Fraunhofer-Gesellschaft

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Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
Perotin, J.-M.; Schofield, J.P.R.; Wilson, S.J.; Ward, J.; Brandsma, J.; Strazzeri, F.; Bansal, A.; Yang, X.; Rowe, A.; Corfield, J.; Lutter, R.; Shaw, D.E.; Bakke, P.S.; Caruso, M.; Dahlén, B.; Fowler, S.J.; Horváth, I.; Howarth, P.; Krug, N.; Montuschi, P.; Sanak, M.; Sandström, T.; Sun, K.; Pandis, I.; Auffray, C.; Meulder, B. de; Lefaudeux, D.; Riley, J.H.; Sousa, A.R.; Dahlen, S.-E.; Adcock, I.M.; Chung, K.F.; Sterk, P.J.; Skipp, P.J.; Collins, J.E.; Davies, D.E.; Djukanović, R.
Journal Article
2019IL-17–high asthma with features of a psoriasis immunophenotype
Östling, J.; Geest, M. van; Schofield, J.P.R.; Jevnikar, Z.; Wilson, S.; Ward, J.; Lutter, R.; Shaw, D.E.; Bakke, P.S.; Caruso, M.; Dahlen, S.-E.; Fowler, S.J.; Horvath, I.; Krug, N.; Montuschi, P.; Sanak, M.; Sandström, T.; Sun, K.; Pandis, I.; Auffray, C.; Sousa, A.R.; Guo, Y.; Adcock, I.M.; Howarth, P.; Chung, K.F.; Bigler, J.; Sterk, P.J.; Skipp, P.J.; Djukanović, R.; Vaarala, O.
Journal Article
2019Interferon Response Genes in Nasal Epithelium to Rhinovirus16 Challenge in Asthma Patients Links to Viral Clearance and Common Cold Scores
Ravi, A.; Chang, M.; Pol, M.A. van de; Yang, S.; Aliprantis, Antonios; Thornton, Bob; Hohlfeld, Jens M.; Sterk, Peter J.; Krug, Norbert; Lutter, René
Abstract
2019Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma
Tariq, K.; Schofield, James P.R.; Nicholas, Ben; Burg, Dominic; Brandsma, Joost; Bansal, Aruna T.; Wilson, Susan J.; Lutter, René; Fowler, Stephen J.; Bakke, Per; Caruso, Massimo; Dahlén, Barbro; Horvath, Ildiko; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandstrom, Thomas; Geiser, Thomas; Pandis, Ioannis; Sousa, Ana R.; Adcock, Ian M.; Shaw, Dominick E.; Auffray, Charles; Howarth, Peter H.; Sterk, Peter J.; Chung, Kian Fan; Skipp, Paul J.; Dimitrov, Borislav; Djukanovic, Ratko
Journal Article
2019Stratification of asthma phenotypes by airway proteomic signatures
Schofield, J.P.R.; Burg, D.; Nicholas, B.; Strazzeri, F.; Brandsma, J.; Staykova, D.; Folisi, C.; Bansal, A.T.; Xian, Y.; Guo, Y.; Rowe, A.; Corfield, J.; Wilson, S.; Ward, J.; Lutter, R.; Shaw, D.E.; Bakke, P.S.; Caruso, M.; Dahlen, S.-E.; Fowler, S.J.; Horvath, I.; Howarth, P.; Krug, N.; Montuschi, P.; Sanak, M.; Sandström, T.; Sun, K.; Pandis, I.; Riley, J.; Auffray, C.; Meulder, B. De; Lefaudeux, D.; Sousa, A.R.; Adcock, I.M.; Chung, K.F.; Sterk, P.J.; Skipp, P.J.; Djukanović, R.
Journal Article
2018Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort
Emma, Rosalia; Bansal, Aruna T.; Kolmert, Johan; Wheelock, Craig E.; Dahlén, Sven-Erik; Loza, Matthew J.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Dahlén, Barbro; Bakke, Per S.; Chanez, Pascal; Fowler, Stephen J.; Horvath, Ildiko; Montuschi, Paolo; Krug, Norbert; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Fleming, Louise J.; Djukanovic, Ratko; Howarth, Peter H.; Singer, Florian; Sousa, Ana R.; Sterk, Peter J.; Corfield, Julie; Pandis, Ioannis; Chung, Kian F.; Adcock, Ian M.; Lutter, René; Fabbella, Lorena; Caruso, Massimo
Journal Article
2018Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome
Burg, Dominic; Schofield, James P.R.; Brandsma, Joost; Staykova, Doroteya; Folisi, Caterina; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horvath, Ildiko; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian F.; Sterk, Peter J.; Djukanovic, Ratko; Skipp, Paul J.
Journal Article
2018Pathway discovery using transcriptomic profiles in adult-onset severe asthma
Hekking, Pieter-Paul; Loza, Matt J.; Pavlidis, Stelios; Meulder, Bertrand de; Lefaudeux, Diane; Baribaud, Fred; Auffray, Charles; Wagener, Ariane H.; Brinkman, Paul; Lutter, René; Bansal, Aruna T.; Sousa, Ana R.; Bates, Steve A.; Pandis, Yannis; Fleming, Louise J.; Shaw, Dominique E.; Fowler, Stephen J.; Guo, Y.; Meiser, Andrea; Sun, Kai; Corfield, Julie; Howarth, Peter H.; Bel, Elisabeth H.; Adcock, Ian M.; Chung, Kian Fan; Djukanović, Ratko; Sterk, Peter J.
Journal Article
2018Rhinovirus challenge in asthmatics and healthy volunteers to evaluate the safety and appropriate dose of a GMP human rhinovirus 16 preparation for challenge studies in mild-moderate asthmatics taking ICS
Krug, Norbert; Hohlfeld, Jens M.; Aliprantis, Antonios; Carayannopoulos, Leonidas; Bautmans, An; Robberechts, Martine; Lepeleire, Inge de; Ziehr, Holger; Singh, Dave; Diamant, Zuzana; Yang, Shan; Fitch, Neil; Thornton, Bob; Sterk, Peter J.; Lutter, René
Abstract
2018Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: An exploratory analysis
Takahashi, Kentaro; Pavlidis, Stelios; Ng Kee Kwong, Francois; Hoda, Uruj; Rossios, Christos; Sun, Kai; Loza, Matthew; Baribaud, Fred; Chanez, Pascal; Fowler, Steve J.; Horvath, Ildiko; Montuschi, Paolo; Singer, Florian; Musial, Jacek; Dahlén, Barbro; Dahlén, Sven-Erik; Krug, Norbert; Sandström, Thomas; Shaw, Dominick E.; Lutter, René; Bakke, Per; Fleming, Louise J.; Howarth, Peter H.; Caruso, Massimo; Sousa, Ana R.; Corfield, Julie; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Djukanovic, Ratko; Sterk, Peter J.; Guo, Yike; Adcock, Ian M.; Chung, Kian Fan
Journal Article
2018Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA
Schofield, James P.R.; Bigler, Jeanette; Boedigheimer, Michael; Affleck, Karen; Taylor, Adam; Pavlidis, Stelios; Riley, John H.; Strazzeri, Fabio; Roberts, Graham; Brandsma, Joost; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Per, Bakke; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horváth, Ildikó; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandstrom, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Knowles, Richard; Fitch, Neil; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian Fan; Sterk, Peter J.; Skipp, Paul; Djukanović, Ratko
Abstract
2017U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
Lefaudeux, D.; De Meulder, B.; Loza, M.J.; Peffer, N.; Rowe, A.; Baribaud, F.; Bansal, A.T.; Lutter, R.; Sousa, A.R.; Corfield, J.; Pandis, I.; Bakke, P.S.; Caruso, M.; Chanez, P.; Dahlén, S.-E.; Fleming, L.J.; Fowler, S.J.; Horvath, I.; Krug, N.; Montuschi, P.; Sanak, M.; Sandstrom, T.; Shaw, D.E.; Singer, F.; Sterk, P.J.; Roberts, G.; Adcock, I.M.; Djukanovic, R.; Auffray, C.; Chung, K.F.
Journal Article
2015Prevalence Of Gastro-Oesophageal Reflux (GORD) And Associations With Clinical Phenotypic Markers In Adult Severe Asthmatics In The U-Biopred Cohort
Tariq, K.; Nicholas, B.L.; Lutter, R.; Bel, E.; Bansal, A.; Wagers, S.S.; Bisgaard, H.; Sandström, T.; Larsson, L.; Vestbo, J.; Montuschi, P.; Higgenbottam, T.W.; Compton, C.; Myles, D.; Chanez, P.; Pahus, L.; Murray, C.S.; Woodcock, A.; Musial, J.; Nordlund, B.; Hashimoto, S.; Hedlin, G.L.; Dahlen, S.E.K.; Middelveld, R.; Dahlen, B.; Krug, N.; Vissing, N.; Polosa, R.; Horvath, I.; Singer, F.; Bakke, P.; Roberts, G.; Fichtner, K.; Rowe, A.; Jeyasingham, E.; Riley, J.; Fleming, L.; Fowler, S.J.; Shaw, D.E.; Corfield, J.; Sousa, A.R.; Chung, K.; Howarth, P.H.; Sterk, P.J.; Djukanovic, R.
Abstract