Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2014Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model
Winkler, C.; Bahlmann, O.; Viereck, J.; Knudsen, L.; Wedekind, D.; Hoymann, H.G.; Madsen, J.; Thum, T.; Hohlfeld, J.M.; Ochs, M.
Journal Article
2010Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease
Thum, T.; Batkai, S.; Malinski, P.G.; Becker, T.; Mevius, I.; Klempnauer, J.; Meyer, H.H.; Frölich, J.C.; Borlak, J.; Tsikas, D.
Journal Article
2008Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes
Thum, T.; Borlak, J.
Journal Article
2008Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper
Beineke, A; Markus, S.; Borlak, J.; Thum, T.; Baumgärtner, W.
Journal Article
2008Lox-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor OCT-1 in human coronary arterial endothelium
Thum, T.; Borlak, J.
Journal Article
2007Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone mediated increase of insulin-like growth factor-1
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Galuppo, P.; Jakob, M.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Journal Article
2007Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
Thum, T.; Hoeber, S.; Klink, I.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2007Enhanced systemic no bioavailability by growth-hormone mediated IGF-1 increase improves number and function of endothelial progenitor cells in aged individuals
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Galuppo, P.; Jakob, M.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Ertl, G.; Bauersachs, J.
Abstract
2007MicroRNAs in the human heart
Thum, T.; Galuppo, P.; Wolf, C.; Fiedler, J.; Kneitz, S.; Laake, L.W. van; Doevendans, P.A.; Mummery, C.L.; Borlak, J.; Haverich, A.; Gross, C.; Engelhardt, S.; Ertl, G.; Bauersachs, J.
Journal Article
2006Acetylsalicylic acid (aspirin) reduces endothelial cell senescence
Scalera, F.; Borlak, J.; Schubert, B.; Martens-Lobenhoffer, J.; Thum, T.; Frolich, J.C.; Bode-Boger, S.M.
Abstract
2006Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone-mediated increase of insulin-like growth factor-1
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2006Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone-mediated increase of insulin-like growth factor-1
Thum, T.; Hoeber, S.; Froese, S.; Klink, I.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2006The age-related disturbance of endothelial progenitor cells is corrected through growth hormone medicated increase of the insulin like growth factor-1.
Thum, T.; Hoeber, S.; Froese, S.; Ivonne, K.; Stichtenoth, D.O.; Tsikas, D.; Anker, S.D.; Poole-Wilson, P.A.; Borlak, J.; Ertl, G.; Bauersachs, J.
Abstract
2006Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
Thum, T.; Erpenbeck, V.J.; Moeller, J.; Hohlfeld, J.M.; Krug, N.; Borlak, J.
Journal Article
2006Statins delay endothelial cell senescence
Scalera, F.; Borlak, J.; Schubert, B.; Martens-Lobenhoffer, J.; Thum, T.; Frölich, J.C.; Bode-Boger, S.M.
Abstract
2005Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB
Gerhard, R.; Tatge, H.; Genth, H.; Thum, T.; Borlak, J.; Fritz, G.; Just, I.
Journal Article
2005PCR-Reaktionsgemisch fuer Fluoreszenz-basierende Genexpressions- und Genmutationsanalysen
Borlak, J.; Thum, T.
Patent
2005Toxicogenomics applied to cardiovascular toxicity
Thum, T.; Borlak, J.
Book Article
2004Androgen metabolism in thymus of fetal and adult rats
Borlak, J.; Schulte, I.; Thum, T.
Journal Article
2004Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence
Scalera, F.; Borlak, J.; Beckmann, B.; Martens-Lobenhoffer, J.; Thum, T.; Tager, M.; Bode-Böger, S.M.
Journal Article
2004Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury
Thum, T.; Borlak, J.
Journal Article
2004Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
Thum, T.; Borlak, J.
Journal Article
2003Aspirin reduces endothelial-cell senescence
Scalera, F.; Thum, T.; Borlak, J.; Schubert, B.; Frolich, J.C.; Bode-Boger, S.M.
Conference Paper
2003Gene expression profiles in the closing ductus and the great vessels
Bökenkamp, R.; Thum, T.; Borlak, J.
Journal Article
2003Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line
Thum, T.; Tsikas, D.; Frölich, J.F.; Borlak, J.
Journal Article
2003Hallmarks of ion channel gene expression in end-stage heart failure
Borlak, J.; Thum, T.
Journal Article
2003Metabolism of verapamil
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Journal Article
2003Oct-1 protein/DNA interaction - implications for cytochrome- P450 monooxygenase gene-expression
Thum, T.; Borlak, J.
Journal Article
2003OCT-1: A key player in vascular biology - Implications for cardiovascular toxicity
Thum, T.; Borlak, J.
Journal Article
2003Oxidized LDL represses cytochrome-P450 monooxygenase catalyzed EDHF production in human coronary arterial endothelium through diminished NF-1 availability
Thum, T.; Borlak, J.
Journal Article
2003A rapid and simple CYP2D6 genotyping assay - Case study with the analgetic tramadol
Borlak, J.; Hermann, R.; Erb, K.; Thum, T.
Journal Article
2003Verapamil: Identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS[n] and LC-NMR
Borlak, J.; Walles, M.; Elend, M.; Thum, T.; Preiss, A.; Levsen, K.
Journal Article
2003Verapamil: Metabolism in cultures of primary human coronary arterial endothelial cells
Borlak, J.; Walles, M.; Levsen, K.; Thum, T.
Journal Article
2002Altered cytochrome P450 monooxygenase activity in heart tissue of spontaneously hypertensive rats
Thum, T.; Borlak, J.
Conference Paper, Journal Article
2002Aroclor 1254 modulates gene expression of nuclear transcription factors
Borlak, J.; Dangers, M.; Thum, T.
Journal Article
2002Derailed steroid metabolism in cardiac hypertrophy
Borlak, J.; Thum, T.
Journal Article
2002The effects of PCB's on the gene expression of transcription factors and other heart specific genes in cultures of primary cardiomyocytes
Thum, T.; Borlak, J.
Journal Article
2002Genotyping of major NAT2 single nucleotide polymorphisms in a German population using fluorescence resonance energy transfer (FRET) analysis
Borlak, J.; Thum, T.
Journal Article
2002Identification of major CYP2C9 and CP2C19 polymorphisms by fluorescence resonance energy transfer analysis
Borlak, J.; Thum, T.
Journal Article
2002Identification of major CYP2C9 polymorphisms using fluorescence resonance energy transfer (FRET) analysis
Thum, T.; Borlak, J.
Journal Article
2002Is there a universal housekeeping gene?
Lindemann, M.; Thum, T.; Borlak, J.
Journal Article
2002A new method for identification of major CYP2C19 polymorphisms
Borlak, J.; Thum, T.
Journal Article
2002Novel phase I and phase II metabolites of Verapamil identified in cell cultures of rat hepatocytes by LC-MS(n)
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Conference Paper, Journal Article
2002Oxidized LDL modulates cytochrome P450 monooxygease gene expression and protein function in human arterial coronary endothelial cells
Thum, T.; Borlak, J.
Conference Paper, Journal Article
2002oxLDL inhibits eNOS and cytochrome P450 monooxygenases in human arterial coronary endothelial cells
Thum, T.; Borlak, J.
Journal Article
2002PCBs alter gene expression of nuclear transcription factors and other heart-specific genes in cultures of primary cardiomyocytes
Borlak, J.; Thum, T.
Journal Article
2002Testosterone, cytochrome P450, and cardiac hypertrophy
Thum, T.; Borlak, J.
Journal Article
2002Verapamil. New insight into the molecular mechanism of drug oxidation in the human heart
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Journal Article
2002Verapamil: Identification of novel metabolites in the human heart
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Conference Paper, Journal Article
2001Butanedione monoxime increases the viability and yield of adult cardiomyocytes in primary cultures
Thum, T.; Borlak, J.
Journal Article
2001Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors
Thum, T.
Dissertation
2001Cytochrome P450 enzyme activity and mRNA expression in primary rat alveolar epithelial type II cells
Borlak, J.; Vata, I.; Thum, T.; Hansen, T.
Journal Article
2001Drug oxidation in the human heart
Thum, T.; Borlak, J.
Journal Article
2001Gene expression and testosterone metabolism in distinct regions of the rat heart
Thum, T.; Borlak, J.
Journal Article
2001Die Hochregulierung S-Adenosyl-L-Methionin-abhängiger Methyltransferasen führt zu einer gesteigerten Bildung von ADMA unter hypercholesterinämischen Bedingungen
Sydow, K.; Bode-Böger, S.M.; Thum, T.; Borlak, J.; Münzel, T.; Böger, R.H.
Conference Paper, Journal Article
2001Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures
Borlak, J.; Thum, T.
Journal Article
2001Reprogramming of gene expression in cultures cardiomyocytes by the myosin ATPase inhibitor butanedione monoxime
Thum, T.; Borlak, J.
Journal Article
2001Tramadol disposition in CYP2D6 genotyped human subjects. Genetic variations in susceptibility to xenobiotics
Borlak, J.; Thum, T.
Journal Article
2001Transcriptional activation of liver enriched transcription factors and the albumin gene in rat hepatocytes by Aroclor 1254
Borlak, J.; Thum, T.
Journal Article
2001Verapamil metabolism in distinct regions of the heart and in cultures of cardiomyocytes of adult rats
Walles, M.; Thum, T.; Levsen, K.; Borlak, J.
Journal Article
2001Verapamil metabolism in primary cultures of cardiomyocytes of adult rats and in distinct regions of explanted hearts
Thum, T.; Borlak, J.
Journal Article
2001Verapamil metabolism in rat heart tissue
Thum, T.; Walles, M.; Levsen, K.; Borlak, J.
Conference Paper, Journal Article
2000Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: Implications for endothelial dysfunction and vascular biology
Thum, T.; Haverich, A.; Borlak, J.
Journal Article
2000Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: Implications for endothelial dysfunction and vascular biology
Thum, T.; Borlak, J.
Journal Article
2000Cytochrome P450 monooxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat
Thum, T.; Borlak, J.
Journal Article
2000Cytochrome P450 monooxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat
Thum, T.; Borlak, J.
Journal Article
2000Gene expression in distinct regions of the heart
Thum, T.; Borlak, J.
Journal Article
2000Gene expression in distinct regions of the human heart - implications for drug treatment of cardiovascular disease
Thum, T.; Borlak, J.
Journal Article
2000Increased formation of ADMA, an endogenous NOS inhibitor, in hyperchloresterolemia
Sydow, K.; Bode-Boger, S.M.; Thum, T.; Borlak, J.; Boger, R.H.
Book Article
2000Increased formation of ADMA, an endogenous nos inhibitor, in hypercholesterolemia - up-regulation of s-adenosylmethionine-dependent methyltransferases
Sydow, K.; Bodeboger, S.M.; Thum, T.; Borlak, J.; Boger, R.H.
Journal Article
2000Isolation and cultivation of calcium (Ca2+) tolerant cardiomyocytes from the adult rat. Improvements and applications
Thum, T.; Borlak, J.
Journal Article
2000LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
Böger, R.H.; Sydow, K.; Borlak, J.; Thum, T.; Lenzen, H.; Schubert, B.; Tsikas, D.; Bode-Böger, S.M.
Journal Article
2000Molecular diagnosis of a familial non heamolytic hyperbilirubinemia (Gilbert's Syndrome) in healthy subjects
Borlak, J.; Thum, T.; Landt, O.; Erb, K.; Hermann, R.
Journal Article
2000Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects
Borlak, J.; Thum, T.; Landt, O.; Erb, K.; Hermann, R.
Journal Article
2000The myosin ATPase inhibitor BDM modulates ANP gene expression and confers cytoprotection in cultures of adult cardiomyocytes
Thum, T.; Borlak, J.
Journal Article
2000Reprogramming of gene expression in cultured cardiomyocytes by the myosin ATPase inhibitor butanedione monoxime
Thum, T.; Borlak, J.
Journal Article