Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Plant cell packs: A scalable platform for recombinant protein production and metabolic engineering
Rademacher, T.; Sack, M.; Blessing, D.; Fischer, R.; Holland, T.; Buyel, J.
Journal Article
2018Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites
Chouman, Karinna; Korioth-Schmitz, Birgit; Sack, Markus; Engelbert Schmitz, Jörn; Tuan Pham, Anh; Fischer, Rainer; Barth, Stefan; Klockenbring, Torsten; Fendel, Rolf
Journal Article
2017Antibodies from plants for bionanomaterials
Edgue, G.; Twyman, R.M.; Beiss, V.; Fischer, R.; Sack, M.
Journal Article
2017Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K-521 Polymorphism
Braig, F.; Kriegs, M.; Voigtlaender, M.; Habel, B.; Grob, T.; Biskup, K.; Blanchard, V.; Sack, M.; Thalhammer, A.; Ben Batalla, I.; Braren, I.; Laban, S.; Danielczyk, A.; Goletz, S.; Jakubowicz, E.; Märkl, B.; Trepel, M.; Knecht, R.; Riecken, K.; Fehse, B.; Loges, S.; Bokemeyer, C.; Binder, M.
Journal Article
2016Overcoming low yields of plant-made antibodies by a protein engineering approach
Zischewski, J.; Sack, M.; Fischer, R.
Journal Article
2016Putting the spotlight back on plant suspension cultures
Santos, R.B.; Abranches, R.; Fischer, R.; Sack, M.; Holland, T.
Journal Article
2016SNAP-Tag Technology: A Useful Tool to Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments
Niesen, J.; Sack, M.; Seidel, M.; Fendel, R.; Barth, S.; Fischer, R.; Stein, C.
Journal Article
2015Application of a scalable plant transient gene expression platform for malaria vaccine development
Spiegel, H.; Boes, A.; Voepel, N.; Beiss, V.; Edgue, G.; Rademacher, T.; Sack, M.; Schillberg, S.; Reimann, A.; Fischer, R.
Journal Article
2015From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants
Sack, M.; Rademacher, T.; Spiegel, H.; Boes, A.; Hellwig, S.; Drossard, J.; Stoger, E.; Fischer, R.
Journal Article
2015Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein
Beiss, V.; Spiegel, H.; Boes, A.; Kapelski, S.; Scheuermayer, M.; Edgue, G.; Sack, M.; Fendel, R.; Reimann, A.; Schillberg, S.; Pradel, G.; Fischer, R.
Journal Article
2015The increasing value of plant-made proteins
Sack, M.; Hofbauer, A.; Fischer, R.; Stoger, E.
Journal Article
2015Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants
Ma, J.K.-C.; Drossard, J.; Lewis, D.; Altmann, F.; Boyle, J.; Christou, P.; Cole, T.; Dale, P.; van Dolleweerd, C.J.; Isitt, V.; Katinger, D.; Lobedan, M.; Mertens, H.; Paul, M.J.; Rademacher, T.; Sack, M.; Hundleby, P.A.C.; Stiegler, G.; Stoger, E.; Twyman, R.M.; Vcelar, B.; Fischer, R.
Journal Article
2014Novel vaccines against apicomplexan pathoges
Boes, Alexander; Edgü, Güven; Beiß, Véronique; Sack, Markus; Reimann, Andreas; Fischer, Rainer
Patent
2013The in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology
Holland, T.; Blessing, D.; Hellwig, S.; Sack, M.
Journal Article
2013Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins
Arcalis, E.; Stadlmann, J.; Rademacher, T.; Marcel, S.; Sack, M.; Altmann, F.; Stoger, E.
Journal Article
2011Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco
Boes, A.; Spiegel, H.; Delbrück, H.; Fischer, R.; Schillberg, S.; Sack, M.
Journal Article
2011From recombinant proteins to plant-made-pharmaceuticals
Stoger, E.; Rademacher, T.; Arcalis, E.; Sack, M.; Stiegler, G.; Altmann, F.; Fischer, R.
Journal Article
2010Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture
Holland, T.; Sack, M.; Rademacher, T.; Schmale, K.; Altmann, F.; Stadlmann, J.; Fischer, R.; Hellwig, S.
Journal Article
2010Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody
Sainsbury, F.; Sack, M.; Stadlmann, J.; Quendler, H.; Fischer, R.; Lomonossoff, G.P.
Journal Article
2009Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody
Floss, D.M.; Sack, M.; Arcalis, E.; Stadlmann, J.; Quendler, H.; Rademacher, T.; Stoger, E.; Scheller, J.; Fischer, R.; Conrad, U.
Journal Article
2008Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants
Floss, D.M.; Sack, M.; Stadlmann, J.; Rademacher, T.; Scheller, J.; Stöger, E.; Fischer, R.; Conrad, U.
Journal Article
2008Generation and characterization of a recombinant antibody fragment that binds to the coat protein of grapevine leafroll-associated virus 3
Orecchia, M.; Nölke, G.; Saldarelli, P.; Dell´Orco, M.; Uhde-Holzem, K.; Sack, M.; Martelli, G.; Fischer, R.; Schillberg, S.
Journal Article
2008Phage-display derived single-chain fragment variable (scFv) antibodies recognizing conformational epitopes of Escherichia coli heat-labile enterotoxin B-subunit
Chung, W.Y.; Sack, M.; Carter, R.; Spiegel, H.; Fischer, R.; Hirst, T.R.; Williams, N.A.; James, R.F.L.
Journal Article
2007Design of protein-membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V
Segers, K.; Sperandio, O.; Sack, M.; Fischer, R.; Miteva, M.A.; Rosing, J.; Nicolaes, G.A.F.; Villoutreix, B.O.
Journal Article
2007Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures
Sack, M.; Paetz, A.; Kunert, R.; Bomble, M.; Hesse, F.; Stiegler, G.; Fischer, R.; Katinger, H.; Stöger, E.; Rademacher, T.
Journal Article
2005DURCH MOLEKULARES PATHOGENICID VERMITTELTE KRANKHEITSRESISTENZ IN PFLANZEN
Fischer, R.; Schillberg, S.; Naehring, J.; Sack, M.; Monecke, M.; Liao, Y.; Spiegel, H.; Zimmerman, S.; Emans, N.; Holzem, A.
Patent
2005Komplexbildung zur Stabilisierung und Reinigung eines Proteins von Interesse
Sack, M.; Vaquero-Martin, C.; Fischer, R.
Patent
2005Recent progress in plantibody technology
Stoger, E.; Sack, M.; Nicholson, L.; Fischer, R.; Christou, P.
Journal Article
2005Recombinant soluble human Fc(gamma) receptor I with picomolar affinity for immunoglobulin G
Paetz, A.; Sack, M.; Thepen, T.; Tur, M.K.; Brüll, D.; Finnern, R.; Fischer, R.; Barth, S.
Journal Article
2004Glycosylation of recombinant antibody in plants
Sriraman, R.; Sack, M.; Talwar, G.P.; Fischer, R.
Conference Paper
2004Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues
Sriraman, R.; Bardor, M.; Sack, M.; Vaquero, C.; Faye, L.; Fischer, R.; Finnern, R.; Lerouge, P.
Journal Article
2003Roboter zur Inspektion und/oder Reinigung und/oder Sanierung von Kanaelen
Altrock, M.; Felsch, T.; Saenz, J.; Elkmann, N.; Sack, M.
Patent
2003Using plants as a production system for N-Glycosylated proteins of therapeutic relevance
Hellwig, S.; Sack, M.; Spiegel, H.; Drossard, J.; Fischer, R.
Journal Article
2002Analysis of an anti-GnRH chimeric antibody purified from tobacco leaves
Nath, R.; Sack, M.; Finnern, R.; Talwar, G.P.; Fischer, R.
Poster
2002A carcinoembryonic antigen-specific diabody produced in tobacco
Vaquero, C.; Sack, M.; Schuster, F.; Finnern, R.; Drossard, J.; Schumann, D.; Reimann, A.; Fischer, R.
Journal Article
2002Design, assembly and characterization of a humanized scFv framework library
Spiegel, H.; Sack, M.; Finnern, R.; Fischer, R.
Presentation
2002Efficacy of plant-produced recombinant antibodies against HCG
Kathuria, S.; Sriraman, R.; Nath, R.; Sack, M.; Pal, R.; Artsaenko, O.; Talwar, G.P.; Fischer, R.; Finnern, R.
Journal Article
2002Innovative service robot systems for facade cleaning of difficult-to- access areas
Elkmann, N.; Felsch, T.; Sack, M.; Saenz, J.; Hortig, J.
Conference Paper
2002Intelligent control of modular kinematics - the robot platform STRIUS
Sack, M.; Elkmann, N.; Felsch, T.; Böhme, T.
Conference Paper
2002Plantibodies. Applications, advantages and bottlenecks
Stoger, E.; Sack, M.; Fischer, R.; Christou, P.
Journal Article
2002Les planticorps
Stoger, E.; Sack, M.; Fischer, R.; Christou, P.
Journal Article
2002Practical considerations for pharmaceutical antibody production in different crop systems
Stoger, E.; Sack, M.; Perrin, Y.; Vaquero, C.; Torres, E.; Twyman, R.M.; Christou, P.; Fischer, R.
Journal Article
2002Rapid large-scale production of recombinant antibodies in agro-infiltrated leaves
Sack, M.; Vaquero, C.; Finnern, R.; Fischer, R.
Presentation
2000Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies
Stöger, E.; Vaquero, C.; Torres, E.; Sack, M.; Nicholson, L.; Drossard, J.; Williams, S.; Keen, D.; Perrin, Y.; Christou, P.; Fischer, R.
Journal Article
2000SIRIUS - Roboter zur vollautomatischen Reinigung von Hochhausfassaden
Sack, M.; Elkmann, N.; Felsch, T.; Böhme, T.
Conference Paper
2000SIRIUS(c): Vollautomatisierter Fassadenreinigungsroboter
Elkmann, N.; Sack, M.; Böhme, T.; Felsch, T.; Saenz, J.
Conference Paper
2000Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy
Perrin, Y.; Vaquero, C.; Gerrard, I.; Sack, M.; Drossard, J.; Stöger, E.; Christou, P.; Fischer, R.
Journal Article
1999Accumulation of antibody fusion proteins in the cytoplasm and ER of plant cells
Spiegel, H.; Schillberg, S.; Sack, M.; Holzem, A.; Nähring, J.; Monecke, M.; Liao, Y.C.; Fischer, R.
Journal Article
1999Engineering and expression of bispecific single chain Fv fragments in transgenic tobacco plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants
Fischer, R.; Schumann, D.; Zimmermann, S.; Drossard, J.; Sack, M.; Schillberg, S.
Journal Article
1999Modular climbing robot for outdoor operations
Elkmann, N.; Felsch, T.; Sack, M.; Böhme, T.
Conference Paper
1999Modular climbing robot for service-sector applications
Elkmann, N.; Felsch, T.; Sack, M.; Böhme, T.
Journal Article
1999Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies
Torres, E.; Vaquero, C.; Nicholson, L.; Sack, M.; Stöger, E.; Drossard, J.; Christou, P.; Fischer, R.; Perrin, Y.
Journal Article
1999Towards molecular farming in the future: transient protein expression in plants
Fischer, R.; Vaquero-Martin, C.; Sack, M.; Drossard, J.; Emans, N.; Commandeur, U.
Journal Article
1999Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
Vaquero, C.; Sack, M.; Chandler, J.; Drossard, J.; Schuster, F.; Monecke, M.; Schillberg, S.; Fischer, R.
Journal Article