Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021AGMO Inhibitor Reduces 3T3-L1 Adipogenesis
Fischer, C.; Wilken-Schmitz, A.; Hernandez-Olmos, V.; Proschak, E.; Stark, H.; Fleming, I.; Weigert, A.; Thurn, M.; Hofmann, M.; Werner, E.R.; Geisslinger, G.; Niederberger, E.; Watschinger, K.; Tegeder, I.
Journal Article
2021Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells
Kornstädt, L.; Pierre, S.; Weigert, A.; Ebersberger, S.; Schäufele, T.J.; Kolbinger, A.; Schmid, T.; Cohnen, J.; Thomas, D.; Ferreirós, N.; Brüne, B.; Ebersberger, I.; Scholich, K.
Journal Article
2021IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis
Huard, A.; Do, H.N.; Frank, A.-C.; Sirait-Fischer, E.; Fuhrmann, D.; Hofmann, M.C.J.; Raue, R.; Palmer, G.; Brüne, B.; Bruin, N. de; Weigert, A.
Journal Article
2021Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
Rappl, P.; Rösser, S.; Maul, P.; Bauer, R.; Huard, A.; Schreiber, Y.; Thomas, D.; Geisslinger, G.; Jakobsson, P.-J.; Weigert, A.; Brüne, B.; Schmid, T.
Journal Article
2021Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin
Mertens, C.; Schnetz, M.; Rehwald, C.; Grein, S.; Elwakeel, E.; Weigert, A.; Brüne, B.; Jung, M.
Journal Article
2021Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages
Mota, A.C.; Dominguez, M.; Weigert, A.; Snodgrass, R.G.; Namgaladze, D.; Brüne, B.
Journal Article
2020Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis
Queck, A.; Fink, A.F.; Sirait-Fischer, E.; Rüschenbaum, S.; Thomas, D.; Snodgrass, R.G.; Geisslinger, G.; Baba, H.A.; Trebicka, J.; Zeuzem, S.; Weigert, A.; Lange, C.M.; Brüne, B.
Journal Article
2020Ceramide synthase 5 deficiency aggravates dextran sodium sulfate-induced colitis and colon carcinogenesis and impairs T-cell activation
El-Hindi, K.; Brachtendorf, S.; Hartel, J.C.; Oertel, S.; Birod, K.; Trautmann, S.; Thomas, D.; Ulshöfer, T.; Weigert, A.; Utermöhlen, O.; Krönke, M.; Grösch, S.
Journal Article
2020Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer
Kesavan, R.; Frömel, T.; Zukunft, S.; Laban, H.; Geyer, A.; Naeem, Z.; Heidler, J.; Wittig, I.; Elwakeel, E.; Brüne, B.; Weigert, A.; Popp, R.; Fleming, I.
Journal Article
2020Histone deacetylation inhibitors as modulators of regulatory T cells
Knethen, A. von; Heinicke, U.; Weigert, A.; Zacharowski, K.; Brüne, B.
Journal Article
2020IL-36 family cytokines in protective versus destructive inflammation
Han, Y.; Huard, A.; Mora, J.; da Silva, P.; Brüne, B.; Weigert, A.
Journal Article
2020Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model
Sirait-Fischer, E.; Olesch, C.; Fink, A.F.; Berkefeld, M.; Huard, A.; Schmid, T.; Takeda, K.; Brüne, B.; Weigert, A.
Journal Article
2020The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma
Rehwald, C.; Schnetz, M.; Urbschat, A.; Mertens, C.; Meier, J.K.; Bauer, R.; Baer, P.; Winslow, S.; Roos, F.C.; Zwicker, K.; Huard, A.; Weigert, A.; Brüne, B.; Jung, M.
Journal Article
2020The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain
Osthues, T.; Zimmer, B.; Rimola, V.; Klann, K.; Schilling, K.; Mathoor, P.; Angioni, C.; Weigert, A.; Geisslinger, G.; Münch, C.; Scholich, K.; Sisignano, M.
Journal Article
2020Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer
Salazar, Y.; Zheng, X.; Brunn, D.; Raifer, H.; Picard, F.; Zhang, Y.; Winter, H.; Guenther, S.; Weigert, A.; Weigmann, B.; Dumoutier, L.; Renauld, J.-C.; Waisman, A.; Schmall, A.; Tufman, A.; Fink, L.; Brüne, B.; Bopp, T.; Grimminger, F.; Seeger, W.; Pullamsetti, S.S.; Huber, M.; Savai, R.
Journal Article
2020Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer
Sarode, P.; Zheng, X.; Giotopoulou, G.A.; Weigert, A.; Kuenne, C.; Günther, S.; Friedrich, A.; Gattenlöhner, S.; Stiewe, T.; Brüne, B.; Grimminger, F.; Stathopoulos, G.T.; Pullamsetti, S.S.; Seeger, W.; Savai, R.
Journal Article
2020S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion
Olesch, C.; Sirait-Fischer, E.; Berkefeld, M.; Fink, A.F.; Susen, R.M.; Ritter, B.; Michels, B.E.; Steinhilber, D.; Greten, F.R.; Savai, R.; Takeda, K.; Brüne, B.; Weigert, A.
Journal Article
2020S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model
Schuster, C.; Huard, A.; Sirait-Fischer, E.; Dillmann, C.; Brüne, B.; Weigert, A.
Journal Article
2020The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways
Möller, M.; Wasel, J.; Schmetzer, J.; Weiß, U.; Meissner, M.; Schiffmann, S.; Weigert, A.; Möser, C.V.; Niederberger, E.
Journal Article
2020Sphingosine kinases are involved in macrophage NLRP3 inflammasome transcriptional induction
Syed, S.N.; Weigert, A.; Brüne, B.
Journal Article
2020Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis
Waidmann, O.; Pleli, T.; Weigert, A.; Imelmann, E.; Kakoschky, B.; Schmithals, C.; Döring, C.; Frank, M.; Longerich, T.; Köberle, V.; Hansmann, M.-L.; Brüne, B.; Zeuzem, S.; Piiper, A.; Dikic, I.
Journal Article
2019Cancer-induced inflammation and inflammation-induced cancer in colon: A role for S1P lyase
Schwiebs, A.; Herrero San Juan, M.; Schmidt, K.G.; Wiercinska, E.; Anlauf, M.; Ottenlinger, F.; Thomas, D.; Elwakeel, E.; Weigert, A.; Farin, H.F.; Bonig, H.; Scholich, K.; Geisslinger, G.; Pfeilschifter, J.M.; Radeke, H.H.
Journal Article
2019Comparisons of Solder Joints Fatigue Life Predictions and Several Long-Term Testing Results
Dudek, R.; Kreyssig, K.; Rzepka, S.; Novak, M.; Grübl, W.; Frühauf, P.; Weigert, A.
Conference Paper
2019Divergent evolution in the genomes of closely related lacertids, Lacerta viridis and L. bilineata, and implications for speciation
Kolora, S.R.R.; Weigert, A.; Saffari, A.; Kehr, S.; Costa, M.B.W.; Spröer, C.; Indrischek, H.; Chintalapati, M.; Lohse, K.; Doose, G.; Overmann, J.; Bunk, B.; Bleidorn, C.; Grimm-Seyfarth, A.; Henle, K.; Nowick, K.; Faria, R.; Stadler, P.F.; Schlegel, M.
Journal Article
2019IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells
Han, Y.; Mora, J.; Huard, A.; Silva, P. da; Wiechmann, S.; Putyrski, M.; Schuster, C.; Elwakeel, E.; Lang, G.; Scholz, A.; Scholz, T.; Schmid, T.; Bruin, N. de; Billuart, P.; Sala, C.; Burkhardt, H.; Parnham, M.J.; Ernst, A.; Brüne, B.; Weigert, A.
Journal Article
2019Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation
Syed, S.N.; Raue, R.; Weigert, A.; Knethen, A. von; Brüne, B.
Journal Article
2019Maintaining hepatic PD-L1 expression improves sepsis survival in a murine polymicrobial sepsis model by tolerizing CTL
Knethen, A. von; Schäfer, A.; Kuchler, L.; Knape, T.; Christen, U.; Hintermann, E.; Fisslthaler, B.; Schröder, K.; Brandes, R.P.; Genz, B.; Abshagen, K.; Pützer, B.M.; Sha, L.K.; Weigert, A.; Syed, S.N.; Schulz, M.; Shah, A.M.; Ernst, A.; Putyrski, M.; Finkelmeier, F.; Pesic, M.; Greten, F.; Hoghardt, M.; Kempf, V.A.J.; Gunne, S.; Parnham, M.J.; Brüne, B.
Journal Article
2019Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development
Elwakeel, E.; Brüggemann, M.; Fink, A.F.; Schulz, M.H.; Schmid, T.; Savai, R.; Brüne, B.; Zarnack, K.; Weigert, A.
Journal Article
2019Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation
Weigert, A.; Knethen, A. von; Thomas, D.; Faria, I.; Namgaladze, D.; Zezina, E.; Fuhrmann, D.; Petcherski, A.; Meyer zu Heringdorf, D.; Radeke, H.H.; Brüne, B.
Journal Article
2019Sphingosine-1-Phosphate and Macrophage Biology - How the Sphinx Tames the Big Eater
Weigert, A.; Olesch, C.; Brüne, B.
Journal Article
2019Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis
Knethen, A. von; Schäfer, A.; Kuchler, L.; Knape, T.; Christen, U.; Hintermann, E.; Fißlthaler, B.; Schröder, K.; Brandes, R.P.; Genz, B.; Abshagen, K.; Pützer, B.M.; Sha, L.K.; Weigert, A.; Syed, S.N.; Schulz, M.; Shah, A.M.; Ernst, A.; Putyrski, M.; Finkelmeier, F.; Pesic, M.; Greten, F.; Hogardt, M.; Kempf, V.A.J.; Gunne, S.; Parnham, M.J.; Brüne, B.
Journal Article
2018Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Ringleb, J.; Strack, E.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Weigert, A.; Brüne, B.
Journal Article
2018Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma
Sekar, D.; Govene, L.; Del Río, M.-L.; Sirait-Fischer, E.; Fink, A.F.; Brüne, B.; Rodriguez-Barbosa, J.I.; Weigert, A.
Journal Article
2018The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue
Kern, K.; Schäfer, S.M.G; Cohnen, J.; Pierre, S.; Osthues, T.; Tarighi, N.; Hohmann, S.; Ferreiros, N.; Brüne, B.; Weigert, A.; Geisslinger, G.; Sisignano, M.; Scholich, K.
Journal Article
2018An in vitro test system for compounds that modulate human inflammatory macrophage polarization
Shiratori, H.; Feinweber, C.; Luckhardt, S.; Wallner, N.; Geisslinger, G.; Weigert, A.; Parnham, M.J.
Journal Article
2018The portal vein as a distinct immunological compartment
Queck, A.; Rueschenbaum, S.; Kubesch, A.; Cai, C.; Zeuzem, S.; Weigert, A.; Brüne, B.; Nour-Eldin, A.; Gruber-Rouh, T.; Vogl, T.; Lange, C.M.
Journal Article
2018The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage
Treutlein, E.-M.; Kern, K.; Weigert, A.; Tarighi, N.; Schuh, C.-D.; Nüsing, R.M.; Schreiber, Y.; Ferreirós, N.; Brüne, B.; Geisslinger, G.; Pierre, S.; Scholich, K.
Journal Article
2018Redox-signals and macrophage biology
Weigert, A.; Knethen, A. von; Fuhrmann, D.; Dehne, N.; Brüne, B.
Journal Article
2017Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis
Netzer, C.; Knape, T.; Kuchler, L.; Weigert, A.; Zacharowski, K.; Pfeilschifter, W.; Sempowski, G.; Parnham, M.J.; Brüne, B.; Knethen, A. von
Journal Article
2017Beyond Immune Cell Migration
Olesch, C.; Ringel, C.; Brüne, B.; Weigert, A.
Journal Article
2017Cancer cell and macrophage cross-talk in the tumor microenvironment
Dehne, N.; Mora, J.; Namgaladze, D.; Weigert, A.; Brüne, B.
Journal Article
2017Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice
Oertel, S.; Scholich, K.; Weigert, A.; Thomas, D.; Schmetzer, J.; Trautmann, S.; Wegner, M.S.; Radeke, H.H.; Filmann, N.; Brüne, B.; Geisslinger, G.; Tegeder, I.; Grösch, S.
Journal Article
2017The complete mitochondrial genome of Lacerta bilineata and comparison with its closely related congener L. Viridis
Kolora, S.R.; Faria, R.; Weigert, A.; Schaffer, S.; Grimm, A.; Henle, K.; Sahyoun, A.H.; Stadler, P.F.; Nowick, K.; Bleidorn, C.; Schlegel, M.
Journal Article
2017Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis
Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Knape, T.; Angioni, C.; Ferreiros, N.; Schmidt, M.V.; Weigert, A.; Brüne, B.; Knethen, A. von
Journal Article
2017GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency
Scholz, T.; Weigert, A.; Brüne, B.; Sadik, C.D.; Böhm, B.; Burkhardt, H.
Journal Article
2017Iron handling in tumor-associated macrophages - is there a new role for lipocalin-2?
Jung, M.; Weigert, A.; Mertens, C.; Rehwald, C.; Brüne, B.
Journal Article
2017Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
Mertens, C.; Mora, J.; Ören, B.; Grein, S.; Winslow, S.; Scholich, K.; Weigert, A.; Malmström, P.; Forsare, C.; Fernö, M.; Schmid, T.; Brüne, B.; Jung, M.
Journal Article
2017S1P provokes tumor lymphangiogenesis via macrophage-derived mediators such as IL-1β or Lipocalin-2
Syed, S.N.; Jung, M.; Weigert, A.; Brüne, B.
Journal Article
2017S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β
Weichand, B.; Popp, R.; Dziumbla, S.; Mora, J.; Strack, E.; Elwakeel, E.; Frank, A.-C.; Scholich, K.; Pierre, S.; Syed, S.N.; Olesch, C.; Ringleb, J.; Ören, B.; Döring, C.; Savai, R.; Jung, M.; Knethen, A. von; Levkau, B.; Fleming, I.; Weigert, A.; Brüne, B.
Journal Article
2017THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro
Shiratori, H.; Feinweber, C.; Luckhardt, S.; Linke, B.; Resch, E.; Geisslinger, G.; Weigert, A.; Parnham, M.J.
Journal Article
2016Apoptosis-induced tolerance. Role of the novel cytokine IL-38
Mora, J.; Han, Y.; Wittig, I.; Putyrski, M.; Ernst, A.; Brüne, B.; Weigert, A.
Journal Article
2016Cellular analysis of the histamine H4 receptor in human myeloid cells
Capelo, R.; Lehmann, C.; Ahmad, K.; Snodgrass, R.; Diehl, O.; Ringleb, J.; Flamand, N.; Weigert, A.; Stark, H.; Steinhilber, D.; Kahnt, A.S.
Journal Article
2016Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses
Mora, J.; Schlemmer, A.; Wittig, I.; Richter, F.; Putyrski, M.; Frank, A.-C.; Han, Y.; Jung, M.; Ernst, A.; Weigert, A.; Brüne, B.
Journal Article
2016N-terminally truncated interleukin-38
Weigert, Andreas; Mora, Javier; Brüne, Bernhard; Dillmann, Christina; Parnham, Michael John
Patent
2016Tumour stroma‐derived lipocalin‐2 promotes breast cancer metastasis
Ören, B.; Urosevic, J.; Mertens, C.; Mora, J.; Guiu, M.; Gomis, R.R.; Weigert, A.; Schmid, T.; Grein, S.; Brüne, B.; Jung, M.
Journal Article
2015Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling
Winkel, A.F.; Engel, C.K.; Margerie, D.; Kannt, A.; Szillat, H.; Glombik, H.; Kallus, C.; Ruf, S.; Güssregen, S.; Riedel, J.; Herling, A.W.; Knethen, A. von; Weigert, A.; Brüne, B.; Schmoll, D.
Journal Article
2015Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability
Sha, L.K.; Sha, W.; Kuchler, L.; Daiber, A.; Giegerich, A.K.; Weigert, A.; Knape, T.; Snodgrass, R.; Schröder, K.; Brandes, R.P.; Brüne, B.; Knethen, A. von
Journal Article
2015MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
Olesch, C.; Sha, W.; Angioni, C.; Sha, L.K.; Acaf, E.; Patrignani, P.; Jakobsson, P.-J.; Radeke, H.H.; Grösch, S.; Geisslinger, G.; Knethen, A. von; Weigert, A.; Brüne, B.
Journal Article
2014Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity
Kallenborn-Gerhardt, W.; Hohmann, S.W.; Syhr, K.M.J.; Schröder, K.; Sisignano, M.; Weigert, A.; Lorenz, J.E.; Lu, R.R.; Brüne, B.; Brandes, R.P.; Geisslinger, G.; Schmidtko, A.
Journal Article
2014PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis
Schiffmann, S.; Weigert, A.; Männich, J.; Eberle, M.; Birod, K.; Häussler, A.; Ferreiros, N.; Schreiber, Y.; Kunkel, H.; Grez, M.; Weichand, B.; Brüne, B.; Pfeilschifter, W.; Nüsing, R.; Niederberger, E.; Grösch, S.; Scholich, K.; Geisslinger, G.
Journal Article
2014Prostacyclin mediates neuropathic pain through interleukin 1β‐expressing resident macrophages
Schuh, C.D.; Pierre, S.; Weigert, A.; Weichand, B.; Altenrath, K.; Schreiber, Y.; Ferreirós, N.; Zhang, D.D.; Suo, J.; Treutlein, E.M.; Henke, M.; Kunkel, H.; Grez, M.; Nüsing, R.; Brüne, B.; Geisslinger, G.; Scholich, K.
Journal Article
2014Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression
Kuchler, L.; Sha, L.K.; Giegerich, A.K.; Knape, T.; Weigert, A.; Brüne, B.; Knethen, A. von
Journal Article