Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021Do biomarkers allow a differentiation between osteonecrosis of the femoral head and osteoarthritis of the hip? - A biochemical, histological and gene expression analysis
Floerkemeier, T.; Budde, S.; Willbold, E.; Schwarze, M.; Niehof, M.; Lichtinghagen, R.; Windhagen, H.; Weizbauer, A.; Reifenrath, J.
Journal Article
2021A modified protocol for successful miRNA profiling in human precision-cut lung slices (PCLS)
Niehof, M.; Reamon-Buettner, S.M.; Danov, O.; Hansen, T.; Sewald, K.
Journal Article
2020In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection
Ritter, Detlef; Knebel, Jan; Niehof, Monika; Loinaz, Iraida; Marradi, Marco; Gracia, Raquel; Welscher, Yvonne te; Nostrum, Cornelus F. van; Falciani, Chiara; Pini, Alessandro; Strandh, Magnus; Hansen, Tanja
Journal Article
2019Cigarette smoke induced pathophysiological changes in the extracellular matrix but not inflammation as early events in fresh human lung tissue
Obernolte, Helena; Ritter, Detlef; Knebel, Jan; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Warnecke, G.; Zardo, P.; Fieguth, H.-G.; Pfennig, Olaf; Braun, Armin; Sewald, Katherina
Journal Article
2019Hazard characterisation of acrylates by in vitro and ex vivo models - an update of the ExITox project
Schramm, Sinja-Fee; Wehr, Matthias; Danov, Olga; Obernolte, Helena; Knebel, Jan; Koschmann, J.; Meckbach, C.; Niehof, Monika; Braubach, Peter; Jonigk, Danny; Hansen, Tanja; Braun, Armin; Sewald, Katherina; Escher, Sylvia E.
Journal Article
2019Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Brown, Peter; Zhou, Yaoqi; Niehof, M.; Biedermann, P.H.W.; Schwotzer, D.; Strehlow, J.
Journal Article
2019Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices
Reamon-Buettner, S.M.; Niehof, M.; Hirth, N.; Danov, O.; Obernolte, H.; Braun, A.; Warnecke, J.; Sewald, K.; Wronski, S.
Journal Article
2018Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II
Schwotzer, Daniela; Niehof, Monika; Schaudien, Dirk; Kock, Heiko; Hansen, Tanja; Dasenbrock, Clemens; Creutzenberg, Otto H.
Journal Article
2018Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system
Knebel, Jan W.; Ritter, Detlef; Niehof, Monika; Hansen, Tanja; Strandh, M.; Falciani, C.; Flores, M.; Welscher, Y. te; Nostrum, C. van; Gracia, R.; Marradi, M.; Loinaz, I.
Journal Article
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Journal Article
2017RNA isolation from precision-cut lung slices (PCLS) from different species
Niehof, Monika; Hildebrandt, Tobias; Danov, Olga; Arndt, Kirsten; Koschmann, Jeannette; Dahlmann, Franziska; Hansen, Tanja; Sewald, Katherina
Journal Article
2016Development of an in vitro testing platform for aerosols containing inhalable antiobiotically active compounds as a part of the EU-project "PNeumoNP"
Ritter, D.; Knebel, J.; Wronski, S.; Montes, A.; Niehof, M.
Journal Article
2016Functional, histological and biochemical endpoints for assessing antifibrotic efficacy in a rat model of pulmonary fibrosis
Hoymann, H.G.; Schaudien, D.; Hansen, T.; Niehof, M.; Braun, A.
Journal Article
2016Toxicity of CeO2 nanoparticles estimated in a 90-day nose-only inhalation study
Schwotzer, Daniela; Niehof, Monika; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Ernst, Heinrich; Creutzenberg, Otto H.
Journal Article
2016Toxicity of cerium dioxide nanoparticles - effects from a 90-day inhalation study
Schwotzer, D.; Niehof, M.; Hansen, T.; Tillmann, T.; Ernst, H.; Creutzenberg, O.
Journal Article
2015An overview of the InhalT-90 project - a 90-day inhalation toxicity study with CeO2 nanoparticles
Schwotzer, Daniela; Hansen, Tanja; Niehof, Monika; Creutzenberg, Otto
Journal Article
2014Cytochrome P450 monooxygenases expression in human bronchial epithelial calu-3 cells under different culture conditions
Hansen, Tanja; Niehof, Monika; Knebel, Jan
Journal Article
2014Establishment of pathway-specific gene expression analysis using the example of the paraquat action on human lung epithelial cells
Niehof, Monika; Augustin, Christian; Hansen, Tanja
Journal Article
2014Multiwalled carbon nanotubes (MWCNT) induce DNA damage and cellular senescence in human peritoneal mesothelial LP9 cells
Reamon-Büttner, Stella Marie; Bellmann, Bernd; Hackbarth, Anja; Leonhardt, Albrecht; Niehof, Monika; Ziemann, Christina
Journal Article
2014Optimizing gene-expression analysis for induced sputum
Holz, Olaf; Hansen, Tanja; Homburg, Ursula; Garn, Holger; Hohlfeld, Jens Michael; Niehof, Monika
Journal Article
2014Untersuchung der CYP450 Expression in primären humanen Hepatozyten und Hepatozyten-ähnlichen Zellsystemen
Heiermann, Steffen
: Pfitzner, Reinhard (Erstprüfer); Niehof, Monika (Zweitprüfer)
Bachelor Thesis
2014Untersuchungen zum Wirkmechanismus von nanostrukturiertem Carbon Black mit unterschiedlicher Oberflächenbeschaffenheit
Tautenhahn, Sven
: Scharfenberg, Klaus (1. Gutachter); Hansen, Tanja (2. Gutachter); Niehof, Monika (Wiss. Betreuung)
Bachelor Thesis
2013Cytochrome P450 monooxygenases expression in human epithelial lung cell lines
Niehof, Monika; Hansen, Tanja
Journal Article
2013Studies on the mode of action of Multi-Walled Carbon Nanotubes onto human bronchial epithelial cells
Walter, Dorothee; Niehof, Monika; Hackbarth, Anja; Hansen, Tanja
Journal Article
2013Untersuchungen zum Wirkmechanismus von Multi-Walled Carbon Nanotubes an Bronchialepithelzellen
Walter, Dorothee
: Steinberg, Pablo (Erstprüfer); Hansen, Tanja (Zweitprüfer); Niehof, Monika (Betreuer)
Master Thesis
2012Etablierung pathway-spezifischer Genexpressionsanalysen am Beispiel der Wirkung von Paraquat auf humane Lungenepithelzellen
Augustin, Christian
: Pfitzner, Reinhard (Erstprüfer); Niehof, Monika (Zweitprüfer)
Bachelor Thesis
2011HNF4alpha dysfunction as a molecular rational for cyclosporine induced hypertension
Niehof, M.; Borlak, J.
Journal Article
2009Expression of HNF4alpha in the human and rat choroid plexus - implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier
Niehof, M.; Borlak, J.
Journal Article
2009HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus
Borlak, J.; Niehof, M.
Journal Article
2008EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4 alpha splice variants in hepatocellular carcinomas
Niehof, M.; Borlak, J.
Journal Article
2008Genome wide prediction of HNF4 alpha functional binding sites by the use of local and global sequence context
Kel, A.E.; Niehof, M.; Matys, V.; Zemlin, R.; Borlak, J.
Journal Article
2008HNF4 alpha and the Ca-Channel TRPC1 are novel disease candidate genes in diabetic nephropathy
Niehof, M.; Borlak, J.
Journal Article
2006Use of novel HNFAalpha target genes and their gene products
Borlak, J.; Niehof, M.
Patent
2005Chromatin immunoprecipitation-based identification of gene regulatory networks
Niehof, M.; Borlak, J.
Book Article
2005In vivo chip cloning of novel HNF4a gene targets
Borlak, J.; Zemlin, R.; Niehof, M.
Journal Article
2005RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain
Niehof, M.; Borlak, J.
Journal Article
2003Altered protein/DNA interactions of liver-enriched transcription factors as predictors for toxicity - implications for toxicogenomic research
Borlak, J.; Sowa, A.; Niehof, M.
Journal Article
2003An optimized method for the isolation and identification of membrane proteins
Lehner, I.; Niehof, M.; Borlak, J.
Journal Article
2001Autoregulation enables different pathways to control CCAAT/enhancer binding protein beta (C/EBP beta) transcription
Niehof, M.; Kubicka, S.; Zender, L.; Manns, M.P.; Trautwein, C.
Journal Article
2001Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3
Niehof, M.; Streetz, K.; Rakemann, T.; Bischoff, S.; Manns, M.P.; Horn, F.; Trautwein, C.
Journal Article