Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Critical analysis of the commercial potential of plants for the production of recombinant proteins
Schillberg, S.; Raven, N.; Spiegel, H.; Rasche, S.; Buntru, M.
Journal Article
2019Genome Editing in Agriculture: Technical and Practical Considerations
Jansing, Julia; Schiermeyer, Andreas; Schillberg, Stefan; Fischer, Rainer; Bortesi, Luisa
Journal Article
2019The immunome of soy bean allergy: Comprehensive identification and characterization of epitopes
Kern, Karolin; Havenith, Heide; Delaroque, Nicolas; Rautenberger, Paul; Lehmann, Jörg; Fischer, Markus; Spiegel, Holger; Schillberg, Stefan; Ehrentreich-Förster, Eva; Aurich, Stefanie; Treudler, Regina; Szardenings, Michael
Journal Article
2019The Integration of Algal Carbon Concentration Mechanism Components into Tobacco Chloroplasts Increases Photosynthetic Efficiency and Biomass
Nölke, G.; Barsoum, M.; Houdelet, M.; Arcalis, E.; Kreuzaler, F.; Fischer, R.; Schillberg, S.
Journal Article
2019Monoclonal Antibody AP3 Binds Galactomannan Antigens Displayed by the Pathogens Aspergillus flavus, A. fumigatus, and A. parasiticus
Schubert, M.; Xue, S.; Ebel, F.; Vaggelas, A.; Krylov, V.B.; Nifantiev, N.E.; Chudobova, I.; Schillberg, S.; Nölke, G.
Journal Article
2019Organismen als Produzenten: Produktion von Wertstoffen mithilfe von Mikroorganismen, Algen und Pflanzenzellen
Rasche, Stefan; Schillberg, Stefan; Derwenskus, Felix; Schmid-Staiger, Ulrike; Schließmann, Ursula
Book Article
2019Simplified tracking of a soy allergen in processed food using a monoclonal antibody-based sandwich ELISA targeting the soybean 2S albumin gly m 8
Ueberham, Elke; Spiegel, Holger; Havenith, Heide; Rautenberger, Paul; Lidzba, Norbert; Schillberg, Stefan; Lehmann, Jörg
Journal Article
2019Targeted insertion of large DNA sequences by homology-directed repair or non-homologous end joining in engineered tobacco BY-2 cells using designed zinc finger nucleases
Schiermeyer, Andreas; Schneider, Katja; Kirchhoff, Janina; Schmelter, Thomas; Koch, Natalie; Ke, Jiang; Herwartz, Denise; Blue, Ryan; Marri, Pradeep; Samuel, Pon; Corbin, David R.; Webb, Steven R.; Gonzalez, Delkin O.; Folkerts, Otto; Fischer, Rainer; Schinkel, Helga; Ainley, W. Michael; Schillberg, Stefan
Journal Article
2018Aspergillus-specific antibodies: Targets and applications
Schubert, M.; Spiegel, H.; Schillberg, S.; Nölke, G.
Journal Article
2018Cell-free protein synthesis system
Buntru, Matthias; Schillberg, Stefan; Vogel, Simon
Patent
2018Promoter construct for cell-free protein synthesis
Buntru, Matthias; Schillberg, Stefan; Vogel, Simon
Patent
2018Proteomic analysis of CHO cell lines producing high and low quantities of a recombinant antibody before and after selection with methotrexate
Hausmann, R.; Chudobová, I.; Spiegel, H.; Schillberg, S.
Journal Article
2017Animal component-free Agrobacterium tumefaciens cultivation media for better GMP-compliance increases biomass yield and pharmaceutical protein expression in Nicotiana benthamiana
Houdelet, M.; Galinski, A.; Holland, T.; Wenzel, K.; Schillberg, S.; Buyel, J.F.
Journal Article
2017Characteristics of Genome Editing Mutations in Cereal Crops
Zhu, C.; Bortesi, L.; Baysal, C.; Twyman, R.M.; Fischer, R.; Capell, T.; Schillberg, S.; Christou, P.
Journal Article
2017Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants
Havenith, Heide; Kern, Karolin; Rautenberger, Paul; Spiegel, Holger; Szardenings, Michael; Ueberham, Elke; Lehmann, Jörg; Buntru, Matthias; Vogel, Simon; Treudler, Regina; Fischer, Rainer; Schillberg, Stefan
Journal Article
2017Combined 15N-Labeling and TandemMOAC Quantifies Phosphorylation of MAP Kinase Substrates Downstream of MKK7 in Arabidopsis
Huck, N.V.; Leissing, F.; Majovsky, P.; Buntru, M.; Aretz, C.; Flecken, M.; Müller, J.P.J.; Vogel, S.; Schillberg, S.; Hoehenwarter, W.; Conrath, U.; Beckers, G.J.M.
Journal Article
2017Contained molecular farming using plant cell and tissue cultures
Schillberg, S.; Raven, Nicole; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Book Article
2017Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candiate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRpm2 Does Not Improve the In Vitro Efficacy
Spiegel, H.; Boes, A.; Fendel, R.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2016Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail
Boes, A.; Spiegel, H.; Kastilan, R.; Bethke, S.; Voepel, N.; Chudobova, I.; Bolscher, J.M.; Dechering, K.J.; Fendel, R.; Buyel, J.F.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2016Antibody-Mediated Pathogen Resistance in Plants
Peschen, D.; Schillberg, S.; Fischer, R.
Book Article
2016CRISPR/Cas9 activity in the rice OsBEIIb gene does not induce off-target effects in the closely related paralog OsBEIIa
Baysal, C.; Bortesi, L.; Zhu, C.; Farré, G.; Schillberg, S.; Christou, P.
Journal Article
2016Developments in the production of mucosal antibodies in plants
Vasilev, Nikolay; Smales, C. Mark; Schillberg, Stefan; Fischer, Rainer; Schiermeyer, Andreas
Journal Article
2016Genetically modified higher plants with increased photosynthesis and/or biomass production, methods and uses thereof
Kreuzaler, Fritz; Nölke, Greta; Schillberg, Stefan; Barsoum, Mirna; Fischer, Rainer
Patent
2016Genome editing: intellectual property and product development in plant biotechnology
Schinkel, H.; Schillberg, S.
Journal Article
2016Molecular farming
Fischer, R.; Schillberg, S.
Book Article
2016More for less: Improving the biomass yield of a pear cell suspension culture by design of experiments
Rasche, S.; Herwartz, D.; Schuster, F.; Jablonka, N.; Weber, A.; Fischer, R.; Schillberg, S.
Journal Article
2016Next-generation sequencing of amplicons is a rapid and reliable method for the detection of polymorphisms relevant for barley breeding
Fritsch, L.; Soeur, R.; Hansen, C.; Fischer, R.; Schillberg, S.; Schröper, F.
Journal Article
2016Patterns of CRISPR/Cas9 activity in plants, animals and microbes
Bortesi, L.; Zhu, C.; Zischewski, J.; Perez, L.; Bassié, L.; Nadi, R.; Forni, G.; Lade, S.B.; Soto, E.; Jin, X.; Medina, V.; Villorbina, G.; Munoz, P.; Farré, G.; Fischer, R.; Twyman, R.M.; Capell, T.; Christou, P.; Schillberg, S.
Journal Article
2016Plant Cell-Based Recombinant Antibody Manufacturing with a 200 L Orbitally Shaken Disposable Bioreactor
Raven, N.; Schillberg, S.; Rasche, S.
Book Article
2016A Plant-Based Transient Expression System for the Rapid Production of Malaria Vaccine Candidates
Boes, A.; Reimann, A.; Twyman, R.M.; Fischer, R.; Schillberg, S.; Spiegel, H.
Book Article
2016Statistical experimental designs for the production of secondary metabolites in plant cell suspension cultures
Schmitz, C.; Fritsch, L.; Fischer, R.; Schillberg, S.; Rasche, S.
Journal Article
2016Structured plant metabolomics for the simultaneous exploration of multiple factors
Vasilev, N.; Boccard, J.; Lang, G.; Grömping, U.; Fischer, R.; Goepfert, S.; Rudaz, S.; Schillberg, S.
Journal Article
2016Tackling unwanted proteolysis in plant production hosts used for molecular farming
Mandal, Manoj K.; Ahvari, Houtan; Schillberg, Stefan; Schiermeyer, Andreas
Journal Article
2016Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut
Schneider, Katja; Schiermeyer, Andreas; Dolls, Anja; Koch, Natalie; Herwartz, Denise; Kirchhoff, Janina; Fischer, Rainer; Russell, Sean M.; Cao, Zehui; Corbin, David R.; Sastry-Dent, Lakshmi; Ainley, W. Michael; Webb, Steven R.; Schinkel, Helga; Schillberg, Stefan
Journal Article
2015Analysis of a multi-component multi-stage malaria vaccine candidate-tackling the cocktail challenge
Boes, A.; Spiegel, H.; Voepel, N.; Edgue, G.; Beiss, V.; Kapelski, S.; Fendel, R.; Scheuermayer, M.; Pradel, G.; Bolscher, J.M.; Behet, M.C.; Dechering, K.J.; Hermsen, C.C.; Sauerwein, R.W.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Application of a scalable plant transient gene expression platform for malaria vaccine development
Spiegel, H.; Boes, A.; Voepel, N.; Beiss, V.; Edgue, G.; Rademacher, T.; Sack, M.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits
Boes, A.; Spiegel, H.; Edgue, G.; Kapelski, S.; Scheuermayer, M.; Fendel, R.; Remarque, E.; Altmann, F.; Maresch, D.; Reimann, A.; Pradel, G.; Schillberg, S.; Fischer, R.
Journal Article
2015Duplex-Real-Time-PCR zur Zygositäts-bestimmung in transgenen Pflanzen
Fritsch, L.D.; Schillberg, S.; Schröper, F.
Journal Article
2015Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein
Beiss, V.; Spiegel, H.; Boes, A.; Kapelski, S.; Scheuermayer, M.; Edgue, G.; Sack, M.; Fendel, R.; Reimann, A.; Schillberg, S.; Pradel, G.; Fischer, R.
Journal Article
2015High-value products from plants: the challenges of process optimization
Fischer, R.; Vasilev, N.; Twyman, R.M.; Schillberg, S.
Journal Article
2015Next-generation sequencing is a robust strategy for the high-throughput detection of zygosity in transgenic maize
Fritsch, L.; Fischer, R.; Wambach, C.; Dudek, M.; Schillberg, S.; Schroper, F.
Journal Article
2015Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites
Spiegel, H.; Schinkel, H.; Kastilan, R.; Dahm, P.; Boes, A.; Scheuermayer, M.; Chudobova, I.; Maskus, D.; Fendel, R.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Plant expression and characterization of the transmission-blocking vaccine candidate PfGAP50
Beiss, V.; Spiegel, H.; Boes, A.; Scheuermayer, M.; Reimann, A.; Schillberg, S.; Fischer, R.
Journal Article
2015Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor
Raven, N.; Rasche, S.; Kuehn, C.; Anderlei, T.; Klöckner, W.; Schuster, F.; Henquet, M.; Bosch, D.; Büchs, J.; Fischer, R.; Schillberg, S.
Journal Article
2015Simple and portable magnetic immunoassay for rapid detection and sensitive quantification of plant viruses
Rettcher, S.; Jungk, F.; Kühn, C.; Krause, H.J.; Nölke, G.; Commandeur, U.; Fischer, R.; Schillberg, S.; Schröper, F.
Journal Article
2015The stage-specific in vitro efficacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccines
Spiegel, H.; Boes, A.; Kastilan, R.; Kapelski, S.; Edgue, G.; Beiss, V.; Chubodova, I.; Scheuermayer, M.; Pradel, G.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015Thanatin confers partial resistance against aflatoxigenic fungi in maize (Zea mays)
Schubert, M.; Houdelet, M.; Kogel, K.-H.; Fischer, R.; Schillberg, S.; Nölke, G.
Journal Article
2015A versatile coupled cell-free transcription–translation system based on tobacco BY-2 cell lysates
Buntru, M.; Vogel, S.; Stoff, K.; Spiegel, H.; Schillberg, S.
Journal Article
2015Yeast surface display is a novel tool for the rapid immunological characterization of plant-derived food allergens
Popovic, M.; Prodanovic, R.; Ostafe, R.; Schillberg, S.; Fischer, R.; Gavrovic-Jankulovic, M.
Journal Article
2014Assessment of Cultivation Factors that Affect Biomass and Geraniol Production in Transgenic Tobacco Cell Suspension Cultures
Vasilev, N.; Schmitz, C.; Grömping, U.; Fischer, R.; Schillberg, S.
Journal Article
2014Comparative evaluation of heterologous production systems for recombinant pulmonary surfactant protein D
Salgado, D.; Fischer, R.; Schillberg, S.; Twyman, R.M.; Rasche, S.
Journal Article
2014Comparison of plant-based expression platforms for the heterologous production of geraniol
Vasilev, N.; Schmitz, C.; Dong, L.; Ritala, A.; Imseng, N.; Häkkinen, S.T.; Krol, S. van der; Eibl, R.; Oksman-Caldentey, K.-M.; Bouwmeester, H.; Fischer, R.; Schillberg, S.
Journal Article
2014A downstream process allowing the efficient isolation of a recombinant amphiphilic protein from tobacco leaves
Gecchele, E.; Schillberg, S.; Merlin, M.; Pezzotti, M.; Avesani, L.
Journal Article
2014Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway
Ritala, A.; Dong, L.; Imseng, N.; Seppänen-Laakso, T.; Vasilev, N.; Krol, S. van der; Rischer, H.; Maaheimo, H.; Virkki, A.; Brändli, J.; Schillberg, S.; Eibl, R.; Bouwmeester, H.; Oksman-Caldentey, K.-M.
Journal Article
2014The expression of a recombinant glycolate dehydrogenase polyprotein in potato (solanum tuberosum) plastids strongly enhances photosynthesis and tuber yield
Nölke, G.; Houdelet, M.; Kreuzaler, F.; Peterhänsel, C.; Schillberg, S.
Journal Article
2014Image-based analysis of cell-specific productivity for plant cell suspension cultures
Havenith, H.; Raven, N.; Fiore, S. di; Fischer, R.; Schillberg, S.
Journal Article
2014An immunohistochemical assay on human tissue using a human primary antibody
Peuscher, A.; Gassler, N.; Schneider, U.; Thom, P.; Rasche, S.; Spiegel, H.; Schillberg, S.
Journal Article
2014Inhibition of protease activity by antisense RNA improves recombinant protein production in Nicotiana tabacum cv. Bright Yellow 2 (BY-2) suspension cells
Mandal, Manoj K.; Fischer, Rainer; Schillberg, Stefan; Schiermeyer, Andreas
Journal Article
2014Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high level in plants
Voepel, N.; Boes, A.; Edgue, G.; Beiss, V.; Kapelski, S.; Reimann, A.; Schillberg, S.; Pradel, G.; Fendel, R.; Scheuermayer, M.; Spiegel, H.; Fischer, R.
Journal Article
2014Molecular Farming in Plants. The Long Road to the Market
Fischer, R.; Buyel, J.F.; Schillberg, S.; Twyman, R.M.
Book Article
2014Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody
Häkkinen, S.T.; Raven, N.; Henquet, M.; Laukkanen, M.-L.; Anderlei, T.; Pitkänen, J.-P.; Twyman, R.M.; Bosch, D.; Oksman-Caldentey, K.-M.; Schillberg, S.; Ritala, A.
Journal Article
2014Molecular pharming in plants and plant cell cultures: a great future ahead?
Ritala, A.; Häkkinen, S.T.; Schillberg, S.
Journal Article
2014The production of recombinant cationic α-helical antimicrobial peptides in plant cells induces the formation of protein bodies derived from the endoplasmic reticulum
Company, N.; Nadal, A.; La Paz, J.-L.; Martínez, S.; Rasche, S.; Schillberg, S.; Montesinos, E.; Pla, M.
Journal Article
2014Suspension culture of plant cells under heterotrophic conditions
Imseng, N.; Schillberg, S.; Schürch, C.; Schmid, D.; Schütte, K.; Gorr, G.; Eibl, D.; Eibl, R.
Book Article
2014Tobacco BY-2 cell-free lysate: An alternative and highly-productive plant-based in vitro translation system
Buntru, M.; Vogel, S.; Spiegel, H.; Schillberg, S.
Journal Article
2013Abscisic acid and the herbicide safener cyprosulfamide cooperatively enhance abiotic stress tolerance in rice
Dashevskaya, S.; Horn, R.; Chudobova, I.; Schillberg, S.; Vélez, S.M.R.; Capell, T.; Christou, P.
Journal Article
2013Commercial aspects of pharmaceutical protein production in plants
Fischer, R.; Schillberg, S.; Buyel, J.F.; Twyman, R.M.
Journal Article
2013Correlation between mass transfer coefficient kLa and relevant operating parameters in cylindrical disposable shaken bioreactors on a bench-to-pilot scale
Klöckner, W.; Gacem, R.; Anderlei, T.; Raven, N.; Schillberg, S.; Lattermann, C.; Büchs, J.
Journal Article
2013Generation and expression in plants of a single-chain variable fragment antibody against the immunodominant membrane protein of Candidatus Phytoplasma aurantifolia
Shahryari, F.; Safarnejad, M.R.; Shams-Bakhsh, M.; Schillberg, S.; Nölke, G.
Journal Article
2013Molecular farming of pharmaceutical proteins using plant suspension cell and tissue cultures
Schillberg, S.; Raven, N.; Fischer, R.; Twyman, R.M.; Schiermeyer, A.
Journal Article
2013Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method
Vasilev, N.; Grömping, U.; Lipperts, A.; Raven, N.; Fischer, R.; Schillberg, S.
Journal Article
2013Optimizing the yield of recombinant pharmaceutical proteins in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Journal Article
2013Plant-based production of recombinant plasmodium surface protein Pf38 and evaluation of its potential as a vaccine candidate
Feller, Tanja; Thom, Pascal; Koch, Natalie; Spiegel, Holger; Addai-Mensah, Otchere; Fischer, Rainer; Reimann, Andreas; Pradel, Gabriele; Fendel, Rolf; Schillberg, Stefan; Scheuermayer, Matthias; Schinkel, Helga
Journal Article
2013Protective oral vaccination against Infectious bursal disease virus using the major viral antigenic protein VP2 produced in Pichia pastoris
Taghavian, O.; Spiegel, H.; Hauck, R.; Hafez, H.M.; Fischer, R.; Schillberg, S.
Journal Article
2013Simultaneous treatment with tebuconazole and abscisic acid induces drought and salinity stress tolerance in arabidopsis thaliana by maintaining key plastid protein levels
Horn, Ruth; Chudobova, Ivana; Hänsel, Ulrike; Herwartz, Denise; Koskull-Döring, Pascal von; Schillberg, Stefan
Journal Article
2012Comprehensive characterization of two different Nicotiana tabacum cell lines leads to doubled GFP and HA protein production by media optimization
Ullisch, David A.; Müller, Christina A.; Maibaum, Sabrina; Kirchhoff, Janina; Schiermeyer, Andreas; Schillberg, Stefan; Roberts, Jean L.; Treffenfeldt, Wiltrud; Büchs, Jochen
Journal Article
2012Corrigendum to "Antibody-mediated resistance against plant pathogens" [Biotechnol Adv 29 (6) (2011) 961-971] (DOI:10.1016/j.biotechadv.2011.08.011)
Safarnejad, M.R.; Jouzani, G.S.; Tabatabaei, M.; Twyman, R.M.; Schillberg, S.
Journal Article
2012Development of an optimized tetracycline-inducible expression system to increase the accumulation of interleukin-10 in tobacco BY-2 suspension cells
Bortesi, Luisa; Rademacher, Thomas; Schiermeyer, Andreas; Schuster, Flora; Pezzotti, Mario; Schillberg, Stefan
Journal Article
2012GMP issues for recombinant plant-derived pharmaceutical proteins
Fischer, R.; Schillberg, S.; Hellwig, S.; Twyman, R.M.; Drossard, J.
Journal Article
2012Light-weight optical sensor for standoff detection of fluorescent biosensors
Wehner, M.; Thombansen, U.; Raven, N.; Kühn, C.; Schillberg, S.
Conference Paper
2012Method for the generation of a monoclonal plant cell line
Kirchhoff, Janina; Schillberg, Stefan; Schiermeyer, Andreas; Schinkel, Helga; Fischer, Rainer
Patent
2012Monoclonal tobacco cell lines with enhanced recombinant protein yields can be generated from heterogeneous cell suspension cultures by flow sorting
Kirchhoff, Janina; Raven, Nicole; Boes, Alexander; Roberts, Jean L.; Russell, Sean; Treffenfeldt, Wiltrud; Fischer, Rainer; Schinkel, Helga; Schiermeyer, Andreas; Schillberg, Stefan
Journal Article
2012Plant molecular pharming, pharmaceuticals for human health
Schiermeyer, Andreas; Schillberg, S.
Book Article
2012A potential nanobiotechnology platform based on infectious bursal disease subviral particles
Taghavian, Omid; Mandal, Manoj K.; Steinmetz, Nicole F.; Rasche, Stefan; Spiegel, Holger; Fischer, Rainer; Schillberg, Stefan
Journal Article
2012The production of vaccines and therapeutic antibodies in plants
Twyman, Richard M.; Schillberg, S.; Fischer, R.
Book Article
2012Prozessentwicklung und -übertragung vom 50-ml- auf den 10-l-Maßstab
Brändli, J.; Müller, M.; Imseng, N.; Schillberg, S.; Eibl, R.
Journal Article
2012Tackling heterogeneity: A leaf disc-based assay for the high-throughput screening of transient gene expression in tobacco
Piotrzkowski, Natalia; Schillberg, Stefan; Rasche, Stefan
Journal Article
2011Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco
Boes, A.; Spiegel, H.; Delbrück, H.; Fischer, R.; Schillberg, S.; Sack, M.
Journal Article
2011Antibody-mediated resistance against plant pathogens
Safarnejad, M.R.; Jouzani, G.S.; Tabatabaie, M.; Twyman, R.M.; Schillberg, Stefan
Journal Article
2011Growth of BY-2 suspension cells and plantibody production in single-use bioreactors
Raven, N.; Schillberg, S.; Kirchhoff, J.; Brändli, J.; Imseng, N.; Eibl, R.
Book Article
2011Impedance-controlled cell entrapment using microhole-array chips allows the isolation and identification of single, highly productive cells
Kurz, C.M.; Maurer, A.; Thees, K.; Schillberg, S.; Velen, T.; Thielecke, H.
Journal Article
2011Der mobile Pflanzendoktor
Jungk, F.; Schillberg, S.; Krause, H.-J.; Schröper, F.
Journal Article
2011One-step protein purification: Use of a novel epitope tag for highly efficient detection and purification of recombinant proteins
Rasche, S.; Martin, A.; Holzem, A.; Fischer, R.; Schinkel, H.; Schillberg, S.
Journal Article
2010Biochemical properties of the matrix metalloproteinase NtMMP1 from Nicotiana tabacum cv. BY-2 suspension cells
Mandal, M.K.; Fischer, R.; Schillberg, S.; Schiermeyer, A.
Journal Article
2010A monoclonal antibody that specifically binds chitosan in vitro and in situ on fungal cell walls
Schubert, M.; Agdour, S.; Fischer, R.; Olbrich, Y.; Schinkel, H.; Schillberg, S.
Journal Article
2010Pharmaceuticals
Schiermeyer, A.; Schillberg, S.
Book Article
2009An assay for the detection of grapevine leafroll-associated virus 3 using a single-chain fragment variable antibody
Cogotzi, L.; Giampetruzzi, A.; Nölke, G.; Orecchia, M.; Elicio, V.; Castellano, M.A.; Martelli, G.P.; Fischer, R.; Schillberg, S.; Saldarelli, P.
Journal Article
2009Grapevine fanleaf virus (GFLV)-specific antibodies confer GFLV and Arabis mosaic virus (ArMV) resistance in Nicotiana benthamiana
Nölke, G.; Cobanov, P.; Uhde-Holzem, K.; Reustle, G.; Fischer, R.; Schillberg, S.
Journal Article
2009A membrane-bound matrix-metalloproteinase from Nicotiana tabacum cv. BY-2 is induced by bacterial pathogens
Schiermeyer, A.; Hartenstein, H.; Mandal, M.K.; Otte, B.; Wahner, V.; Schillberg, S.
Journal Article
2009Molecular farming of antibodies in plants
Fischer, R.; Schillberg, S.; Twyman, R.M.
Book Article
2009Molecular farming of human tissue transglutaminase in tobacco plants
Sorrentino, A.; Schillberg, S.; Fischer, R.; Porta, R.; Mariniello, L.
Journal Article
2009Plant biotechnology
Schillberg, S.
Book Article
2009Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco
Bortesi, L.; Rossato, M.; Schuster, F.; Raven, N.; Stadlmann, J.; Avesani, L.; Falorni, A.; Bazzoni, F.; Bock, R.; Schillberg, S.; Pezzotti, M.
Journal Article
2008Generation and characterization of a recombinant antibody fragment that binds to the coat protein of grapevine leafroll-associated virus 3
Orecchia, M.; Nölke, G.; Saldarelli, P.; Dell´Orco, M.; Uhde-Holzem, K.; Sack, M.; Martelli, G.; Fischer, R.; Schillberg, S.
Journal Article
2008Generation and evaluation of movement protein-specific single-chain antibodies for delaying symptoms of Tomato spotted wilt virus infection in tobacco
Zhang, M.Y.; Zimmermann, S.; Fischer, R.; Schillberg, S.
Journal Article
2008Identification of differential protein expression in response to the application of bioregulators that enhance plant productivity and quality
Horn, R.; Zimmermann, D.; Schillberg, S.
Conference Paper
2008Infrared picosecond laser for perforation of single plant cells
Schinkel, H.; Jacobs, P.; Schillberg, S.; Wehner, M.
Journal Article
2008Modulation of polyamine biosynthesis in transformed tobacco plants by targeting ornithine decarboxylase to an atypical subcellular compartment
Nölke, G.; Schneider, B.; Agdour, S.; Drossard, J.; Fischer, R.; Schillberg, S.
Journal Article
2007Facing the future with pharmaceuticals from plants
Fischer, R.; Twyman, R.M.; Hellwig, S.; Drossard, J.; Schillberg, S.
Conference Paper
2007Laser-mediated perforation of plant cells
Wehner, M.; Jacobs, P.; Esser, D.; Schinkel, H.; Schillberg, S.
Conference Paper
2007Molecular farming of antibodies in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Book Article
2007Pflanzenbiotechnologie
Schillberg, S.
Book Article
2007Pharma-planta: Recombinant pharmaceuticals from plants for human health
Schillberg, S.; Twyman, R.M.
Book Article
2007Production of therapeutic antibodies in plants
Twyman, R.M.; Schillberg, S.; Fischer, R.
Book Article
2006Antibody-based metabolic engineering in plants
Nölke, G.; Fischer, R.; Schillberg, S.
Journal Article
2006Plantibody-based disease resistance in plants
Zimmermann, S.; Emans, N.; Fischer, R.; Schillberg, S.
Book Article
2005Biopharmaceutical production in cultured cells
Schillberg, S.; Twyman, R.M.; Fischer, R.
Book Article
2005DURCH MOLEKULARES PATHOGENICID VERMITTELTE KRANKHEITSRESISTENZ IN PFLANZEN
Fischer, R.; Schillberg, S.; Naehring, J.; Sack, M.; Monecke, M.; Liao, Y.; Spiegel, H.; Zimmerman, S.; Emans, N.; Holzem, A.
Patent
2005Immunomodulation of polyamine biosynthesis in tobacco plants has a significant impact on polyamine levels and generates a dwarf phenotype
Nölke, G.; Schneider, B.; Fischer, R.; Schillberg, S.
Journal Article
2005Molecular farming for new drugs and vaccines
Ma, J.K.-C.; Barros, E.; Bock, R.; Christou, P.; Dale, P.J.; Dix, P.J.; Fischer, R.; Irwin, J.; Mahoney, R.; Pezzotti, M.; Schillberg, S.; Sparrow, P.; Stoger, E.; Twyman, R.M.
Journal Article
2005Opportunities for recombinant antigen and antibody expression in transgenic plants - technology assessment
Schillberg, S.; Twyman, R.M.; Fischer, R.
Journal Article
2005Plant cells
Fischer, R.; Twyman, R.M.; Drossard, J.; Hellwig, S.; Schillberg, S.
Book Article
2005Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells
Schinkel, H.; Schiermeyer, A.; Soeur, R.; Fischer, R.; Schillberg, S.
Journal Article
2005Production of Desmodus rotundus plasminogen activator alpha1 (DSPA alpha1) in tobacco is hampered by proteolysis
Schiermeyer, A.; Schinkel, H.; Apel, S.; Fischer, R.; Schillberg, S.
Journal Article
2005Production of recombinant human serum albumin in transgenic plant suspension cell cultures
Mavituna, M.; Fischer, R.; Schillberg, S.
Abstract
2005Recombinant human tissue transglutaminase produced into tobacco suspension cell cultures is active and recognizes autoantibodies in the serum of coeliac patients
Sorrentino, A.; Schillberg, S.; Fischer, R.; Rao, R.; Porta, R.; Mariniello, L.
Journal Article
2005Transgenic plants in the biopharmaceutical market
Twyman, R.M.; Schillberg, S.; Fischer, R.
Journal Article
2004Antibody production in transgenic plants
Stoger, E.; Schillberg, S.; Twyman, R.M.; Fischer, R.; Christou, P.
Book Article
2004Antibody-based pathogen resistance in plants
Nölke, G.; Fischer, R.; Schillberg, S.
Journal Article
2004Emerging production systems for antibodies in plants
Schillberg, S.; Twyman, R.M.
Book Article
2004Engineering and production of recombinant antibodies in plants
Fischer, R.; Commandeur, U.; Schillberg, S.; Twyman, R.M.
Conference Paper
2004Improvement of grapevine using current biotechnology
Fischer, R.; Nölke, G.; Orecchia, M.; Schillberg, S.; Twyman, R.M.
Conference Paper
2004Molecular farming in plants: Technology platforms
Fischer, R.; Emans, N.; Twyman, R.M.; Schillberg, S.
Book Article
2004Molecular farming. Plant-made pharmaceuticals and technical proteins
: Fischer, R.; Schillberg, S.
Book
2004Pflanzen produzieren Medikamente
Schillberg, S.
Book Article
2004Plant-based production of biopharmaceuticals
Fischer, R.; Stoger, E.; Schillberg, S.; Christou, P.; Twyman, R.M.
Journal Article
2004Transient gene expression of recombinant terpenoid indole alkaloid enzymes in Catharanthus roseus leaves
Fiore, S. di; Hoppmann, V.; Fischer, R.; Schillberg, S.
Journal Article
2003'Molecular farming' of antibodies in plants
Schillberg, S.; Fischer, R.; Emans, N.
Journal Article
2003Molecular farming in plants: Host systems and expression technology
Twyman, R.M.; Stoger, E.; Schillberg, S.; Christou, P.; Fischer, R.
Journal Article
2003Molecular farming of industrial proteins in plants
Fischer, R.; Emans, N.; Twyman, R.M.; Schillberg, S.
Book Article
2003Molecular farming of recombinant antibodies in plants
Schillberg, S.; Fischer, R.; Emans, N.
Journal Article
2003Production of antibodies in plants and their use for global health
Fischer, R.; Twyman, R.M.; Schillberg, S.
Journal Article
2003Production of therapeutic antibodies in plants
Nölke, G.; Fischer, R.; Schillberg, S.
Journal Article
2002Antibody expression in plants
Verch, T.; Lewandowski, D.; Schillberg, S.; Yusibov, V.; Koprowski, H.; Fischer, R.
Book Article
2002Antibody molecular farming in plants and plant cells
Schillberg, S.; Emans, N.; Fischer, R.
Journal Article
2002Construction and characterization of a single-chain antibody fragment derived from thymus of a patient with myasthenia gravis
Meng, F.; Stassen, M.H.W.; Schillberg, S.; Fischer, R.; Baets, M.H. de
Journal Article
2002Molecular Farming
Commandeur, U.; Fischer, R.; Schillberg, S.
Journal Article
2002Molecular farming antibodies in plants
Fischer, R.; Finnern, R.; Emans, N.; Schillberg, S.
Book Article
2002Molecular Farming. Produktion hochwertiger Proteine in Pflanzen
Mavituna, M.; Schillberg, S.; Fischer, R.
Journal Article
2002The potato granule bound starch synthase chloroplast transit peptide directs recombinant proteins to plastids
Hoppmann, V.; Fiore, S. di; Zimmermann, S.; Emans, N.; Rademacher, T.; Fischer, R.; Schillberg, S.
Journal Article
2002Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype
Fiore, S. di; Li, Q.; Leech, M.J.; Schuster, F.; Emans, N.; Fischer, R.; Schillberg, S.
Journal Article
2001Achieving plant disease resistance by antibody expression
Fischer, R.; Emans, N.; Schillberg, S.
Journal Article
2001Antibody-based resistance to plant pathogens
Schillberg, S.; Zimmermann, S.; Zhang, M.Y.; Fischer, R.
Journal Article
2001GST fusion proteins cause false positives during selection of viral movement protein specific single chain antibodies
Zhang, M.Y.; Schillberg, S.; Zimmermann, S.; Liao, Y.C.; Breuer, G.; Fischer, R.
Journal Article
2001Molecular Farming
Schillberg, S.; Fischer, R.
Journal Article
2001Molecular farming
Schillberg, S.; Fischer, R.
Book Article
2001Molecular farming of medicines. A field of growing promise
Fischer, R.; Schillberg, S.; Emans, N.
Journal Article
2001Polypeptid-Tag's fuer den Nachweis und die Aufreinigung von Polypeptiden
Fischer, R.; Helgers, Y.; Hoffmann, K.; Holzem, A.; Monecke, M.; Naehring, J.; Schillberg, S.
Patent
2001Produktion pharmazeutischer Proteine durch "Molecular Farming" in Pflanzen
Schillberg, S.; Fischer, R.
Journal Article
2000Antibody production by molecular farming in plants
Fischer, R.; Hoffmann, K.; Schillberg, S.; Emans, N.
Journal Article
2000The molecular farming of therapeutic antibodies
Fischer, R.; Vaquero, C.; Finnern, R.; Schillberg, S.
Conference Paper
2000Molekulares Farming. Die Pflanze als Biofabrik zur Produktion pharmazeutischer Proteine
Henke, M.; Schillberg, S.; Fischer, R.
Journal Article
2000Plasma membrane display of anti-viral single chain Fv fragments confers resistance to tobacco mosaic virus
Schillberg, S.; Zimmermann, S.; Findley, K.; Fischer, R.
Journal Article
2000Produktion rekombinanter Proteine durch "Molekulares Farming"
Schillberg, S.; Henke, M.; Fischer, R.
Journal Article
2000Transient transformation of the rust fungus Puccinia graminis f. sp. tritici
Schillberg, S.; Tiburzy, R.; Fischer, R.
Journal Article
1999Accumulation of antibody fusion proteins in the cytoplasm and ER of plant cells
Spiegel, H.; Schillberg, S.; Sack, M.; Holzem, A.; Nähring, J.; Monecke, M.; Liao, Y.C.; Fischer, R.
Journal Article
1999Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum
Schillberg, S.; Zimmermann, S.; Voss, A.; Fischer, R.
Journal Article
1999Engineering and expression of bispecific single chain Fv fragments in transgenic tobacco plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Molecular farming of recombinant antibodies in plants
Fischer, R.; Liao, Y.C.; Hoffmann, K.; Schillberg, S.; Emans, N.
Journal Article
1999Optimizing expression of a rare codon-rich viral protein in Escherichia coli using the IMPACT system
Zhang, M.Y.; Schillberg, S.; Prins, M.; Fischer, R.
Journal Article
1999Towards molecular farming in the future: moving from diagnostic protein and antibody production in microbes to plants
Fischer, R.; Drossard, J.; Commandeur, U.; Schillberg, S.; Emans, N.
Journal Article
1999Transgenic plants as bioreactors for the expression of recombinant antibodies and their downstream processing
Fischer, R.; Hellwig, S.; Drossard, J.; Emans, N.; Schillberg, S.
Conference Paper
1999Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
Vaquero, C.; Sack, M.; Chandler, J.; Drossard, J.; Schuster, F.; Monecke, M.; Schillberg, S.; Fischer, R.
Journal Article
1998Transgenic plants as bioreactors for the expression of recombinant antibodies
Fischer, R.; Drossard, J.; Hellwig, S.; Emans, N.; Schillberg, S.
Conference Paper