Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices
Reamon-Buettner, S.M.; Niehof, M.; Hirth, N.; Danov, O.; Obernolte, H.; Braun, A.; Warnecke, J.; Sewald, K.; Wronski, S.
Journal Article
2018Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices
Neuhaus, Vanessa; Danov, Olga; Konzok, Sebastian; Obernolte, Helena; Dehmel, Susann; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Zardo, Patrick; Warnecke, Gregor; Martin, Christian; Braun, Armin; Sewald, Katherina
Journal Article
2018Early biomarkers indicating COPD can be induced by whole cigarette smoke in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Warnecke, Gregor; Zardo, Patrick; Fieguth, Hans-Gerd; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Abstract
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2018Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs
Danov, Olga; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Seehase, Sophie; Dehmel, Susann; Braubach, Peter; Fieguth, Hans-Gerd; Matschiner, Gabriele; Fitzgerald, Mary; Jonigk, Danny; Knauf, Sascha; Pfennig, Olaf; Warnecke, Gregor; Wichmann, Judy; Braun, Armin; Sewald, Katherina
Journal Article
2018Inflammatory exacerbation and inadequate interferone response to RV1b infection in HDM-sensitized lung tissue
Danov, Olga; Laßwitz, Lisa; Obernolte, Helena; Hesse, Christina; Braun, Armin; Wronski, Sabine; Sewald, Katherina
Abstract
2018Mechanism of NK1-mediated bronchoconstriction in passively sensitized human lung tissue
Dehmel, Susann; Jiménez Delgado, Sharon Melissa; Obernolte, Helena; Reamon-Buettner, Stella Marie; Jonigk, Danny; Pfennig, Olaf; Braubach, Peter; Warnecke, Gregor; Fieguth, Hans-Gerd; Sewald, Katherina; Braun, Armin
Abstract
2018Transcriptomic analyses reveal anti-viral responses of epithelial cells and multiple immune cell types in HRV infected human lung tissue
Obernolte, Helena; Braubach, Peter; Jonigk, Danny; Beinke, Soren; Belyaev, Nikolai N.; Lennon, Mark; Warnecke, Gregor; Fieguth, Hans-Gerd; Hessel, Edith M.; Braun, Armin; Sewald, Katherina; Wronski, Sabine; Twisterling, Serrao E.
Abstract
2017Anti-viral and inflammatory host response to rhinovirus is induced in vital ex vivo human lung tissue and reduced by anti-viral treatments
Obernolte, H.; Braubach, P.; Jonigk, D.; Kruger, M.; Warnecke, G.; Pfennig, O.; Fieguth, H.-G.; Braun, A.; Sewald, K.; Wronski, S.
Abstract
2016BI 1002494, a novel potent and selective oral spleen tyrosine kinase inhibitor, displays differential potency in human basophils and B cells
Lamb, David J.; Wollin, Stefan Lutz; Schnapp, Andreas; Bischoff, Daniel; Erb, Klaus J.; Bouyssou, Thierry; Guilliard, Bernd; Strasser, Christine; Wex, Eva; Blum, Sylvia; Thaler, Eva; Nickel, Helga; Radmacher, Oliver; Haas, Hannah; Swantek, Jennifer L.; Souza, Don; Canfield, Melissa; White, Della; Panzenbeck, Mark; Kashem, Mohammed A.; Sanville-Ross, Mary; Kono, Takeshi; Sewald, Katherina; Braun, Armin; Obernolte, Helena; Danov, Olga; Schaenzle, Gerhard; Rast, Georg; Maier, Gerd-Michael; Hoffmann, Matthias
Journal Article
2016Cigarette smoke and cigarette smoke condensate induce early biomarkers of inflammation and cytotoxicity in precision-cut lung slices
Obernolte, H.; Ritter, D.; Knebel, J.W.; Braubach, P.; Jonigk, D.; Fieguth, H.-G.; Braun, A.; Sewald, K.
Abstract
2016Transient Receptor Potential (TRP) ion channels activation in vital human precision-cut lung slices lead to bronchoconstriction and is neuropeptide substance P-dependent
Delgado, S.M.J.; Obernolte, H.; Hobbie, S.; Schindler, S.; Jonigk, D.; Warnecke, G.; Braubach, P.; Bersch, C.; Pfennig, O.; Fieguth, H.G.; Sewald, K.; Braun, A.
Abstract
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices
Obernolte, Helena; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract
2015Cigarette smoke condensate and cigarette smoke induce cytotoxicity and inflammation in human and rodent Precision-Cut Lung Slices of different species
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan W.; Braubach, Peter; Jonigk, Danny; Braun, Armin; Sewald, Katherina
Abstract