Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Computer-Aided Selective Optimization of Side Activities of Talinolol
Hiesinger, K.; Kramer, J.S.; Achenbach, J.; Moser, D.; Weber, J.; Wittmann, S.K.; Morisseau, C.; Angioni, C.; Geisslinger, G.; Kahnt, A.S.; Kaiser, A.; Proschak, A.; Steinhilber, D.; Pogoryelov, D.; Wagner, K.; Hammock, B.D.; Proschak, E.
Journal Article
2019Elucidation of chemical modifier reactivity towards peptides and proteins and the analysis of specific fragmentation by matrix‐assisted laser desorption/ionization collision‐induced dissociation tandem mass spectrometry
Rühl, M.; Kühn, B.; Roos, J.; Maier, T.J.; Steinhilber, D.; Karas, M.
Journal Article, Conference Paper
2019Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
Göbel, T.; Diehl, O.; Heering, J.; Merk, D.; Angioni, C.; Wittmann, S.K.; Buscato, E. la; Kottke, R.; Weizel, L.; Schader, T.; Maier, T.J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Steinhilber, D.; Proschak, E.; Kahnt, A.S.
Journal Article
2018Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells
Kühn, B.; Brat, C.; Fettel, J.; Hellmuth, N.; Maucher, I.V.; Bulut, I.; Hock, K.J.; Grimmer, J.; Manolikakes, G.; Rühl, M.; Kühn, A.; Zacharowski, K.; Matrone, C.; Urbschat, A.; Roos, J.; Steinhilber, D.; Maier, T.J.
Journal Article
2018Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Ringleb, J.; Strack, E.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Weigert, A.; Brüne, B.
Journal Article
2018Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
Schierle, S.; Flauaus, C.; Heitel, P.; Willems, S.; Schmidt, J.; Kaiser, A.; Weizel, L.; Goebel, T.; Kahnt, A.S.; Geisslinger, G.; Steinhilber, D.; Wurglics, M.; Rovati, G.E.; Schmidtko, A.; Proschak, E.; Merk, D.
Journal Article
2018Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases
Büttner, D.; Kramer, J.S.; Klingler, F.-M.; Wittmann, S.K.; Hartmann, M.R.; Kurz, C.G.; Kohnhäuser, D.; Weizel, L.; Brüggerhoff, A.; Frank, D.; Steinhilber, D.; Wichelhaus, T.A.; Pogoryelov, D.; Proschak, E.
Journal Article
2018Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways
Brand, S.; Roy, S.; Schröder, P.; Rathmer, B.; Roos, J.; Kapoor, S.; Patil, S.; Pommerenke, C.; Maier, T.; Janning, P.; Eberth, S.; Steinhilber, D.; Schade, D.; Schneider, G.; Kumar, K.; Ziegler, S.; Waldmann, H.
Journal Article
2018Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase
Roos, J.; Peters, M.; Maucher, I.V.; Kühn, B.; Fettel, J.; Hellmuth, N.; Brat, C.; Sommer, B.; Urbschat, A.; Piesche, M.; Vogel, A.; Proschak, E.; Blöcher, R.; Buscató, E.; Häfner, A.-K.; Matrone, C.; Werz, O.; Heidler, J.; Wittig, I.; Angioni, C.; Geisslinger, G.; Parnham, M.J.; Zacharowski, K.; Steinhilber, D.; Maier, T.J.
Journal Article
2018How to effectively treat acute leukemia patients bearing MLL-rearrangements?
Steinhilber, D.; Marschalek, R.
Journal Article
2018Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade
Sala, A.; Proschak, E.; Steinhilber, D.; Rovati, G.E.
Journal Article
2017Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
Hosseini, S.K.; Kolterer, S.; Steiner, M.; Manstein, V. von; Gerlach, K.; Trojan, J.; Waidmann, O.; Zeuzem, S.; Schulze, J.O.; Hahn, S.; Steinhilber, D.; Gatterdam, V.; Tampé, R.; Biondi, R.M.; Proschak, E.; Zörnig, M.
Journal Article
2017CarbORev‐5901: The First Carborane‐Based Inhibitor of the 5‐Lipoxygenase Pathway
Kuhnert, R.; Sárosi, M.-B.; George, S.; Lönnecke, P.; Hofmann, B.; Steinhilber, D.; Murganic, B.; Mijatovic, S.; Maksimovic‐Ivanic, D.; Hey‐Hawkins, E.
Journal Article
2017Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12
Ball, A.-K.; Beilstein, K.; Wittmann, S.; Sürün, D.; Saul, M.J.; Schnütgen, F.; Flamand, N.; Capelo, R.; Kahnt, A.S.; Frey, H.; Schaefer, L.; Marschalek, R.; Häfner, A.-K.; Steinhilber, D.
Journal Article
2017Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles
Kretschmer, S.B.M.; Woltersdorf, S.; Vogt, D.; Lillich, F.F.; Rühl, M.; Karas, M.; Maucher, I.V.; Roos, J.; Häfner, A.-K.; Kaiser, A.; Wurglics, M.; Schubert-Zsilavecz, M.; Angioni, C.; Geisslinger, G.; Stark, H.; Steinhilber, D.; Hofmann, B.
Journal Article
2017Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
Meirer, K.; Glatzel, D.; Kretschmer, S.; Wittmann, S.K.; Hartmann, M.; Blöcher, R.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Hofmann, B.; Fürst, R.; Proschak, E.
Journal Article
2017A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter nonalcoholic steatohepatitis
Schmidt, J.; Rotter, M.; Weiser, T.; Wittmann, S.; Weizel, L.; Kaiser, A.; Heering, J.; Goebel, T.; Angioni, C.; Wurglics, M.; Paulke, A.; Geisslinger, G.; Kahnt, A.; Steinhilber, D.; Proschak, E.; Merk, D.
Journal Article
2017Editorial: Special issue of the 6th European Workshop on Lipid Mediators
Steinhilber, D.; Uydeş-Doğan, B.S.; Topal, G.; Clària, J.; Norel, X.; Schebb, N.H.; Bannenberg, G.
Journal Article
2017Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
Maucher, I.V.; Rühl, M.; Kretschmer, S.B.M.; Hofmann, B.; Kühn, B.; Fettel, J.; Vogel, A.; Flügel, K.-T.; Manolikakes, G.; Hellmuth, N.; Häfner, A.-K.; Golghalyani, V.; Ball, A.K.; Piesche, M.; Matrone, C.; Geisslinger, G.; Parnham, M.J.; Karas, M.; Steinhilber, D.; Roos, J.; Maier, T.J.
Journal Article
2017R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4
Wobst, I.; Ebert, L.; Birod, K.; Wegner, M.-S.; Hoffmann, M.; Thomas, D.; Angioni, C.; Parnham, M.J.; Steinhilber, D.; Tegeder, I.; Geisslinger, G.; Grösch, S.
Journal Article
2017TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation
Saul, M.J.; Groher, F.; Hegewald, A.B.; Müller-McNicoll, M.; Marschalek, R.; Suess, B.; Steinhilber, D.
Journal Article
2016Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells
Guillem-Llobat, P.; Dovizio, M.; Bruno, A.; Ricciotti, E.; Cufino, V.; Sacco, A.; Grande, R.; Alberti, S.; Arena, V.; Cirillo, M.; Patrono, C.; FitzGerald, G.A.; Steinhilber, D.; Sgambato, A.; Patrignani, P.
Journal Article
2016Cellular analysis of the histamine H4 receptor in human myeloid cells
Capelo, R.; Lehmann, C.; Ahmad, K.; Snodgrass, R.; Diehl, O.; Ringleb, J.; Flamand, N.; Weigert, A.; Stark, H.; Steinhilber, D.; Kahnt, A.S.
Journal Article
2016Development of novel aminothiazole-comprising 5-LO inhibitors
Kretschmer, S.B.M.; Woltersdorf, S.; Rödl, C.B.; Vogt, D.; Häfner, A.-K.; Steinhilber, D.; Stark, H.; Hofmann, B.
Journal Article
2016Epigenetic Control of Microsomal Prostaglandin E Synthase-1 by HDAC Mediated Recruitment of p300
Fork, C.; Vasconez, A.E.; Janetzko, P.; Angioni, C.; Schreiber, Y.; Ferreiros, N.; Geisslinger, G.; Leisegang, M.S.; Steinhilber, D.; Brandes, R.P.
Journal Article
2016The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration
Gu, L.; Hitzel, J.; Moll, F.; Kruse, C.; Malik, R.A.; Preussner, J.; Looso, M.; Leisegang, M.S.; Steinhilber, D.; Brandes, R.P.; Fork, C.
Journal Article
2016Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase
Häfner, A.-K.; Beilstein, K.; Graab, P.; Ball, A.-K.; Saul, M.J.; Hofmann, B.; Steinhilber, D.
Journal Article
2016N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators
Blöcher, R.; Lamers, C.; Wittmann, S.K.; Merk, D.; Hartmann, M.; Weizel, L.; Diehl, O.; Brüggerhoff, A.; Boss, M.; Kaiser, A.; Schader, T.; Gobel, T.; Grundmann, M.; Angioni, C.; Heering, J.; Geisslinger, G.; Wurglics, M.; Kostenis, E.; Brüne, B.; Steinhilber, D.; Schubert-Zsilavecz, M.; Kahnt, A.S.; Proschak, E.
Journal Article
2016PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells
Josipovic, I.; Fork, C.; Preussner, J.; Prior, K.-K.; Iloska, D.; Vasconez, A.E.; Labocha, S.; Angioni, C.; Thomas, D.; Ferreirós, N.; Looso, M.; Pullamsetti, S.S.; Geisslinger, G.; Steinhilber, D.; Brandes, R.P.; Leisegang, M.S.
Journal Article
2016Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors
Roos, J.; Grösch, S.; Werz, O.; Schröder, P.; Ziegler, S.; Fulda, S.; Paulus, P.; Urbschat, A.; Kühn, B.; Maucher, I.; Fettel, J.; Vorup-Jensen, T.; Piesche, M.; Matrone, C.; Steinhilber, D.; Parnham, M.J.; Maier, T.J.
Journal Article
2016Thermodynamic properties of leukotriene A4 hydrolase inhibitors
Wittmann, S.K.; Kalinowsky, L.; Kramer, J.S.; Bloecher, R.; Knapp, S.; Steinhilber, D.; Pogoryelov, D.; Proschak, E.; Heering, J.
Journal Article
2016UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance
Saul, M.J.; Stein, S.; Grez, M.; Jakobsson, P.-J.; Steinhilber, D.; Suess, B.
Journal Article
20155-Lipoxygenase is a direct p53 target gene in humans
Gilbert, B.; Ahmad, K.; Roos, J.; Lehmann, C.; Chiba, T.; Ulrich-Rückert, S.; Smeenk, L.; Heeringen, S. van; Maier, T.J.; Groner, B.; Steinhilber, D.
Journal Article
2015AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3
Ahmad, K.; Scholz, B.; Capelo, R.; Schweighöfer, I.; Kahnt, A.S.; Marschalek, R.; Steinhilber, D.
Journal Article
2015Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein
Lehmann, C.; Homann, J.; Ball, A.-K.; Blöcher, R.; Kleinschmidt, T.K.; Basavarajappa, D.; Angioni, C.; Ferreirós, N.; Häfner, A.-K.; Radmark, O.; Proschak, E.; Haeggström, J.Z.; Geisslinger, G.; Parnham, M.J.; Steinhilber, D.; Kahnt, A.S.
Journal Article
2015Small molecules with anti-inflammatory properties in clinical development
Hanke, T.; Merk, D.; Steinhilber, D.; Geisslinger, G.; Schubert-Zsilavecz, M.
Journal Article
2014Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators
Homann, J.; Lehmann, C.; Kahnt, A.S.; Steinhilber, D.; Parnham, M.J.; Geisslinger, G.; Ferreirós, N.
Journal Article
2014Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation
Awwad, K.; Steinbrink, S.D.; Frömel, T.; Lill, N.; Isaak, J.; Häfner, A.K.; Roos, J.; Hofmann, B.; Heide, H.; Geisslinger, G.; Steinhilber, D.; Freeman, B.A.; Maier, T.J.; Fleming, I.
Journal Article
2013Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity
Kahnt, A.S.; Rörsch, F.; Diehl, O.; Hofmann, B.; Lehmann, C.; Steinbrink, S.D.; Angioni, C.; Geisslinger, G.; Grösch, S.; Steinhilber, D.; Maier, T.J.
Journal Article
2013Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps
Aschenbach, J.; Klingler, F.M.; Blöcher, R.; Moser, D.; Häfner, A.K.; Rödl, C.B.; Kretschmer, S.; Krüger, B.; Löhr, F.; Stark, H.; Hofmann, B.; Steinhilber, D.; Proschak, E.
Journal Article