Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Ceramides as Novel Disease Biomarkers
Kurz, J.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
Journal Article
2019Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab
Mojtahed Poor, S.; Ulshöfer, T.; Gabriel, L.A.; Henke, M.; Köhm, M.; Behrens, F.; Geisslinger, G.; Parnham, M.J.; Burkhardt, H.; Schiffmann, S.
Journal Article
2019Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
Kurz, J.; Barthelmes, J.; Blum, L.; Ulshöfer, T.; Wegner, M.-S.; Ferreiros, N.; Roser, L.; Geisslinger, G.; Grösch, S.; Schiffmann, S.
Journal Article
2019Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy
Feczkó, T.; Piiper, A.; Ansar, S.; Blixt, F.W.; Ashtikar, M.; Schiffmann, S.; Ulshöfer, T.; Parnham, M.J.; Harel, Y.; Israel, L.L.; Lellouche, J.-P.; Wacker, M.G.
Journal Article
2018Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression
Blum, L.; Tafferner, N.; Spring, I.; Kurz, J.; deBruin, N.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
Journal Article
2018Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy
Lötsch, J.; Schiffmann, S.; Schmitz, K.; Brunkhorst, R.; Lerch, F.; Ferreiros, N.; Wicker, S.; Tegeder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2018The relevance of ceramides and their synthesizing enzymes for multiple sclerosis
Kurz, J.; Brunkhorst, R.; Foerch, C.; Blum, L.; Henke, M.; Gabriel, L.; Ulshöfer, T.; Ferreiros, N.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
Journal Article
2017Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis
Schmitz, K.; Brunkhorst, R.; Bruin, N. de; Mayer, C.A.; Häussler, A.; Ferreiros, N.; Schiffmann, S.; Parnham, M.J.; Tunaru, S.; Chun, J.; Offermanns, S.; Foerch, C.; Scholich, K.; Vogt, J.; Wicker, S.; Lötsch, J.; Geisslinger, G.; Tegeder, I.
Journal Article
2017Machine-learned data structures of lipid marker serum concentrations in multiple sclerosis patients differ from those in healthy subjects
Lötsch, J.; Thrun, M.; Lerch, F.; Brunkhorst, R.; Schiffmann, S.; Thomas, D.; Tegder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2016Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE
Tafferner, N.; Barthelmes, J.; Eberle, M.; Ulshöfer, T.; Henke, M.; deBruin, N.; Mayer, C.A.; Foerch, C.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
Journal Article
2016The enigma of ceramide synthase regulation in mammalian cells
Wegner, M.-S.; Schiffmann, S.; Parnham, M.J.; Geisslinger, G.; Grösch, S.
Journal Article
2016Induction of experimental autoimmune encephalomyelitis in mice and evaluation of the disease-dependent distribution of immune cells in various tissues
Barthelmes, J.; Tafferner, N.; Kurz, J.; de Bruin, N.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
Journal Article
2016Lack of CerS2 Suppresses the Development of Experimental Autoimmune Encephalomyelitis by Impairing the Migratory Potential of Neutrophils
Mayer, C.; Barthelmes, J.; Pewzner-Jung, Y.; Schmitz, K.; Maenner, A.; Foerch, C.; Eberle, M.; Taffemer, N.; Ferreiros, N.; Birod, K.; Geisslinger, G.; Futerman, A.; Grösch, S.; Schiffmann, S.; Schuhmann, C.
Abstract
2015Ceramide synthase6 / C16-ceramides mediate anti-inflammatory effects during the development of EAE and MS possibly by suppressing the migration and by deactivation of neutrophils: a new target for anti-inflammatory therapy in MS?
Mayer, C.A.; Männer de Bazo, A.; Foerch, C.; Eberle, M.; Ebel, P.; Barthelmes, J.; Tafferner, N.; Ferreiros, N.; Ulshöfer, T.; Henke, M.; Grösch, S.; Geisslinger, G.; Willecke, K.; Schiffmann, S.
Abstract
2015Different pathophysiological relevance of branched fatty acid metabolism in mice and men: alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis
Mayer, C.A.; Tafferner, N.; Barthelmes, J.; Eberle, M.; Ferreiros, N.; Ulshöfer, T.; Henke, M.; Bruin, N. de; Geisslinger, G.; Foerch, C.; Parnham, M.J.; Schiffmann, S.
Abstract
2015Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils
Eberle, M.; Ebel, P.; Mayer, C.A.; Barthelmes, J.; Tafferner, N.; Ferreiros, N.; Ulshöfer, T.; Henke, M.; Foerch, C.; Männer de Bazo, A.; Grösch, S.; Geisslinger, G.; Willecke, K.; Schiffmann, S.
Journal Article
2015Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils
Barthelmes, J.; Bazo, A.M. de; Pewzner-Jung, Y.; Schmitz, K.; Mayer, C.A.; Foerch, C.; Eberle, M.; Tafferner, N.; Ferreiros, N.; Henke, M.; Geisslinger, G.; Futerman, A.H.; Grösch, S.; Schiffmann, S.
Journal Article
2015Nanocarriers for photodynamic therapy - rational formulation design and medium-scale manufacture
Villa Nova, M.; Janas, C.; Schmidt, M.; Ulshoefer, T.; Gräfe, S.; Schiffmann, S.; Bruin, N. de; Wiehe, A.; Albrecht, V.; Parnham, M.J.; Bruschi, M.L.; Wacker, M.G.
Journal Article
2014Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells
Wegner, M.S.; Wanger, R.A.; Oertel, S.; Brachtendorf, S.; Hartmann, D.; Schiffmann, S.; Marschalek, R.; Schreiber, Y.; Ferreirós, N.; Geisslinger, G.; Grösch, S.
Journal Article
2014PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis
Schiffmann, S.; Weigert, A.; Männich, J.; Eberle, M.; Birod, K.; Häussler, A.; Ferreiros, N.; Schreiber, Y.; Kunkel, H.; Grez, M.; Weichand, B.; Brüne, B.; Pfeilschifter, W.; Nüsing, R.; Niederberger, E.; Grösch, S.; Scholich, K.; Geisslinger, G.
Journal Article
2014Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent
Eberle, M.; Ebel, P.; Wegner, M.S.; Männich, J.; Tafferner, N.; Ferreiros, N.; Birod, K.; Schreiber, Y.; Krishnamoorthy, G.; Willecke, K.; Geisslinger, G.; Grösch, S.; Schiffmann, S.
Journal Article
2014Role of alpha-metylacyl-CoA racemase in immune cells during the development of experimental autoimmune encephalomyelitis
Tafferner, N.; Männich, J.; Eberle, M.; Ferreiros, N.; Debruin, N.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
Journal Article
2013Ceramide metabolism in mouse tissue
Schiffmann, S.; Birod, K.; Männich, J.; Eberle, M.; Wegner, M.-S.; Wanger, R.; Hartmann, D.; Ferreiros, N.; Geisslinger, G.; Grösch, S.
Journal Article
2013Nano-LC–MS/MS for the quantitation of ceramides in mice cerebrospinal fluid using minimal sample volume
Thomas, D.; Eberle, M.; Schiffmann, S.; Zhang, D.; Geisslinger, G.; Ferreiros, N.
Journal Article
2004Double chip protein arrays using recombinant single-chain Fv antibody fragments
Gilbert, I.; Schiffmann, S.; Rubenwolf, S.; Jensen, K.; Mai, T.; Albrecht, C.; Lankenau, A.; Beste, G.; Blank, K.; Gaub, H.E.; Clausen-Schaumann, H.
Conference Paper, Journal Article