Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-abeta formation
Hartlage-Rübsamen, Maike; Bluhm, Alexandra; Piechotta, Anke; Linnert, Miriam; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; Lues, Inge; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F.; Roßner, Steffen; Höfling, Corinna
Journal Article
2018Passive Aβ immunotherapy: Current achievements and future perspectives
Schilling, Stephan; Rahfeld, Jens-Ulrich; Lues, Inge; Lemere, Cynthia A.
Journal Article
2017Glutaminyl cyclase inhibitor PQ912 improves cognition in mouse models of Alzheimer's disease - studies on relation to effective target occupancy
Hoffmann, T.; Meyer, A.; Heiser, U.; Kurat, S.; Böhme, L.; Kleinschmidt, M.; Bühring, K.-U.; Hutter-Paier, B.; Farcher, M.; Demuth, H.-U.; Lues, I.; Schilling, S.
Journal Article
2017Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy
Piechotta, A.; Parthier, C.; Kleinschmidt, M.; Gnoth, K.; Pillot, T.; Lues, I.; Demuth, H.U.; Schilling, S.; Rahfeld, J.U.; Stubbs, M.T.
Journal Article
2016Phagocytic characterization and therapeutic efficacy of an anti-PyroGlutamate-3 Aβ IgG2a antibody in aged APP/PS1dE9 mice
Lemere, C.; Crehan, H.; Liu, B.; Kleinschmidt, M.; Rahfeld, J.-U.; Fitzpatrick, E.; Caldarone, B.; Le, K.; Frost, J.; O'Nuallain, B.; Park, M.-A.; DiCarli, M.; Reiser, V.; Trigg, W.; Lues, I.; Schilling, S.
Abstract
2016The pyroglutamate modification of toxic Aβ resulted new therapeutic aproaches: Inhibitors of glutaminyl cyclase and highly specific antibodies - a status report
Demuth, H.-U.; Schilling, S.; Lues, I.
Abstract
2015An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice
Frost, Jeffrey L.; Liu, Bin; Rahfeld, Jens-Ulrich; Kleinschmidt, Martin; O'Nuallain, Brian; Le, Kevin X.; Lues, Inge; Caldarone, Babara J.; Schilling, Stephan; Demuth, Hans-Ulrich; Lemere, Cynthia A.
Journal Article
2013Inhibitors of glutaminyl cyclase prevent pE-A beta mediated neurotoxicity: A new concept for the treatment of Alzheimer's disease
Heiser, U.; Schilling, S.; Cynis, H.; Buchholz, M.; Ramsbeck, D.; Hoffmann, T.; Demuth, H.U.; Lues, I.; Glund, K.
Abstract