Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Cigarette smoke induced pathophysiological changes in the extracellular matrix but not inflammation as early events in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Warnecke, G.; Zardo, P.; Fieguth, H.-G.; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2019Dosing considerations for in vitro inhalation testing of VOCs in air-lifted Interphase (ALI) cultures
Hansen, T.; Ritter, D.; Knebel, J.
Abstract
2018Acute inhalation toxicity in vitro and ex vivo test battery prior to regulatory OECD 403 studies
Schwarz, Katharina; Hansen, Tanja; Ritter, Detlef; Walter, Dorothee; Knebel, Jan
Abstract
2018Air-liquid interface in vitro models for respiratory toxicology research: Consensus workshop and recommendations
Lacroix, Ghislaine; Koch, Wolfgang; Ritter, Detlef; Gutleb, Arno C.; Larsen, Søren Thor; Loret, Thomas; Zanetti, Filippo; Constant, Samuel; Chortarea, Savvina; Rothen-Rutishauser, Barbara M.; Hiemstra, Pieter S.; Frejafon, Emeric; Hubert, Philippe; Gribaldo, Laura; Kearns, Peter; Aublant, Jean-Marc; Diabaté, Silvia; Weiss, Carsten; Groot, Antoinette de; Kooter, Ingeborg
Journal Article
2018A combination of in-vitro and ex-vivo test models as an upstream alternative to regulatory OECD 403 animal studies
Walter, Dorothee; Ritter, Detlef; Knebel, Jan; Schwarz, Katharina; Hansen, Tanja
Abstract
2018Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system
Knebel, Jan W.; Ritter, Detlef; Niehof, Monika; Hansen, Tanja; Strandh, M.; Falciani, C.; Flores, M.; Welscher, Y. te; Nostrum, C. van; Gracia, R.; Marradi, M.; Loinaz, I.
Abstract
2018Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process
Ritter, Detlef; Bitsch, Annette; Elend, Manfred; Schuchardt, Sven; Hansen, Tanja; Brodbeck, Carsten; Knebel, Jan; Fuchs, Anne; Gronewold, Claas; Fautz, Rolf
Journal Article
2018Early biomarkers indicating COPD can be induced by whole cigarette smoke in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Zardo, Patrick; Fieguth, Hans-Gerd; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2017Applying CFD for the Design of an Air-Liquid Interface In-Vitro Testing Method for Inhalable Compounds
Brodbeck, Carsten; Knebel, Jan; Ritter, Detlef; Wolf, Klaus
Book Article
2016Cigarette smoke and cigarette smoke condensate induce early biomarkers of inflammation and cytotoxicity in precision-cut lung slices
Obernolte, H.; Ritter, D.; Knebel, J.W.; Braubach, P.; Jonigk, D.; Fieguth, H.-G.; Braun, A.; Sewald, K.
Abstract
2016Development of an in vitro testing platform for aerosols containing inhalable antiobiotically active compounds as a part of the EU-project "PNeumoNP"
Ritter, D.; Knebel, J.; Wronski, S.; Montes, A.; Niehof, M.
Abstract
2016Expositionsvorrichtung
Brodbeck, Carsten; Ritter, Detlef; Knebel, Jan; Wolf, Klaus
Patent
2016Use of computational fluid dynamics for optimization of cell-based in vitro methods in inhalation research
Brodbeck, C.; Wolf, K.; Ritter, D.; Knebel, J.
Abstract
2015Acute inhalation toxicity of volatile organic compounds - application of an improved cell-based in vitro procedure
Ritter, Detlef; Krakor, E.; Knebel, Jan
Abstract
2015Acute toxicity testing of inhalable/gaseous compounds by cell-based methods in vitro - application to volatile organic compounds
Ritter, Detlef; Knebel, Jan
Abstract
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette Smoke Exposure Induces Cytotoxicity And Inflammation In Viable Lung Tissue Slices
Obernolte, H.; Lauenstein, L.; Switalla, S.; Ritter, D.; Knebel, J.; Jonigk, D.; Braubach, P.; Kruger, M.; Braun, A.; Sewald, K.
Abstract
2015Expositionsapparat
Ritter, Detlef; Knebel, Jan
Patent
2015Improvements of an air-liquid interface in-vitro testing method for inhalable compounds using CFD-methods
Brodbeck, C.; Ritter, D.; Knebel, J.
Conference Paper
2014An active 60-90 GHz single pole double throw switch MMIC
Dyskin, A.; Wagner, S.; Ritter, D.; Kallfass, I.
Journal Article
2014Biological effects of inhalable compounds improvements of the in vitro testing method
Ritter, Detlef; Knebel, Jan; Brodbeck, Carsten; Javala, Pasi
Abstract
2014Biological effects of inhalable substances - development of a concept to standardize in vitro studies using aerosols
Ritter, Detlef; Arndt, Hendrik; Knebel, Jan
Journal Article, Conference Paper
2014Building up a co-culture and surfactant model for routine use in ali exposures
Javala, Pasi; Ritter, Detlef; Knebel, Jan
Abstract
2014Fundamental improvements of the air-liquid interface technique for use in in vitro inhalation toxicology
Knebel, Jan; Ritter, Detlef; Brodbeck, Carsten
Abstract
2014Improvements of the ALI in vitro testing method for inhalable compounds
Ritter, Detlef; Knebel, Jan; Brodbeck, Carsten
Abstract
2014Investigations of the biological effects of airborne and inhalable substances by cell-based in vitro methods
Ritter, Detlef; Knebel, Jan
Journal Article
2014Validation requirements for alternative methods in inhalation toxicology - case study of a German two phase prevalidation project
Liebsch, M.; Pirow, R.; Smirnova, L.; Tharmann, J.; Linsel, G.; Troeller, S.; Huettig, N.; Bauer, M.; Graebsch, C.; Berger-Preiß, Edith; Kock, Heiko; Oertel, Antje; Ritter, Detlef; Knebel, Jan
Abstract
2013An asymmetrical 60-90 GHz single-pole double throw switch MMIC
Dyskin, A.; Peleg, N.; Wagner, S.; Ritter, D.; Kallfass, I.
Conference Paper
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Journal Article
2013Performance comparison for millimeter-wave single-pole double throw switches
Dyskin, A.; Wagner, S.; Ritter, D.; Kallfass, I.
Conference Paper
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2012Ultra wideband cascade low noise amplifier implemented in 100-nm GaAs metamorphic-HEMTS technology
Dyskin, A.; Ritter, D.; Kallfass, I.
Conference Paper
2011A 10-GS/s multibit delta-sigma analog-to-digital converter in an InP HBT technology
Kraus, S.; Kallfass, I.; Makon, R.E.; Driad, R.; Moyal, M.; Ritter, D.
Conference Paper
2011A 20-GHz bipolar latched comparator with improved sensitivity implemented in InP HBT technology
Kraus, S.; Kallfass, I.; Makon, R.E.; Driad, R.; Moyal, M.; Ritter, D.
Journal Article
2011Discrepancy between high clastogenic activity of trans-beta-nitrostyrene in vitro and lack in carcinogenicity might be related to inactivating metabolism and its high reactivity towards thiol groups
Ziemann, Christina; Apitius, Florian; Elend, Manfred; Baumgartner, S.; Volk, J.; Ritter, Detlef; Steinfelder, H.J.; Schuchardt, Sven
Conference Paper, Journal Article
2011High-speed selector-driver using abrupt delta-doped InP/InGaAs/InP DHBTs
Driad, R.; Makon, R.E.; Ritter, D.
Journal Article
2011Improvement of experimental methods for toxicological characterization of inhalable substances in vitro by in situ analysis of the cellular status based on fluorescence stainings
Ritter, Detlef; Knebel, Jan
Conference Paper, Journal Article
2011Prävalidierungsstudie zur Prüfung der toxischen Wirkung von inhalativ wirksamen Stoffen (Gase)
Knebel, Jan; Ritter, Detlef; Berger-Preiß, Edith; Kock, Heiko; Liebsch, Manfred; Smirnova, Lena; Pirow, Ralph; Linsel, Gunter; Bauer, Mario; Graebsch, Carolin
Study
2011Toxicological characterization of inhalable substances and aerosols in vitro: Enhancement of experimental methods by in situ fluorescence analysis of the cellular status during exposure
Ritter, Detlef; Knebel, Jan
Journal Article, Conference Paper
2011Untersuchungen zum biologischen Effekt inhalierbarer Aerosole in vitro
Lange, Carsten
: Scharfenberg, Klaus (Erstprüfer); Dasenbrock, Clemens (Zweitprüfer); Knebel, Jan (Betreuer); Ritter, Detlef (Betreuer)
Bachelor Thesis
2010Comparative mechanistical investigations on the genotoxic potential of nitrovinyluracil derivatives
Heinemann, D.; Ritter, D.; Kasper, C.; Eger, K.; Steinfelder, H.J.; Ziemann, C.
Abstract
2010Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air-liquid interface (ALI) culture
Switalla, S.; Knebel, J.; Ritter, D.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010High linearity 2-bit current steering InP/GaInAs DHBT digital-to-analog converter
Kraus, S.; Kallfass, I.; Makon, R.E.; Rosenzweig, J.; Driad, R.; Moyal, M.; Ritter, D.
Conference Paper
2010PCLS (Precision Cut Lung Slices) as a putative model for genotoxicity testing by application of the comet assay
Ritter, D.; Switalla, S.; Sewald, K.; Knebel, J.
Abstract
2010Sensitivity of a 20-GS/s InP DHBT latched comparator
Kraus, S.; Makon, R.E.; Kallfass, I.; Driad, R.; Moyal, M.; Ritter, D.
Conference Paper
2010Testing of the toxicity of volatile compounds on human lung cells using the Air/Liquid Interface (ALI) culturing and exposure technique: A prevalidation study
Pirow, R.; Smirnova, L.; Liebsch, M.; Tharmann, J.; Luch, A.; Graebsch, C.; Bauer, M.; Linsel, G.; Siemers, R.; Otto, C.; Berger-Preiß, E.; Kock, H.; Oertel, A.; Ritter, D.; Knebel, J.
Journal Article, Conference Paper
2009Anordnung zur Durchfuehrung eines Verfahrens zur Untersuchung der Wirkung eines gasfoermigen Mediums auf ein biologisches Pruefsystem unter Verwendung eines extrazellulaeren Metabolisierungssystems
Knebel, J.; Ritter, D.
Patent
2009Cytokine production after acute exposure of precision cut lung slices to NO2 and O3
Switalla, S.; Ritter, D.; Krug, N.; Knebel, J.; Braun, A.; Sewald, K.
Abstract
2009Geltraeger zur Durchfuehrung des COMET-Assays mit Automatisierungsmoeglichkeit im Roboter-gestuetzten Analysebetrieb zur Realisierung eines Hochdurchsatz-Verfahrens
Ritter, D.; Knebel, J.
Patent
2009Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay
Ritter, D.; Knebel, J.
Journal Article, Conference Paper
2008Precision cut lung slices for testing of gaseous compounds
Switalla, S.; Sewald, K.; Ritter, D.; Henjakovic, M.; Krug, N.; Knebel, J.; Braun, A.
Conference Paper, Journal Article
2008Referenzpraeparat fuer eine Untersuchungsmethode unter Verwendung eines bildgebenden Erfassungs- und Auswertungsverfahrens
Ritter, D.; Knebel, J.
Patent
2008Standardization of the COMET-assay
Ritter, D.; Knebel, J.
Conference Paper, Journal Article
2007Development of a procedure for high content and higher throughput analysis of DNA-damage based on the COMET-assay
Ritter, D.; Knebel, J.; Krueger, D.
Conference Paper, Journal Article
2007Geltraeger zur Durchfuehrung des COMET-Assays mit Automatisierungsmoeglichkeit im Roboter-gestuetzten Analysebetrieb zur Realisierung eines Hochdurchsatz-Verfahrens
Ritter, D.; Knebel, J.
Patent
2007Verfahren zur Untersuchung der Wirkung eines gasfoermigen Mediums auf ein biologisches Pruefsystem unter Verwendung eines extrazellulaeren Metabolisierungssystems sowie Vorrichtung zur Durchfuehrung des Verfahrens
Knebel, J.; Ritter, D.
Patent
2004Comparative assessment of toxicities of mainstream smoke from commercial cigarettes
Ritter, D.; Knebel, J.W.; Aufderheide, M.
Journal Article
2003Exposure of human lung cells to inhalable substances
Ritter, D.; Knebel, J.W.; Aufderheide, M.
Journal Article
2003An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke
Aufderheide, M.; Knebel, J.W.; Ritter, D.
Journal Article
2003Novel approaches for studying pulmonary toxicity in vitro
Aufderheide, M.; Knebel, J.W.; Ritter, D.
Journal Article
2002Direct exposure of human lung cells to native cigarette mainstream smoke
Ritter, D.; Knebel, J.; Aufderheide, M.
Conference Paper
2002Exposure of human lung cells to native diesel motor exhaust - development of an optimized in vitro test strategy
Knebel, J.W.; Ritter, D.; Aufderheide, M.
Journal Article
2002A method for the in vitro exposure of human cells to environmental and complex gaseous mixtures
Aufderheide, M.; Knebel, J.W.; Ritter, D.
Journal Article
2002A new system for the direct in vitro exposure of human lung cells to native cigarette mainstream smoke
Ritter, D.; Knebel, J.W.; Aufderheide, M.
Conference Paper
2001Development and validation of a semiautomatic system for generation and deposition of sprays on isolated cells of the respiratory tract
Knebel, J.W.; Ritter, D.; Hoffmann, K.; Lödding, H.; Windt, H.; Koch, W.; Aufderheide, M.
Journal Article
2001In vitro exposure of isolated cells to native gaseous compounds - development and validation of an optimized system for human lung cells
Ritter, D.; Knebel, J.W.; Aufderheide, M.
Journal Article
2001A method for in vitro analysis of the biological activity of complex mixtures such as sidestream cigarette smoke
Aufderheide, M.; Ritter, D.; Knebel, J.W.; Scherer, G.
Journal Article
2000Entwicklung eines Systems zur Untersuchung der biologischen Aktivität atmospherischer Gase in vitro
Ritter, D.
: Alves, J. (Prüfer); Aufderheide, M. (Prüfer)
Dissertation
1999Development of a cell culture model system for routine testing of substances inducing oxidative stress
Ritter, D.; Knebel, J.W.; Aufderheide, M.; Mohr, U.
Journal Article
1998Development of an in vitro system for studying effects of native and photochemically transformed gaseous compounds using an air/liquid culture technique
Knebel, J.W.; Ritter, D.; Aufderheide, M.
Journal Article
1997Development of a cell culture system for studying effects of native and photochemically transformed gaseous compounds using an air/liquid culture technique
Ritter, D.; Knebel, J.W.; Aufderheide, M.; Palm, W.-U.; Zetzsch, C.
Conference Paper