Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2014Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS)
Lauenstein, L.; Switalla, S.; Prenzler, F.; Seehase, S.; Pfennig, O.; Förster, C.; Fieguth, H.; Braun, A.; Sewald, K.
Journal Article
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Journal Article
2013Ein translationales LPS-Modell zur präklinischen Testung anti-inflammatorischer Substanzen im Weißbüschelaffen (Callithrix jacchus)
Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz Josef; Schlumbohm, Christina; Fuchs, E.; Lauenstein, Hans Dieter; Sewald, Katherina; Hohlfeld, Jens M.; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2012Assessment of lung toxicity induced by chemical allergens in human precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Prenzler, Frauke; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Abstract
2012LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing
Seehase, S.; Lauenstein, H.D.; Schlumbohm, C.; Switalla, S.; Neuhaus, V.; Förster, C.; Fieguth, H.G.; Pfennig, O.; Fuchs, E.; Kaup, F.J.; Bleyer, M.; Hohlfeld, J.M.; Braun, A.; Sewald, K.; Knauf, S.
Journal Article
2012A new model for testing human specific anti-inflammatory drugs: LPS-induced lung inflammation in the common marmoset
Knauf, Sascha; Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz-Josef; Schlumbohm, Christina; Fuchs, Eberhard; Lauenstein, Hand D.; Sewald, Katherina; Hohlfeld, Jens Michael; Braun, Armin
Abstract
2011Bronchoconstriction in nonhuman primates: A species comparison
Seehase, S.; Schlepütz, M.; Switalla, S.; Mätz-Rensing, K.; Kaup, F.J.; Zöller, M.; Schlumbohm, C.; Fuchs, E.; Lauenstein, H.-D.; Winkler, C.; Kuehl, A.R.; Uhlig, S.; Braun, A.; Sewald, K.; Martin, C.
Journal Article
2011Characterization of local respiratory irritation and inflammation after acute exposure to biological and chemical substances in PCLS
Switalla, S.
: Steinhagen, D. (Referent); Braun, Armin (Korreferent); Bicker, Gerd (Korreferent)
Dissertation
2011Mechanisms of bronchoconstriction in precision-cut lung slices of non-human primates are comparable to human
Seehase, Sophie; Schlepütz, M.; Switalla, Simone; Fuchs, E.; Kaup, F.-J.; Ressmeyer, A.R.; Uhlig, S.; Lauenstein, Hans-Dieter; Braun, Armin; Martin, C.; Sewald, Katherina
Conference Paper, Journal Article
2011The phosphodiesterase-4-inhibitor Roflumilast reduces LPS-induced lung inflammation in common marmoset monkeys
Seehase, Sophie; Switalla, Simone; Prenzler, Frauke; Fuchs, E.; Schlumbohm, C.; Kaup, F.-J.; Sewald, Katherina; Lauenstein, Hans-Dieter; Braun, Armin
Conference Paper, Journal Article
2010Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air-liquid interface (ALI) culture
Switalla, S.; Knebel, J.; Ritter, D.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices
Switalla, S.; Lauenstein, L.; Prenzler, F.; Knothe, S.; Förster, C.; Fieguth, H.-G.; Pfennig, O.; Schaumann, F.; Martin, C.; Guzman, C.A.; Ebensen, T.; Müller, M.; Hohlfeld, J.M.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010PCLS (Precision Cut Lung Slices) as a putative model for genotoxicity testing by application of the comet assay
Ritter, D.; Switalla, S.; Sewald, K.; Knebel, J.
Abstract
2009Cytokine production after acute exposure of precision cut lung slices to NO2 and O3
Switalla, S.; Ritter, D.; Krug, N.; Knebel, J.; Braun, A.; Sewald, K.
Abstract
2009Different cytokine pattern in human precision cut lung slices after treatment with respiratory and contact allergens
Switalla, S.; Wang, L.; Foerster, C.; Hohlfeld, J.; Krug, N.; Braun, A.; Sewald, K.
Abstract
2009Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models
Nassimi, M.; Schleh, C.; Lauenstein, H.-D.; Hussein, R.; Lübbers, K.; Pohlmann, G.; Switalla, S.; Sewald, K.; Müller, M.; Krug, N.; Müller-Goymann, C.C.; Braun, A.
Journal Article
2009Precision cut lung slices (PCLS) as a tool to predict effective LPS concentrations for in vivo use in common marmoset monkeys
Seehase, S.; Switalla, S.; Schlumbohm, C.; Knöchelmann, N.; Krug, N.; Sewald, K.; Kaup, F.-J.; Fuchs, E.; Braun, A.
Abstract
2009Respiratory toxicology and immunotoxicology in human precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Wang, L.; Pfennig, O.; Förster, C.; Krug, N.; Braun, A.
Abstract
2009Trimellitic anhydride-induced immune responses in murine and human precision-cut lung slices
Wang, L.; Switalla, S.; Förster, C.; Krug, N.; Hohlfeld, J.; Braun, A.; Sewald, K.
Abstract
2008Ex vivo testing of immune responses in precision-cut lung slices
Henjakovic, M.; Sewald, K.; Switalla, S.; Kaiser, D.; Müller, M.; Veres, T.Z.; Martin, C.; Uhlig, S.; Krug, N.; Braun, A.
Journal Article
2008Precision cut lung slices for prediction of sensitizing potential of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Mueller, M.; Veres, T.; Krug, N.; Braun, A.
Abstract
2008Precision cut lung slices for testing of gaseous compounds
Switalla, S.; Sewald, K.; Ritter, D.; Henjakovic, M.; Krug, N.; Knebel, J.; Braun, A.
Conference Paper, Journal Article
2008Respiratory toxicology and immunotoxicology in precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Henjakovic, M.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Precision cut lung slices (PCLS) for respiratory sensitisation potential testing of allergens and irritants
Henjakovic, M.; Sewald, K.; Switalla, S.; Veres, T.; Mätz-Rensing, K.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Precision cut lung slices as tool for assessment of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Veres, T.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2006Identifizierung und Charakterisierung dendritischer Zellen in PCLS
Switalla, S.
Thesis