Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2012Cellular imaging of human atherosclerotic lesions by intravascular electric impedance spectroscopy
Streitner, I.; Goldhofer, M.; Cho, S.; Kinscherf, R.; Thielecke, H.; Borggrefe, M.; Süselbeck, T.; Streitner, F.
Journal Article
2011Biocompatible micro-sized cell culture chamber for the detection of nanoparticle-induced IL8 promoter activity on a small cell population
Kohl, Y.; Oostingh, G.J.; Sossalla, A.; Duschl, A.; Briesen, H. von; Thielecke, H.
Journal Article
2011Characterisation of the deflection of thin perforated SiN membranes of micro-hole array chips used for the cell selection
Kurz, C.M.; Thielecke, H.
Journal Article
2011Chip-based impedance measurement on single cells for monitoring sub-toxic effects on cell membranes
Kurz, C.V.; Büth, H.; Sossalla, A.; Vermeersch, V.; Toncheva, V.; Dubruel, P.; Schacht, E.; Thielecke, H.
Journal Article
2011Development and evaluation of biofunctionalized polyimide membranes for ocular applications
Julien, S.; Vlierberghe, S. van; Peters, T.; Zrenner, E.; Sirova, M.; Thielecke, H.; Rihova, B.; Schacht, E.; Dubruel, P.
Conference Paper
2011Effect of gold nanoparticles on adipogenic differentiation of human mesenchymal stem cells
Kohl, Y.; Gorjup, E.; Katsen-Globa, A.; Büchel, C.; Briesen, H. von; Thielecke, H.
Journal Article
2011Impedance-controlled cell entrapment using microhole-array chips allows the isolation and identification of single, highly productive cells
Kurz, C.M.; Maurer, A.; Thees, K.; Schillberg, S.; Velen, T.; Thielecke, H.
Journal Article
2011Implantation of ultrathin, biofunctionalized polyimide membranes into the subretinal space of rats
Julien, S.; Peters, T.; Ziemssen, F.; Arango-Gonzalez, B.; Beck, S.; Thielecke, H.; Büth, H.; Vlierberghe, S. van; Sirova, M.; Rossmann, P.; Rihova, B.; Schacht, E.; Dubruel, P.; Zrenner, E.; Schraermeyer, U.
Journal Article
2011Near-infrared dye-loaded PLGA nanoparticles prepared by spray drying for photoacoustic applications
Kohl, Y.; Kaiser, C.; Bost, W.; Stracke, F.; Thielecke, H.; Wischke, C.; Lendlein, A.; Kratz, K.; Lemor, R.
Journal Article
2011On-chip integrated lensless fluorescence microscopy/spectroscopy module for cell-based sensors
Li, W.; Knoll, T.; Sossalla, A.; Bueth, H.; Thielecke, H.
Conference Paper
2011Preparation and biological evaluation of multifunctional PLGA-nanoparticles designed for photoacoustic imaging
Kohl, Y.; Kaiser, C.; Bost, W.; Stracke, F.; Fournelle, M.; Wischke, C.; Thielecke, H.; Lendlein, A.; Kratz, K.; Lemor, R.M.
Journal Article
2011Problems and challenges in the development and validation of human cell-based assays to determine nanoparticle-induced immunomodulatory effects
Oostingh, G.J.; Casals, E.; Italiani, P.; Colognato, R.; Stritzinger, R.; Ponti, J.; Pfaller, T.; Kohl, Y.; Ooms, D.; Favilli, F.; Leppens, H.; Lucchesi, D.; Rossi, F.; Nelissen, I.; Thielecke, H.; Puntes, V.F.; Duschl, A.; Boraschi, D.
Journal Article
2011A scaffold-free in vitro model for osteogenesis of human mesenchymal stem cells
Hildebrandt, C.; Büth, H.; Thielecke, H.
Journal Article
2011Towards a cellular multi-parameter analysis platform: Fluorescence in situ hybridization (FISH) on microhole-array chips
Kurz, C.M.; Moosdijk, S. van der; Thielecke, H.; Velten, T.
Conference Paper
2010Detection of the osteogenic differentiation of mesenchymal stem cells in 2D and 3D cultures by electrochemical impedance spectroscopy
Hildebrandt, C.; Büth, H.; Cho, S.; Thielecke, I.; Thielecke, H.
Journal Article
2010Evaluation of nanoparticles as contrast agent for photoacoustic imaging in living cells
Kohl, Y.; Thielecke, H.; Bost, W.; Lemor, R.; Stracke, F.; Kaiser, C.; Schroeter, M.; Kratz, K.; Henkel, A.; Sönnichsen, C.
Conference Paper
2010Influence of the electrode radius on the impedance spectra of cell-covered disc electrode
Cho, S.; Thielecke, H.
Conference Paper, Journal Article
2010Influence of transfection process on single cell impedance
Kurz, C.M.; Büth, H.; Thielecke, H.
Conference Paper
2010On-chip integrated lensless microscopy module for optical monitoring of adherent growing mammalian cells
Li, W.; Knoll, T.; Thielecke, H.
Conference Paper
2010Probing cytotoxicity of gadolinium hydroxide nanostructures
Hemmer, E.; Kohl, Y.; Colquhoun, V.; Thielecke, H.; Soga, K.; Mathur, S.
Journal Article
2010Solvothermal synthesis of Gadolinium hydroxide and oxide powders and their potential for biomedical applications
Hemmer, E.; Kohl, Y.; Mathur, S.; Thielecke, H.; Soga, K.
Conference Paper
2010Surface modification of polyimide sheets for regenerative medicine applications
Vlierberghe, S. van; Sirova, M.; Rossmann, P.; Thielecke, H.; Boterberg, V.; Rihova, B.; Schacht, E.; Dubruel, P.
Journal Article
2010A system for the rapid detection of bacterial contamination in cell-based therapeutica
Bolwien, C.; Erhardt, C.; Sulz, G.; Thielecke, H.; Johann, R.; Pudlas, M.; Walles, H.; Mertsching, H.; Koch, S.
Conference Paper
2009Chip-based time-continuous monitoring of toxic effects on stem cell differentiation
Cho, S.; Gorjup, E.; Thielecke, H.
Journal Article
2009Discrimination of microorganisms and cells in tissue engineering by Raman spectroscopy
Koch, S.; Dreiling, M.; Gutekunst, M.; Bolwien, C.; Thielecke, H.; Mertsching, H.
Conference Paper
2009Electric impedance spectroscopy of human atherosclerotic lesions
Streitner, I.; Goldhofer, M.; Cho, S.; Thielecke, H.; Kinscherf, R.; Streitner, F.; Metz, J.; Haase, K.K.; Borggrefe, M.; Suselbeck, T.
Journal Article
2009Influence of cell culture media conditions on the osteogenic differentiation of cord blood-derived mesenchymal stem cells
Hildebrandt, C.; Büth, H.; Thielecke, H.
Journal Article
2009Non-invasive characterization of the osteogenic differentiation of hMSCs in 3D by impedance spectroscopy
Hildebrandt, C.; Impidjati; Thielecke, H.
Conference Paper
2008Dependence of impedance of embedded single cells on cellular behaviour
Cho, S.; Castellarnau, M.; Samitier, J.; Thielecke, H.
Journal Article
2008Electrical characterization of human mesenchymal stem cell growth on microelectrode
Cho, S.; Thielecke, H.
Conference Paper, Journal Article
2008Electrical impedance monitoring of cell monolayer growth in vitro
Cho, S.; Thielecke, H.
Book Article
2008Live cell monitoring - development of an automated cell cultivation and monitoring system
Malthan, Dirk; Huchler, Roland; Brandenburg, Albrecht; Thielecke, Hagen; Hildebrandt, Cornelia; Zühlke, Dietlind
Conference Paper
2008Rapid detection of bacterial contamination in cell or tissue cultures based on Raman spectroscopy
Bolwien, C.; Sulz, G.; Becker, S.; Thielecke, H.; Mertsching, H.; Koch, S.
Conference Paper
2008Schnelle Sterilitätskontrolle von Zell- und Gewebekulturen mittels Raman-Spektroskopie
Bolwien, C.; Sulz, G.; Becker, S.; Thielecke, H.; Mertsching, H.; Koch, S.
Conference Paper
2008Zell Array: optimierte optische Einzelzellanalyse mittels Mikrochips
Büth, H.; Kohl, Y.; Thielecke, H.
Journal Article
2007Impedance monitoring of herpes simplex virus-induced cytopathic effect in Vero cells
Cho, S.; Becker, S.; Briesen, H. von; Thielecke, H.
Journal Article
2007Impedance monitoring of virus-induced cytopathic effect in cells
Cho, S.; Becker, S.; Briesen, H.; Thielecke, H.
Conference Paper
2007Intravascular electric impedance spectroscopy of human atherosclerotic lesions using a new impedance catheter system
Streitner, I.I.; Goldhofer, M.; Cho, S.; Kinscherf, R.; Thielecke, H.; Metz, J.; Grobholz, R.; Suselbeck, T.
Abstract
2007Micro hole-based cell chip with impedance spectroscopy
Cho, S.; Thielecke, H.
Journal Article
2007Mikrosystem zur Kontrolle der Wirkstoffabgabe aus einem Wirkstoffreservoir sowie Implantat mit Mikrosystem
Thielecke, H.; Robitzki, A.
Patent
2007Vorrichtung und Verfahren zur Charakterisierung von Sphaeroiden
Thielecke, H.; Robitzki, A.
Patent
2006Biopsy on living cells by ultra slow instrument movement
Thielecke, H.; Impidjati; Fuhr, G.R.
Journal Article
2006Influence of electrode position on the characterization of artery stenotic plaques by using impedance catheter
Cho, S.; Thielecke, H.
Journal Article
2006Technologien für die Zellforschung und Zelltherapie
Hildebrandt, C.; Thielecke, H.
Journal Article
2006Verfahren und Vorrichtungen zur Bearbeitung einzelner biologischer Zellen
Fuhr, G.; Thielecke, H.
Patent
2006Vorrichtung und Verfahren zur Analyse biologischer Proben
Mertsching, H.; Sulz, G.; Thielecke, H.; Bolwien, C.; Koch, S.
Patent
2005Cell signalling during sea urichin development: A model for assessing toxicology of environmental contaminats
Angelini, C.; Aluigi, M.G.; Sgro, M.; Trombino, S.; Thielecke, H.; Falugi, C.
Book Article
2005Design of electrode array for impedance measurement of lesions in arteries
Cho, S.; Thielecke, H.
Journal Article
2005Evaluation of a capillary measuring system for the characterisation of small tissue samples by impedance spectroscopy at higher frequencies
Impidjati; Leonard, F.; Thielecke, H.
Conference Paper
2005Gentle cell handling with an ultra-slow instrument: creep-manipulation of cells
Thielecke, H.; Impidjati; Zimmermann, H.; Fuhr, G.R.
Journal Article
2005Impedanzsensorik für den Einsatz in Kathetersystemen und Endoskopen
Thielecke, H.
Journal Article
2005Impedanzspektroskopie für gewebebasierte Biosensoren
Thielecke, H.
Journal Article
2005In vivo intravascular electric impedance spectroscopy using a new catheter with integrated microelectrodes
Süselbeck, T.; Thielecke, H.; Weinschenk, I.; Reininger-Mack, A.; Stieglitz, T.; Metz, J.; Borggrefe, M.; Robitzki, A.; Haase, K.K.
Journal Article
2005Interaction between organophosphate compounds and cholinergic functions during development
Aluigi, M.G.; Angelini, C.; Falugi, C.; Fossa, R.; Genever, P.; Gallus, L.; Layer, P.G.; Prestipino, G.; Rakonczay, Z.; Sgro, M.; Thielecke, H.; Trombino, S.
Conference Paper, Journal Article
2005Intravascular electric impedance spectroscopy of atherosclerotic lesions using a new impedance catheter system
Süselbeck, T.; Thielecke, H.; Köchlin, J.; Cho, S.; Weinschenk, I.; Metz, J.; Borggrefe, M.; Haase, K.K.
Journal Article
2005A more aggressive breast cancer spheroid model coupled to an electronic capillary sensor system for a high-content screening of cytotoxic agents in cancer therapy: 3-dimensional in vitro tumor spheroids as a screening model
Bartholomä, P.; Impidjati; Reininger-Mack, A.; Zhang, Z.; Thielecke, H.; Robitzki, A.A.
Journal Article
2005Simulated impedance of atheroma versus position of electrode array
Cho, S.; Thielecke, H.
Conference Paper
2005Three-dimensional in vitro reaggregates of embryonic cardiomyocytes: A potential model system for monitoring effects of bioactive agents
Bartholomä, P.; Gorjup, E.; Monz, D.; Reininger-Mack, A.; Thielecke, H.; Robitzki, A.
Journal Article
2005Verfahren zur Kultivierung einer Zellkultur in einem automatisierten Zellkultursystem sowie automatisiertes Zellkultursystem
Brandenburg, A.; Thielecke, H.; Hoffmann, C.; Malthan, D.; Schwarz, R.
Patent
2004"Lebende" Sensoren
Thielecke, H.; Monz, D.
Journal Article
2004Evaluation of impedance spectroscopy for the characterization of small biological samples in tissue-based test systems
Thielecke, H.; Fleckenstein, J.; Bartholomä, P.; Rübe, C.
Conference Paper
2003Capillary chip based characterisation of small tissue samples
Thielecke, H.
Journal Article
2003Endovascular impedance spectroscopy. A new technique for tissue imaging
Sueselbeck, T.; Thielecke, H.; Weinschenk, I.; Mack, A.; Stieglitz, T.; Robitzki, A.; Metz, J.; Borggrefe, M.; Haase, K.K.
Conference Paper, Journal Article
2003In vitro Gewebe-basierte Biosensoren für den potentiellen Einsatz in toxikologischen Untersuchungen im Lebensmittel- und Umweltbereich
Thielecke, H.; Reininger-Mack, A.
Conference Paper
2003In vitro tissue based test system for evaluation of anti cancer radiotherapies
Thielecke, H.; Fleckenstein, J.; Bartholomä, P.; Rübe, C.
Conference Paper
2003Modeling and experimental evaluation of impedance-based marker free, functional characterization of single cells and 3D in vitro tissues
Thielecke, H.
Conference Paper
2003Untersuchungen im Rahmen einer Konzeption und Entwicklung eines neuen biohybriden Mikrosystems für den Einsatz im pharmazeutischen »Screening«
Thielecke, H.
Dissertation
2003Vorrichtung und Verfahren zur Erfassung bioelektrischer Signale aus elektrophysiologisch aktiven Bereichen in Sphaeroiden
Thielecke, H.; Robitzki, A.
Patent
20023D-Biohybrid systems: Applications in drug screening
Reininger-Mack, A.; Thielecke, H.; Robitzki, A.
Journal Article
2002Development of a novel microcapillary array: Characterization of in vitro 3D tissue models by bioimpedance spectroscopy
Robitzki, A.; Thielecke, H.; Reininger-Mack, A.
Conference Paper
2002Endoluminales expandierbares Implantat mit integrierter Sensorik
Thielecke, H.; Robitzki, A.; Mack, A.; Stieglitz, T.; Scholz, O.; Haase, K.K.; Sueselbeck, T.
Patent
2002Funktionelles Biomonitoring mit 3D-Gewebe-Mikrokapillar-Arrays: Automatisiertes Screening von Wirkstoffen und Toxinen an 3D in vitro Gewebemodellen
Robitzki, A.; Thielecke, H.; Reininger-Mack, A.
Journal Article
2002Microchip-based techniques with benefits for single cell characterization using optical analyses systems
Thielecke, H.; Robitzki, A.
Conference Paper
2001Biohybrid microarrays - Impedimetric biosensors with 3D in vitro tissues for toxicological and biomedical screening
Thielecke, H.; Mack, A.; Robitzki, A.
Journal Article
2001A multicellular spheroid-based sensor for anti-cancer therapeutics
Thielecke, H.; Mack, A.; Robitzki, A.
Journal Article
2000Living Chips: Cell Sensors for Toxicity and Therapeutical Biomonitoring
Thielecke, H.; Mack, A.; Robitzki, A.
Conference Paper
1998A Novel Cell- Positioning Technique for Extracellular Recording and Impedance Measurement on Single Cells Using Planar Electrode Substrates
Thielecke, H.; Stieglitz, T.; Beutel, H.; Matthies, T.; Meyer, J.-U.
Conference Paper