Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet
Mühlemann, Markus; Zdzieblo, Daniela; Friedrich, Alexandra; Berger, Constantin; Otto, Christoph; Walles, Heike; Koepsell, Hermann; Metzger, Marco
Journal Article
2018A combined tissue-engineered/in silico signature tool patient stratification in lung cancer
Göttlich, Claudia; Kunz, Meik; Zapp, Cornelia; Nietzer, Sarah L.; Walles, Heike; Dandekar, Thomas; Dandekar, Gudrun
Journal Article
2018Deformation strain is the main physical driver for skeletal precursors to undergo osteogenesis in earlier stages of osteogenic cell maturation
Ramani-Mohan, Ram-Kumar; Schwedhelm, Ivo; Finne-Wistrand, Anna; Krug, Melanie; Schwarz, Thomas; Jakob, Franz; Walles, Heike; Hansmann, Jan
Journal Article
2018Evaluation of a miniaturized biologically vascularized scaffold in vitro and in vivo
Kress, Sebastian; Baur, Johannes; Otto, Christoph; Burkard, Natalie; Braspenning, Joris; Walles, Heike; Nickel, Joachim; Metzger, Marco
Journal Article
2018High-resolution and semidynamic vessel wall imaging kinetics obtained from stable radical MRI in ex-vivo porcine aorta
Pali, M.; Terekhov, M.; Wittke, C.; Wagner, N.; Schroeder, D.; Walles, Heike; Erguen, S.; Zernecke-Madsen, A.; Schreiber, L.M.
Abstract
2018An in vitro coculture system composed of THP-1 cells and 3D reconstructed human epidermis to assess activation of dendritic cells by sensitizing chemicals
Schellenberger, M.T.; Bock, U.; Hennen, J.; Gröber-Becker, F.; Walles, Heike; Blömeke, B.
Abstract
2018Obstructed defecation - an enteric neuropathy? An exploratory study of patient samples
Kim, M.; Rosenbaum, C.; Schlegel, N.; Grumaz, C.; Sohn, K.; Isbert, C.; Walles, H.; Metzger, M.
Journal Article
2018Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration
Hafen, B.; Wiesner, S.; Schlegelmilch, K.; Keller, A.; Seefried, L.; Ebert, R.; Walles, H.; Jakob, F.; Schütze, N.
Journal Article
2018Possible benefits of ultra high field MRI in cardiac diffusion tensor imaging
Lohr, D.; Terekhov, M.; Weng, A.M.; Schroeder, D.; Walles, Heike; Schreiber, L.M.
Abstract
2018Rapid analysis of cell-nanoparticle interactions using single-cell raman trapping microscopy
Steinke, Maria; Zunhammer, Florian; Chatzopoulou, Elisavet I.; Teller, Henrik; Schütze, Karin; Walles, Heike; Rädler, Joachim O.; Grüttner, Cordula
Journal Article
2018Recombinant collagen I peptide microcarriers for cell expansion and their potential use as cell delivery system in a bioreactor model
Suarez Muñoz, Melva; Confalonieri, Davide; Walles, Heike; Dongen, Elisabeth M.W.M. van; Dandekar, Gudrun
Journal Article
2018Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
Lotz, Christian; Kiesewetter, L.; Schmid, Freia F.; Hansmann, Jan; Walles, Heike; Groeber-Becker, Florian Kai
Journal Article
2018Site-directed immobilization of bone morphogenetic protein 2 to solid surfaces by click chemistry
Siverino, Claudia; Tabisz, Barbara; Lühmann, Tessa; Meinel, Lorenz; Müller, Thomas D.; Walles, Heike; Nickel, Joachim
Journal Article
2018A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation
Schmid, Freia F.; Groeber-Becker, Florian; Schwab, Stefanie; Thude, Sibylle; Goebeler, Matthias; Walles, Heike; Hansmann, Jan
Journal Article
2018Tissue Mimicry in Morphology and Composition Promotes Hierarchical Matrix Remodeling of Invading Stem Cells in Osteochondral and Meniscus Scaffolds
Stuckensen, Kai; Schwab, Andrea; Knauer, Markus; Muiños-López, Emma; Ehlicke, Franziska; Reboredo, Jenny W.; Granero-Moltó, Froilán; Gbureck, Uwe; Prósper, Felipe; Walles, Heike; Groll, Jürgen
Journal Article
2017Calcium fluoride based multifunctional nanoparticles for multimodal imaging
Straßer, Marion; Schrauth, Joachim H.X.; Dembski, Sofia; Haddad, Daniel; Ahrens, Bernd; Schweizer, Stefan; Christ, Bastian; Cubukova, Alevtina; Metzger, Marco; Walles, Heike; Jakob, Peter M.; Sextl, Gerhard
Journal Article
2017A comparative multi-parametric in vitro model identifies the power of test conditions to predict the fibrotic tendency of a biomaterial
Jannasch, Maren; Gätzner, Sabine; Weigel, Tobias; Walles, Heike; Schmitz, Tobias; Hansmann, Jan
Journal Article
2017Cross-linked collagen hydrogel matrix resisting contraction to facilitate full-thickness skin equivalents
Lotz, C.; Schmid, F.F.; Oechsle, E.; Monaghan, M.G.; Walles, H.; Groeber-Becker, F.
Journal Article
2017Enlarged islet size, altered insulin(+) and glucagon(+) cell frequencies and modified blood-values for GLP-1, insulin and glucagon in Sglt1 knockout mice
Muehlemann, M.; Zdzieblo, D.; Friedrich, A.; Hofmann, M.; Otto, C.; Koepsell, H.; Walles, H.; Metzger, M.
Abstract
2017Establishment of a human blood-brain barrier co-culture model based on human multipotent and pluripotent stem cells mimicking the neurovascular unit
Appelt-Menzel, A.; Cubukova, A.; Neuhaus, W.; Piontek, J.; Walles, H.; Metzger, M.
Abstract
2017Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluri- and multipotent stem cells
Appelt-Menzel, Antje; Cubukova, Alevtina; Günther, Katharina; Edenhofer, Frank; Piontek, Jörg; Krause, Gerd; Stüber, Tanja; Walles, Heike; Neuhaus, Winfried; Metzger, Marco
Journal Article
2017Flexible tissue-like electrode as a seamless tissue-electronic interface
Weigel, T.; Pfister, T.; Schmitz, T.; Jannasch, M.; Schürlein, S.; Hijailan, R.A.; Walles, H.; Hansmann, J.
Journal Article
2017High-Throughput Screening Techniques
Brendtke, R.; Wever, B. de; Groeber, F.; Hansmann, J.; Schmid, F.; Walles, H.
Book Article
2017Human barrier models for the in vitro assessment of drug delivery
Schweinlin, Matthias; Rossi, Angela; Lodes, Nina; Lotz, Christian; Hackenberg, Stephan; Steinke, Maria; Walles, Heike; Groeber, Florian
Journal Article
2017In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction
Jannasch, Maren; Weigel, Tobias; Engelhardt, Lisa; Wiezoreck, Judith; Gaetzner, Sabine; Walles, Heike; Schmitz, Tobias; Hansmann, Jan
Journal Article
2017Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells
Grabinger, T.; Bode, K.J.; Demgenski, J.; Seitz, C.; Delgado, M.E.; Kostadinova, F.; Reinhold, C.; Etemadi, N.; Wilhelm, S.; Schweinlin, M.; Hänggi, K.; Knop, J.; Hauck, C.; Walles, H.; Silke, J.; Wajant, H.; Nachbur, U.; Wei-Lynn, W.W.; Brunner, T.
Journal Article
2017A multilayered electrospun graft as vascular access for hemodialysis
Radakovic, Dejan; Reboredo, Jenny W.; Helm, M.; Weigel, Tobias; Schürlein, Sebastian; Kupczyk, E.; Leyh, Rainer G.; Walles, Heike; Hansmann, Jan
Journal Article
2017Non-coding RNAs in lung cancer: Contribution of bioinformatics analysis to the development of non-invasive diagnostic tools
Kunz, M.; Wolf, B.; Schulze, H.; Atlan, D.; Walles, T.; Walles, H.; Dandekar, T.
Journal Article
2017Osteogenesis and mineralization of mesenchymal stem cells in collagen type I-based recombinant peptide scaffolds
Pawelec, K.M.; Confalonieri, D.; Ehlicke, F.; Boxtel, H.A. van; Walles, H.; Kluijtmans, S.G.J.M.
Journal Article
2017A pancreas‐specific ECM scaffold – human iPS cell culture and pancreatic differentiation goes 3D
Berger, Constantin; Bjørlykke, Yngvild; Mühlemann, Markus; Ræder, Helge; Walles, Heike; Metzger, Marco; Zdzieblo, Daniela
Abstract
2017Preparation of a three-dimensional full thickness skin equivalent
Reuter, C.; Walles, H.; Groeber, F.
Book Article
2017Screening applications to test cellular fitness in transwell® models after nanoparticle treatment
Christ, Bastian; Fey, Christina; Cubukova, Alevtina; Walles, Heike; Dembski, Sofia; Metzger, Marco
Book Article
2017Three-Dimensional Coculture of Meniscal Cells and Mesenchymal Stem Cells in Collagen Type I Hydrogel on a Small Intestinal Matrix-A Pilot Study Toward Equine Meniscus Tissue Engineering
Kremer, A.; Ribitsch, I.; Reboredo, J.; Dürr, J.; Egerbacher, M.; Jenner, F.; Walles, H.
Journal Article
2017Tissue Engineering of primary human in vitro models – Influence of mechanical and biochemical stimulation on tissue functionality
Appelt-Menzel, Antje; Zdzieblo, Daniela; Schürlein, Sebastian; Schwarz, Thomas; Hansmann, Jan; Metzger, Marco; Walles, Heike
Abstract
2017A versatile modular bioreactor platform for Tissue Engineering
Schürlein, Sebastian; Schwarz, Thomas; Krziminski, Steffan; Gätzner, Sabine; Hoppensack, Anke; Schwedhelm, Ivo; Schweinlin, Matthias; Walles, Heike; Hansmann, Jan
Journal Article
20163D in vitro tissue models for infection studies with human pathogens
Schweinlin, Matthias; Steinke, Maria; Groeber, Florian; Gross, Roy; Reuter, Christian; Seidensticker, Katharina; Schulte, Leon; Metzger, Marco; Engstler, Markus; Walles, Heike
Abstract
2016Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo
Rosenbaum, C.; Schick, M.A.; Wollborn, J.; Heider, A.; Scholz, C.-J.; Cecil, A.; Niesler, B.; Hirrlinger, J.; Walles, H.; Metzger, M.
Journal Article
2016Alternative methods for the replacement of eye irritation testing
Lotz, Christian; Schmid, Freia F.; Rossi, Angela; Kurdyn, Szymon; Kampik, Daniel; Wever, Bart de; Walles, Heike; Groeber, Florian
Journal Article
2016ATERA: Advanced 3D human tissue models and exclusive testing services for cosmetic, consumer product and pharmaceutical industry
Wever, Bart de; Varlet, Beatrice le; Groeber, Florian; Ginosian, Anna; Guillon, Fabien; Walles, Heike
Abstract
2016BioVaSc-TERM - a platform technology to engineer human barrier models
Rossi, Angela; Schweinlin, Matthias; Steinke, Maria; Groeber, Florian; Walles, Heike
Abstract
2016Cartilage Tissue Engineering: Investigation of Migration and Differentiation of Human Mesenchymal Stem Cells on Five-Layered Collagenous Electrospun Scaffold Mimicking Native Cartilage Structure (Adv. Healthcare Mater. 17/2016)
Reboredo, J.W.; Weigel, T.; Steinert, A.; Rackwitz, L.; Rudert, M.; Walles, H.
Journal Article
2016Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase II)
Groeber, Florian; Schober, Lena; Schmid, Freia F.; Traube, Andrea; Kolbus-Hernandez, Silvia; Daton, K.; Hoffmann, Sebastian; Petersohn, Dirk; Schäfer-Korting, Monika; Walles, Heike; Mewes, Karsten R.
Journal Article
2016A combined 3D tissue engineered in Vitro/in silico lung tumor model for predicting drug effectiveness in specific mutational backgrounds
Göttlich, Claudia; Müller, Lena C.; Kunz, Meik; Schmitt, Franziska; Walles, Heike; Walles, Thorsten; Dandekar, Thomas; Dandekar, Gudrun; Nietzer, Sarah L.
Journal Article
2016Complex skin models and impedance spectroscopy as new tools for hazard identification and efficacy testing
Groeber, Florian; Engelhardt, Lisa; Guillon, Fabien; Varlet, Beatrice le; Wever, Bart de; Walles, Heike
Abstract
2016Development of a 3D organotypic lung tumor model in combination with FDG-PET to monitor treatment response
Fecher, D.; Schwarz, T.; Nietzer, S.; Walles, H.; Dandekar, G.; Lückerath, K.; Steinke, M.
Abstract
2016Development of an advanced primary human in vitro model of the small intestine
Schweinlin, Matthias; Wilhelm, Sabine; Schwedhelm, Ivo; Hansmann, Jan; Rietscher, Rene; Jurowich, Christian; Walles, Heike; Metzger, Marco
Journal Article
2016Differential regulation of SOX9 protein during chondrogenesis of induced pluripotent stem cells versus mesenchymal stromal cells: A shortcoming for cartilage formation
Diederichs, Solvig; Gabler, Jessica; Autenrieth, Jennifer; Kynast, Katharina L.; Merle, Christian; Walles, Heike; Utikal, Jochen; Richter, Wiltrud
Journal Article
2016Establishment and characterization of a 3D mamma carcinoma test system on a decellularized scaffold
Müller, L.; Walles, H.; Nietzer, S.; Dandekar, G.
Abstract
2016Evaluation of various bioreactor process systems for the production of induced pluripotent stem cells
Appelt-Menzel, Antje; Schwedhelm, Ivo; Kühn, Fabian; Cubukova, Alevtina; Edenhofer, Frank; Walles, Heike; Hansmann, Jan
Journal Article
2016Feasibility study on a microwave-based sensor for measuring hydration level using human skin models
Brendtke, R.; Wiehl, M.; Groeber, F.; Schwarz, T.; Walles, H.; Hansmann, J.
Journal Article
2016A first vascularized skin equivalent for as an alternative to animal experimentation
Groeber, Florian; Engelhardt, Lisa; Lange, Julia; Kurdyn, Szymon; Schmid, Freia F.; Rücker, Christoph; Mielke, Stephan; Walles, Heike; Hansmann, Jan
Journal Article
2016Human organotypic lung tumor models: Suitable for preclinical 18F-FDG PET-imaging
Fecher, David; Hofmann, Elisabeth; Buck, Andreas; Bundschuh, Ralph; Nietzer, Sarah; Dandekar, Gudrun; Walles, Thorsten; Walles, Heike; Lückerath, Katharina; Steinke, Maria
Journal Article
2016Hybrid cell detachment-free cell expansion system for adherent cell culturing and related proceeding protocol
Confalonieri, Davide; Hansmann, Jan; Walles, Heike; Krziminski, Steffan
Patent
2016Individualized drug response predictions based on a combined in silico and in vitro lung cancer model on a biological scaffold
Göttlich, C.; Kunz, M.; Walles, T.; Walles, H.; Dandekar, T.; Dandekar, G.; Nietzer, S.
Abstract
2016Interactions of donor sources and media influence the histo-morphological quality of full-thickness skin models
Lange, J.; Weil, F.; Riegler, C.; Groeber, F.; Rebhan, S.; Kurdyn, S.; Alb, M.; Kneitz, H.; Gelbrich, G.; Walles, H.; Mielke, S.
Journal Article
2016Investigation of migration and differentiation of human mesenchymal stem cells on five-layered collagenous electrospun scaffold mimicking native cartilage structure
Reboredo, Jenny; Weigel, Tobias; Steinert, Andre; Rackwitz, Lars; Rudert, Maximilian; Walles, Heike
Journal Article
2016Isotropic versus bipolar functionalized biomimetic artificial basement membranes and their evaluation in long-term human cell co-culture
Rossi, Angela; Wistlich, Laura; Heffels, Karl-Heinz; Walles, Heike; Groll, Jürgen
Journal Article
2016Mimicking metastases including tumor stroma: A new technique to generate a three-dimensional colorectal cancer model based on a biological decellularized intestinal scaffold
Nietzer, Sarah; Baur, Florentin; Sieber, Stefan; Hansmann, Jan; Schwarz, Thomas; Stoffer, Carolin; Häfner, Heide; Gasser, Martin; Waaga-Gasser, Ana Maria; Walles, Heike; Dandekar, Gudrun
Journal Article
2016Monitoring der Substanzwirkung bei in vitro Geweben
Groeber, Florian; Hansmann, Jan; Walles, Heike
Patent
2016Rapid monolayer neural induction of induced pluripotent stem cells yields stably proliferating neural stem cells
Günther, Katharina; Appelt-Menzel, Antje; Kwok, Chee Keong; Walles, Heike; Metzger, Marco; Edenhofer, Frank
Journal Article
2016Recent developments of disease and human in vitro models of the blood-brain barrier
Appelt-Menzel, Antje; Piontek, Jörg; Kraemer, Tobias; Riethmüller, Christoph; Gaiser, Fabian; Neuhoff, Anja; Mahringer, Anne; Thal, Serge; Förster, Carola; Walles, Heike; Metzger, Marco; Neuhaus, Winfried
Abstract
2016Stem cell labeling with iron oxide nanoparticles: Impact of 3D culture on cell labeling maintenance
Kilian, Teresa; Fidler, Florian; Kasten, Annika; Nietzer, Sarah; Landgraf, Veronika; Weiß, Katrin; Walles, Heike; Westphal, Fritz; Hackenberg, Stephan; Grüttner, Cordula; Steinke, Maria
Journal Article
2016Strategies and first advances in the development of prevascularized bone implants
Rücker, Christoph; Kirch, Holger; Pullig, Oliver; Walles, Heike
Journal Article
2016Targeted therapies of two different Braf mutated colorectal carcinoma cell lines and the establishment of a 3D tumor model on the basis of a decellularized intestinal matrix
Baur, F.; Dandekar, G.; Nietzer, S.; Walles, H.
Abstract
2016Tissue Engineering 4.0
Walles, Heike
Journal Article, Conference Paper
2015A 3D human lung tumor test system on an acellular scaffold: Simulation of a biomarker-guided therapy
Göttlich, C.; Nietzer, S.; Dandekar, G.; Walles, H.
Abstract
2015Biovasc-term (R): A platform technology to engineer of vascularised human tissues
Walles, H.; Steinke, M.; Ruecker, C.; Hansmann, J.; Groeber, F.; Blunk, T.; Metzger, M.; Dandekar, G.; Pullig, O.
Conference Paper, Journal Article
2015Development and application of three-dimensional skin equivalents for the investigation of percutaneous worm invasion
Jannasch, M.; Groeber, F.; Brattig, N.W.; Unger, C.; Walles, H.; Hansmann, J.
Journal Article
2015Development of an improved primary in vitro model of the human small intestine
Schweinlin, Matthias; Wilhelm, Sabine; Walles, Heike; Metzger, Marco
Conference Paper, Journal Article
2015Ex vivo osteo-chondral organ culture
Schwab, Andrea; Ehlicke, Franziska; Hansmann, Jan; Walles, Heike
Journal Article
2015Generation of a three-dimensional full thickness skin equivalent and automated wounding
Rossi, Angela; Appelt-Menzel, Antje; Kurdyn, Szymon; Walles, Heike; Groeber, Florian
Journal Article
2015Host-integration of a tissue-engineered airway patch: Two-year follow-up in a single patient
Steinke, Maria; Dally, Iris; Friedel, Godehard; Walles, Heike; Walles, Thorsten
Journal Article
2015Impedance spectroscopy for the non-destructive evaluation of In vitro epidermal models
Groeber, F.; Engelhardt, L.; Egger, S.; Werthmann, H.; Monaghan, M.; Walles, H.; Hansmann, J.
Journal Article
2015Influence of hematopoietic components of the bone marrow on in vitro bone formation assays
Confalonieri, Davide; Ehlicke, Franziska; Walles, Heike
Conference Paper, Journal Article
2015Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology
Gordon, S.; Daneshian, M.; Bouwstra, J.; Caloni, F.; Constant, S.; Davies, D.E.; Dandekar, G.; Guzman, C.A.; Fabian, E.; Haltner, E.; Hartung, T.; Hasiwa, N.; Hayden, P.; Kandarova, H.; Khare, S.; Krug, H.F.; Kneuer, C.; Leist, M.; Lian, G.; Marx, U.; Metzger, M.; Ott, K.; Prieto, P.; Roberts, M.S.; Roggen, E.L.; Tralau, T.; Van Den Braak, C.; Walles, H.; Lehr, C.-M.
Journal Article
2015A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects
Kleinhans, Claudia; Mohan, Ramkumar Ramani; Vacun, Gabriele; Schwarz, T.; Haller, B.; Sun, Yang; Kahlig, A.; Kluger, Petra; Finne-Wistrand, Anna.; Walles, Heike; Hansmann, Jan
Journal Article
2015Physiological impact of odorants: Immediate versus post-ingestion and post-inhalation effects
Buettner, A.; Beauchamp, J.; Freiherr, Jessica; Heinlein, Anja; Kessler, Artur; Leuner, Kristina; Metzger, Marco; Pischetsrieder, Monika; Villmann, Carmen; Walles, Heike
Conference Paper
2015Pre-vascularized bone implant composed of cell-seeded naturally derived collagen matrix and synthetic ß-TCP
Rücker, Christoph; Henkel, J.; Stigler, R.G.; Hutmacher, Dietmar W.; Rasse, M.; Walles, Heike
Journal Article, Conference Paper
2015Self organizing vascularized cardiac scaffolds from human atrial appendages
Beck, Carolin; Werner, Martina; Walles, Heike; Leistner, Marcus
Conference Paper, Journal Article
2015Site-directed immobilization of BMP-2 and Noggin inhibitory peptides onto collagen beads for bone regeneration
Siverino, Claudia; Nickel, Joachim; Walles, Heike
Conference Paper, Journal Article
2015Stem cell vitality assessment using magnetic particle spectroscopy
Fidler, F.; Steinke, M.; Kraupner, A.; Grüttner, C.; Hiller, K.-H.; Briel, A.; Westphal, F.; Walles, H.; Jakob, P.M.
Journal Article
2015Study of the effect of collagenous microcarriers on the vasculogenic potential of endothelial cells obtained from different sources
Suarez Munoz, M.; Dandekar, Gudrun; Walles, Heike
Conference Paper, Journal Article
2015Two-photon polymerization of inorganic-organic polymers for biomedical and microoptical applications
Burmeister, Frank; Steenhusen, Sönke; Houbertz, Ruth; Asche, T.S.; Nickel, J.; Nolte, Stefan; Tucher, Nico; Josten, P.; Obel, Kerstin; Wolter, Herbert; Fessel, S.; Schneider, A.M.; Gärtner, K.-H.; Beck, C.; Behrens, P.; Tünnermann, Andreas; Walles, Heike
Book Article
2014Bioassays: Humane 3D-in vitro-Testsysteme für die präklinische Forschung
Rossi, A.; Fecher, D.; Egner, S.; Schweinlin, M.; Steinke, M.; Walles, H.
Journal Article
2014Development of nanoelectrodes for cell stimulation and reduced foreign body reaction
Weigel, Tobias; Schmitz, T.; Jannasch, Maren; Gätzner, S.; Walles, Heike; Hansmann, Jan
Abstract
2014An engineered 3D human airway mucosa model based on an SIS scaffold
Steinke, M.; Gross, R.; Walles, H.; Gangnus, R.; Schütze, K.; Walles, T.
Journal Article
2014A human in vitro model that mimics the renal proximal tubule
Hoppensack, A.; Kazanecki, C.C.; Colter, D.; Gosiewska, A.; Schanz, J.; Walles, H.; Schenke-Layland, K.
Journal Article
2014Next generation tissue models as a replacement for animal experiments
Groeber, Florian; Schmid, Franziska; Schober, Lena; Traube, Andrea; Walles, Heike
Abstract
2014Organ-like three dimensional test systems
Rossi, Angela; Groeber, Florian; Steinke, Maria; Dandekar, Gudrun; Nietzer, Sarah; Metzger, Marco; Walles, Heike
Abstract
2014The role of enteric glial cells in inflammatory diseases of the bowel
Moll, Corinna; Heider, A.; Brede, Christian; Scholz, Claus-Jürgen; Cecil, Alexander; Walles, Heike; Metzger, Marco
Abstract
2014Transport of hop aroma compounds across Caco-2 monolayers
Heinlein, A.; Metzger, M.; Walles, H.; Buettner, A.
Journal Article
2013Ammonia plasma treatment of polystyrene surfaces enhances proliferation of primary human mesenchymal stem cells and human endothelial cells
Kleinhans, C.; Barz, J.; Wurster, S.; Willig, M.; Oehr, C.; Müller, M.; Walles, H.; Hirth, T.; Kluger, P.J.
Journal Article
2013A bioreactor system for interfacial culture and physiological perfusion of vascularized tissue equivalents
Groeber, F.; Kahlig, A.; Loff, S.; Walles, H.; Hansmann, J.
Journal Article
2013Bioreactors in tissue engineering - Principles, applications and commercial constraints
Hansmann, J.; Groeber, F.; Kahlig, A.; Kleinhans, C.; Walles, H.
Journal Article
2013Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing
Vörsmann, H.; Groeber, F.; Walles, H.; Busch, S.; Beissert, S.; Walczak, H.; Kulms, D.
Journal Article
2013Editorial: Strategies in tissue engineering and regenerative medicine
Schenke-Layland, Katja; Walles, Heike
Journal Article
2013Entwicklung eines humanen In-vitro-Modells des renalen proximalen Tubulus
Hoppensack, A.
: Walles, H. (Prüfer)
Dissertation
2013A human airway mucosa tissue model to investigate whooping cough
Steinke, M.; Gross, R.; Bauer, S.; Walles, T.; Walles, H.
Journal Article
2013In silico approaches for the identification of optimal culture condition for tissue engineered bone substitutes
Kahlig, A.; Hansmann, J.; Groeber, F.; Schwarz, T.; Weyhmuller, J.; Illig, A.; Kleinhans, C.; Walles, H.
Journal Article
2013An in vitro model of the renal proximal tubule composed of small intestinal submucosa (SIS) and human kidney-derived cells (hKDCs)
Hoppensack, Anke; Schanz, Johanna; Kazanecki, Christian; Colter, David; Walles, Heike
Journal Article, Conference Paper
2013Integrating biological vasculature into a multi-organ-chip microsystem
Schimek, K.; Busek, M.; Brincker, S.; Groth, B.; Hoffmann, S.; Lauster, R.; Lindner, G.; Lorenz, A.; Menzel, U.; Sonntag, F.; Walles, H.; Marx, U.; Horland, R.
Journal Article
2013Tissue engineering of a human 3D in vitro tumor test system
Moll, C.; Reboredo, J.; Schwarz, T.; Appelt, A.; Schürlein, S.; Walles, H.; Nietzer, S.
Non Book Material, Journal Article
2013Upcyte(R). Microvascular endothelial cells repopulate decellularized scaffold
Scheller, Katharina; Dally, Iris; Hartmann, Nadja; Münst, Bernhard; Braspenning, Joris; Walles, Heike
Journal Article
2012'Human-on-a-chip' developments: A translational cuttingedge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man?
Marx, U.; Walles, H.; Hoffmann, S.; Lindner, G.; Horland, R.; Sonntag, F.; Klotzbach, U.; Sakharov, D.; Tonevitsky, A.; Lauster, R.
Journal Article
2012Automatic image quantification for structural analysis of in vitro dermal samples
Gryanik, Alexander; Wittenberg, Thomas; Walles, Heike; Steckhan, Dirk; Thude, Sibylle; Kaufmann, Michaela; Münzenmayer, Christian
Conference Paper, Journal Article
2012Cell adhesion and proliferation of adipose derived stem cells on low pressure plasma modified surfaces
Schmohl, L.; Kleinhans, C.; Barz, J.; Müller, M.; Walles, H.; Schenke-Layland, K.; Kluger, P.
Journal Article
2012Design of a compact multi-sensor system for non-invasive glucose monitoring using optical spectroscopy
Abdallah, Omar; Bolz, Armin; Hansmann, Jan; Walles, Heike; Hirth, Thomas
Conference Paper
2012Development of a vascularized skin equivalent with a physiological perfused vascular network
Groeber, F.K.; Hansmann, J.; Kaufmann, M.; Walles, H.
Conference Paper, Journal Article
2012Development of full-thickness skin equivalents including immunological cell types
Kurdyn, Szymon; Weil, Frederick; Nickel, Joachim; Mielke, Stephan; Walles, Heike
Abstract
2012Dynamic culture of human mesenchymal stem cells in a perfusion bioreactor on ß-TCP cylinder
Kleinhans, C.; Haller, B.; Kahlig, A.; Vacun, G.; Schanz, J.; Hansmann, J.; Walles, H.; Kluger, P.
Journal Article
2012Impedance spectroscopy - A tool for the characterization of skin equivalents
Hansmann, J.; Groeber, F.; Walles, H.
Conference Paper, Journal Article
2012In situ guided tissue regeneration in musculoskeletal diseases and aging
Jakob, F.; Ebert, R.; Rudert, M.; Nöth, U.; Walles, H.; Docheva, D.; Schieker, M.; Meinel, L.; Groll, J.
Journal Article
2012Isolation and culture of primary human subcutaneous adipocytes and construction of a fatty tissue equivalent
Huber, B.; Klechowitz, N.; Borchers, K.; Walles, H.; Hirth, T.; Kluger, P.J.
Journal Article
2012Keynote: Bioreactor technology and automatization in the production of human 3D tissues
Walles, H.
Conference Paper, Journal Article
2012Metabolic oligosaccharide engineering as a tool to enhance cell adhesion on titanium implant surfaces
Ruff, M.; Wieland, D.; Bach, M.; Tovar, G.; Walles, H.; Hirth, T.; Wittmann, V.; Kluger, P.J.
Journal Article
2012Non-contact, label-free monitoring of cells and extracellular matrix using Raman spectroscopy
Votteler, M.; Carvajal Berrio, D.A.; Pudlas, M.; Walles, H.; Schenke-Layland, K.
Non Book Material, Journal Article
2012Oligonucleotide and parylene surface coating of polystyrene and ePTFE for improved endothelial cell attachment and hemocompatibility
Schleicher, M.; Hansmann, J.; Elkin, B.; Kluger, P.J.; Liebscher, S.; Huber, A.J.T.; Fritze, O.; Schille, C.; Müller, M.; Schenke-Layland, K.; Seifert, M.; Walles, H.; Wendel, H.-P.; Stock, U.A.
Journal Article
2012Optical spectroscopy and obstacles by non-invasive detection of glucose concentration by home monitoring
Abdallah, O.; Qananwah, Q.; Bolz, A.; Hansmann, J.; Walles, H.; Hirth, T.
Conference Paper
2012Raman spectroscopy for the non-contact and non-destructive monitoring of collagen damage within tissues
Votteler, M.; Berrio, D.A.C.; Pudlas, M.; Walles, H.; Stock, U.A.; Schenke-Layland, K.
Journal Article
2012Small intestinal submucosa (SIS) as a natural biomaterial that promotes the epithelial morphogenesis of renal tubular cells
Hoppensack, A.; Schanz, J.; Kazanecki, C.; Colter, D.; Walles, H.
Journal Article
2012Three dimensional tissue models for research in oncology
Nietzer, S.; Dandekar, G.; Wasik, M.; Walles, H.
Book Article
2012Tissue Engineering: Menschliche Gewebe aus dem Labor
Schanz, J.; Walles, H.; Walles, T.
Journal Article
2011Angiogenetic structures in a 3-dimensional dynamic cultivation system
Hinderer, S.; Novosel, E.; Hansmann, J.; Kluger, P.; Walles, H.
Abstract
2011Artificial small diameter blood vessels based on new biofunctionalized 3D-printable polymers
Novosel, Esther; Klechowitz, Nadine; Meyer, Wolfdietrich; Schuh, Christian; Borchers, Kirsten; Wegener, Michael; Krüger, Hartmut; Walles, Heike; Hirth, Thomas; Tovar, Günter; Kluger, Petra
Journal Article, Conference Paper
2011Biofunctionalization and dynamical culture of endothelial cells on new 3D-printable polymers for small diameter grafts
Novosel, E.C.; Klechowitz, N.; Schuh, C.; Fischer, A.; Meyer, W.; Wegener, M.; Krüger, H.; Borchers, K.; Walles, H.; Hirth, T.; Tovar, G.E.M.; Kluger, P.J.
Conference Paper
2011Characterization of endothelial cell-biomaterial interaction on newly developed 3D-printable polymer surfaces for vascular grafts
Novosel, E.; Meyer, W.; Wegener, M.; Kruger, H.; Borchers, K.; Kluger, P.; Tovar, G.; Walles, H.; Hirth, T.
Abstract
2011Covalent heparin immobilization on new developed 3D-printable biomaterials
Novosel, E.; Meyer, W.; Wegener, M.; Kruger, H.; Borchers, K.; Kluger, P.; Tovar, G.; Walles, H.; Hirth, T.
Abstract
2011Detection and discrimination of cells and cell viability in tissue engineering by Raman micro-spectroscopy
Koch, S.; Pudlas, M.; Bolwien, C.; Walles, H.
Abstract
2011Development of a dynamic intestinal tissue equivalent that enables the analysis of new drug candidates in vitro
Gohler, S.; Pusch, J.; Sawodny, B.; Walles, H.; Hirth, T.
Abstract
2011Development of a vascularised skin equivalent
Groeber, F.K.; Hansmann, J.; Kaufmann, M.; Walles, H.
Abstract
2011Development of a vascularized skin equivalent
Groeber, F.; Hansmann, J.; Kaufmann, M.; Walles, H.
Abstract
2011Development of a vascularized skin equivalent
Groeber, F.; Hansmann, J.; Kaufmann, M.; Walles, H.
Abstract
2011Development of high volume producible nano- and microstructured surfaces
Kluger, P.; Pretzsch, F.; Buth, H.; Novosel, E.; Maierle, J.; Wenzel, C.; Walles, H.
Abstract
2011Diamond containing scaffolds
Steinmüller-Nethl, Doris; Walles, Heike
Patent
2011Effect of plasma-treated polystyrene surfaces on human dermal microvascular endothelial cells
Wurster, S.; Zschoerper, N.; Müller, M.; Hirth, T.; Walles, H.; Kluger, P.J.
Abstract
2011Endothelialization of oligonucleotide coated diX AM surfaces for in vivo tissue engineering
Schleicher, M.; Hansmann, J.; Elkin, B.; Kluger, P.J.; Liebscher, S.; Huber, A.J.; Fitze, O.; Schenke-Layland, K.; Schille, C.; Hellmer, K.H.; Walles, H.; Wendel, H.-P.; Stock, U.A.
Abstract
2011Evaluation of cell-material interactions on newly designed, printable polymers for tissue engineering applications
Novosel, E.C.; Meyer, W.; Klechowitz, N.; Krüger, H.; Wegener, M.; Walles, H.; Tovar, G.E.M.; Hirth, T.; Kluger, P.J.
Journal Article
2011Evaluation of plasma-functionalized bone substitutes on the adhesion, proliferation and differentiation of human mesenchymal stem cells
Kleinhans, C.; Schneider, S.; Müller, M.; Schiestel, T.; Heymer, A.; Walles, H.; Hirth, T.; Kluger, P.J.
Conference Paper
2011GMP conform manufacturing process of an autologous melanocyte graft
Linke, K.; Schandar, M.; Pusch, J.; Anadere, I.; Kaufmann, M.; Walles, H.
Abstract
2011Impact of new functionalized biomaterials on the adhesion and proliferation of human mesenchymal stem cells
Kleinhans, C.; Kluger, P.; Wurster, S.; Müller, M.; Walles, H.; Hirth, T.
Abstract
2011In vitro culture of native jejunal segments for use as 3D intestinal testing system
Tordy, D.; Schanz, J.; Pusch, J.; Schröder, B.; Walles, H.; Hirth, T.
Abstract
2011In vitro development of a vascularised tracheal patch to restore airway defects after resection
Dally, I.; Schandar, M.; Linke, K.; Pusch, J.; Walles, T.; Walles, H.
Abstract
2011In vitro- Testsystem für virale Infektionen
Burger-Kentischer, A.; Hogk, I.; Finkelmeier, D.; Walles, H.; Rupp, S.; Kaufmann, M.
Patent
2011Non-contact discrimination of human bone marrow-derived mesenchymal stem cells and fibroblasts using Raman spectroscopy
Pudlas, M.; Berrio, D.A.C.; Votteler, M.; Koch, S.; Thude, S.; Walles, H.; Schenke-Layland, K.
Journal Article
2011The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine
Pusch, J.; Votteler, M.; Göhler, S.; Engl, J.; Hampel, M.; Walles, H.; Schenke-Layland, K.
Journal Article
2011Raman spectroscopy: A noninvasive analysis tool for the discrimination of human skin cells
Pudlas, M.; Koch, S.; Bolwien, C.; Thude, S.; Jenne, N.; Hirth, T.; Walles, H.; Schenke-Layland, K.
Journal Article
2011Raman spectroscopy: A powerful tool for the non-contact discrimination of bone marrow mesenchymal stem cells and fibroblasts
Pudlas, M.; Koch, S.; Bolwien, C.; Hirth, T.; Walles, H.; Schenke-Layland, K.
Conference Paper
2011Regeneration of the intervertebral disc (IVD) using in vitro differentiated stem cells
Ehlicke, F.; Freimark, D.; Pudlas, M.; Dorresteijn, A.; Walles, H.; Czermak, P.
Abstract
2011The skin factory
Walles, H.; Pickert, D.
Journal Article
2011Skin from the factory - Automated Tissue Engineering on Demand
Walles, H.; Kaufmann, M.; Traube, A.; Pretsch, F.; Bernhardt, F.; Stolzing, A.
Abstract
2011Structural analysis of artificial skin equivalents
Schmitt, R.; Marx, U.; Walles, H.; Schober, L.
Conference Paper
2011Validation of artificial skin equivalents as in vitro testing systems
Schmitt, R.; Marx, U.; Walles, H.; Schober, L.
Conference Paper
2011Vollautomatisierte Herstellung von Gewebemodellen
Walles, Heike
Journal Article
2010Characterization of endothelial cell-biomaterial interaction on newly developed 3D-printable polymer surfaces for vascular grafts
Novosel, E.C.; Meyer, W.; Wegener, M.; Krüger, H.; Borchers, K.; Tovar, G.; Kluger, P.; Walles, H.; Hirth, T.
Poster
2010Characterization of human skin cells for tissue engineering applications by Raman spectroscopy
Pudlas, M.; Koch, S.; Bolwien, C.; Walles, H.
Conference Paper
2010Charakterisierung des Zellverhaltens primärer humaner Endothelzellen auf neu entwickelten 3D-verdruckbaren Biopolymeren
Novosel, E.C.; Klechowitz, N.; Meyer, W.; Wegener, M.; Krüger, H.; Borchers, K.; Tovar, G.; Kluger, P.; Walles, H.; Hirth, T.
Poster
2010Covalent heparin immobilization on new developed 3D-printable biomaterials
Novosel, E.C.; Klechowitz, N.; Meyer, W.; Wegener, M.; Krüger, H.; Borchers, K.; Tovar, G.; Kluger, P.; Walles, H.; Hirth, T.
Poster
2010Einfluss plasmafunktionalisierter Biomaterialien auf das Adhäsions- und Proliferationsverhalten mesenchymaler Stammzellen
Kleinhans, C.; Kluger, P.; Müller, M.; Walles, H.; Hirth, T.
Poster
2010Electrospun poly(D/L-lactide-co-L-lactide) hybrid matrix: A novel scaffold material for soft tissue engineering
Kluger, P.J.; Wyrwa, R.; Weisser, J.; Maierle, J.; Votteler, M.; Rode, C.; Schnabelrauch, M.; Walles, H.; Schenke-Layland, K.
Journal Article
2010Evaluation of primary endothelial cells cultured on newly developed 3D-printable polymer surfaces
Novosel, E.C.; Meyer, W.; Wegener, M.; Krüger, H.; Borchers, K.; Tovar, G.; Kluger, P.; Walles, H.; Hirth, T.
Poster
2010Impact of new functionalized biomaterials on the adhesion and proliferation of human mesenchymal stem cells
Kleinhans, C.; Kluger, P.; Vacun, G.; Wurster, S.; Müller, M.; Walles, H.; Hirth, T.
Poster
2010Impact of plasma-functionalized substrates on the behaviour of musculoskeletal cells
Heymer, A.; Maierle, J.; Kluger, P.; Walles, H.
Poster
2010In vitro culture of native jejunal segments for use as 3D intestinal testing system
Tordy, D.M.; Schanz, J.E.; Pusch, J.; Schröder, B.; Hirth, T.; Walles, H.
Poster
2010Optical coherence tomography investigation of growth cycles of engineered skin tissue
Schmitt, R.; Marx, U.; Walles, H.; Heymer, A.
Conference Paper
2010Organe aus dem Automaten
Kaufmann, M.; Walles, H.
Journal Article
2010Raman spectroscopy as a tool for quality and sterility analysis for tissue engineering applications like cartilage transplants
Pudlas, M.; Koch, S.; Bolwien, C.; Walles, H.
Journal Article
2010Stem cell microenvironments - unveiling the secret of how stem cell fate is defined
Votteler, M.; Kluger, P.J.; Walles, H.; Schenke-Layland, K.
Journal Article
2010A system for the rapid detection of bacterial contamination in cell-based therapeutica
Bolwien, C.; Erhardt, C.; Sulz, G.; Thielecke, H.; Johann, R.; Pudlas, M.; Walles, H.; Mertsching, H.; Koch, S.
Conference Paper
2010Vascularised human tissue models. A new approach for the refinement of biomedical research
Schanz, J.; Pusch, J.; Hansmann, J.; Walles, H.
Journal Article