Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Clinical Usefulness of Self-Rated Olfactory Performance - A Data Science-Based Assessment of 6000 Patients
Lötsch, J.; Hummel, T.
Journal Article
2019Computational functional genomics-based reduction of disease-related gene sets to their key components
Lippmann, C.; Ultsch, A.; Lötsch, J.
Journal Article
2019A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients with Dementia
Gurke, R.; Etyemez, S.; Prvulovic, D.; Thomas, D.; Fleck, S.C.; Reif, A.; Geisslinger, G.; Lötsch, J.
Journal Article
2019Effects of continuous theta-burst stimulation of the primary motor and secondary somatosensory areas on the central processing and the perception of trigeminal nociceptive input in healthy volunteers
Annak, O.; Heidegger, T.; Walter, C.; Deichmann, R.; Nöth, U.; Hansen-Goos, O.; Ziemann, U.; Lötsch, J.
Journal Article
2019Machine Learning in Human Olfactory Research
Lötsch, J.; Kringel, D.; Hummel, T.
Journal Article
2019A machine-learned analysis suggests non-redundant diagnostic information in olfactory subtests
Lötsch, J.; Hummel, T.
Journal Article
2019Potential biomarkers for persistent and neuropathic pain therapy
Sisignano, M.; Lötsch, J.; Parnham, M.J.; Geisslinger, G.
Journal Article
2019TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers
Weyer-Menkhoff, I.; Lötsch, J.
Journal Article
2018Computational functional genomics-based approaches in analgesic drug discovery and repurposing
Lippmann, C.; Kringel, D.; Ultsch, A.; Lötsch, J.
Journal Article
2018Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings
Lötsch, J.; Weyer-Menkhoff, I.; Tegeder, I.
Journal Article
2018Human pharmacological approaches to TRP-ion-channel-based analgesic drug development
Weyer-Menkhoff, I.; Lötsch, J.
Journal Article
2018Machine learning in pain research
Lötsch, J.; Ultsch, A.
Journal Article
2018A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes
Kringel, D.; Lippmann, C.; Parnham, M.J.; Kalso, E.; Ultsch, A.; Lötsch, J.
Journal Article
2018Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects
Weyer-Menkhoff, I.; Thrun, M.C.; Lötsch, J.
Journal Article
2018Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery
Lötsch, J.; Sipilä, R.; Dimova, V.; Kalso, E.
Journal Article
2018Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy
Lötsch, J.; Schiffmann, S.; Schmitz, K.; Brunkhorst, R.; Lerch, F.; Ferreiros, N.; Wicker, S.; Tegeder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2018Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy
Lötsch, J.; Sipilä, R.; Tasmuth, T.; Kringel, D.; Estlander, A.-M.; Meretoja, T.; Kalso, E.; Ultsch, A.
Journal Article
2018Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications
Lötsch, J.; Kringel, D.
Journal Article
2017A data science based standardized Gini index as a Lorenz dominance preserving measure of the inequality of distributions
Ultsch, A.; Lötsch, J.
Journal Article
2017Data visualizations to detect systematic errors in laboratory assay results
Lötsch, J.
Journal Article
2017A data-driven approach to responder subgroup identification after paired continuous theta burst stimulation
Heidegger, T.; Hansen-Goos, O.; Batlaeva, O.; Annak, O.; Ziemann, U.; Lötsch, J.
Journal Article
2017Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis
Schmitz, K.; Brunkhorst, R.; Bruin, N. de; Mayer, C.A.; Häussler, A.; Ferreiros, N.; Schiffmann, S.; Parnham, M.J.; Tunaru, S.; Chun, J.; Offermanns, S.; Foerch, C.; Scholich, K.; Vogt, J.; Wicker, S.; Lötsch, J.; Geisslinger, G.; Tegeder, I.
Journal Article
2017Effects of oral Δ9-tetrahydrocannabinol on the cerebral processing of olfactory input in healthy non-addicted subjects
Walter, C.; Oertel, B.G.; Felden, L.; Nöth, U.; Vermehren, J.; Deichmann, R.; Lötsch, J.
Journal Article
2017Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses
Kringel, D.; Ultsch, A.; Zimmermann, M.; Jansen, J.P.; Ilias, W.; Freynhagen, R.; Griessinger, N.; Kopf, A.; Stein, C.; Doehring, A.; Resch, E.; Lötsch, J.
Journal Article
2017Integrated computational analysis of genes associated with human hereditary insensitivity to pain
Lötsch, J.; Lippmann, C.; Kringel, D.; Ultsch, A.
Journal Article
2017Machine-learned cluster identification in high-dimensional data
Ultsch, A.; Lötsch, J.
Journal Article
2017Machine-learned data structures of lipid marker serum concentrations in multiple sclerosis patients differ from those in healthy subjects
Lötsch, J.; Thrun, M.; Lerch, F.; Brunkhorst, R.; Schiffmann, S.; Thomas, D.; Tegder, I.; Geisslinger, G.; Ultsch, A.
Journal Article
2017Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeq (TM) panel
Kringel, D.; Sisignano, M.; Zinn, S.; Lötsch, J.
Journal Article
2017Prediction of persistent post-surgery pain by preoperative cold pain sensitivity: Biomarker development with machine-learning-derived analysis
Lötsch, J.; Ultsch, A.; Kalso, E.
Journal Article
2017Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects
Lötsch, J.; Geisslinger, G.; Heinemann, S.; Lerch, F.; Oertel, B.G.; Ultsch, A.
Journal Article
2017Using a Standardized Clinical Quantitative Sensory Testing Battery to Judge the Clinical Relevance of Sensory Differences Between Adjacent Body Areas
Dimova, V.; Oertel, B.G.; Lötsch, J.
Journal Article
2016Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations
Walter, C.; Knothe, C.; Lötsch, J.
Journal Article
2016Brain lesion-pattern analysis in patients with olfactory dysfunctions following head trauma
Lötsch, J.; Ultsch, A.; Eckhardt, M.; Huart, C.; Rombaux, P.; Hummel, T.
Journal Article
2016Brain Mapping-Based Model of Δ9-Tetrahydrocannabinol Effects on Connectivity in the Pain Matrix
Walter, C.; Oertel, B.G.; Felden, L.; Kell, C.A.; Nöth, U.; Vermehren, J.; Kaiser, J.; Deichmann, R.; Lötsch, J.
Journal Article
2016A data science approach to candidate gene selection of pain regarded as a process of learning and neural plasticity
Ultsch, A.; Kringel, D.; Kalso, E.; Mogil, J.S.; Lötsch, J.
Journal Article
2016Disagreement between two common biomarkers of global DNA methylation
Knothe, C.; Shiratori, H.; Resch, E.; Ultsch, A.; Geisslinger, G.; Doehring, A.; Lötsch, J.
Journal Article
2016ESOM visualizations for quality assessment in clustering
Ultsch, A.; Behnisch, M.; Lötsch, J.
Conference Paper
2016High-throughput analysis of global DNA methylation using methyl-sensitive digestion
Shiratori, H.; Feinweber, C.; Knothe, C.; Lötsch, J.; Thomas, D.; Geisslinger, G.; Parnham, M.J.; Resch, E.
Journal Article
2016How many and which odor identification items are needed to establish normal olfactory function?
Lötsch, J.; Ultsch, A.; Hummel, T.
Journal Article
2016A machine-learned computational functional genomics-based approach to drug classification
Lötsch, J.; Ultsch, A.
Journal Article
2016Machine-learned pattern identification in olfactory subtest results
Lötsch, J.; Hummel, T.; Ultsch, A.
Journal Article
2016Methadone induces hypermethylation of human DNA
Knothe, C.; Doehring, A.; Ultsch, A.; Lötsch, J.
Journal Article
2016Next-generation sequencing of human opioid receptor genes based on a custom AmpliSeq™ library and ion torrent personal genome machine
Kringel, D.; Lötsch, J.
Journal Article
2016Pharmacoepigenetics of the role of DNA methylation in μ-opioid receptor expression in different human brain regions
Knothe, C.; Oertel, B.G.; Ultsch, A.; Kettner, M.; Schmidt, P.H.; Wunder, C.; Toennes, S.W.; Geisslinger, G.; Lötsch, J.
Journal Article
2016Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy
Lötsch, J.; Ultsch, A.
Journal Article
2016A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects
Lötsch, J.; Dimova, V.; Ultsch, A.; Lieb, I.; Zimmermann, M.; Geisslinger, G.; Oertel, B.G.
Journal Article
2016Smell of pain: Intersection of nociception and olfaction
Lötsch, J.; Hähner, A.; Gossrau, G.; Hummel, C.; Walter, C.; Ultsch, A.; Hummel, T.
Journal Article
2016A unifying data-driven model of human olfactory pathology representing known etiologies of dysfunction
Lötsch, J.; Ultsch, A.; Hummel, T.
Journal Article
2015Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery
Dimova, V.; Lötsch, J.; Hühne, K.; Winterpacht, A.; Heesen, M.; Parthum, A.; Weber, P.G.; Carbon, R.; Griessinger, N.; Sittl, R.; Lautenbacher, S.
Journal Article
2015A brain-lesion pattern based algorithm for the diagnosis of posttraumatic olfactory loss
Lötsch, J.; Reither, N.; Bogdanov, V.; Hähner, A.; Ultsch, A.; Hill, K.; Hummel, T.
Journal Article
2015Drug-target based cross-sectional analysis of olfactory drug effects
Lötsch, J.; Daiker, H.; Hähner, A.; Ultsch, A.; Hummel, T.
Journal Article
2015Identification of molecular fingerprints in human heat pain thresholds by use of an interactive mixture model r toolbox (Adaptgauss)
Ultsch, A.; Thrun, M.C.; Hansen-Goos, O.; Lötsch, J.
Journal Article
2015Inverted perceptual judgment of nociceptive stimuli at threshold level following inconsistent cues
Walter, C.; Dimova, V.; Bu, J.; Parnham, M.J.; Oertel, B.G.; Lötsch, J.
Journal Article
2015Lack of fluconazole effects on human chemosensation
Oertel, B.G.; Huynh, T.T.; Hummel, T.; Lötsch, J.
Journal Article
2015A more pessimistic life orientation is associated with experimental inducibility of a neuropathy-like pain pattern in healthy individuals
Dimova, V.; Oertel, B.G.; Kabakci, G.; Zimmermann, M.; Hermens, H.; Lautenbacher, S.; Ultsch, A.; Lötsch, J.
Journal Article
2015Multimodal distribution of human cold pain thresholds
Lötsch, J.; Dimova, V.; Lieb, I.; Zimmermann, M.; Oertel, B.G.; Ultsch, A.
Journal Article
2015Olfactory drug effects approached from human-derived data
Lötsch, J.; Knothe, C.; Lippmann, C.; Ultsch, A.; Hummel, T.; Walter, C.
Journal Article
2015Pain research funding by the European Union Seventh Framework Programme
Kringel, D.; Lötsch, J.
Journal Article
2015Reply to "Can topical capsaicin induce a neuropathic pain?". Letter
Lötsch, J.; Dimova, V.; Oertel, B.G.
Journal Article
2015THC may reproducibly induce electrical hyperalgesia in healthy volunteers
Walter, C.; Oertel, B.G.; Lötsch, J.
Journal Article
2014Cannabinoid-Related Olfactory Neuroscience in Mice and Humans
Lötsch, J.; Hummel, T.
Journal Article
2014Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation
Lötsch, J.; Hummel, T.; Warskulat, U.; Coste, O.; Häussinger, D.; Geisslinger, G.; Tegeder, I.
Journal Article
2014Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli
Schütz, M.; Oertel, B.G.; Heimann, D.; Doehring, A.; Walter, C.; Dimova, V.; Geisslinger, G.; Lötsch, J.
Journal Article
2014Cytochrome P450 Epoxygenase Dependence of Opioid Analgesia
Oertel, B.G.; Vermehren, J.; Huynh, T.T.; Doehring, A.; Ferreirós, N.; Zimmermann, M.; Geisslinger, G.; Lötsch, J.
Journal Article
2014Effects of 20 mg oral Delta(9)-tetrahydrocannabinol on the olfactory function of healthy volunteers
Walter, C.; Oertel, B.G.; Ludyga, D.; Ultsch, A.; Hummel, T.; Lötsch, J.
Journal Article
2014Exploiting the structures of the U-matrix
Lötsch, J.; Ultsch, A.
Conference Paper
2014Functional abstraction as a method to discover knowledge in gene ontologies
Ultsch, A.; Lötsch, J.
Journal Article
2014Functional genomics suggest neurogenesis in the adult human olfactory bulb
Lötsch, J.; Schaeffeler, E.; Mittelbronn, M.; Winter, S.; Gudziol, V.; Schwarzacher, S.W.; Hummel, T.; Doehring, A.; Schwab, M.; Ultsch, A.
Journal Article
2014Human models of pain for the prediction of clinical analgesia
Lötsch, J.; Oertel, B.G.; Ultsch, A.
Journal Article
2014Non-Invasive Method for Prediction of Opioid-Analgesia and Opioid-Blood-Concentrations
Lötsch, Jörn; Ultsch, Alfred; Oertel, Bruno; Geisslinger, Gerd
Patent
2014Quantitation of ribavirin in human plasma and red blood cells using LC-MS/MS
Ferreiros, N.; Labocha, S.; El-Duweik, J.; Schlecker, C.; Lötsch, J.; Geisslinger, G.
Journal Article
2014R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice
Schmitz, K.; Bruin, N. de; Bishay, P.; Männich, J.; Häussler, A.; Altmann, C.; Ferreirós, N.; Lötsch, J.; Ultsch, A.; Parnham, M.J.; Geisslinger, G.; Tegeder, I.
Journal Article
2014Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans
Sailler, S.; Schmitz, K.; Jäger, E.; Ferreirós, N.; Wicker, S.; Zschiebsch, K.; Pickert, G.; Geisslinger, G.; Walter, C.; Tegeder, I.; Lötsch, J.
Journal Article
2014Similar Maximum Systemic but not Local Cyclooxygenase-2 Inhibition by 50 mg Lumiracoxib and 90 mg Etoricoxib
Felden, L.; Walter, C.; Angioni, C.; Schreiber, Y.; Hentig, N. von; Ferreiros, N.; Geisslinger, G.; Lötsch, J.
Journal Article
2013µ-opioid receptor gene variant OPRM1 118 A > G: a summary of its molecular and clinical consequences for pain. Review
Walter, C.; Doehring, A.; Oertel, B.G.; Lötsch, J.
Journal Article
2013Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain
Doehring, A.; Oertel, B.G.; Sittl, R.; Lötsch, J.
Journal Article
2013Clinical pharmacology of analgesics assessed with human experimental pain models: Bridging basic and clinical research
Oertel, B.G.; Lötsch, J.
Journal Article
2013Common non-epigenetic drugs as epigenetic modulators
Lötsch, J.; Schneider, G.; Reker, D.; Parnham, M.J.; Schneider, P.; Geisslinger, G.; Doehring, A.
Journal Article
2013Functional genomics of pain in analgesic drug development and therapy
Lötsch, J.; Doehring, A.; Mogil, J.S.; Arndt, T.; Geisslinger, G.; Ultsch, A.
Journal Article
2013Linkage between increased nociception and olfaction via a SCN9A haplotype
Heimann, D.; Lötsch, J.; Hummel, T.; Doehring, A.; Oertel, B.G.
Journal Article
2013A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain
Lötsch, J.; Ultsch, A.
Journal Article
2013Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia
Lötsch, J.; Skarke, C.; Darimont, J.; Zimmermann, M.; Bräutigam, L.; Geisslinger, G.; Ultsch, A.; Oertel, B.G.
Journal Article
2013Pharmacokinetics of non-intravenous formulations of fentanyl
Lötsch, J.; Walter, C.; Parnham, M.J.; Oertel, B.G.; Geisslinger, G.
Journal Article
2013Simultaneous and sensitive LC–MS/MS determination of tetrahydrocannabinol and metabolites in human plasma
Ferreirós, N.; Labocha, S.; Walter, C.; Lötsch, J.; Geisslinger, G.
Journal Article