Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019A fast and simple fluorometric method to detect cell death in 3D intestinal organoids
Bode, Konstantin J.; Mueller, Stefanie; Schweinlin, Matthias; Metzger, Marco; Brunner, Thomas
Journal Article
2019Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
Colunga, Thomas; Hayworth, Miranda; Kress, Sebastian; Reynolds, David M.; Chen, Luoman; Nazor, Kristopher L.; Baur, Johannes; Singh, Amar M.; Loring, Jeanne F.; Metzger, Marco; Dalton, Stephen
Journal Article
2019Obstructed defecation - an enteric neuropathy? An exploratory study of patient samples
Kim, M.; Rosenbaum, C.; Schlegel, N.; Grumaz, C.; Sohn, K.; Isbert, C.; Walles, H.; Metzger, M.
Journal Article
2018Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet
Mühlemann, Markus; Zdzieblo, Daniela; Friedrich, Alexandra; Berger, Constantin; Otto, Christoph; Walles, Heike; Koepsell, Hermann; Metzger, Marco
Journal Article
2018Alterung und Lebensdauer
Hartrott, P. von; Metzger, M.; Rockenhäuser, C.; Skrotzki, B.
Journal Article
2018Alterung und Lebensdauer - Lebensdauerberechnung von Aluminium-Radialverdichterrädern unter Berücksichtigung der Werkstoffalterung
Rockenhäuser, C.; Hartrott, P. von; Metzger, M.; Karlin, J.; Skrotzki, B.; Schweizer, C.
Report
2018Computational assessment of the microstructure-dependent plasticity of lamellar gray cast iron - Part IV: Assessment of the yield surface after plastic loading
Metzger, M.; Seifert, T.
Journal Article
2018Development of lacrimal gland spheroids for lacrimal gland tissue regeneration
Massie, Isobel; Spaniol, Kristina; Barbian, Andreas; Geerling, Gerd; Metzger, Marco; Schrader, Stefan
Journal Article
2018Erweiterte Schädingungskonzepte für thermomechanische Beanspruchung unter variablen Amplituden und plastischer Deformation
Schackert, S.; Bosch, A.; Metzger, M.; Schweizer, C.; Vormwald, M.
Report
2018Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluripotent stem cells
Appelt-Menzel, A.; Cubukova, A.; Metzger, M.
Journal Article
2018Evaluation of a miniaturized biologically vascularized scaffold in vitro and in vivo
Kress, Sebastian; Baur, Johannes; Otto, Christoph; Burkard, Natalie; Braspenning, Joris; Walles, Heike; Nickel, Joachim; Metzger, Marco
Journal Article
2018Laser-capture microdissection for layer-specific analysis of enteric ganglia
Rosenbaum, Corinna; Böttner, Martina; Wedel, Thilo; Metzger, Marco
Book Article
2018Lebensdauerberechnung von Aluminium-Radialverdichterrädern unter Berücksichtigung der Werkstoffalterung
Rockenhäuser, C.; Hartrott, P. von; Metzger, M.; Schriever, S.; Augenstein, E.; Karlin, J.; Piesker, B.; Schweizer, C.; Skrotzki, B.
Conference Paper
2018Stem cell-based human blood-brain barrier co-culture models for pre-clinical development
Appelt-Menzel, Antje; Cubukova, Alevtina; Piontek, Jörg; Walles, Heike; Neuhaus, Winfried; Metzger, Marco
Journal Article, Conference Paper
2018TurboSubst - Integrales Verfahren zur systematischen Substitution von Legierungselementen am Beispiel von Turbinenrädern für Abgasturbolader
Friedmann, V.; Augenstein, E.; Zapara, M.; Metzger, M.; Kertsch, L.; Helm, D.; Schweizer, C.
Report
2017Calcium fluoride based multifunctional nanoparticles for multimodal imaging
Straßer, Marion; Schrauth, Joachim H.X.; Dembski, Sofia; Haddad, Daniel; Ahrens, Bernd; Schweizer, Stefan; Christ, Bastian; Cubukova, Alevtina; Metzger, Marco; Walles, Heike; Jakob, Peter M.; Sextl, Gerhard
Journal Article
2017Enlarged islet size, altered insulin(+) and glucagon(+) cell frequencies and modified blood-values for GLP-1, insulin and glucagon in Sglt1 knockout mice
Muehlemann, M.; Zdzieblo, D.; Friedrich, A.; Hofmann, M.; Otto, C.; Koepsell, H.; Walles, H.; Metzger, M.
Abstract
2017Establishment of a human blood-brain barrier co-culture model based on human multipotent and pluripotent stem cells mimicking the neurovascular unit
Appelt-Menzel, A.; Cubukova, A.; Neuhaus, W.; Piontek, J.; Walles, H.; Metzger, M.
Abstract
2017Establishment of a human blood-brain barrier co-culture model mimicking the neurovascular unit using induced pluri- and multipotent stem cells
Appelt-Menzel, Antje; Cubukova, Alevtina; Günther, Katharina; Edenhofer, Frank; Piontek, Jörg; Krause, Gerd; Stüber, Tanja; Walles, Heike; Neuhaus, Winfried; Metzger, Marco
Journal Article
2017Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome
Massie, I.; Spaniol, K.; Barbian, A.; Poschmann, G.; Stühler, K.; Geerling, G.; Metzger, M.; Mertsch, S.; Schrader, S.
Journal Article
2017miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome
Wohlfarth, C.; Schmitteckert, S.; Härtle, J.D.; Houghton, L.A.; Dweep, H.; Fortea, M.; Assadi, G.; Braun, A.; Mederer, T.; Pöhner, S.; Becker, P.P.; Fischer, C.; Granzow, M.; Mönnikes, H.; Mayer, E.A.; Sayuk, G.; Boeckxstaens, G.; Wouters, M.M.; Simren, M.; Lindberg, G.; Ohlsson, B.; Schmidt, P.T.; Dlugosz, A.; Agreus, L.; Andreasson, A.; D'Amato, M.; Burwinkel, B.; Bermejo, J.L.; Röth, R.; Lasitschka, F.; Vicario, M.; Metzger, M.; Santos, J.; Rappold, G.A.; Martinez, C.; Niesler, B.
Journal Article
2017Mucus detachment by host metalloprotease meprin β requires shedding of its inactive pro-form, which is abrogated by the pathogenic protease RgpB
Wichert, Rielana; Ermund, Anna; Schmidt, Stefanie; Schweinlin, Matthias; Ksiazek, Miroslaw; Arnold, Philipp; Knittler, Katharina; Wilkens, Frederike; Potempa, Barbara; Rabe, Björn; Stirnberg, Marit; Lucius, Ralph; Bartsch, Jörg W.; Nikolaus, Susanna; Falk-Paulsen, Maren; Rosenstiel, Philip; Metzger, Marco; Rose-John, Stefan; Potempa, Jan; Hansson, Gunnar C.; Dempsey, Peter J.; Becker-Pauly, Christoph
Journal Article
2017A pancreas‐specific ECM scaffold – human iPS cell culture and pancreatic differentiation goes 3D
Berger, Constantin; Bjørlykke, Yngvild; Mühlemann, Markus; Ræder, Helge; Walles, Heike; Metzger, Marco; Zdzieblo, Daniela
Abstract
2017Screening applications to test cellular fitness in transwell® models after nanoparticle treatment
Christ, Bastian; Fey, Christina; Cubukova, Alevtina; Walles, Heike; Dembski, Sofia; Metzger, Marco
Book Article
2017Tissue Engineering of primary human in vitro models – Influence of mechanical and biochemical stimulation on tissue functionality
Appelt-Menzel, Antje; Zdzieblo, Daniela; Schürlein, Sebastian; Schwarz, Thomas; Hansmann, Jan; Metzger, Marco; Walles, Heike
Abstract
20163D in vitro tissue models for infection studies with human pathogens
Schweinlin, Matthias; Steinke, Maria; Groeber, Florian; Gross, Roy; Reuter, Christian; Seidensticker, Katharina; Schulte, Leon; Metzger, Marco; Engstler, Markus; Walles, Heike
Abstract
2016Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo
Rosenbaum, C.; Schick, M.A.; Wollborn, J.; Heider, A.; Scholz, C.-J.; Cecil, A.; Niesler, B.; Hirrlinger, J.; Walles, H.; Metzger, M.
Journal Article
2016Computational assessment of the microstructure-dependent plasticity of lamellar gray cast iron - Part III: A new yield function derived from microstructure-based models
Metzger, M.; Seifert, T.
Journal Article
2016Development of an advanced primary human in vitro model of the small intestine
Schweinlin, Matthias; Wilhelm, Sabine; Schwedhelm, Ivo; Hansmann, Jan; Rietscher, Rene; Jurowich, Christian; Walles, Heike; Metzger, Marco
Journal Article
2016Mikrostruktur- und mechanismusbasierte Werkstoffmodelle zur Beschreibung des Deformations- und Lebensdauerverhaltens von thermomechanisch beanspruchten Graugusswerkstoffen
Metzger, Mario
: Riedel, H.; Böhlke, T.; Seifert, T.
Dissertation
2016Nanoparticle-based mucosal vaccines targeting tumor-associated antigens to human dendritic cells
Brito Baleeiro, R.; Schweinlin, Matthias; Rietscher, R.; Diedrich, A.; Czaplewska, J.A.; Metzger, Marco; Lehr, Claus-Michael; Scherließ, R.; Hanefeld, A.; Gottschaldt, M.; Walden, P.
Journal Article
2016Rapid monolayer neural induction of induced pluripotent stem cells yields stably proliferating neural stem cells
Günther, Katharina; Appelt-Menzel, Antje; Kwok, Chee Keong; Walles, Heike; Metzger, Marco; Edenhofer, Frank
Journal Article
2016Recent developments of disease and human in vitro models of the blood-brain barrier
Appelt-Menzel, Antje; Piontek, Jörg; Kraemer, Tobias; Riethmüller, Christoph; Gaiser, Fabian; Neuhoff, Anja; Mahringer, Anne; Thal, Serge; Förster, Carola; Walles, Heike; Metzger, Marco; Neuhaus, Winfried
Abstract
2016Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes
Schriemer, D.; Sribudiani, Y.; IJpma, A.; Natarajan, D.; MacKenzie, K.C.; Metzger, M.; Binder, E.; Burns, A.J.; Thapar, N.; Hofstra, R.M.W.; Eggen, B.J.L.
Journal Article
2016White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
Burns, Alan J.; Goldstein, Allan M.; Newgreen, Donald F.; Stamp, Lincon; Schäfer, Karl-Herbert; Metzger, Marco; Hotta, Ryo; Young, Heather M.; Andrews, Peter W.; Thapar, Nikhil; Belkind-Gerson, Jaime; Bondurand, Nadege; Bornstein, Joel C.; Chan, Wood Yee; Cheah, Kathryn; Gershon, Michael D.; Heuckeroth, Robert O.; Hofstra, Robert M.W.; Just, Lothar; Kapur, Raj P.; King, Sebastian K.; McCann, Conor J.; Nagy, Nandor; Ngan, Elly; Obermayr, Florian; Pachnis, Vassilis; Pasricha, Pankaj J.; Sham, Mai Har; Tam, Paul; Berghe, Pieter Vanden
Journal Article
2015Biovasc-term (R): A platform technology to engineer of vascularised human tissues
Walles, H.; Steinke, M.; Ruecker, C.; Hansmann, J.; Groeber, F.; Blunk, T.; Metzger, M.; Dandekar, G.; Pullig, O.
Conference Paper, Journal Article
2015Computational assessment of the microstructure-dependent plasticity of lamellar gray cast iron - Part I: Methods and microstructure-based models
Metzger, M.; Seifert, T.
Journal Article
2015Computational assessment of the microstructure-dependent plasticity of lamellar gray cast iron - Part II: Initial yield surfaces and directions
Metzger, M.; Seifert, T.
Journal Article
2015Development of an improved primary in vitro model of the human small intestine
Schweinlin, Matthias; Wilhelm, Sabine; Walles, Heike; Metzger, Marco
Conference Paper, Journal Article
2015Does the cyclic J -integral Delta J describe the crack-tip opening displacement in the presence of crack closure?
Metzger, M.; Seifert, T.; Schweizer, C.
Journal Article
2015Engineering of a secretory active three-dimensional lacrimal gland construct on the basis of decellularized lacrimal gland tissue
Spaniol, Kristina; Metzger, Marco; Roth, Mathias; Greve, Burkhard; Mertsch, Sonja; Geerling, Gerd; Schrader, Stefan
Journal Article
2015Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro
Meir, Michael; Flemming, Sven; Burkard, Natalie; Bergauer, Lisa; Metzger, Marco; Germer, Christoph-Thomas; Schlegel, Nicolas
Journal Article
2015Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology
Gordon, S.; Daneshian, M.; Bouwstra, J.; Caloni, F.; Constant, S.; Davies, D.E.; Dandekar, G.; Guzman, C.A.; Fabian, E.; Haltner, E.; Hartung, T.; Hasiwa, N.; Hayden, P.; Kandarova, H.; Khare, S.; Krug, H.F.; Kneuer, C.; Leist, M.; Lian, G.; Marx, U.; Metzger, M.; Ott, K.; Prieto, P.; Roberts, M.S.; Roggen, E.L.; Tralau, T.; Van Den Braak, C.; Walles, H.; Lehr, C.-M.
Journal Article
2015Physiological impact of odorants: Immediate versus post-ingestion and post-inhalation effects
Buettner, A.; Beauchamp, J.; Freiherr, Jessica; Heinlein, Anja; Kessler, Artur; Leuner, Kristina; Metzger, Marco; Pischetsrieder, Monika; Villmann, Carmen; Walles, Heike
Conference Paper
2014Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection
Hetz, Susan; Acikgoez, Ali; Moll, Corinna; Jahnke, Heinz-Georg; Robitzki, Andrea; Metzger, Roman; Metzger, Marco
Journal Article
2014In vivo transplantation of neurosphere-like bodies derived from the human postnatal and adult enteric nervous system: A pilot study
Hetz, Susan; Acikgoez, Ali; Voss, Ulrike; Nieber, Karen; Holland, Heidrun; Hegewald, Cindy; Till, Holger; Metzger, Roman; Metzger, Marco
Journal Article
2014Lifetime prediction of EN-GJV 450 cast iron cylinder heads under combined thermo-mechanical and high cycle fatigue loading
Metzger, Mario; Leidenfrost, M.; Werner, E.; Riedel, H.; Seifert, T.
Journal Article
2014Organ-like three dimensional test systems
Rossi, Angela; Groeber, Florian; Steinke, Maria; Dandekar, Gudrun; Nietzer, Sarah; Metzger, Marco; Walles, Heike
Abstract
2014The role of enteric glial cells in inflammatory diseases of the bowel
Moll, Corinna; Heider, A.; Brede, Christian; Scholz, Claus-Jürgen; Cecil, Alexander; Walles, Heike; Metzger, Marco
Abstract
2014Transport of hop aroma compounds across Caco-2 monolayers
Heinlein, A.; Metzger, M.; Walles, H.; Buettner, A.
Journal Article
2013Lifetime prediction of cast iron materials under combined thermomechanical fatigue and high cycle fatigue loading using a mechanism-based model
Metzger, M.; Nieweg, B.; Schweizer, C.; Seifert, T.
Journal Article, Conference Paper
2013On the exploitation of Armstrong-Frederik type nonlinear kinematic hardening in the numerical integration and finite-element implementation of pressure dependent plasticity models
Metzger, M.; Seifert, T.
Journal Article
2012Lebensdauervorhersage für die Graugusswerkstoffe EN GJS700, EN GJV450 und EN GJL250 bei kombinierter nieder- und hochfrequenter Belastung
Metzger, M.; Nieweg, B.; Seifert, T.
Journal Article
2012A mechanism-based model for LCF/HCF and TMF/HCF life prediction
Metzger, M.; Seifert, T.
Journal Article
2011Materialmodell zur Lebensdauervorhersage von Bauteilen aus Eisengusswerkstoffen
Metzger, M.; Warkentin, M.; Seifert, T.
Journal Article
2008Organotypical tissue cultures from adult murine colon as an in vitro model of intestinal mucosa
Bareiss, P.M.; Metzger, M.; Sohn, K.; Rupp, S.; Frick, J.S.; Autenrieth, I.B.; Lang, F.; Schwarz, H.; Skutella, T.; Just, L.
Journal Article
2005Phase transitions of FOX-7 studied by x-ray diffraction and thermal analysis
Kempa, P.-B.; Herrmann, M.J.; Metzger, M.F.; Thome, V.
Conference Paper
2004Phase transitions of FOX-7 studied by x-ray diffraction and thermal analysis
Kempa, P.-B.; Herrmann, M.M.; Metzger, M.; Thome, V.; Kjellström, A.; Latypov, N.
Conference Paper
2003High performance computer codes and their application to optimize crystal growth processes
Czarny, O.; Droll, P.; Ganaoui, M. el; Fischer, B.; Hainke, M.; Kadinski, L.; Kaufmann, P.; Krastev, K.; Mesic, E.; Metzger, M.; Raspo, I.; Serre, E.; Bontoux, P.; Durst, F.; Müller, G.; Schäfer, M.
Conference Paper
2002Equipment and process modeling of industrial crystal growth using the finite volume codes CrysVUN and STHAMAS
Hainke, M.; Jung, T.; Friedrich, J.; Fischer, B.; Metzger, M.; Müller, G.
Conference Paper
1986Structured deposition of SiO2 and poly-Si by Ar+ -Laser pyrolysis
Sigmund, H.; Metzger, M.; Stumpff, C.
Conference Paper
1983Implantation doping of germanium with Be, Mg, Zn und B-ions
Metzger, M.; Zhang, Z.; Schmiedt, B.; Ryssel, H.
Book Article