konferenzbeitrag
2003DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes
Borlak, J.; Hock, A.; Hansen, T.; Richter, E.
Zeitschriftenaufsatz
2003Expression of a short cyclin E1 splice variant inversely correlates with cell cycle progression of hepatocytes
Zschemisch, N.H.; Liedtke, C.; Wustefeld, T.; Halter, R.; Borlak, J.; Manns, M.P.; Trautwein, C.
Konferenzbeitrag, Zeitschriftenaufsatz
2003Expression of drug-metabolism enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells
Borlak, J.; Zwadlo, C.
Zeitschriftenaufsatz
2003Gene expression profiles in the closing ductus and the great vessels
Bökenkamp, R.; Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2003Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line
Thum, T.; Tsikas, D.; Frölich, J.F.; Borlak, J.
Zeitschriftenaufsatz
2003Hallmarks of ion channel gene expression in end-stage heart failure
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2003Increased ROS production of 3-NBA treated human epithelial lung-cells - effects on cell-cycle and apoptosis
Hansen, T.; Borlak, J.
Zeitschriftenaufsatz
2003Isolation and identification of Cyclin E1 isoforms in murine hepatocellular carcinomas (HCC)
Zschemisch, N.-H.; Liedtke, C.; Halter, R.; Borlak, J.; Manns, M.P.; Trautwein, C.
Zeitschriftenaufsatz
2003Lack of caspase-8 expression in murine hepatocellular carcinomas is associated with hypermethylation at SPL binding-sites in the murine caspase-8 promoter
Liedtke, C.; Zschemisch, N.H.; Cohrs, A.; Borlak, J.; Manns, M.P.
Konferenzbeitrag, Zeitschriftenaufsatz
2003Medikamente ohne Nebenwirkungen
Borlak, J.
Zeitschriftenaufsatz
2003Metabolism of verapamil
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Zeitschriftenaufsatz
2003Oct-1 protein/DNA interaction - implications for cytochrome- P450 monooxygenase gene-expression
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2003OCT-1: A key player in vascular biology - Implications for cardiovascular toxicity
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2003An optimized method for the isolation and identification of membrane proteins
Lehner, I.; Niehof, M.; Borlak, J.
Zeitschriftenaufsatz
2003Oxidized LDL represses cytochrome-P450 monooxygenase catalyzed EDHF production in human coronary arterial endothelium through diminished NF-1 availability
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2003Pharmacokinetic interaction between retigabine and lamotrigine in healthy-subjects
Hermann, R.; Knebel, N.G.; Niebch, G.; Richards, L.; Borlak, J.; Locher, M.
Zeitschriftenaufsatz
2003A rapid and simple CYP2D6 genotyping assay - Case study with the analgetic tramadol
Borlak, J.; Hermann, R.; Erb, K.; Thum, T.
Zeitschriftenaufsatz
2003Verapamil: Identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS[n] and LC-NMR
Borlak, J.; Walles, M.; Elend, M.; Thum, T.; Preiss, A.; Levsen, K.
Zeitschriftenaufsatz
2003Verapamil: Metabolism in cultures of primary human coronary arterial endothelial cells
Borlak, J.; Walles, M.; Levsen, K.; Thum, T.
Zeitschriftenaufsatz
2002Altered cytochrome P450 monooxygenase activity in heart tissue of spontaneously hypertensive rats
Thum, T.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002Application of restricted access material (RAM) with precolumn-switching and matrix solid-phase dispersion (MSPD) to the study of the metabolism and pharmacokinetics of Verapamil
Walles, M.; Borlak, J.; Levsen, K.
Zeitschriftenaufsatz
2002Aroclor 1254 modulates gene expression of nuclear transcription factors
Borlak, J.; Dangers, M.; Thum, T.
Zeitschriftenaufsatz
2002Automated in-tube solid-phase microextraction coupled with HPLC for the determination of N-nitrosamines in cell cultures
Mullett, W.M.; Levsen, K.; Borlak, J.; Wu, J.C.; Pawliszyn, J.
Zeitschriftenaufsatz
2002Compound profiling using CDNA array based differential gene expression of human and rat hepatocytes
Hansen, T.; Dangers, M.; Borlak, J.; Gerstmayer, B.; Tomiuk, S.; Hofmann, K.; Hübel, F.; Bosio, A.
Zeitschriftenaufsatz
2002Derailed steroid metabolism in cardiac hypertrophy
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2002The effects of PCB's on the gene expression of transcription factors and other heart specific genes in cultures of primary cardiomyocytes
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2002The environmental carcinogen 3-nitrobenzanthrone induces production of reactive oxygen intermediates in human epithelial lung cells
Hansen, T.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002Expression of markers for cellular differentiation and of CYP monooxygenases in cultures of rat alveolar type II cells
Hansen, T.; Blickwede, M.; Vata, I.; Borlak, J.
Zeitschriftenaufsatz
2002Gene expression profiling in cultures of HepG2 and primary human hepatocytes
Hewitt, P.G.; Kramer, P.J.; Bosio, A.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002Genotyping of major NAT2 single nucleotide polymorphisms in a German population using fluorescence resonance energy transfer (FRET) analysis
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2002Identification of major CYP2C9 and CP2C19 polymorphisms by fluorescence resonance energy transfer analysis
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2002Identification of major CYP2C9 polymorphisms using fluorescence resonance energy transfer (FRET) analysis
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2002Inhalation and intravenous plasma kinetics of Verapamil in cynomolgus monkeys
Appelqvist, T.; Walles, M.; Windt, H.; Koch, W.; Borlak, J.; Forster, R.
Konferenzbeitrag, Zeitschriftenaufsatz
2002An inproved protocol for the isolation and culture of primary porcine alveolar epithelial types II cells
Borlak, J.; Blickwede, M.
Konferenzbeitrag, Zeitschriftenaufsatz
2002Interspecies comparison of hepatotoxic stress response using microarrays of ortholog CDNA fragments
Bosio, A.; Gerstmayer, B.; Tomiuk, S.; Hofmann, K.; Hübel, F.; Buss, K.; Borlak, J.
Zeitschriftenaufsatz
2002Is there a universal housekeeping gene?
Lindemann, M.; Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2002Isolation and characterization of alveolar epithelial type II cells from pig lung tissue
Borlak, J.; Blickwede, M.
Zeitschriftenaufsatz
2002Liver-enriched transcription factors in liver function and development. Part I: The hepatocyte nuclear factor network and liver-specific gene expression
Schrem, H.; Klempnauer, J.; Borlak, J.
Zeitschriftenaufsatz
2002A new method for identification of major CYP2C19 polymorphisms
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2002Novel phase I and phase II metabolites of Verapamil identified in cell cultures of rat hepatocytes by LC-MS(n)
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002Oxidized LDL modulates cytochrome P450 monooxygease gene expression and protein function in human arterial coronary endothelial cells
Thum, T.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002oxLDL inhibits eNOS and cytochrome P450 monooxygenases in human arterial coronary endothelial cells
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2002PCBs alter gene expression of nuclear transcription factors and other heart-specific genes in cultures of primary cardiomyocytes
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2002Retigabine
Hermann, R.; Schneider, E.; Menth, M.; Knebel, N.; Ferron, G.; Borlak, J.; Erb, K.; Partiot, A.; Germain, J.-M.; Locher, M.; Porter, R.
Zeitschriftenaufsatz
2002Testosterone, cytochrome P450, and cardiac hypertrophy
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2002A toxicogenomic approach to predict teratogenicity of new drug candidates
Borlak, J.; Bosio, A.; Kramer, P.J.; Hewitt, P.G.
Zeitschriftenaufsatz
2002Toxicogenomics applied to cardiovascular and hepatotoxicity
Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002Toxicogenomics: Interspecies comparison and compound profiling using cDNA microarrays
Buss, K.; Hansen, T.; Tomiuk, S.; Hofmann, K.; Gerstmayer, B.; Bosio, A.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2002The use of toxicogenomics
Borlak, J.; Bosio, A.
Konferenzbeitrag
2002Verapamil drug metabolism studies by automated in-tube solid phase microextraction
Walles, M.; Mullett, W.M.; Levsen, K.; Borlak, J.; Wünsch, G.; Pawliszyn, J.
Zeitschriftenaufsatz
2002Verapamil. New insight into the molecular mechanism of drug oxidation in the human heart
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Zeitschriftenaufsatz
2002Verapamil: Identification of novel metabolites in the human heart
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2001Butanedione monoxime increases the viability and yield of adult cardiomyocytes in primary cultures
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2001Co-cultures of A/J mouse alveolar epithelial type II cells and Clara cells to study pulmonary metabolism
Hansen, T.; Borlak, J.
Zeitschriftenaufsatz
2001Cytochrome P450 enzyme activity and mRNA expression in primary rat alveolar epithelial type II cells
Borlak, J.; Vata, I.; Thum, T.; Hansen, T.
Zeitschriftenaufsatz
2001Drug oxidation in the human heart
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2001Gene expression and testosterone metabolism in distinct regions of the rat heart
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2001Die Hochregulierung S-Adenosyl-L-Methionin-abhängiger Methyltransferasen führt zu einer gesteigerten Bildung von ADMA unter hypercholesterinämischen Bedingungen
Sydow, K.; Bode-Böger, S.M.; Thum, T.; Borlak, J.; Münzel, T.; Böger, R.H.
Konferenzbeitrag, Zeitschriftenaufsatz
2001Housekeeping genes in gene expression studies
Lindemann, M.; Borlak, J.
Zeitschriftenaufsatz
2001Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2001Inhalation studies with the Göttingen minipig
Koch, W.; Windt, H.; Walles, M.; Borlak, J.; Clausing, P.
Zeitschriftenaufsatz
2001Microarray-based gene expression profiles applied to pharmaco- and toxicogenomics
Bosio, A.; Borlak, J.
Zeitschriftenaufsatz
2001Reprogramming of gene expression in cultures cardiomyocytes by the myosin ATPase inhibitor butanedione monoxime
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2001Steroid metabolism in co-cultures of A/J mouse alveolar epithelial type II cells and Clara cells
Hansen, T.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2001Tramadol disposition in CYP2D6 genotyped human subjects. Genetic variations in susceptibility to xenobiotics
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2001Transcriptional activation of liver enriched transcription factors and the albumin gene in rat hepatocytes by Aroclor 1254
Borlak, J.; Thum, T.
Zeitschriftenaufsatz
2001Verapamil metabolism in distinct regions of the heart and in cultures of cardiomyocytes of adult rats
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Zeitschriftenaufsatz
2001Verapamil metabolism in primary cultures of cardiomyocytes of adult rats and in distinct regions of explanted hearts
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2001Verapamil metabolism in rat heart tissue
Thum, T.; Walles, M.; Levsen, K.; Borlak, J.
Konferenzbeitrag, Zeitschriftenaufsatz
2000ACE-gene polymorphism is associated with the development of allograft vascular disease in heart transplant recipients
Pethig, K.; Heublein, B.; Hoffmann, A.; Borlak, J.; Wahlers, T.; Haverich, H.
Zeitschriftenaufsatz
2000Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: Implications for endothelial dysfunction and vascular biology
Thum, T.; Haverich, A.; Borlak, J.
Zeitschriftenaufsatz
2000Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: Implications for endothelial dysfunction and vascular biology
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures
Hansen, T.; Borlak, J.; Bader, A.
Zeitschriftenaufsatz
2000Cytochrome P450 monooxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000Cytochrome P450 monooxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000Gene expression in distinct regions of the heart
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000Gene expression in distinct regions of the human heart - implications for drug treatment of cardiovascular disease
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000Increased formation of ADMA, an endogenous NOS inhibitor, in hyperchloresterolemia
Sydow, K.; Bode-Boger, S.M.; Thum, T.; Borlak, J.; Boger, R.H.
Aufsatz in Buch
2000Increased formation of ADMA, an endogenous nos inhibitor, in hypercholesterolemia - up-regulation of s-adenosylmethionine-dependent methyltransferases
Sydow, K.; Bodeboger, S.M.; Thum, T.; Borlak, J.; Boger, R.H.
Zeitschriftenaufsatz
2000Isolation and cultivation of calcium (Ca2+) tolerant cardiomyocytes from the adult rat. Improvements and applications
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
Böger, R.H.; Sydow, K.; Borlak, J.; Thum, T.; Lenzen, H.; Schubert, B.; Tsikas, D.; Bode-Böger, S.M.
Zeitschriftenaufsatz
2000Metabolism and DNA-binding of 3-nitrobenzanthrone in primary rat alveolar type II cells, in human fetal bronchial and rat epithelial cell lines
Borlak, J.; Hansen, T.; Yuan, Z.-X.; Sikka, H.C.; Kumar, S.; Schmidbauer, S.; Frank, H.; Jacob, J.; Heinrich, U.
Zeitschriftenaufsatz
2000Metabolism and DNA-binding of 3-nitrobenzanthrone in primary rat alveolar type II cells, in human fetal bronchial, rat epithelial and mesenchymal cell lines
Borlak, J.; Hansen, T.; Yuan, Z.-X.; Kumar, S.; Sikka, H.C.; Frank, H.; Seidel, A.
Zeitschriftenaufsatz
2000Molecular diagnosis of a familial non heamolytic hyperbilirubinemia (Gilbert's Syndrome) in healthy subjects
Borlak, J.; Thum, T.; Landt, O.; Erb, K.; Hermann, R.
Zeitschriftenaufsatz
2000Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects
Borlak, J.; Thum, T.; Landt, O.; Erb, K.; Hermann, R.
Zeitschriftenaufsatz
2000The myosin ATPase inhibitor BDM modulates ANP gene expression and confers cytoprotection in cultures of adult cardiomyocytes
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
2000Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions
Bader, A.; Hansen, T.; Kirchner, G.; Allmeling, C.; Haverich, A.; Borlak, J.
Zeitschriftenaufsatz
2000Reprogramming of gene expression in cultured cardiomyocytes by the myosin ATPase inhibitor butanedione monoxime
Thum, T.; Borlak, J.
Zeitschriftenaufsatz
1999Enhanced oxygen delivery reverses anaerobic metabolic states in prolonged sandwich rat hepatocyte culture
Bader, A.; Frühauf, N.; Tiedge, M.; Drinkgern, M.; DeBartolo, L.; Borlak, J.; Steinhoff, G.; Haverich, A.
Zeitschriftenaufsatz
1999Expression of CYP-enzymes in primary porcine enterocytes and hepatocyte cultures
Hansen, T.; Borlak, J.; Bader, A.
Zeitschriftenaufsatz
1999Halogenated hydrocarbons
Bolt, H.; Borlak, J.
Aufsatz in Buch
1999Medizinische Biotechnologie als Motor der Pharmaforschung
Borlak, J.; Heinrich, U.; Paul, D.
Aufsatz in Buch
1997Hepatocytes sandwich cultures to study biotransformation of cytochrome P450 substrates
Bader, A.; Borlak, J.; Steinkamp, A.; Zech, K.; Fuhrmann, U.; Frühauf, N.; Crome, O.; Fahrig, R.; Sewing, K.-F.
Zeitschriftenaufsatz
1993Does the type of fat influence intestinal and hepatic microsomal metabolism?
Chinery, R.; Goodlad, R.A.; Wright, N.A.; Borlak, J.T.
Konferenzbeitrag