Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Current status and perspectives of the molecular farming landscape
Spiegel, H.; Stöger, E.; Twyman, R.M.; Buyel, J.F.
Book Article
2018The FT/FD-dependent initiation of flowering under long-day conditions in the day-neutral species Nicotiana tabacum originates from the facultative short-day ancestor Nicotiana tomentosiformis
Beinecke, F.A.; Grundmann, L.; Wiedmann, D.R.; Schmidt, F.J.; Caesar, A.S.; Zimmermann, M.; Lahme, M.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2017Antibodies from plants for bionanomaterials
Edgue, G.; Twyman, R.M.; Beiss, V.; Fischer, R.; Sack, M.
Journal Article
2017Characteristics of Genome Editing Mutations in Cereal Crops
Zhu, C.; Bortesi, L.; Baysal, C.; Twyman, R.M.; Fischer, R.; Capell, T.; Schillberg, S.; Christou, P.
Journal Article
2017Contained molecular farming using plant cell and tissue cultures
Schillberg, S.; Raven, Nicole; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Book Article
2017Very-large-scale production of antibodies in plants: The biologization of manufacturing
Buyel, J.F.; Twyman, R.M.; Fischer, R.
Journal Article
2016Patterns of CRISPR/Cas9 activity in plants, animals and microbes
Bortesi, L.; Zhu, C.; Zischewski, J.; Perez, L.; Bassié, L.; Nadi, R.; Forni, G.; Lade, S.B.; Soto, E.; Jin, X.; Medina, V.; Villorbina, G.; Munoz, P.; Farré, G.; Fischer, R.; Twyman, R.M.; Capell, T.; Christou, P.; Schillberg, S.
Journal Article
2016A Plant-Based Transient Expression System for the Rapid Production of Malaria Vaccine Candidates
Boes, A.; Reimann, A.; Twyman, R.M.; Fischer, R.; Schillberg, S.; Spiegel, H.
Book Article
2015The characteristics and potential applications of structural lipid droplet proteins in plants
Laibach, N.; Post, J.; Twyman, R.M.; Schulze Gronover, C.; Prüfer, D.
Journal Article
2015Extraction and downstream processing of plant-derived recombinant proteins
Buyel, J.F.; Twyman, R.M.; Fischer, R.
Journal Article
2015High-value products from plants: the challenges of process optimization
Fischer, R.; Vasilev, N.; Twyman, R.M.; Schillberg, S.
Journal Article
2015Identification of a Taraxacum brevicorniculatum rubber elongation factor protein that is localized on rubber particles and promotes rubber biosynthesis
Laibach, N.; Hillebrand, A.; Twyman, R.M.; Prüfer, D.; Schulze Gronover, C.
Journal Article
2015Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria
Rahnamaeian, M.; Cytrynska, M.; Zdybicka-Barabas, A.; Dobslaff, K.; Wiesner, J.; Twyman, R.M.; Zuchner, T.; Sadd, B.; Regoes, R.R.; Schmid-Hempel, P.; Vilcinskas, A.
Journal Article
2015Insects as models to study the epigenetic basis of disease
Mukherjee, K.; Twyman, R.M.; Vilcinskas, A.
Journal Article
2015Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants
Ma, J.K.-C.; Drossard, J.; Lewis, D.; Altmann, F.; Boyle, J.; Christou, P.; Cole, T.; Dale, P.; van Dolleweerd, C.J.; Isitt, V.; Katinger, D.; Lobedan, M.; Mertens, H.; Paul, M.J.; Rademacher, T.; Sack, M.; Hundleby, P.A.C.; Stiegler, G.; Stoger, E.; Twyman, R.M.; Vcelar, B.; Fischer, R.
Journal Article
2015A rubber transferase activator is necessary for natural rubber biosynthesis in dandelion
Epping, J.; Deenen, N. van; Niephaus, E.; Stolze, A.; Fricke, J.; Huber, C.; Eisenreich, W.; Twyman, R.M.; Prüfer, D.; Gronover, C.S.
Journal Article
2014Characterization of five subgroups of the sieve element occlusion gene family in Glycine max reveals genes encoding non-forisome P-proteins, forisomes and forisome tails
Zielonka, S.; Ernst, A.M.; Hawat, S.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2014Comparative evaluation of heterologous production systems for recombinant pulmonary surfactant protein D
Salgado, D.; Fischer, R.; Schillberg, S.; Twyman, R.M.; Rasche, S.
Journal Article
2014Establishment of an ex vivo laticifer cell suspension culture from Taraxacum brevicorniculatum as a production system for cis-isoprene
Post, J.; Eisenreich, W.; Huber, C.; Twyman, R.M.; Prüfer, D.; Schulze Gronover, C.
Journal Article
2014Molecular and ultrastructural analysis of forisome subunits reveals the principles of forisome assembly
Müller, B.; Groscurth, S.; Menzel, M.; Rüping, B.A.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2014Molecular Farming in Plants. The Long Road to the Market
Fischer, R.; Buyel, J.F.; Schillberg, S.; Twyman, R.M.
Book Article
2014Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody
Häkkinen, S.T.; Raven, N.; Henquet, M.; Laukkanen, M.-L.; Anderlei, T.; Pitkänen, J.-P.; Twyman, R.M.; Bosch, D.; Oksman-Caldentey, K.-M.; Schillberg, S.; Ritala, A.
Journal Article
2014Uncertain role of MtSEO-F3 in assembly of Medicago truncatula forisomes
Groscurth, S.; Müller, B.; Visser, F.; Blob, B.; Menzel, M.; Rüping, B.A.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2013Cellulases from insects
Fischer, R.; Ostafe, R.; Twyman, R.M.
Book Article
2013Commercial aspects of pharmaceutical protein production in plants
Fischer, R.; Schillberg, S.; Buyel, J.F.; Twyman, R.M.
Journal Article
2013Molecular farming of pharmaceutical proteins using plant suspension cell and tissue cultures
Schillberg, S.; Raven, N.; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Journal Article
2013Optimizing the yield of recombinant pharmaceutical proteins in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Journal Article
2013P-proteins in Arabidopsis are heteromeric structures involved in rapid sieve tube sealing
Jekat, S.B.; Ernst, A.M.; Bohl, A. von; Zielonka, S.; Twyman, R.M.; Noll, G.A.; Prüfer, D.
Journal Article
2012Artificial forisomes are Ideal models of forisome assembly and activity that allow the development of technical devices
Groscurth, S.; Müller, B.; Schwan, S.; Menzel, M.; Diekstall, F.; Senft, M.; Kendall, A.; Kommor, B.A.; Neumann, U.; Kalischuk, M.; Kawchuk, L.M.; Krzyzanek, V.; Heilmann, A.; Stubbs, G.; Twyman, R.M.; Prüfer, D.; Noll, G.A.
Journal Article
2012Corrigendum to "Antibody-mediated resistance against plant pathogens" [Biotechnol Adv 29 (6) (2011) 961-971] (DOI:10.1016/j.biotechadv.2011.08.011)
Safarnejad, M.R.; Jouzani, G.S.; Tabatabaei, M.; Twyman, R.M.; Schillberg, S.
Journal Article
2012GMP issues for recombinant plant-derived pharmaceutical proteins
Fischer, R.; Schillberg, S.; Hellwig, S.; Twyman, R.M.; Drossard, J.
Journal Article
2012Laticifer-specific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum
Post, J.; Deenen, N. van; Fricke, J.; Kowalski, N.; Wurbs, D.; Schaller, H.; Eisenreich, W.; Huber, C.; Twyman, R.M.; Prüfer, D.; Gronover, C.S.
Journal Article
2012Multiple cis-regulatory elements are involved in the complex regulation of the sieve element-specific MtSEO-F1 promoter from Medicago truncatula
Bucsenez, M.; Rüping, B.; Behrens, S.; Twyman, R.M.; Noll, G.A.; Prüfer, D.
Journal Article
2012Sieve element occlusion (SEO) genes encode structural phloem proteins involved in wound sealing of the phloem
Ernst, A.M.; Jekat, S.B.; Zielonka, S.; Müller, B.; Neumann, U.; Rüping, B.; Twyman, R.M.; Krzyzanek, V.; Prüfer, D.; Noll, G.A.
Journal Article
2011Antibody-mediated resistance against plant pathogens
Safarnejad, M.R.; Jouzani, G.S.; Tabatabaie, M.; Twyman, R.M.; Schillberg, Stefan
Journal Article
2011Characteristics of artificial forisomes from plants and yeast
Noll, G.A.; Müller, B.; Ernst, A.M.; Rüping, B.; Groscurth, S.; Twyman, R.M.; Kawchuk, L.M.; Prüfer, D.
Journal Article
2011Native and artificial forisomes: Functions and applications
Noll, G.A.; Müller, B.; Ernst, A.M.; Rüping, B.; Twyman, R.M.; Prüfer, D.
Journal Article
2010Recombinant artificial forisomes provide ample quantities of smart biomaterials for use in technical devices
Müller, B.; Noll, G.A.; Ernst, A.M.; Rüping, B.; Groscurth, S.; Twyman, R.M.; Kawchuk, L.M.; Prüfer, D.
Journal Article
2009Molecular farming of antibodies in plants
Fischer, R.; Schillberg, S.; Twyman, R.M.
Book Article
2009Polyphenoloxidase silencing affects latex coagulation in taraxacum species
Wahler, D.; Schulze Gronover, C.; Richter, C.; Foucu, F.; Twyman, R.M.; Moerschbacher, B.M.; Fischer, R.; Muth, J.; Prüfer, D.
Journal Article
2009The promoters of forisome genes MtSEO2 and MtSEO3 direct gene expression to immature sieve elements in Medicago truncatula and Nicotiana tabacum
Noll, G.A.; Rüping, B.; Ernst, A.M.; Bucsenez, M.; Twyman, R.M.; Fischer, R.; Prüfer, D.
Journal Article
2008Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants
Spök, A.; Twyman, R.M.; Fischer, R.; Ma, J.K.-C.; Sparrow, P.A.C.
Journal Article
2008Plantibody-mediated inhibition of the potato leafroll virus P1 protein reduces virus accumulation
Nickel, H.; Kawchuk, L.; Twyman, R.M.; Zimmermann, S.; Junghans, H.; Winter, S.; Fischer, R.; Prüfer, D.
Journal Article
2008Precision breeding for novel starch variants in potato
Muth, J.; Hartje, S.; Twyman, R.M.; Hofferbert, H.R.; Tacke, E.; Prüfer, D.
Journal Article
2007Facing the future with pharmaceuticals from plants
Fischer, R.; Twyman, R.M.; Hellwig, S.; Drossard, J.; Schillberg, S.
Conference Paper
2007Molecular farming of antibodies in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Book Article
2007Pharma-planta: Recombinant pharmaceuticals from plants for human health
Schillberg, S.; Twyman, R.M.
Book Article
2007Production of therapeutic antibodies in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Book Article
2006The potential of plant virus vectors for vaccine production
Yusibov, V.; Rabindran, S.; Commandeur, U.; Twyman, R.M.; Fischer, R.
Journal Article
2005Biopharmaceutical production in cultured cells
Schillberg, S.; Twyman, R.M.; Fischer, R.
Book Article
2005Molecular farming for new drugs and vaccines
Ma, J.K.-C.; Barros, E.; Bock, R.; Christou, P.; Dale, P.J.; Dix, P.J.; Fischer, R.; Irwin, J.; Mahoney, R.; Pezzotti, M.; Schillberg, S.; Sparrow, P.; Stoger, E.; Twyman, R.M.
Journal Article
2005Opportunities for recombinant antigen and antibody expression in transgenic plants - technology assessment
Schillberg, S.; Twyman, R.M.; Fischer, R.
Journal Article
2005Plant cells
Fischer, R.; Twyman, R.M.; Drossard, J.; Hellwig, S.; Schillberg, S.
Book Article
2005Plant-derived pharmaceuticals - the road forward
Ma, J.K.-C.; Chikwamba, R.; Sparrow, P.; Fischer, R.; Mahoney, R.; Twyman, R.M.
Journal Article
2005Transgenic plants in the biopharmaceutical market
Twyman, R.M.; Schillberg, S.; Fischer, R.
Journal Article
2004Antibody production in transgenic plants
Stoger, E.; Schillberg, S.; Twyman, R.M.; Fischer, R.; Christou, P.
Book Article
2004Chip-based biosensor technology for the detection of pathogens
Fischer, R.; Ribbert, M.; Finnern, R.; Twyman, R.M.
Conference Paper
2004Crop plants for molecular farming
Stoger, E.; Marcel, S.; Twyman, R.M.
Book Article
2004Dedifferentiation-mediated changes in transposition behavior make the Activator transposon an ideal tool for functional genomics in rice
Kohli, A.; Prynne, M.Q.; Miro, B.; Pereira, A.; Twyman, R.M.; Capell, T.; Christou, P.
Journal Article
2004Emerging production systems for antibodies in plants
Schillberg, S.; Twyman, R.M.
Book Article
2004Engineering and production of recombinant antibodies in plants
Fischer, R.; Commandeur, U.; Schillberg, S.; Twyman, R.M.
Conference Paper
2004Improvement of grapevine using current biotechnology
Fischer, R.; Nölke, G.; Orecchia, M.; Schillberg, S.; Twyman, R.M.
Conference Paper
2004Molecular farming in plants: Technology platforms
Fischer, R.; Emans, N.; Twyman, R.M.; Schillberg, S.
Book Article
2004Plant cell cultures for the production of recombinant proteins
Hellwig, S.; Drossard, J.; Twyman, R.M.; Fischer, R.
Journal Article
2004Plant transformation technology: Particle bombardment
Twyman, R.M.; Christou, P.
Book Article
2004Plant-based production of biopharmaceuticals
Fischer, R.; Stoger, E.; Schillberg, S.; Christou, P.; Twyman, R.M.
Journal Article
2004The potential of genetically enhanced plants to address food insecurity
Christou, P.; Twyman, R.M.
Journal Article
2003The biosafety of molecular farming in plants
Commandeur, U.; Twyman, R.M.; Fischer, R.
Journal Article
2003Cell factories
Twyman, R.M.; Stöger, E.; Christou, P.
Book Article
2003Genetic engineering of secondary metabolism - alcaloids
Twyman, R.M.; Verpoorte, R.; Memelink, J.; Christou, P.
Book Article
2003Molecular farming
Twyman, R.M.; Stöger, E.; Christou, P.
Book Article
2003Molecular farming in plants: Host systems and expression technology
Twyman, R.M.; Stoger, E.; Schillberg, S.; Christou, P.; Fischer, R.
Journal Article
2003Molecular farming of industrial proteins in plants
Fischer, R.; Emans, N.; Twyman, R.M.; Schillberg, S.
Book Article
2003Production of antibodies in plants and their use for global health
Fischer, R.; Twyman, R.M.; Schillberg, S.
Journal Article
2003Transgene integration, organization and interaction in plants
Kohli, A.; Twyman, R.M.; Abranches, R.; Wegel, E.; Stoger, E.; Christou, P.
Journal Article
2002Practical considerations for pharmaceutical antibody production in different crop systems
Stoger, E.; Sack, M.; Perrin, Y.; Vaquero, C.; Torres, E.; Twyman, R.M.; Christou, P.; Fischer, R.
Journal Article
2001Native and artificial reticuloplasmins co-accumulate in distinct domains of the endoplasmic reticulum and in post-endoplasmic reticulum compartments
Torres, E.; Gonzalez-Melendi, P.; Stöger, E.; Shaw, P.; Twyman, R.M.; Nicholson, L.; Vaquero, C.; Fischer, R.; Christou, P.; Perrin, Y.
Journal Article