Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020Amyloid-beta peptides trigger aggregation of alpha-synuclein in vitro
Köppen, Janett; Schulze, Anja; Machner, Lisa; Wermann, Michael; Eichentopf, Rico; Guthardt, Max; Hähnel, Angelika; Klehm, Jessica; Kriegeskorte, Marie-Christin; Hartlage-Rübsamen, Maike; Morawski, Markus; Hörsten, Stephan von; Demuth, Hans-Ulrich; Roßner, Steffen; Schilling, Stephan
Journal Article
2020Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice
Crehan, Helen; Liu, Bin; Kleinschmidt, Martin; Rahfeld, Jens-Ulrich; Le, Kevin X.; Caldarone, Barbara J.; Frost, Jeffrey L.; Hettmann, Thore; Hutter-Paier, Birgit; O'Nuallain, Brian; Park, Mi-Ae; DiCarli, Marcelo F.; Lues, Inge; Schilling, Stephan; Lemere, Cynthia A.
Journal Article
2018Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Schulze, Anja; Wermann, Michael; Demuth, Hans-Ulrich; Yoshimoto, Tadashi; Ramsbeck, Daniel; Schlenzig, Dagmar; Schilling, Stephan
Journal Article
2018Dipeptidyl-peptidase activity of meprin β links N-truncation of Aβ with glutaminyl cyclase-catalyzed pGlu-Aβ formation
Schlenzig, Dagmar; Cynis, Holger; Hartlage-Rübsamen, Maike; Zeitschel, Ulrike; Menge, Katja; Fothe, Anja; Ramsbeck, Daniel; Spahn, Claudia; Wermann, Michael; Roßner, Steffen; Buchholz, Mirko; Schilling, Stephan; Demuth, Hans-Ulrich
Journal Article
2018Passive Aβ immunotherapy: Current achievements and future perspectives
Schilling, Stephan; Rahfeld, Jens-Ulrich; Lues, Inge; Lemere, Cynthia A.
Journal Article
2018Structure-guided design, synthesis, and characterization of next-generation meprin β inhibitors
Ramsbeck, Daniel; Hamann, Antje; Richter, Georg; Schlenzig, Dagmar; Geißler, Stefanie; Nykiel, Vera; Cynis, Holger; Schilling, Stephan; Buchholz, Mirko
Journal Article
2018Tertiary‐amine‐based inhibitors of the astacin protease meprin α
Tan, Kathrin; Jäger, Christian; Schlenzig, Dagmar; Schilling, Stephan; Buchholz, Mirko; Ramsbeck, Daniel
Journal Article
2017Posttranslational modification impact on the mechanism by which amyloid‐β induces synaptic dysfunction
Grochowska, Katarzyna M.; Yuanxiang, PingAn; Bär, Julia; Raman, Rajeev; Brugal, Gemma; Sahu, Giriraj; Schweizer, Michaela; Bikbaev, Arthur; Schilling, Stephan; Demuth, Hans-Ulrich; Kreutz, Michael R.
Journal Article
2017Recent progress in translational research on neurovascular and neurodegenerative disorders
Demuth, Hans-Ulrich; Dijkhuizen, Rick M.; Farr, Tracy D.; Gelderblom, Mathias; Horsburgh, Karen; Iadecola, Costantino; Mcleod, Damian D.; Michalski, Dominik; Murphy, Tim H.; Orbe, Josune; Otte, Wilem M.; Petzold, Gabor C.; Plesnila, Nikolaus; Reiser, Georg; Reymann, Klaus G.; Rueger, Maria P.; Saur, Dorothee; Savitz, Sean; Schilling, Stephan; Spratt, Neil J.; Turner, Renée J.; Vermuganti, Raghu; Vivien, Denis; Yepes, Manuel; Zille, Marietta; Boltze, Johannes
Journal Article
2015An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice
Frost, Jeffrey L.; Liu, Bin; Rahfeld, Jens-Ulrich; Kleinschmidt, Martin; O'Nuallain, Brian; Le, Kevin X.; Lues, Inge; Caldarone, Babara J.; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A.
Journal Article
2015Development of a strategy for the purification of different β-Amyloid species using preparative gel electrophoresis
Spahn, Claudia
: Schilling, Stephan (Supervisor); Pietzsch, Markus (Supervisor)
Master Thesis
2015Expression, purification and initial characterization of human meprin β from Pichia pastoris
Schlenzig, Dagmar; Wermann, Michael; Ramsbeck, Daniel; Moenke-Wedler, Thurid; Schilling, Stephan
Journal Article
2015Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes
Waniek, Alexander; Hartlage-Rübsamen, Maike; Höfling, Corinna; Kehlen, Astrid; Schilling, Stephan; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2015Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease
Hartlage-Rübsamen, Maike; Waniek, Alexander; Meißner, Juliane; Morawski, Markus; Schilling, Stephan; Jäger, Carsten; Kleinschmidt, Martin; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2014Glutaminyl cyclase in human cortex: Correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease
Morawski, Markus; Schilling, Stephan; Kreuzberger, Moritz; Waniek, Alexander; Jäger, Carsten; Koch, Birgit; Cynis, Holger; Kehlen, Astrid; Arendt, Thomas; Hartlage-Rübsamen, Maike; Demuth, Hans-Ulrich; Roßner, Steffen
Journal Article
2014Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
Höfling, Corinna; Indrischek, Henrike; Höpcke, Theodor; Waniek, Alexander; Cynis, Holger; Koch, Birgit; Schilling, Stephan; Morawski, Markus; Demuth, Hans-Ulrich; Roßner, Steffen; Hartlage-Rübsamen, Maike
Journal Article
2013Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration
Becker, Andreas; Kohlmann, Stephanie; Alexandru, Anca; Jagla, Wolfgang; Canneva, Fabio; Bäuscher, Christoph; Cynis, Holger; Sedlmeier, Reinhard; Graubner, Sigrid; Schilling, Stephan; Demuth, Hans-Ulrich; Hörsten, Stephan von
Journal Article
2013Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice
Cynis, Holger; Kehlen, Astrid; Haegele, Monique; Hoffmann, Torsten; Heiser, Ulrich; Fujii, Masato; Shibazaki, Yuichiro; Yoneyama, Hiroyuki; Schilling, Stephan; Demuth, Hans-Ulrich
Journal Article
2013Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease–like transgenic mouse models
Frost, Jeffrey L.; Le, Kevin X.; Cynis, H.; Ekpo, Elisabeth; Kleinschmidt, Martin; Palmour, Roberta M.; Ervin, Frank R.; Snigdha, Shikha; Cotman, Carl W.; Saido, Takaomi C.; Vassar, Robert J.; George-Hyslop, Peter S.; Ikezu, Tsuneya; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A.
Journal Article
2013A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues
Güttler, Bert H.-O.; Cynis, Holger; Seifert, Franziska; Ludwig, Hans-Henning; Porzel, Andrea; Schilling, Stephan
Journal Article