Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Elimination of different leukaemia subtypes using novel CD89-specific human cytolytic fusion proteins
Gresch, G.; Schenke, L.; Mladenov, R.; Zwirner, S.; Cremer, C.; Niesen, J.; Grieger, E.; Brümmendorf, T.; Jost, E.; Fischer, R.; Stockmeyer, B.; Barth, S.; Nachreiner, T.; Stein, C.
Journal Article
2017Fine Tuning Antibody Conjugation Methods using SNAP-tag Technology
Chouman, K.; Woitok, M.; Mladenov, R.; Kessler, C.; Weinhold, E.; Hanz, G.; Fischer, R.; Meinhold-Heerlein, I.; Bleilevens, A.; Gresch, G.; Haugg, A.M.; Zeppernick, F.; Bauerschlag, D.; Maass, N.; Stickeler, E.; Kolberg, K.; Hussain, A.F.
Journal Article
2017Human MAP tau based targeted cytolytic fusion proteins
Akinrinmade, O.A.; Jordaan, S.; Hristodorov, D.; Mladenov, R.; Mungra, N.; Chetty, S.; Barth, S.
Journal Article
2016CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo
Mladenov, R.; Hristodorov, D.; Cremer, C.; Gresch, G.; Grieger, G.; Schenke, L.; Klose, D.; Amoury, M.; Woitok, M.; Jost, E.; Brümmerdorf, T.H.; Fendel, R.; Fischer, R.; Stein, C.; Thepen, T.; Barth, S.
Journal Article
2016Fully human MAP-fusion protein selectively targets and eliminates proliferating CD64+ M1 macrophages
Hristodorov, D.; Mladenov, R.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2016Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model
Amoury, M.; Kolberg, K.; Pham, A.-T.; Hristodorov, D.; Mladenov, R.; Fiore, S. di; Helfrich, W.; Kiessling, F.; Fischer, R.; Pardo, A.; Thepen, T.; Hussain, A.F.; Nachreiner, T.; Barth, S.
Journal Article
2016A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein
Amoury, M.; Mladenov, R.; Nachreiner, T.; Pham, A.-T.; Hristodorov, D.; Di Fiore, S.; Helfrich, W.; Pardo, A.; Fey, G.; Schwenkert, M.; Thepen, T.; Kiessling, F.; Hussain, A.F.; Fischer, R.; Kolberg, K.; Barth, S.
Journal Article
2015The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia
Mladenov, R.; Hristodorov, D.; Cremer, C.; Hein, L.; Kreutzer, F.; Stroisch, T.; Niesen, J.; Brehm, H.; Blume, T.; Brummendorf, T.H.; Jost, E.; Thepen, T.; Fischer, R.; Stockmeyer, B.; Barth, S.; Stein, C.
Journal Article
2015Novel angiogenin mutants with increased cytotoxicity enhance the depletion of pro-inflammatory macrophages and leukemia cells ex vivo
Cremer, C.; Braun, H.; Mladenov, R.; Schenke, L.; Cong, X.; Jost, E.; Brümmendorf, T.H.; Fischer, R.; Carloni, P.; Barth, S.; Nachreiner, T.
Journal Article
2015Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein
Brehm, H.; Hristodorov, D.; Pardo, A.; Mladenov, R.; Niesen, J.; Fischer, R.; Tur, M.K.; Barth, S.
Journal Article
2015Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies
Hristodorov, D.; Mladenov, R.; Felbert, V. von; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2014 Recombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody
Hristodorov, D.; Mladenov, R.; Brehm, H.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2014A CSPG4-specific immunotoxin kills rhabdomyosarcoma cells and binds to primary tumor tissues
Brehm, H.; Niesen, J.; Mladenov, R.; Stein, C.; Pardo, A.; Fey, G.; Helfrich, W.; Fischer, R.; Gattenlöhner, S.; Barth, S.
Journal Article
2014EpCAM-Selective Elimination of Carcinoma Cells by a Novel MAP-Based Cytolytic Fusion Protein
Hristodorov, D.; Amoury, M.; Mladenov, R.; Niesen, J.; Arens, K.; Berges, N.; Hein, L.; Fiore, S. di; Pham, A.T.; Huhn, M.; Helfrich, W.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2014Human microtubule-associated protein tau mediates targeted killing of CD30+ lymphoma cells in vitro and inhibits tumour growth in vivo
Hristodorov, D.; Nordlohne, J.; Mladenov, R.; Huhn, M.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2013Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells
Schiffer, S.; Letzian, S.; Jost, E.; Mladenov, R.; Hristodorov, D.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2013Macrophage-targeted therapy of chronic wounds
Hristodorov, D.; Mladenov, R.; Aslanian, E.; Huhn, M.; Barth, S.; Thepen, T.
Book Article
2013Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo
Hristodorov, D.; Mladenov, R.; Pardo, A.; Pham, A.-T.; Huhn, M.; Fischer, R.; Thepen, T.; Barth, S.
Journal Article
2013Species-Dependent Functionality of the Human Cytolytic Fusion Proteins Granzyme B-H22(scFv) and H22(scFv)-Angiogenin in Macrophages
Schiffer, S.; Hristodorov, D.; Mladenov, R.; Aslanian, E.; Huhn, M.; Fischer, R.; Barth, S.; Thepen, T.
Journal Article
2012Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases. Review
Hristodorov, D.; Mladenov, R.; Huhn, M.; Barth, S.; Thepen, T.
Journal Article