Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Computational functional genomics-based reduction of disease-related gene sets to their key components
Lippmann, C.; Ultsch, A.; Lötsch, J.
Journal Article
2018Computational functional genomics-based approaches in analgesic drug discovery and repurposing
Lippmann, C.; Kringel, D.; Ultsch, A.; Lötsch, J.
Journal Article
2018Identification of disease-distinct complex biomarker patterns by means of unsupervised machine-learning using an interactive R toolbox (Umatrix)
Lötsch, J.; Lerch, F.; Djaldetti, R.; Tegder, I.; Ultsch, A.
Journal Article
2018Machine learning in pain research
Lötsch, J.; Ultsch, A.
Journal Article
2018A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes
Kringel, D.; Lippmann, C.; Parnham, M.J.; Kalso, E.; Ultsch, A.; Lötsch, J.
Journal Article
2018Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy
Lötsch, J.; Schiffmann, S.; Schmitz, K.; Brunkhorst, R.; Lerch, F.; Ferreiros, N.; Wicker, S.; Tegeder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2018Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy
Lötsch, J.; Sipilä, R.; Tasmuth, T.; Kringel, D.; Estlander, A.-M.; Meretoja, T.; Kalso, E.; Ultsch, A.
Journal Article
2017A data science based standardized Gini index as a Lorenz dominance preserving measure of the inequality of distributions
Ultsch, A.; Lötsch, J.
Journal Article
2017Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses
Kringel, D.; Ultsch, A.; Zimmermann, M.; Jansen, J.P.; Ilias, W.; Freynhagen, R.; Griessinger, N.; Kopf, A.; Stein, C.; Doehring, A.; Resch, E.; Lötsch, J.
Journal Article
2017Integrated computational analysis of genes associated with human hereditary insensitivity to pain
Lötsch, J.; Lippmann, C.; Kringel, D.; Ultsch, A.
Journal Article
2017Machine-learned cluster identification in high-dimensional data
Ultsch, A.; Lötsch, J.
Journal Article
2017Machine-learned data structures of lipid marker serum concentrations in multiple sclerosis patients differ from those in healthy subjects
Lötsch, J.; Thrun, M.; Lerch, F.; Brunkhorst, R.; Schiffmann, S.; Thomas, D.; Tegder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2017Prediction of persistent post-surgery pain by preoperative cold pain sensitivity: Biomarker development with machine-learning-derived analysis
Lötsch, J.; Ultsch, A.; Kalso, E.
Journal Article
2017Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects
Lötsch, J.; Geisslinger, G.; Heinemann, S.; Lerch, F.; Oertel, B.G.; Ultsch, A.
Journal Article
2016Brain lesion-pattern analysis in patients with olfactory dysfunctions following head trauma
Lötsch, J.; Ultsch, A.; Eckhardt, M.; Huart, C.; Rombaux, P.; Hummel, T.
Journal Article
2016A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes
Lotsch, J.; Ultsch, A.
Journal Article
2016A data science approach to candidate gene selection of pain regarded as a process of learning and neural plasticity
Ultsch, A.; Kringel, D.; Kalso, E.; Mogil, J.S.; Lötsch, J.
Journal Article
2016Disagreement between two common biomarkers of global DNA methylation
Knothe, C.; Shiratori, H.; Resch, E.; Ultsch, A.; Geisslinger, G.; Doehring, A.; Lötsch, J.
Journal Article
2016ESOM visualizations for quality assessment in clustering
Ultsch, A.; Behnisch, M.; Lötsch, J.
Conference Paper
2016How many and which odor identification items are needed to establish normal olfactory function?
Lötsch, J.; Ultsch, A.; Hummel, T.
Journal Article
2016A machine-learned computational functional genomics-based approach to drug classification
Lötsch, J.; Ultsch, A.
Journal Article
2016Machine-learned pattern identification in olfactory subtest results
Lötsch, J.; Hummel, T.; Ultsch, A.
Journal Article
2016Methadone induces hypermethylation of human DNA
Knothe, C.; Doehring, A.; Ultsch, A.; Lötsch, J.
Journal Article
2016Pharmacoepigenetics of the role of DNA methylation in μ-opioid receptor expression in different human brain regions
Knothe, C.; Oertel, B.G.; Ultsch, A.; Kettner, M.; Schmidt, P.H.; Wunder, C.; Toennes, S.W.; Geisslinger, G.; Lötsch, J.
Journal Article
2016Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy
Lötsch, J.; Ultsch, A.
Journal Article
2016A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects
Lötsch, J.; Dimova, V.; Ultsch, A.; Lieb, I.; Zimmermann, M.; Geisslinger, G.; Oertel, B.G.
Journal Article
2016Smell of pain: Intersection of nociception and olfaction
Lötsch, J.; Hähner, A.; Gossrau, G.; Hummel, C.; Walter, C.; Ultsch, A.; Hummel, T.
Journal Article
2016A unifying data-driven model of human olfactory pathology representing known etiologies of dysfunction
Lötsch, J.; Ultsch, A.; Hummel, T.
Journal Article
2015A brain-lesion pattern based algorithm for the diagnosis of posttraumatic olfactory loss
Lötsch, J.; Reither, N.; Bogdanov, V.; Hähner, A.; Ultsch, A.; Hill, K.; Hummel, T.
Journal Article
2015Computational functional genomics based analysis of pain-relevant micro-RNAs
Lotsch, J.; Niederberger, E.; Ultsch, A.
Journal Article
2015Computed ABC analysis for rational selection of most informative variables in multivariate data
Ultsch, A.; Lotsch, J.
Journal Article
2015Drug-target based cross-sectional analysis of olfactory drug effects
Lötsch, J.; Daiker, H.; Hähner, A.; Ultsch, A.; Hummel, T.
Journal Article
2015Identification of molecular fingerprints in human heat pain thresholds by use of an interactive mixture model r toolbox (Adaptgauss)
Ultsch, A.; Thrun, M.C.; Hansen-Goos, O.; Lötsch, J.
Journal Article
2015A more pessimistic life orientation is associated with experimental inducibility of a neuropathy-like pain pattern in healthy individuals
Dimova, V.; Oertel, B.G.; Kabakci, G.; Zimmermann, M.; Hermens, H.; Lautenbacher, S.; Ultsch, A.; Lötsch, J.
Journal Article
2015Multimodal distribution of human cold pain thresholds
Lötsch, J.; Dimova, V.; Lieb, I.; Zimmermann, M.; Oertel, B.G.; Ultsch, A.
Journal Article
2015Olfactory drug effects approached from human-derived data
Lötsch, J.; Knothe, C.; Lippmann, C.; Ultsch, A.; Hummel, T.; Walter, C.
Journal Article
2015Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects
Lotsch, J.; Dimova, V.; Hermens, H.; Zimmermann, M.; Geisslinger, G.; Oertel, B.G.; Ultsch, A.
Journal Article
2014Effects of 20 mg oral Delta(9)-tetrahydrocannabinol on the olfactory function of healthy volunteers
Walter, C.; Oertel, B.G.; Ludyga, D.; Ultsch, A.; Hummel, T.; Lötsch, J.
Journal Article
2014Exploiting the structures of the U-matrix
Lötsch, J.; Ultsch, A.
Conference Paper
2014Functional abstraction as a method to discover knowledge in gene ontologies
Ultsch, A.; Lötsch, J.
Journal Article
2014Functional genomics suggest neurogenesis in the adult human olfactory bulb
Lötsch, J.; Schaeffeler, E.; Mittelbronn, M.; Winter, S.; Gudziol, V.; Schwarzacher, S.W.; Hummel, T.; Doehring, A.; Schwab, M.; Ultsch, A.
Journal Article
2014Human models of pain for the prediction of clinical analgesia
Lötsch, J.; Oertel, B.G.; Ultsch, A.
Journal Article
2014Non-Invasive Method for Prediction of Opioid-Analgesia and Opioid-Blood-Concentrations
Lötsch, Jörn; Ultsch, Alfred; Oertel, Bruno; Geisslinger, Gerd
Patent
2014R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice
Schmitz, K.; Bruin, N. de; Bishay, P.; Männich, J.; Häussler, A.; Altmann, C.; Ferreirós, N.; Lötsch, J.; Ultsch, A.; Parnham, M.J.; Geisslinger, G.; Tegeder, I.
Journal Article
2014What do all the (human) micro-RNAs do?
Ultsch, A.; Lotsch, J.
Journal Article
2013Functional genomics of pain in analgesic drug development and therapy
Lötsch, J.; Doehring, A.; Mogil, J.S.; Arndt, T.; Geisslinger, G.; Ultsch, A.
Journal Article
2013A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain
Lötsch, J.; Ultsch, A.
Journal Article
2013Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia
Lötsch, J.; Skarke, C.; Darimont, J.; Zimmermann, M.; Bräutigam, L.; Geisslinger, G.; Ultsch, A.; Oertel, B.G.
Journal Article