Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2015Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Schaumann, Frank; Müller, Meike; Scholl, Dorothea; Hidi, R.; McLeod, Alison; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2015Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: A proof of concept study
Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Winkler, Carla; Faulenbach, Cornelia; Jakob, Peter; Schaumann, Frank; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Otmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Journal Article
2014A human in vitro allergy model showing allergen specific immune responses using house dust mite or grass pollen allergen
Müller, Meike; Schaumann, Frank; Braun, Armin
Abstract
2014Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
Winkler, C.; Witte, L.; Moraw, N.; Faulenbach, C.; Müller, M.; Holz, O.; Schaumann, F.; Hohlfeld, J.M.
Journal Article
2014Phase-contrast MRI for detection of mild systemic hemodynamic response after segmental allergen challenge in asthmatic patients
Hinrichs, Jan; Schaumann, Frank; Renne, Julius; Schönfeld, Christian; Faulenbach, Cornelia; Winkler, Carla; Gutberlet, Marcel; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2014Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging
Vogel-Claussen, Jens; Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Schaumann, Frank; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens Michael
Journal Article
2013Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
Janssen, Ole; Schaumann, Frank; Holz, Olaf; Lavae-Mokhtari, Bianca; Welker, Lutz; Winkler, Carla; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2012Alternative activation of macrophages during the allergic airway inflammation alters antigen presenting capacities
Winkler, Carla; Carstens, Hauke; Müller, Meike; Schaumann, Frank; Faulenbach, Cornelia; Hohlfeld, Jens M.
Abstract
2012Depletion of neutrophils from induced sputum using a novel bead and sieve-separation system
Holz, Olaf; Schaumann, Frank; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Krug, Norbert; Heinrich, J.M.; Hohlfeld, Jens M.
Abstract
2012Low-dose endotoxin inhalation in healthy volunteers: A challenge model for early clinical drug development of novel anti-inflammatory compounds
Schaumann, Frank; Holz, Olaf; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Abstract
2012Pollen starch granules in bronchial inflammation
Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2012Semi-quantitative assessment of localized pulmonary inflammation by magnetic resonance imaging in patients with mild allergic asthma following segmental allergen challenge
Vogel-Claussen, Jens; Schaumann, Frank; Renne, Julius; Hinrichs, Jan; Schoenfeld, Christian; Gutberlet, Marcel; Hüper, Klaudia; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.
Abstract
2011Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael
Journal Article
2011Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Schaumann, F.; Hohlfeld, J.M.; Krug, N.; Sousa, A.R.; Murdoch, R.
Journal Article
2011Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans
Atochina-Vasserman, E.N.; Winkler, C.; Abramova, H.; Schaumann, F.; Krug, N.; Gow, A.J.; Beers, M.F.; Hohlfeld, J.M.
Journal Article
2010Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices
Switalla, S.; Lauenstein, L.; Prenzler, F.; Knothe, S.; Förster, C.; Fieguth, H.-G.; Pfennig, O.; Schaumann, F.; Martin, C.; Guzman, C.A.; Ebensen, T.; Müller, M.; Hohlfeld, J.M.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2009Prolonged pro-inflammatory effects of ultrafine particles in the lung of allergic asthmatics
Schaumann, F.; Dijkstra, D.; Froemke, C.; Windt, H.; Karg, E.; Mueller, M.; Braun, A.; Hohlfeld, J.; Koch, W.; Schulz, H.; Krug, N.
Abstract
2009Therapeutic surfactants modulate the viability of Eosinophils and induce inflammatory mediator release
Erpenbeck, V.J.; Fischer, I.; Wiese, K.; Schaumann, F.; Schmiedl, A.; Nassenstein, C.; Krug, N.; Hohlfeld, J.M.
Journal Article
2008Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma
Schaumann, F.; Müller, M.; Braun, A.; Luettig, B.; Peden, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2008Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial
Hohlfeld, J.M.; Schönfeld, K.; Lavae-Mokhtari, M.; Schaumann, F.; Müller, M.; Bredenbröker, D.; Krug, N.; Hermann, R.
Journal Article
2004Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects
Schaumann, F.; Borm, P.J.A.; Herbrich, A.; Knoch, J.; Pitz, M.; Schins, R.P.F.; Luettig, B.; Hohlfeld, J.M.; Heinrich, J.; Krug, N.
Journal Article