Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Alpha-1 antitrypsin inhibits ATP-mediated release of interleukin-1β via CD36 and nicotinic acetylcholine receptors
Siebers, Kathrin; Fink, Bijan; Zakrzewicz, Anna; Agné, Alisa; Richter, Katrin; Konzok, Sebastian; Hecker, Andreas; Zukunft, Sven; Küllmar, Mira; Klein, Jochen; McIntosh, J. Michael; Timm, Thomas; Sewald, Katherina; Padberg, Winfried; Aggarwal, Nupur; Chamulitrat, Walee; Santoso, Sentot; Xia, Wendy; Janciauskiene, Sabina; Grau, Veronika
Journal Article
2018Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Konzok, Sebastian; Obernolte, Helena; Dehmel, Susann; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Zardo, Patrick; Warnecke, Gregor; Martin, Christian; Braun, Armin; Sewald, Katherina
Journal Article
2018Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
Ackermann, Mania; Kempf, Henning; Hetzel, Miriam; Hesse, Christina; Hashtchin, Anna Rafiei; Brinkert, Kerstin; Schott, Juliane Wilhelmine; Haake, Kathrin; Kühnel, Mark Philipp; Glage, Silke; Figueiredo, Constanca; Jonigk, Danny; Sewald, Katherina; Schambach, Axel; Wronski, Sabine; Moritz, Thomas; Martin, Ulrich; Zweigerdt, Robert; Munder, Antje; Lachmann, Nico
Journal Article
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2018Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin
Müller, Laura; Murgia, Xabier; Siebenburger, Lorenz; Börger, Carsten; Schwarzkopf, Konrad; Sewald, Katherina; Häussler, Susanne; Braun, Armin; Lehr, Claus-Michael; Hittinger, Marius; Wronski, Sabine
Journal Article
2018Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs
Danov, Olga; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Seehase, Sophie; Dehmel, Susann; Braubach, Peter; Fieguth, Hans-Gerd; Matschiner, Gabriele; Fitzgerald, Mary; Jonigk, Danny; Knauf, Sascha; Pfennig, Olaf; Warnecke, Gregor; Wichmann, Judy; Braun, Armin; Sewald, Katherina
Journal Article
2018Human teratoma-derived hematopoiesis is a highly polyclonal process supported by human umbilical vein endothelial cells
Philipp, Friederike; Selich, Anton; Rothe, Michael; Hoffmann, Dirk; Rittinghausen, Susanne; Morgan, Michael A.; Klatt, Denise; Glage, Silke; Lienenklaus, Stefan; Neuhaus, Vanessa; Sewald, Katherina; Braun, Armin; Schambach, Axel
Journal Article
2018In silico prediction of DILI: extraction of histopathology data from preclinical toxicity studies of the eTOX database for new in silico models of hepatotoxicity
Sullivan, K.; Baker, N.; Cochrane, S.; Enoch, Steven J.; Ezendam, Janine; Patlewicz, G.; Roggen, Erwin L.; Settivari, R.; Sewald, Katherina
Abstract
2017An Adverse Outcome Pathway for Sensitization of the Respiratory Tract by Low-Molecular-Weight Chemicals
Sullivan, K.M.; Enoch, S.J.; Ezendam, J.; Sewald, K.; Roggen, E.L.; Cochrane, S.
Journal Article
2017Anti-viral and inflammatory host response to rhinovirus is induced in vital ex vivo human lung tissue and reduced by anti-viral treatments
Obernolte, H.; Braubach, P.; Jonigk, D.; Kruger, M.; Warnecke, G.; Pfennig, O.; Fieguth, H.-G.; Braun, A.; Sewald, K.; Wronski, S.
Abstract
2017Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality
Neuhaus, V.; Schaudien, D.; Golovina, T.; Temann, U.-A.; Thompson, C.; Lippmann, T.; Bersch, C.; Pfennig, O.; Jonigk, D.; Braubach, P.; Fieguth, H.-G.; Warnecke, G.; Yusibov, V.; Sewald, K.; Braun, A.
Journal Article
2017Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons
Lindner, Karina; Ströbele, Michael; Schlick, Sandra; Webering, Sina; Jenckel, André; Kopf, Johannes; Danov, Olga; Sewald, Katherina; Buj, Christian; Creutzenberg, Otto; Tillmann, Thomas; Pohlmann, Gerhard; Ernst, Heinrich; Ziemann, Christina; Hüttmann, Gereon; Heine, Holger; Bockhorn, Henning; Hansen, Tanja; König, Peter
Journal Article
2017Coagulation factor XII regulates inflammatory responses in human lungs
Hess, R.; Wujak, L.; Hesse, C.; Sewald, K.; Jonigk, D.; Warnecke, G.; Fieguth, H.-G.; Maat, S. de; Maas, C.; Bonella, F.; Preissner, K.T.; Weiss, B.; Schaefer, L.; Kuebler, W.M.; Markart, P.; Wygrecka, M.
Journal Article
2017Comparison Of Bleomycin Models Of Pulmonary Fibrosis In Rats And Mice
Walter, D.; Schaudien, D.; Sewald, K.; Braun, A.; Hoymann, H.G.
Abstract
2017Ex-Vivo Infection Of Fresh Human Lung Tissue With Pseudomonas AerugINOSa
Boge, L.; Muller, M.; Jonigk, D.; Braubach, P.; Fieguth, H.G.; Warnecke, G.; Kruger, M.; Braun, A.; Sewald, K.; Wronski, S.
Abstract
2017FXII promotes proteolytic processing of the LRP1 ectodomain
Wujak, L.; Hesse, C.; Sewald, K.; Jonigk, D.; Braubach, P.; Warnecke, G.; Fieguth, H.-G.; Braun, A.; Lochnit, G.; Markart, P.; Schaefer, L.; Wygrecka, M.
Journal Article
2017Human effector memory T helper cells engage with mouse macrophages and cause Graft-versus-Host-like pathology in skin of humanized mice used in a nonclinical immunization study
Sundarasetty, Balasai; Volk, Valery; Theobald, Sebastian J.; Rittinghausen, Susanne; Schaudien, Dirk; Neuhaus, Vanessa; Figueiredo, Constanca; Schneider, Andreas; Gerasch, Laura; Mucci, Adele; Moritz, Thomas; Kaisenberg, Constantin von; Spineli, Loukia M.; Sewald, Katherina; Braun, Armin; Weigt, Henning; Ganser, Arnold; Stripecke, Renata
Journal Article
2017Interactions Of Cancer Cell Line Mda-Mb-231 With Their Native Tumor Microenvironment And Anti-Cancer Effects Of Bevacizumab And Cisplatin On Cancer Cell Invaded Human Living Lung Tissue
Konzok, S.; Dehmel, S.; Braubach, P.; Kruger, M.; Jonigk, D.; Warnecke, G.; Pfennig, O.; Fieguth, H.G.; Braun, A.; Sewald, K.
Abstract
2017Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
Zmora, Pawel; Molau-Blazejewska, Paulina; Bertram, Stephanie; Walendy-Gnirß, Kerstin; Nehlmeier, Inga; Hartleib, Anika; Moldenhauer, Anna-Sophie; Konzok, Sebastian; Dehmel, Susann; Sewald, Katherina; Brinkmann, Constantin; Curths, Christoph; Knauf, Sascha; Gruber, Jens; Mätz-Rensing, Kerstin; Dahlmann, Franziska; Braun, Armin; Pöhlmann, Stefan
Journal Article
2017RNA isolation from precision-cut lung slices (PCLS) from different species
Niehof, Monika; Hildebrandt, Tobias; Danov, Olga; Arndt, Kirsten; Koschmann, Jeannette; Dahlmann, Franziska; Hansen, Tanja; Sewald, Katherina
Journal Article
2016BI 1002494, a novel potent and selective oral spleen tyrosine kinase inhibitor, displays differential potency in human basophils and B cells
Lamb, David J.; Wollin, Stefan Lutz; Schnapp, Andreas; Bischoff, Daniel; Erb, Klaus J.; Bouyssou, Thierry; Guilliard, Bernd; Strasser, Christine; Wex, Eva; Blum, Sylvia; Thaler, Eva; Nickel, Helga; Radmacher, Oliver; Haas, Hannah; Swantek, Jennifer L.; Souza, Don; Canfield, Melissa; White, Della; Panzenbeck, Mark; Kashem, Mohammed A.; Sanville-Ross, Mary; Kono, Takeshi; Sewald, Katherina; Braun, Armin; Obernolte, Helena; Danov, Olga; Schaenzle, Gerhard; Rast, Georg; Maier, Gerd-Michael; Hoffmann, Matthias
Journal Article
2016Cigarette smoke and cigarette smoke condensate induce early biomarkers of inflammation and cytotoxicity in precision-cut lung slices
Obernolte, H.; Ritter, D.; Knebel, J.W.; Braubach, P.; Jonigk, D.; Fieguth, H.-G.; Braun, A.; Sewald, K.
Abstract
2016Different pathways of inflammasome activation in human precision-cut lung slices (PCLS)
Konzok, S.; Braubach, P.; Peter, D.; Jonigk, D.; Fieguth, H.-G.; Braun, A.; Sewald, K.
Abstract
2016Efficacy assessment of a novel disruptive IgE inhibitor in non-human primate and human precision-cut lung slices
Wichmann, J.; Jimenez-Delgado, S.; Curths, C.; Schmitt, A.; Dunker, S.; Jonigk, D.; Braubach, P.; Kaup, F.-J.; Braun, A.; Eggel, A.; Dahlmann, F.; Sewald, K.; Knauf, S.
Abstract
2016Marmoset monkeys as a model for human allergic asthma
Curths, C.; Jimenez-Delgado, S.; Wichmann, J.; Kap, Y.; Kaup, F.-J.; Braun, A.; Sewald, K.; Knauf, S.; Dahlmann, F.
Abstract
2016No GVHD, but Human Inflammatory "Cytokine Storm" and Mouse Macrophage Activation Upon Accelerated Development of Human CD4+ Effector Memory T Cells in Long-Term Humanized Mice
Sundarasetty, B.S.; Schneider, A.; Sewald, K.; Rittinghausen, S.; Braun, A.; Figueiredo, C.; Ganser, A.; Stripecke, R.
Abstract
2016A novel disruptive IgE inhibitor: Efficacy assessment in non-human primate and human precision-cut lung slices
Wichmann, J.; Jimenez-Delgado, S.; Curths, C.; Schmitt, A.; Dunker, S.; Jonigk, D.; Braubach, P.; Kaup, F.J.; Braun, A.; Dahlmann, F.; Eggel, A.; Sewald, K.; Knauf, S.
Abstract
2016Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity
Hess, A.; Wang-Lauenstein, Lan; Braun, Armin; Kolle, S.N.; Landsiedel, Robert; Liebsch, M.; Ma-Hock, Lan; Pirow, R.; Schneider, X.; Steinfath, M.; Vogel, S.; Martin, C.; Sewald, Katherina
Journal Article
2016Tierversuchsfreie Methoden in der Toxikologie
Koschmann, J.; Sewald, K.; Escher, S.E.
Journal Article
2016Transient Receptor Potential (TRP) ion channels activation in vital human precision-cut lung slices lead to bronchoconstriction and is neuropeptide substance P-dependent
Delgado, S.M.J.; Obernolte, H.; Hobbie, S.; Schindler, S.; Jonigk, D.; Warnecke, G.; Braubach, P.; Bersch, C.; Pfennig, O.; Fieguth, H.G.; Sewald, K.; Braun, A.
Abstract
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Constructing an adverse outcome pathway for sensitization of the respiratory tract: Network thinking meets regulatory utility
Sullivan, K.; Cochrane, S.; Enoch, S.J.; Ezendam, J.; Patlewicz, G.; Roggen, E.L.; Sewald, Katherina
Abstract
2015Development of a human organotypic tumor invasion model of cancer cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS)
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Development of hematological and immunological characteristics in neonatal rats
Sewald, Katherina; Müller, Meike; Buschmann, Jochen; Hansen, Tanja; Lewin, Geertje
Journal Article, Conference Paper
2015Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Inhalation toxicity of carbon black depends on surface coating with polycyclic aromatic hydrocarbons
Hansen, Tanja; König, P.; Creutzenberg, Otto H.; Weinhold, K.; Schlick, S.; Tillmann, Thomas; Pohlmann, Gerhard; Kolling, Angelika; Ziemann, Christina; Kopf, Johannes; Ströbele, Michael; Bockhorn, H.; Danov, Olga; Sewald, Katherina; Müller, B.; Fehrenbach, Heinz
Abstract
2015New investigations into the genotoxicity of cobalt compounds and their impact on overall assessment of genotoxic risk
Kirkland, David; Brock, Tom; Haddouk, Hasnaà; Hargeaves, Victoria; Lloyd, Melvyn; Mc Garry, Sarah; Proudlock, Raymond; Sarlang, Séverine; Sewald, Katherina; Sire, Guillaume; Sokolowski, Andrea; Ziemann, Cristina
Journal Article
2015A novel human organotypic tumor invasion model of cell line MDA-MB-231 in Precision-Cut Lung Slices (PCLS) to reduce animal experiments in preclinical oncology
Konzok, Sebastian; Schindler, Susann; Jonigk, Danny; Braubach, Peter; Braun, Armin; Sewald, Katherina
Abstract
2015Passively sensitized human organotypic tissue as asthma model to study mast cell-nerve interaction
Jiménez Delgado, S.M.; Schindler, S.; Sewald, K.; Armin, B.
Abstract
2015Pathogen reduction by ultraviolet C light effectively inactivates human white blood cells in platelet products
Pohler, Petra; Müller, Meike; Winkler, Carla; Schaudien, Dirk; Sewald, Katherina; Müller, Thomas H.; Seltsam, Axel
Journal Article
2015Peripheral sensory nerves stimulation lead to bronchoconstriction-augment in passive sensitized human precision-cut lung slices and Is histamine 1 receptor dependent
Jiménez Delgado, Sharon Melissa; Schindler, Susann; Sewald, Katherina; Braun, Armin
Abstract
2015Precision-cut lung slices as an alternative model for repeated-dose inhalation toxicity
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Syliva; Braun, Armin; Sewald, Katherina
Abstract
2015Risk assessment of inhalable read-across chemicals with different mode of action showed great differences in cytotoxicity in rat and human precision-cut lung slices
Danov, Olga; Schröder, Katrin; Braubach, Peter; Jonigk, D.; Warnecke, G.; Braun, Armin; Escher, Syliva; Sewald, Katherina
Abstract
2015Species comparison of rat and human precision-cut lung slices as an alternative in risk assessment based on read-across approach
Danov, Olga; Escher, Sylvia E.; Schröder, Katrin; Vorgrimmler, David; Bersch, Claus; Braubach, Peter; Jonigk, Danny; Pfennig, Olaf; Warnecke, Gregor; Braun, Armin; Sewald, Katherina
Abstract
2015Translational models for acute respiratory injury and inflammation using precision cut lung slices
Sewald, Katherina
Abstract
2015Use of ex vivo organotypic lung tissue in translational research of respiratory injury and inflammation diseases
Sewald, Katherina
Abstract
2014Alternative model for repeated dose inhalation toxicity using precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Witte, J.; Romberg, Susanne; Escher, Sylvia; Schaudien, Dirk; Braun, Armin; Sewald, Katherina
Abstract
2014Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS)
Lauenstein, L.; Switalla, S.; Prenzler, F.; Seehase, S.; Pfennig, O.; Förster, C.; Fieguth, H.; Braun, A.; Sewald, K.
Journal Article
2014Biological impact of modified inhalable carbon black nanoparticles assessed in cell and tissue culture models
Danov, Olga; Kopf, Johannes; Ströbele, M.; Bockhorn, H.; Fehrenbach, H.; Braun, Armin; Sewald, Katherina; Hansen, Tanja
Abstract
2014Biomarker for eosinophil and T-cell recruitment induced by interleukin-13 as a therapeutic target for allergic asthma tested in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, H.; Pfennig, Olaf; Förster, C.; Hohlbaum, A.; Audoly, L.; Braun, Armin; Sewald, Katherina
Abstract
2014Characterization of IL-13- and allergen-induced airway hyperreactivity in precision-cut lung slices of different species
Drake, Helena
: Förster, Irmgard (Supervisor); Burgdorf, Sven (Supervisor); Sewald, Katherina (Advisor); Braun, Armin (Advisor)
Master Thesis
2014Ex vivo models for asthma, COPD and lung injury in precision cut lung slices (PCLS)
Sewald, Katherina; Braun, Armin
Abstract
2014Frühe Phase der Allergen-induzierten Atemwegsreaktion beim Weißbüschelaffen nach passiver Sensibilisierung von Lungengewebe mit humanem Blutplasma
Wichmann, Judy; Jiménez Delgado, Sharon Melissa; Curths, Christoph; Becker, Tamara; Kaup, Franz Josef; Braun, Armin; Sewald, Katherina; Knauf, Sascha
Abstract
2014Human organotypic cancer model
Konzok, Sebastian; Schindler, Susann; Braun, Armin; Sewald, Katherina
Abstract
2014IL-13 induced asthma model in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, H.; Seehase, Sophie; Hohlbaum, A.M.; Bersch, C.; Jonigk, D.; Warnecke, G.; Braun, Armin; Sewald, Katherina
Abstract
2014Interleukin-13 as a therapeutic target for allergic asthma tested in human precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Pfennig, Olaf; Forster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Braun, Armin; Sewald, Katherina
Abstract
2014Lung tissue culture model for assessment of cytotoxicity and inflammation induced by inhalable carbon black nanoparticles
Braun, Armin; Danov, Olga; Kopf, Johannes Claudius; Ströbele, Michael; Hansen, Tanja; Fehrenbach, Heinz; Sewald, Katherina
Abstract
2014Murine precision-cut liver slices (PCLS): A new tool for studying tumor microenvironments and cell signaling ex vivo
Koch, Alexandra; Saran, Shashank; Tran, Doan Duy Hai; Klebba-Färber, Sabine; Thiesler, Hauke; Sewald, Katherina; Schindler, Susann; Braun, Armin; Klopfleisch, Robert; Tamura, Teruko
Journal Article
2014A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung
Neuhaus, Vanessa; Chichester, Jessica A.; Ebensen, Thomas; Schwarz, Katharina; Cartman, Caitlin E.; Shoji, Yoko; Guzman, Carlos A.; Yusibov, Vidadi; Sewald, Katherina; Braun, Armin
Journal Article
2014Passively sensitized precision-cut lung slices from marmoset monkeys as a preclinical assay to test novel IgE inhibitors
Wichmann, Judy; Jiménez Delgado, Sharon Melissa; Curths, Christoph; Becker, Tamara; Eggel, Alexander; Kaup, Franz-Josef; Braun, Armin; Sewald, Katherina; Knauf, Sascha
Abstract
2014Pre-validation of the ex vivo model precision-cut lung slices (PCLS) for prediction of acute inhalation toxicity
Sewald, Katherina; Lauenstein, Lan; Schneider, X.; Pirow, R.; Steinfath, M.; Ma-Hock, L.; Liebsch, M.; Landsiedel, R.; Braun, Armin; Martin, C.
Abstract
2014Precision-cut lung slices as alternative to mimic inflammation, lung injury and bronchoconstriction after short and long-term maintenance in culture
Neuhaus, Vanessa; Schaudien, Dirk; Sewald, Katherina; Braun, Armin
Abstract
2014Prevalidation of the ex vivo model PCLS for the prediction of acute inhalation toxicity
Sewald, Katherina; Hess, A.; Lauenstein, Lan; Schneider, X.; Vogel, S.; Steinfath, M.; Pirow, R.; Liebsch, M.; Kolle, S.; Ma-Hock, L.; Landsiedel, R.; Martin, C.; Braun, Armin
Abstract
2014Promises and challenges in constructing an adverse outcome pathway for chemical sensitization of the respiratory tract
Sullivan, K.; Cochrane, S.; Enoch, S.; Kimber, I.; Patlewicz, G.; Roggen, E.; Sewald, Katherina; Ezendam, J.
Abstract
2014Rhinovirus infection in human and mouse precision cut lung slices
Rochlitzer, Sabine; Müller, Meike; Sewald, Katherina; Braun, Armin
Abstract
2014Species comparison of interleukin-13 induced airway hyperreactivity in precision-cut lung slices
Danov, Olga; Jiménez Delgado, Sharon Melissa; Drake, Helena; Schindler, Susann; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Journal Article, Conference Paper
2014Use of rat precision-cut lung slices for long-term functional evaluation
Neuhaus, Vanessa; Braun, Armin; Sewald, Katherina
Abstract
2013Assessment of immunotoxicity using precision-cut tissue slices
Sewald, Katherina; Braun, Armin
Journal Article
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Journal Article
2013Effects of carbon black nanoparticles on human pulmonary cell lines and precision cut lung slices
Hansen, Tanja; Kopf, Johannes Claudius; Danov, Olga; Ströbele, M.; Braun, Armin; Sewald, Katherina; Steinberg, P.; Fehrenbach, H.
Journal Article, Conference Paper
2013Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique
Neuhaus, Vanessa; Schwarz, Katharina; Klee, Anna; Seehase, Sophie; Förster, Christine; Pfennig, Olaf; Jonigk, Danny; Fieguth, Hans-Gerd; Koch, Wolfgang; Warnecke, Gregor; Yusibov, Vidadi; Sewald, Katherina; Braun, Armin
Journal Article
2013IL-13-induced cytokine release and hyperresponsiveness in precision cut lung slices of different species - characterization of a model potentially suitable for translational research of asthma cellular events
Jiménez Delgado, Sharon Melissa; Danov, Olga; Braun, Armin; Pfenning, Olaf; Förster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Hohlfeld, Jens; Sewald, Katherina
Journal Article, Conference Paper
2013In vitro and ex vivo toxicity screening for predicting toxicological effects of synthetic carbon black nanoparticles in humans
Hansen, Tanja; Kopf, Johannes; Danov, Olga; Ströbele, Michael; Braun, Armin; Sewald, Katherina; Bockhorn, H.; Fehrenbach, Heinz
Journal Article, Conference Paper
2013Pre-validation of the ex vivo model precision cut lung slices (PCLuS) for the prediction of respiratory toxicology
Hess, A.; Lauenstein, Lan; Schneider, X.; Vogel, S.; Ma-Hock, L.; Kolle, S.; Martin, C.; Pirow, R.; Steinfath, M.; Liebsch, M.; Landsiedel, R.; Braun, Armin; Sewald, Katherina
Journal Article, Conference Paper
2013Prevalidation of the ex vivo model precision cut lung slices (PCLS) for the prediction of respiratory toxicology
Sewald, Katherina; Lauenstein, Lan; Vogel, S.; Hess, A.; Schneider, X.; Martin, C.; Pirow, R.; Liebsch, M.; Landsiedel, R.; Braun, Armin
Journal Article, Conference Paper
2013Toxicity profile of the GATA-3-specific DNAzyme hgd40 after inhalation exposure
Fuhst, R.; Runge, F.; Buschmann, J.; Ernst, H.; Praechter, C.; Hansen, T.; Erichsen, J. von; Turowska, A.; Hoymann, H.-G.; Müller, M.; Pohlmann, G.; Sewald, K.; Ziemann, C.; Schlüter, G.; Garn, H.
Journal Article
2013A translational non-human primate model for human asthma in the common marmoset (Callithrix Jacchus)
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens M.; Sewald, Katherina; Windt, Horst; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales LPS-Modell zur präklinischen Testung anti-inflammatorischer Substanzen im Weißbüschelaffen (Callithrix jacchus)
Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz Josef; Schlumbohm, Christina; Fuchs, E.; Lauenstein, Hans Dieter; Sewald, Katherina; Hohlfeld, Jens M.; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales Tiermodell für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Becker, T.; Kaup, Franz Josef; Schlumbohm, Christina; Sewald, Katherina; Hohlfeld, Jens M.; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2012Assessment of lung toxicity induced by chemical allergens in human precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Prenzler, Frauke; Pfennig, Olaf; Förster, Christine; Braun, Armin; Sewald, Katherina
Abstract
2012Bacillus Anthracis lethal toxin impairs alveolar epithelial barrier function
Langer, M.; Booth, J.; Duggan, E.S.; Patel, V.I.; Awasthi, S.; Metcalf, J.; Veres, T.Z.; Prenzler, F.; Sewald, K.; Braun, A.; Lupu, F.; Coggeshall, K.
Conference Paper, Journal Article
2012Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function
Langer, Marybeth; Duggan, Elizabeth S.; Booth, John L.; Patel, Vineet I.; Zander, Ryan A.; Silasi-Mansat, Robert; Ramani, Vijay; Veres, Tibor Z.; Prenzler, Frauke; Sewald, Katherina; Williams, Daniel M.; Coggeshall, Kenneth M.; Awasthi, Shanjana; Lupu, Florea; Burian, Dennis; Ballard, Jimmy D.; Braun, Armin; Metcalf, Jordan P.
Journal Article
2012Effect of Tiotropium on in vivo and ex vivo lung function in a rat model of bronchoconstriction
Seehase, Sophie; Köhncke, Sarah-Philine; Hoymann, Heinz-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2012Ex vivo lung culture models of marmoset monkeys and humans for anti-inflammatory drug testing
Seehase, Sophie; Neuhaus, Vanessa; Kaup, Franz-Josef; Pfennig, O.; Förster, Christine; Hohlfeld, Jens Michael; Knauf, Sascha; Braun, Armin; Sewald, Katherina
Abstract
2012Immunotoxic characterization of a nanoparticle-based inhalable influenza vaccine in murine and human precision cut lung slices
Neuhaus, Vanessa; Schwarz, Katharina; Koch, Wolfgang; Sewald, Katherina; Yusibov, V.; Braun, Armin
Abstract
2012LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing
Seehase, S.; Lauenstein, H.D.; Schlumbohm, C.; Switalla, S.; Neuhaus, V.; Förster, C.; Fieguth, H.G.; Pfennig, O.; Fuchs, E.; Kaup, F.J.; Bleyer, M.; Hohlfeld, J.M.; Braun, A.; Sewald, K.; Knauf, S.
Journal Article
2012Neurally mediated airway constriction in human and other species
Schlepütz, M.; Rieg, A.D.; Seehase, S.; Spillner, J.; Perez-Bouza, A.; Braunschweig, T.; Schroeder, T.; Bernau, M.; Lambermont, V.; Schlumbohm, C.; Sewald, K.; Autschbach, R.; Braun, A.; Kramer, B.W.; Uhlig, S.; Martin, C.
Journal Article
2012A new model for testing human specific anti-inflammatory drugs: LPS-induced lung inflammation in the common marmoset
Knauf, Sascha; Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz-Josef; Schlumbohm, Christina; Fuchs, Eberhard; Lauenstein, Hand D.; Sewald, Katherina; Hohlfeld, Jens Michael; Braun, Armin
Abstract
2011Bronchoconstriction in nonhuman primates: A species comparison
Seehase, S.; Schlepütz, M.; Switalla, S.; Mätz-Rensing, K.; Kaup, F.J.; Zöller, M.; Schlumbohm, C.; Fuchs, E.; Lauenstein, H.-D.; Winkler, C.; Kuehl, A.R.; Uhlig, S.; Braun, A.; Sewald, K.; Martin, C.
Journal Article
2011Human Alveolar Epithelial Cells are a Target for Bacillus Anthracis
Metcalf, J.; Langer, M.; Booth, J.; Duggan, E.; Patel, V.; Veres, T.; Prenzler, F.; Sewald, K.; Braun, A.; Coggeshall, K.
Abstract
2011Mechanisms of bronchoconstriction in precision-cut lung slices of non-human primates are comparable to human
Seehase, Sophie; Schlepütz, M.; Switalla, Simone; Fuchs, E.; Kaup, F.-J.; Ressmeyer, A.R.; Uhlig, S.; Lauenstein, Hans-Dieter; Braun, Armin; Martin, C.; Sewald, Katherina
Conference Paper, Journal Article
2011PCLS: From learning about 'in vivo' to reduction and replacement
Sewald, Katherina; Braun, Armin
Book Article
2011The phosphodiesterase-4-inhibitor Roflumilast reduces LPS-induced lung inflammation in common marmoset monkeys
Seehase, Sophie; Switalla, Simone; Prenzler, Frauke; Fuchs, E.; Schlumbohm, C.; Kaup, F.-J.; Sewald, Katherina; Lauenstein, Hans-Dieter; Braun, Armin
Conference Paper, Journal Article
2011Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation
Vandebriel, Rob; Cransveld, Conchita Callant; Crommelin, Daan; Diamant, Zuzana; Glazenburg, Berend; Joos, Guy; Kuper, Frieke; Natsch, Andreas; Nijkamp, Frans; Noteborn, Hub; Pieters, Raymond; Roberts, David; Roggen, Erwin; Rorije, Emiel; Seed, Martin; Sewald, Katharina; Heuvel, Rosette van den; Engelen, Jacqueline van; Verstraelen, Sandra; Loveren, Henk van
Journal Article
2010Analysis of particulate contaminations of infusion solutions in a pediatric intensive care unit
Jack, T.; Brent, B.E.; Böhne, M.; Müller, M.; Sewald, K.; Braun, A.; Wessel, A.; Sasse, M.
Journal Article
2010Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air-liquid interface (ALI) culture
Switalla, S.; Knebel, J.; Ritter, D.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices
Switalla, S.; Lauenstein, L.; Prenzler, F.; Knothe, S.; Förster, C.; Fieguth, H.-G.; Pfennig, O.; Schaumann, F.; Martin, C.; Guzman, C.A.; Ebensen, T.; Müller, M.; Hohlfeld, J.M.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010PCLS (Precision Cut Lung Slices) as a putative model for genotoxicity testing by application of the comet assay
Ritter, D.; Switalla, S.; Sewald, K.; Knebel, J.
Abstract
2010A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung
Nassimi, M.; Schleh, C.; Lauenstein, H.D.; Hussein, R.; Hoymann, H.G.; Koch, W.; Pohlmann, G.; Krug, N.; Sewald, K.; Rittinghausen, S.; Braun, A.; Müller-Goymann, C.
Journal Article
2009Comparison of asthmatic airway responses in rats in vivo and in vitro
Martin, C.; Ressmeyer, A.R.; Dassow, C.; Henjacovic, M.; Sewald, K.; Hoymann, H.G.
Abstract
2009Cytokine production after acute exposure of precision cut lung slices to NO2 and O3
Switalla, S.; Ritter, D.; Krug, N.; Knebel, J.; Braun, A.; Sewald, K.
Abstract
2009Different cytokine pattern in human precision cut lung slices after treatment with respiratory and contact allergens
Switalla, S.; Wang, L.; Foerster, C.; Hohlfeld, J.; Krug, N.; Braun, A.; Sewald, K.
Abstract
2009Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models
Nassimi, M.; Schleh, C.; Lauenstein, H.-D.; Hussein, R.; Lübbers, K.; Pohlmann, G.; Switalla, S.; Sewald, K.; Müller, M.; Krug, N.; Müller-Goymann, C.C.; Braun, A.
Journal Article
2009Precision cut lung slices (PCLS) as a tool to predict effective LPS concentrations for in vivo use in common marmoset monkeys
Seehase, S.; Switalla, S.; Schlumbohm, C.; Knöchelmann, N.; Krug, N.; Sewald, K.; Kaup, F.-J.; Fuchs, E.; Braun, A.
Abstract
2009Respiratory toxicology and immunotoxicology in human precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Wang, L.; Pfennig, O.; Förster, C.; Krug, N.; Braun, A.
Abstract
2009Trimellitic anhydride-induced immune responses in murine and human precision-cut lung slices
Wang, L.; Switalla, S.; Förster, C.; Krug, N.; Hohlfeld, J.; Braun, A.; Sewald, K.
Abstract
2008Chemikalien in der Lunge
Sewald, K.
Journal Article
2008Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies
Henjakovic, M.; Martin, C.; Hoymann, H.G.; Sewald, K.; Ressmeyer, A.R.; Dassow, C.; Pohlmann, G.; Krug, N.; Uhlig, S.; Braun, A.
Journal Article
2008Ex vivo testing of immune responses in precision-cut lung slices
Henjakovic, M.; Sewald, K.; Switalla, S.; Kaiser, D.; Müller, M.; Veres, T.Z.; Martin, C.; Uhlig, S.; Krug, N.; Braun, A.
Journal Article
2008Precision cut lung slices for prediction of sensitizing potential of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Mueller, M.; Veres, T.; Krug, N.; Braun, A.
Abstract
2008Precision cut lung slices for testing of gaseous compounds
Switalla, S.; Sewald, K.; Ritter, D.; Henjakovic, M.; Krug, N.; Knebel, J.; Braun, A.
Conference Paper, Journal Article
2008Respiratory toxicology and immunotoxicology in precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Henjakovic, M.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Precision cut lung slices (PCLS) for respiratory sensitisation potential testing of allergens and irritants
Henjakovic, M.; Sewald, K.; Switalla, S.; Veres, T.; Mätz-Rensing, K.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Precision cut lung slices as tool for assessment of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Veres, T.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2005Integrin 51: A new purification strategy based on immobilized peptides
Wobbe, L.; Zimmermann, D.; Wißbrock, M.; Urman, S.; Sewald, K.; Maleevi, M.; Sewald, N.
Journal Article