Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2016CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo
Mladenov, R.; Hristodorov, D.; Cremer, C.; Gresch, G.; Grieger, G.; Schenke, L.; Klose, D.; Amoury, M.; Woitok, M.; Jost, E.; Brümmerdorf, T.H.; Fendel, R.; Fischer, R.; Stein, C.; Thepen, T.; Barth, S.
Journal Article
2016Fully human MAP-fusion protein selectively targets and eliminates proliferating CD64+ M1 macrophages
Hristodorov, D.; Mladenov, R.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2016Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model
Amoury, M.; Kolberg, K.; Pham, A.-T.; Hristodorov, D.; Mladenov, R.; Fiore, S. di; Helfrich, W.; Kiessling, F.; Fischer, R.; Pardo, A.; Thepen, T.; Hussain, A.F.; Nachreiner, T.; Barth, S.
Journal Article
2016A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein
Amoury, M.; Mladenov, R.; Nachreiner, T.; Pham, A.-T.; Hristodorov, D.; Di Fiore, S.; Helfrich, W.; Pardo, A.; Fey, G.; Schwenkert, M.; Thepen, T.; Kiessling, F.; Hussain, A.F.; Fischer, R.; Kolberg, K.; Barth, S.
Journal Article
2015The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia
Mladenov, R.; Hristodorov, D.; Cremer, C.; Hein, L.; Kreutzer, F.; Stroisch, T.; Niesen, J.; Brehm, H.; Blume, T.; Brummendorf, T.H.; Jost, E.; Thepen, T.; Fischer, R.; Stockmeyer, B.; Barth, S.; Stein, C.
Journal Article
2015Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies
Hristodorov, D.; Mladenov, R.; Felbert, V. von; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2014 Recombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody
Hristodorov, D.; Mladenov, R.; Brehm, H.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2014EpCAM-Selective Elimination of Carcinoma Cells by a Novel MAP-Based Cytolytic Fusion Protein
Hristodorov, D.; Amoury, M.; Mladenov, R.; Niesen, J.; Arens, K.; Berges, N.; Hein, L.; Fiore, S. di; Pham, A.T.; Huhn, M.; Helfrich, W.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2014Human Cytolytic Fusion Proteins
Berges, N.; Hehmann-Titt, G.; Hristodorov, D.; Melmer, G.; Thepen, T.; Barth, S.
Journal Article
2014Human microtubule-associated protein tau mediates targeted killing of CD30+ lymphoma cells in vitro and inhibits tumour growth in vivo
Hristodorov, D.; Nordlohne, J.; Mladenov, R.; Huhn, M.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2014Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins
Schiffer, S.; Rosinke, R.; Jost, E.; Hehmann-Titt, G.; Huhn, M.; Melmer, G.; Barth, S.; Thepen, T.
Journal Article
2013Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model
Schiffer, S.; Hansen, H.P.; Hehmann-Titt, G.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2013Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells
Schiffer, S.; Letzian, S.; Jost, E.; Mladenov, R.; Hristodorov, D.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2013Macrophage-targeted therapy of chronic wounds
Hristodorov, D.; Mladenov, R.; Aslanian, E.; Huhn, M.; Barth, S.; Thepen, T.
Book Article
2013Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo
Hristodorov, D.; Mladenov, R.; Pardo, A.; Pham, A.-T.; Huhn, M.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2013Species-Dependent Functionality of the Human Cytolytic Fusion Proteins Granzyme B-H22(scFv) and H22(scFv)-Angiogenin in Macrophages
Schiffer, S.; Hristodorov, D.; Mladenov, R.; Aslanian, E.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2012In vivo imaging of immunotoxin treatment using Katushka-transfected A-431 cells in a murine xenograft tumour model
Pardo, A.; Stöcker, M.; Kampmeier, F.; Melmer, G.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2012Labeling of anti-MUC-1 binding single chain fv fragments to surface modified upconversion nanoparticles for an initial in vivo molecular imaging proof of principle approach
Hischemöller, A.; Walter, C.; Weiler, V.; Hummel, H.; Thepen, T.; Huhn, M.; Barth, S.; Hoheisel, W.; Köhler, K.; Dimova-Landen, D.; Bremer, C.; Haase, M.; Waldeck, J.
Journal Article
2012Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases. Review
Hristodorov, D.; Mladenov, R.; Huhn, M.; Barth, S.; Thepen, T.
Journal Article
2012Reduction of activated macrophages after ischaemiareperfusion injury diminishes oxidative stress and ameliorates renal damage
Fet, N.G.; Fiebeler, A.; Klinge, U.; Park, J.K.; Barth, S.; Thepen, T.; Tolba, R.H.
Journal Article
2011Expression of CD64 (FcRI) in skin of patients with acute GVHD
Royen-Kerkhof, A. van; Walraven, V.; Sanders, E.A.M.; Weger, R. de; Wichen, D.F. van; Koning, E. de; Thepen, T.; Winkel, J.G.J. van de; Leusen, J.H.W.
Journal Article
2011In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA in a human acute myeloid leukemia xenograft tumor model
Tur, M.K.; Huhn, M.; Jost, E.; Thepen, T.; Brümmendorf, T.H.; Barth, S.
Journal Article
2010Rapid optical imaging of EGF receptor expression with a single-chain antibody SNAP-tag fusion protein
Kampmeier, F.; Niesen, J.; Koers, A.; Ribbert, M.; Brecht, A.; Fischer, R.; Kießling, F.; Barth, S.; Thepen, T.
Journal Article
2010Recombinant, ETA'-based CD64 immunotoxins: Improved efficacy by increased valency, both in vitro and in vivo in a chronic cutaneous inflammation model in human CD64 transgenic mice
Ribbert, T.; Thepen, T.; Tur, M.K.; Fischer, R.; Huhn, M.; Barth, S.
Journal Article
2009Fc gamma receptor 1 (CD64), a target beyond cancer
Thepen, T.; Huhn, M.; Melmer, G.; Tur, M.K.; Barth, S.
Journal Article
2009Recombinant bispecific single chain antibody fragments induce Fc gamma-receptor-mediated elimination of CD30(+) lymphoma cells
Ranft, K.; Thepen, T.; Fischer, R.; Barth, S.; Stöcker, M.
Journal Article
2008Depletion of autoreactive B-lymphocytes by a recombinant myelin oligodendrocyte glycoprotein-based immunotoxin
Nachreiner, T.; Kampmeier, F.; Thepen, T.; Fischer, R.; Barth, S.; Stocker, M.
Journal Article
2008Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes
Stahnke, B.; Thepen, T.; Stöcker, M.; Rosinke, R.; Jost, E.; Fischer, R.; Tur, M.K.; Barth, S.
Journal Article
2006CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model
Vuuren, A.J. van; Roon, J.A.G. van; Walraven, V.; Stuij, I.; Harmsen, M.C.; McLaughlin, P.M.J.; Winkel, J.G.J. van de; Thepen, T.
Journal Article
2005Recombinant soluble human Fc(gamma) receptor I with picomolar affinity for immunoglobulin G
Paetz, A.; Sack, M.; Thepen, T.; Tur, M.K.; Brüll, D.; Finnern, R.; Fischer, R.; Barth, S.
Journal Article
2004Auflösung chronischer Entzündungen durch Bändigung abtrünniger Makrophagen
Thepen, T.; Huhn, M.; Barth, S.
Journal Article
2004m22(scFv)-ETA', a new recombinant anti-CD64 immunotoxin for specific elimination of AML cells
Tur, M.K.; Huhn, M.; Thepen, T.; Stöcker, M.; Krohn, R.; Vogel, S.; Jost, E.; Osieka, R.; Winkel, J.G. van de; Fischer, R.; Barth, S.
Journal Article
2003Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells
Tur, M.K.; Huhn, M.; Thepen, T.; Stocker, M.; Krohn, R.; Vogel, S.; Jost, E.; Osieka, R.; Winkel, J.G. van de; Fischer, R.; Finnern, R.; Barth, S.
Journal Article