Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells
Kornstädt, L.; Pierre, S.; Weigert, A.; Ebersberger, S.; Schäufele, T.J.; Kolbinger, A.; Schmid, T.; Cohnen, J.; Thomas, D.; Ferreirós, N.; Brüne, B.; Ebersberger, I.; Scholich, K.
Journal Article
2021Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
Rappl, P.; Rösser, S.; Maul, P.; Bauer, R.; Huard, A.; Schreiber, Y.; Thomas, D.; Geisslinger, G.; Jakobsson, P.-J.; Weigert, A.; Brüne, B.; Schmid, T.
Journal Article
2021Prodromal sensory neuropathy in Pink1-/-SNCAA53T double mutant Parkinson mice
Valek, L.; Tran, B.; Wilken-Schmitz, A.; Trautmann, S.; Heidler, J.; Schmid, T.; Brüne, B.; Thomas, D.; Deller, T.; Geisslinger, G.; Auburger, G.; Tegeder, I.
Journal Article
2021Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
Schmitz, K.; Trautmann, S.; Hahnefeld, L.; Fischer, C.; Schreiber, Y.; Wilken-Schmitz, A.; Gurke, R.; Brunkhorst, R.; Werner, E.R.; Watschinger, K.; Wicker, S.; Thomas, D.; Geisslinger, G.; Tegeder, I.
Journal Article
2020Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis
Queck, A.; Fink, A.F.; Sirait-Fischer, E.; Rüschenbaum, S.; Thomas, D.; Snodgrass, R.G.; Geisslinger, G.; Baba, H.A.; Trebicka, J.; Zeuzem, S.; Weigert, A.; Lange, C.M.; Brüne, B.
Journal Article
2020An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
Jiménez, M. de los Reyes; Lechner, A.; Alessandrini, F.; Bohnacker, S.; Schindela, S.; Trompette, A.; Haimerl, P.; Thomas, D.; Henkel, F.; Mourão, A.; Geerlof, A.; Costa, C.P. da; Chaker, A.M.; Brüne, B.; Nüsing, R.; Jakobsson, P.-J.; Nockher, W.A.; Feige, M.J.; Haslbeck, M.; Ohnmacht, C.; Marsland, B.J.; Voehringer, D.; Harris, N.L.; Schmidt-Weber, C.B.; Esser-von Bieren, J.
Journal Article
2020Ceramide synthase 5 deficiency aggravates dextran sodium sulfate-induced colitis and colon carcinogenesis and impairs T-cell activation
El-Hindi, K.; Brachtendorf, S.; Hartel, J.C.; Oertel, S.; Birod, K.; Trautmann, S.; Thomas, D.; Ulshöfer, T.; Weigert, A.; Utermöhlen, O.; Krönke, M.; Grösch, S.
Journal Article
2020The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells
Pflüger-Müller, B.; Oo, J.A.; Heering, J.; Warwick, T.; Proschak, E.; Günther, S.; Looso, M.; Rezende, F.; Fork, C.; Geisslinger, G.; Thomas, D.; Gurke, R.; Steinhilber, D.; Schulz, M.; Leisegang, M.S.; Brandes, R.P.
Journal Article
2020Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers
Wolters, M.C.; Schmetzer, J.; Möser, C.V.; Hahnefeld, L.; Angioni, C.; Thomas, D.; Ferreirós, N.; Geisslinger, G.; Niederberger, E.
Journal Article
2020ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies
Mutsaerts, H.J.M.M.; Petr, J.; Groot, P.; Vandemaele, P.; Ingala, S.; Robertson, A.D.; Václavů, L.; Groote, I.; Kuijf, H.; Zelaya, F.; O'Daly, O.; Hilal, S.; Wink, A.M.; Kant, I.; Caan, M.W.A.; Morgan, C.; Bresser, J. de; Lysvik, E.; Schrantee, A.; Bjørnebekk, A.; Clement, P.; Shirzadi, Z.; Kuijer, J.P.A.; Wottschel, V.; Anazodo, U.C.; Pajkrt, D.; Richard, E.; Bokkers, R.P.H.; Reneman, L.; Masellis, M.; Günther, M.; MacIntosh, B.J.; Achten, E.; Chappell, M.A.; Osch, M.J.P. van; Golay, X.; Thomas, D.L.; Vita, E. de; Bjornerud, A.; Nederveen, A.; Hendrikse, J.; Asllani, I.; Barkhof, F.
Journal Article
2020High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease
Klatt-Schreiner, K.; Valek, L.; Kang, J.-S.; Khlebtovsky, A.; Trautmann, S.; Hahnefeld, L.; Schreiber, Y.; Gurke, R.; Thomas, D.; Wilken-Schmitz, A.; Wicker, S.; Auburger, G.; Geisslinger, G.; Lötsch, J.; Pfeilschifter, W.; Djaldetti, R.; Tegeder, I.
Journal Article
2020Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability?
Hahnefeld, L.; Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Trautmann, S.; Snodgrass, I.F.; Kratz, D.; Geisslinger, G.; Ferreiros, N.
Journal Article
2020In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
Blum, L.; Gul, S.; Ulshöfer, T.; Henke, M.; Krieg, R.; Berneburg, I.; Thomas, D.; Trautmann, S.; Kurz, J.; Geyer, J.; Geisslinger, G.; Becker, K.; Parnham, M.J.; Schiffmann, S.
Journal Article
2020Reduced association between dendritic cells and corneal sub‐basal nerve fibers in patients with fibromyalgia syndrome
Klitsch, A.; Evdokimov, D.; Frank, J.; Thomas, D.; Saffer, N.; Altenschildesche, C. Meyer zu; Sisignano, M.; Kampik, D.; Malik, R.A.; Sommer, C.; Üçeyler, N.
Journal Article
2020S1P d20:1, an endogenous modulator of S1P d18:1/S1P2-dependent signaling
Vutukuri, R.; Koch, A.; Trautmann, S.; Schreiber, Y.; Thomas, D.; Mayser, F.; Meyer zu Heringdorf, D.; Pfeilschifter, J.; Pfeilschifter, W.; Brunkhorst, R.
Journal Article
2020UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells
Schömel, N.; Gruber, L.; Alexopoulos, S.J.; Trautmann, S.; Olzomer, E.M.; Byrne, F.L.; Hoehn, K.L.; Gurke, R.; Thomas, D.; Ferreiros, N.; Geisslinger, G.; Wegner, M.-S.
Journal Article
2019Cancer-induced inflammation and inflammation-induced cancer in colon: A role for S1P lyase
Schwiebs, A.; Herrero San Juan, M.; Schmidt, K.G.; Wiercinska, E.; Anlauf, M.; Ottenlinger, F.; Thomas, D.; Elwakeel, E.; Weigert, A.; Farin, H.F.; Bonig, H.; Scholich, K.; Geisslinger, G.; Pfeilschifter, J.M.; Radeke, H.H.
Journal Article
2019Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation
Maric, J.; Ravindran, A.; Mazzurana, L.; Acker, A. van; Rao, A.; Kokkinou, E.; Ekoff, M.; Thomas, D.; Fauland, A.; Nilsson, G.; Wheelock, C.E.; Dahlen, S.-E.; Ferreiros, N.; Geisslinger, G.; Friberg, D.; Heinemann, A.; Konya, V.; Mjösberg, J.
Journal Article
2019A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients with Dementia
Gurke, R.; Etyemez, S.; Prvulovic, D.; Thomas, D.; Fleck, S.C.; Reif, A.; Geisslinger, G.; Lötsch, J.
Journal Article
2019Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics
Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Fleck, S.C.; Geisslinger, G.; Ferreiros, N.
Journal Article
2019Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation
Bärnthaler, T.; Jandl, K.; Sill, H.; Uhl, B.; Schreiber, Y.; Grill, M.; Thomas, D.; Schicho, R.; Marsche, G.; Frank, S.; Heinemann, A.; Schuligoi, R.
Letter to the Editor
2019Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice
Möser, C.V.; Möller, M.; Fleck, S.C.; Thomas, D.; Geisslinger, G.; Niederberger, E.
Journal Article
2019Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization
Astakhova, A.; Chistyakov, D.; Thomas, D.; Geisslinger, G.; Brüne, B.; Sergeeva, M.; Namgaladze, D.
Journal Article
2019The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated
Bazarganipour, S.; Hausmann, J.; Oertel, S.; El-Hindi, K.; Brachtendorf, S.; Blumenstein, I.; Kubesch, A.; Sprinzl, K.; Birod, K.; Hahnefeld, L.; Trautmann, S.; Thomas, D.; Herrmann, E.; Geisslinger, G.; Schiffmann, S.; Grösch, S.
Journal Article
2019Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer
Grill, M.; Högenauer, C.; Blesl, A.; Haybaeck, J.; Golob-Schwarzl, N.; Ferreirós, N.; Thomas, D.; Gurke, R.; Trötzmüller, M.; Köfeler, H.C.; Gallè, B.; Schicho, R.
Journal Article
2019Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
Schwarzkopf, K.M.; Queck, A.; Thomas, D.; Angioni, C.; Cai, C.; Freygang, Y.; Rüschenbaum, S.; Geisslinger, G.; Zeuzem, S.; Welsch, C.; Lange, C.M.
Journal Article
2019Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
Queck, A.; Thomas, D.; Jansen, C.; Schreiber, Y.; Rüschenbaum, S.; Praktiknjo, M.; Schwarzkopf, K.M.; Mücke, M.M.; Schierwagen, R.; Uschner, F.E.; Meyer, C.; Clària, J.; Zeuzem, S.; Geisslinger, G.; Trebicka, J.; Lange, C.M.
Journal Article
2019Selective Inactivation of Cancer Drugs by SAMHD1 Provides a Molecular Rationale for Therapeutic Stratification in AML
Schneider, C.; Oellerich, T.; Knecht, K.M.; Thomas, D.; Buzovetsky, O.; Schliemann, C.; Bohnenberger, H.; Angenendt, L.; Hartmann, W.; Wardelmann, E.; Scheich, S.; Comoglio, F.; Wilke, A.; Ströbel, P.; Serve, H.; Geisslinger, G.; Keppler, O.T.; Xiong, Y.; Cinatl, J.
Journal Article
2019Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
Oellerich, T.; Schneider, C.; Thomas, D.; Knecht, K.M.; Buzovetsky, O.; Kaderali, L.; Schliemann, C.; Bohnenberger, H.; Angenendt, L.; Hartmann, W.; Wardelmann, E.; Rothenburger, T.; Mohr, S.; Scheich, S.; Comoglio, F.; Wilke, A.; Ströbel, P.; Serve, H.; Michaelis, M.; Ferreiros, N.; Geisslinger, G.; Xiong, Y.; Keppler, O.T.; Cinatl, J.
Journal Article
2019Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation
Weigert, A.; Knethen, A. von; Thomas, D.; Faria, I.; Namgaladze, D.; Zezina, E.; Fuhrmann, D.; Petcherski, A.; Meyer zu Heringdorf, D.; Radeke, H.H.; Brüne, B.
Journal Article
2019Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder
Brunkhorst-Kanaan, N.; Klatt-Schreiner, K.; Hackel, J.; Schröter, K.; Trautmann, S.; Hahnefeld, L.; Wicker, S.; Reif, A.; Thomas, D.; Geisslinger, G.; Kittel-Schneider, S.; Tegeder, I.
Journal Article
2019Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation
Tarighi, N.; Menger, D.; Pierre, S.; Kornstädt, L.; Thomas, D.; Ferreiros, N.; Nüsing, R.M.; Geisslinger, G.; Scholich, K.
Journal Article
2019A validated LC-MS/MS method for the determination of homocysteic acid in biological samples
Gurke, R.; Schmidt, D.; Thomas, D.; Fleck, S.C.; Geisslinger, G.; Ferreiros, N.
Journal Article
2019A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1
Deutschmann, J.; Schneider, A.; Gruska, I.; Vetter, B.; Thomas, D.; Kießling, M.; Wittmann, S.; Herrmann, A.; Schindler, M.; Milbradt, J.; Ferreirós, N.; Winkler, T.H.; Wiebusch, L.; Gramberg, T.
Journal Article
201820-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
Tunaru, S.; Bonnavion, R.; Brandenburger, I.; Preussner, J.; Thomas, D.; Scholich, K.; Offermanns, S.
Journal Article
2018Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Pleli, T.; Mondorf, A.; Ferreiros, N.; Thomas, D.; Dvorak, K.; Biondi, R.M.; Heringdorf, D.M.; Zeuzem, S.; Geisslinger, G.; Zimmermann, H.; Waidmann, O.; Piiper, A.
Journal Article
2018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Brachtendorf, S.; Wanger, R.A.; Birod, K.; Thomas, D.; Trautmann, S.; Wegner, M.-S.; Fuhrmann, D.C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2018The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain
Zimmer, B.; Angioni, C.; Osthues, T.; Toewe, A.; Thomas, D.; Pierre, S.C.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2018Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Hitzel, J.; Lee, E.; Zhang, Y.; Bibli, S.I.; Li, X.; Zukunft, S.; Pflüger, B.; Hu, J.; Schürmann, C.; Vasconez, A.E.; Oo, J.A.; Kratzer, A.; Kumar, S.; Rezende, F.; Josipovic, I.; Thomas, D.; Giral, H.; Schreiber, Y.; Geisslinger, G.; Fork, C.; Yang, X.; Sigala, F.; Romanoski, C.E.; Kroll, J.; Jo, H.; Landmesser, U.; Lusis, A.J.; Namgaladze, D.; Fleming, I.; Leisegang, M.S.; Zhu, J.; Brandes, R.P.
Journal Article
2018The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
Knecht, K.M.; Buzovetsky, O.; Schneider, C.; Thomas, D.; Srikanth, V.; Kaderali, L.; Tofoleanu, F.; Reiss, K.; Ferreirós, N.; Geisslinger, G.; Batista, V.S.; Ji, X.; Cinatl, J.; Keppler, O.T.; Xiong, Y.
Journal Article
2017CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages
Kern, K.; Pierre, S.; Schreiber, Y.; Angioni, C.; Thomas, D.; Ferreirós, N.; Geisslinger, G.; Scholich, K.
Journal Article