Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Elimination of HER3-expressing breast cancer cells using aptamer-siRNA chimeras
Nachreiner, I.; Hussain, A.F.; Wullner, U.; Machuy, N.; Meyer, T.F.; Fischer, R.; Gattenlöhner, S.; Meinhold-Heerlein, I.; Barth, S.; Tur, M.K.
Journal Article
2019Molecular Targeting Therapy against EGFR Family in Breast Cancer. Progress and Future Potentials
Maennling, A.E.; Tur, M.K.; Niebert, M.; Klockenbring, Torsten; Zeppernick, F.; Gattenlöhner, S.; Meinhold-Heerlein, I.; Hussain, A.F.
Journal Article
2017Novel PSCA targeting scFv-fusion proteins for diagnosis and immunotherapy of prostate cancer
Kessler, C.; Pardo, A.; Tur, M.K.; Gattenlöhner, S.; Fischer, R.; Kolberg, K.; Barth, S.
Journal Article
2015Phage display-based generation of novel internalizing antibody fragments for immunotoxin-based treatment of acute myeloid leukemia
Fitting, J.; Blume, T.; ten Haaf, A.; Blau, W.; Gattenlöhner, S.; Tur, M.K.; Barth, S.
Journal Article
2015Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein
Brehm, H.; Hristodorov, D.; Pardo, A.; Mladenov, R.; Niesen, J.; Fischer, R.; Tur, M.K.; Barth, S.
Journal Article
2014CD30 as a therapeutic target for lymphoma
Schirrmann, T.; Steinwand, M.; Wezler, X.; Haaf, A. ten; Tur, M.K.; Barth, S.
Journal Article
2014In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells
Niesen, J.; Brehm, H.; Stein, C.; Berges, N.; Pardo, A.; Fischer, R.; Haaf, A. ten; Gattenlöhner, S.; Tur, M.K.; Barth, S.
Journal Article
2013An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in cancers expressing av beta 3 integrin
Hussain, A.F.; Tur, M.K.; Barth, S.
Journal Article
2013Immunokinases
Barth, S.; Gattenlöhner, S.; Tur, M.K.
Book Article
2012Short-chain fluorescent tryptophan tags for on-line detection of functional recombinant proteins
Siepert, E.M.; Gartz, E.; Tur, M.K.; Delbruck, H.; Barth, S.; Buchs, J.
Journal Article
2011Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology
Fitting, J.; Killian, D.; Junghanss, C.; Willenbrock, S.; Murua Escobar, H.; Lange, S.; Nolte, I.; Barth, S.; Tur, M.K.
Journal Article
2011In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA in a human acute myeloid leukemia xenograft tumor model
Tur, M.K.; Huhn, M.; Jost, E.; Thepen, T.; Brümmendorf, T.H.; Barth, S.
Journal Article
2011Reconstitution of pro-apoptotic death-associated protein kinases (DAPK) to re-establish apoptotic sensitivity in CLL
Lilienthal, N.; Boucas, J.; Weit, N.; Popal, W.; Breuer, A.; Mayer, P.; Tur, M.K.; Barth, S.; Hallek, M.; Herling, M.
Abstract
2011SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells
Hussain, A.F.; Kampmeier, F.; Felbert, V. von; Merk, H.F.; Tur, M.K.; Barth, S.
Journal Article
2010Disease-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing Eukaryotic Elongation Factor 2
Tur, M.K.; Hussain, F.A.; Barth, S.
Abstract
2010Generation of internalizing scFv antibodies from human phage display libraries for targeted Leukemia therapy
Fitting, J.; Barth, S.; Tur, M.K.
Abstract
2010Generation of scFv antibodies against pancreatic carcinoma using a naive human phage display library
Siepert, E.M.; Rösgen, C.; Tur, M.K.; Barth, S.
Abstract
2010Novel molecular therapeutic strategies based on the targeted restoration of a defective, tumor-suppressing function by using an immunokinase fusion protein
Tur, M.K.; Barth, S.
Abstract
2010Recombinant, ETA'-based CD64 immunotoxins: Improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice
Ribbert, T.; Thepen, T.; Tur, M.K.; Fischer, R.; Huhn, M.; Barth, S.
Journal Article
2009Fc gamma receptor 1 (CD64), a target beyond cancer
Thepen, T.; Huhn, M.; Melmer, G.; Tur, M.K.; Barth, S.
Journal Article
2009Immunokinases, a novel class of immunotherapeutics for targeted cancer therapy
Tur, M.K.; Neef, I.; Jager, G.; Teubner, A.; Stocker, M.; Melmer, G.; Barth, S.
Journal Article
2009Improved immunotoxins with novel functional elements
Hetzel, C.; Bachran, C.; Tur, M.K.; Fuchs, H.; Stocker, M.
Journal Article
2009Targeted delivery of short interfering RNAs - strategies for in vivo delivery
Wullner, U.; Neef, I.; Tur, M.K.; Barth, S.
Journal Article
2009Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in hodgkin lymphoma cells
Tur, M.K.; Neef, I.; Jost, E.; Galm, O.; Jäger, G.; Stöcker, M.; Ribbert, M.; Osieka, R.; Klinge, U.; Barth, S.
Journal Article
2008Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2
Wullner, U.; Neef, I.; Eller, A.; Kleines, M.; Tur, M.K.; Barth, S.
Journal Article
2008Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes
Stahnke, B.; Thepen, T.; Stöcker, M.; Rosinke, R.; Jost, E.; Fischer, R.; Tur, M.K.; Barth, S.
Journal Article
2005Recombinant soluble human Fc(gamma) receptor I with picomolar affinity for immunoglobulin G
Paetz, A.; Sack, M.; Thepen, T.; Tur, M.K.; Brüll, D.; Finnern, R.; Fischer, R.; Barth, S.
Journal Article
2004Construction of phage display libraries from reactive lymph nodes of breast carcinoma patients and selection for specifically binding human single chain Fv on cell lines
Rothe, A.; Klimka, A.; Tur, M.K.; Pfitzner, T.; Huhn, M.; Sasse, S.; Mallmann, P.; Engert, A.; Barth, S.
Journal Article
2004m22(scFv)-ETA', a new recombinant anti-CD64 immunotoxin for specific elimination of AML cells
Tur, M.K.; Huhn, M.; Thepen, T.; Stöcker, M.; Krohn, R.; Vogel, S.; Jost, E.; Osieka, R.; Winkel, J.G. van de; Fischer, R.; Barth, S.
Journal Article
2004Measurement of antibody-membrane interactions by surface plasmon resonance
Klimka, A.; Tur, M.K.; Huhn, M.; Bierfreund, U.; Terrada, E.; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2004Metalloproteinase inhibition augments anti-tumor efficacy of the anti-CD30 immunotoxin Ki-3(scFv)-ETA' against human lymphomas in vivo
Matthey, B.; Borchmann, P.; Schnell, R.; Tawadros, S.; Lange, H.; Tur, M.K.; Huhn, M.; Klimka, A.; Barth, S.; Engert, A.; Hansen, H.P.
Journal Article
2003A novel approach for immunization, screening and characterization of selected scFv libraries using membrane fractions of tumor cells
Tur, M.K.; Rothe, A.; Huhn, M.; Goerres, U.; Klimka, A.; Stocker, M.; Engert, A.; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2003Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells
Tur, M.K.; Huhn, M.; Thepen, T.; Stocker, M.; Krohn, R.; Vogel, S.; Jost, E.; Osieka, R.; Winkel, J.G. van de; Fischer, R.; Finnern, R.; Barth, S.
Journal Article
2003Secretion of functional anti-CD30 angiogenin immunotoxins into the supernatant of transfected 293T cells
Stöcker, M.; Tur, M.K.; Sasse, S.; Krüßmann, A.; Barth, S.; Engert, A.
Journal Article
2002Detection of disease-related surface antigens by combining phage display and cDNA expression library screening
Weidenmüller, U.; Tur, M.K.; Engert, A.; Barth, S.
Book Article
2001An anti-GD2 single chain Fv selected by phage display and fused to Pseudomonas exotoxin A develops specific cytotoxic activity against neuroblastoma derived cell lines
Tur, M.K.; Sasse, S.; Stöcker, M.; Djabelkhir, K.; Huhn, M.; Matthey, B.; Gottstein, C.; Engert, A.; Barth, S.
Journal Article
2001Human angiogenin fused to human CD30 ligand (Ang-CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma
Huhn, M.; Sasse, S.; Tur, M.K.; Matthey, B.; Schinköthe, T.; Rybak, S.; Barth, S.; Engert, A.
Journal Article
2001Selection of scFv phages on intact cells under low pH conditions leads to a significant loss of insert-free phages
Tur, M.K.; Huhn, M.; Sasse, S.; Engert, A.; Barth, S.
Journal Article
2000Combining phage display and screening of cDNA expression libraries. A new approach for identifying the target antigen of an scFv preselected by phage display
Barth, S.; Weidenmüller, U.; Tur, M.K.; Schmidt, M.F.G.; Engert, A.
Journal Article