Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis
Prasse, Antje; Binder, Harald; Schupp, Jonas C.; Kayser, Gian; Bargagli, Elena; Jäger, Benedikt; Hess, Moritz; Rittinghausen, Susanne; Vuga, Louis; Lynn, Heather; Violette, Shelia; Jung, Birgit; Quast, Karsten; Vanaudenaerde, Bart; Xu, Yan; Hohlfeld, Jens M.; Krug, Norbert; Herazo-Maya, Jose D.; Rottoli, Paola; Wuyts, Wim A.; Kaminski, Naftali
Journal Article
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
Journal Article
2019Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma
Tariq, K.; Schofield, J.P.R.; Nicholas, B.L.; Burg, D.; Brandsma, J.; Bansal, A.T.; Wilson, S.J.; Lutter, R.; Fowler, S.J.; Bakke.; Caruso, M.; Dahlen, B.; Horvath, I.; Krug, N.; Montuschi, P.; Sanak, M.; Sandstrom, T.; Geiser, T.; Pandis, I.; Sousa, A.R.; Adcock, I.M.; Shaw, D.E.; Auffray, C.; Howarth, P.H.; Sterk, P.J.; Chung, K.F.; Skipp, P.J.; Dimitrov, B.; Djukanovic, R.
Journal Article
2019Treatable traits in the European U-BIOPRED adult asthma cohorts
Simpson, A.J.; Hekking, P.-P.; Shaw, D.E.; Fleming, L.J.; Roberts, G.; Riley, J.H.; Bates, S.; Sousa, A.R.; Bansal, A.T.; Pandis, I.; Sun, K.; Bakke, P.S.; Caruso, M.; Dahlen, B.; Dahlen, S.-E.; Horvath, I.; Krug, N.; Montuschi, P.; Sandstrom, T.; Singer, F.; Adcock, I.M.; Wagers, S.S.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.; Fowler, S.J.; Hohlfeld, J.M. et al.
Journal Article
2019Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans
Heusser, K.; Tank, J.; Holz, O.; May, M.; Brinkmann, J.; Engeli, S.; Diedrich, A.; Framke, T.; Koch, A.; Großhennig, A.; Danser, A.H.J.; Sweep, F.C.G.J.; Schindler, C.; Schwarz, K.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2018A computational framework for complex disease stratification from multiple large-scale datasets
Meulder, Bertrand de; Lefaudeux, Diane; Bansal, Aruna T.; Mazein, Alexander; Chaiboonchoe, Amphun; Ahmed, Hassan; Balaur, Irina; Saqi, Mansoor; Pellet, Johann; Ballereau, Stephane; Lemonnier, Nathanaël; Sun, Kai; Pandis, Ioannis; Yang, Xian; Batuwitage, Manohara; Kretsos, Kosmas; Eyll, Jonathan van; Bedding, Alun; Davison, Timothy; Dodson, Paul; Larminie, Christopher; Postle, Anthony; Corfield, Julie; Djukanović, Ratko; Chung, Kian Fan; Adcock, Ian M.; Guo, Yi-Ke; Sterk, Peter J.; Manta, Alexander; Rowe, Anthony; Baribaud, Frédéric; Auffray, Charles; Badorrek, Philipp; Faulenbach, Cornelia; Braun, Armin; Hohlfeld, Jens; Krug, Norbert
Journal Article
2018Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort
Emma, Rosalia; Bansal, Aruna T.; Kolmert, Johan; Wheelock, Craig E.; Dahlén, Sven-Erik; Loza, Matthew J.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Dahlén, Barbro; Bakke, Per S.; Chanez, Pascal; Fowler, Stephen J.; Horvath, Ildiko; Montuschi, Paolo; Krug, Norbert; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Fleming, Louise J.; Djukanovic, Ratko; Howarth, Peter H.; Singer, Florian; Sousa, Ana R.; Sterk, Peter J.; Corfield, Julie; Pandis, Ioannis; Chung, Kian F.; Adcock, Ian M.; Lutter, René; Fabbella, Lorena; Caruso, Massimo
Journal Article
2018Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome
Burg, Dominic; Schofield, James P.R.; Brandsma, Joost; Staykova, Doroteya; Folisi, Caterina; Bansal, Aruna T.; Nicholas, Ben; Xian, Yang; Rowe, Anthony; Corfield, Julie; Wilson, Susan J.; Ward, Jonathan A.; Lutter, René; Fleming, Louise; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlén, Sven-Erik; Fowler, Stephen J.; Hashimoto, Simone; Horvath, Ildiko; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Singer, Florian; Sun, Kai; Pandis, Ioannis; Auffray, Charles; Sousa, Ana R.; Adcock, Ian M.; Chung, Kian F.; Sterk, Peter J.; Djukanovic, Ratko; Skipp, Paul J.
Journal Article
2018Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers
Brandsma, Joost; Goss, Victoria M.; Yang, Xian; Bakke, Per S.; Caruso, Massimo; Chanez, Pascal; Dahlén, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Shaw, Dominick E.; Chung, Kian Fan; Singer, Florian; Fleming, Louise J.; Sousa, Ana R.; Pandis, Ioannis; Bansal, Aruna T.; Sterk, Peter J.; Djukanović, Ratko; Postle, Anthony D.
Journal Article
2018Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: An exploratory analysis
Takahashi, Kentaro; Pavlidis, Stelios; Ng Kee Kwong, Francois; Hoda, Uruj; Rossios, Christos; Sun, Kai; Loza, Matthew; Baribaud, Fred; Chanez, Pascal; Fowler, Steve J.; Horvath, Ildiko; Montuschi, Paolo; Singer, Florian; Musial, Jacek; Dahlén, Barbro; Dahlén, Sven-Erik; Krug, Norbert; Sandström, Thomas; Shaw, Dominick E.; Lutter, René; Bakke, Per; Fleming, Louise J.; Howarth, Peter H.; Caruso, Massimo; Sousa, Ana R.; Corfield, Julie; Auffray, Charles; Meulder, Bertrand de; Lefaudeux, Diane; Djukanovic, Ratko; Sterk, Peter J.; Guo, Yike; Adcock, Ian M.; Chung, Kian Fan
Journal Article
2017Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients
Krug, N.; Hohlfeld, J.M.; Buhl, R.; Renz, J.; Garn, H.; Renz, H.
Journal Article
2017Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study
Tank, J.; Heusser, K.; Holz, O.; May, M.; Brinkmann, J.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Sweep, F.C.G.J.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.
Abstract
2017Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure
Badorrek, Philipp; Müller, Meike; Koch, Wolfgang; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2017A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED
Kuo, C.H.S.; Pavlidis, S.; Loza, M.; Baribaud, F.; Rowe, A.; Pandis, I.; Hoda, U.; Rossios, C.; Souse, A.; Wilson, S.J.; Howarth, P.; Dahlen, B.; Dahlen, S.E.; Chanez, P.; Shaw, D.; Krug, Norbert; Sandström, T.; Meulder, B. de; Lefaudeux, D.; Fowler, S.; Fleming, L.; Corfield, J.; Auffray, C.; Sterk, P.J.; Djukanovic, R.; Guo, Y.K.; Adcock, I.M.; Chung, K.F.
Journal Article
2017U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
Lefaudeux, D.; De Meulder, B.; Loza, M.J.; Peffer, N.; Rowe, A.; Baribaud, F.; Bansal, A.T.; Lutter, R.; Sousa, A.R.; Corfield, J.; Pandis, I.; Bakke, P.S.; Caruso, M.; Chanez, P.; Dahlén, S.-E.; Fleming, L.J.; Fowler, S.J.; Horvath, I.; Krug, N.; Montuschi, P.; Sanak, M.; Sandstrom, T.; Shaw, D.E.; Singer, F.; Sterk, P.J.; Roberts, G.; Adcock, I.M.; Djukanovic, R.; Auffray, C.; Chung, K.F.
Journal Article
2016Longitudinal replication of severe asthma exhaled breath phenotypes by the U-BIOPRED electronic nose platform
Brinkman, P.; Wagener, A.H.; Hekking, P.-P.; Bansal, A.T.; Wang, Y.; Weda, H.; Knobel, H.H.; Vink, T.J.; Rattray, NJ.; D'Amico, A.; Pennazza, G.; Santonico, M.; Bakke, P.S.; Caruso, M.; Chung, K.F.; Corfield, J.; Dahlen, S.E.; Djukanovic, R.; Geiser, T.; Horvath, I.; Krug, N.; Musial, J.; Shaw, D.E.; Pandis, I.; Sandstrom, T.; Sousa, A.R.; Montuschi, P.; Fowler, S.J.; Sterk, P.J.
Abstract
2016Prevalence of ragweed sensitization at a clinical trial unit in northern Germany
Badorrek, P.; Krug, N.; Hohlfeld, J.M.
Abstract
2016Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber
Lüer, Katrin; Biller, Heike; Casper, Anja; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, A.; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Journal Article
2016Severe asthma exists despite suppressed tissue inflammation: Findings of the U-BIOPRED study
Wilson, Susan J.; Ward, Jonathan A.; Sousa, Ana R.; Corfield, Julie; Bansal, Aruna T.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Loza, Matthew J.; Baribaud, Frédéric; Fitch, Neil; Sterk, Peter J.; Chung, Kian Fan; Gibeon, David; Sun, Kai; Guo, Yi-Ke; Adcock, Ian M.; Djukanovic, Ratko; Dahlén, Barbro; Chanez, Pascal; Shaw, Dominick E.; Krug, Norbert; Hohlfeld, Jens; Sandström, Thomas; Howarth, Peter H.
Journal Article
2016Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
Loza, M.J.; Djukanovic, R.; Chung, K.F.; Horowitz, D.; Ma, K.; Branigan, P.; Barnathan, E.S.; Susulic, V.S.; Silkoff, P.E.; Sterk, P.J.; Baribaud, F.; Badorrek, P.; Faulenbach, C.; Braun, A.; Hohlfeld, J.; Krug, N.; et. al.
Journal Article
2015Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
Krug, Norbert; Hohlfeld, Jens Michael; Kirsten, Anne-Marie; Kornmann, Oliver; Beeh, Kai-Michael; Kappeler, Dominik; Korn, Stephanie; Ignatenko, Stanislav; Timmer, Wolfgang; Rogon, Cordelia; Zeitvogel, Jana; Zhang, Nan; Bille, Joachim; Homburg, Ursula; Turowska, Agnieszka; Bachert, Claus; Werfel, Thomas; Buhl, Roland; Renz, Jonas; Garn, Holger; Renz, Harald
Journal Article
2015Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Shaw, Dominick E.; Sousa, Ana R.; Fowler, Stephen J.; Fleming, Louise J.; Roberts, Graham; Corfield, Julie; Pandis, Ioannis; Bansal, Aruna T.; Bel, Elisabeth H.; Auffray, Charles; Compton, Chris H.; Bisgaard, Hans; Bucchioni, Enrica; Caruso, Massimo; Chanez, Pascal; Dahlén, Barbro; Dahlén, Sven-Erik; Dyson, Kerry; Frey, Urs; Geiser, Thomas; Gerhardsson de Verdier, Maria; Gibeon, David; Guo, Yi-Ke; Hashimoto, Simone; Hedlin, Gunilla; Jeyasingham, Elizabeth; Hekking, Pieter-Paul W.; Higenbottam, Tim; Horváth, Ildikó; Knox, Alan J.; Krug, Norbert; Erpenbeck, Veit J.; Larsson, Lars X.; Lazarinis, Nikos; Matthews, John G.; Middelveld, Roelinde; Montuschi, Paolo; Musial, Jacek; Myles, David; Pahus, Laurie; Sandström, Thomas; Seibold, Wolfgang; Singer, Florian; Strandberg, Karin; Vestbo, Jorgen; Vissing, Nadja; Garnier, Christophe von; Adcock, Ian M.; Wagers, Scott; Rowe, Anthony; Howarth, Peter; Wagener, Ariane H.; Djukanovic, Ratko; Sterk, Peter J.; Chung, Kian Fan
Journal Article
2015Controlled exposure to grass pollen in an environmental challenge chamber induces a worsening of cutaneous symptoms in patients with atopic dermatitis
Heratizadeh, A.; Badorrek, P.; Kapp, A.; Niebuhr, M.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Loesche, C.; Jung, T.; Krug, N.; Hohlfeld, J.M.; Werfel, T.
Abstract
2015Determination of markers that predict the individual response of perennial allergic subjects to house dust mite allergen in the Fraunhofer Environmental Challenge Chamber (ECC)
Hohlfeld, J.M.; Lüer, K.; Holz, O.; Häfner, D.; Koch, W.; Krug, N.
Abstract
2015Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis
Badorrek, Philipp; Hohlfeld, Jens M.; Krug, Norbert; Joshi, Abhijeet; Raut, Atul
Journal Article
2015Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T.; Heratizadeh, A.; Niebuhr, M.; Kapp, A.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Lösche, C.; Jung, T.; Krug, N.; Badorrek, P.; Hohlfeld, J.M.
Journal Article
2015Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Schaumann, Frank; Müller, Meike; Scholl, Dorothea; Hidi, R.; McLeod, Alison; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2015Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: A proof of concept study
Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Winkler, Carla; Faulenbach, Cornelia; Jakob, Peter; Schaumann, Frank; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2015A novel universal allergen challenge technique for efficacy testing of immunotherapy
Schwarz, K.; Lueer, K.; Biller, H.; Windt, H.; Badorrek, P.; Hafner, D.; Koch, A.; Krug, N.; Koch, W.; Hohlfeld, J.
Abstract
2015Pharmacological MRI (phMRI) of the human central nervous system
Lanfermann, Heinrich; Schindler, Chris; Jordan, Jens; Krug, Norbert; Raab, Peter
Journal Article
2015Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
Homburg, Ursula; Renz, Harald; Timmer, Wolfgang; Hohlfeld, Jens M.; Seitz, Friedeborg; Lüer, Katrin; Mayer, Alexandra; Wacker, Anja; Schmidt, Oliver; Kuhlmann, Jens; Turowska, Agnieszka; Roller, Julia; Kutz, Klaus; Schlüter, Gerhard; Krug, Norbert; Garn, Holger
Journal Article
2014Cell counting in human endobronchial biopsies - disagreement of 2D versus 3D morphometry
Bratu, Vlad A.; Erpenbeck, Veit J.; Fehrenbach, Antonia; Rausch, Tanja; Rittinghausen, Susanne; Krug, Norbert; Hohlfeld, Jens M.; Fehrenbach, Heinz
Journal Article
2014Dose-range finding of natural birch pollen exposure in patients with seasonal allergic rhinitis in the Fraunhofer Environmental Challenge Chamber
Lüer, Katrin; Windt, Horst; Schwarz, Katharina; Badorrek, Philipp; Sebastian, Ramona; Haefner, Dietrich; Koch, Wolfgang; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014The effect of controlled exposure to grass pollen in an environmental challenge chamber on dermal symptoms in patients with atopic dermatitis
Heratizadeh, Annice; Badorrek, Philipp; Niebuhr, Margarete; Erpenbeck, Veit Johannes; Lösche, C.; Krug, Norbert; Hohlfeld, Jens Michael; Werfel, Thomas
Abstract
2014Effect of sample processing on the analysis of IL4, IL5, and IL13 in sputum supernatants
Holz, Olaf; Müller, Meike; Ignatenko, Stanislav; Kappeler, Dominik; Buhl, Roland; Beeh, Kai-Michael; Kornmann, Oliver; Kirsten, Anne; Homburg, Ursula; Garn, Holger; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Othmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Journal Article
2014Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis
Krug, Norbert; Gupta, Abhy; Badorrek, Philipp; Koennen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M.; Wood, Chester
Journal Article
2014Identification and quantification of basophils in the airways of asthmatics following segmental allergen challenge
Dijkstra, D.; Hennig, C.; Hansen, G.; Biller, H.; Krug, N.; Hohlfeld, J.M.
Journal Article
2014Omalizumab in patients with allergic (IgE-mediated) asthma and IgE/bodyweight combinations above those in the initially approved dosing table
Kornmann, Oliver; Watz, Henrik; Fuhr, Rainard; Krug, Norbert; Erpenbeck, Veit J.; Kaiser, Guenther
Journal Article
2014Phase-contrast MRI for detection of mild systemic hemodynamic response after segmental allergen challenge in asthmatic patients
Hinrichs, Jan; Schaumann, Frank; Renne, Julius; Schönfeld, Christian; Faulenbach, Cornelia; Winkler, Carla; Gutberlet, Marcel; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2014Prevalence and phenotypic characteristics of severe adult-onset asthma in the U-Biopred cohort
Hekking, Pieter-Paul; Wagener, Ariane H.; Sousa, Ana R.; Fowler, Stephen J.; Bakke, Per; Frey, Urs; Krug, Norbert; Hashimoto, Simone; Woodcock, Ashley; Chanez, Pascal; Montuschi, Paolo; Bisgaard, Hans; Corfield, Julie; Howarth, Peter H.; Djukanovic, Ratko; Chung, Kian Fan; Fleming, Louise; Riley, John; Jeyasingham, Elisabeth; Fichtner, Klaus; Rowe, Anthony; Roberts, Graham; Singer, Florian; Geiser, Thomas; Horvath, Ildiko; Riccardo, Polosa; Vissing, Nadja H.; Dahlen, Babro; Musial, Jacek; Murray, Clare S.; Myles, David; Compton, Chris; Higenbottam, Tim W.; Vestbo, J.; Pahus, Laurie; Larsson, Lars; Sandstrom, Thomas; Shaw, Dominic; Wagers, Scott S.; Sterk, Peter J.; Bansal, Aruna T.; Bel, Elisabeth
Abstract
2014Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging
Vogel-Claussen, Jens; Renne, Julius; Hinrichs, Jan; Schönfeld Christian; Gutberlet, Marcel; Schaumann, Frank; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens Michael
Journal Article
2014Severe asthma patients on oral corticosteroid therapy as a distinct phenotype: The european U-BIOPRED cohort
Chung, Kian F.; Gibeon, David; Sousa, Ana R.; Corfield, Julie; Shaw, Dominick E.; Fowler, Stephen J.; Fleming, Louise J.; Riley, John; Jeyasingham, Elisabeth; Rowe, Anthony; Fichtner, Klaus; Roberts, Graham; Bakke, Per; Garnier, Christophe von; Horvath, Ildiko; Riccardo, Polosa; Krug, Norbert; Dahlen, Barbaro; Musial, Jacek; Pahus, Laurie; Myles, David; Compton, Chris; Higenbottam, Tim W.; Montuschi, Paolo; Larsson, Lars; Sandstrom, Thomas; Wagers, Scott S.; Howarth, Peter H.; Bel, Elisabeth; Bansal, Aruna T.; Djukanovic, Ratko; Sterk, Peter J.
Abstract
2013Associated factors with persistent airflow limitation in asthma in U-BIOPRED
Wagener, A.H.; Gibeon, D.; Yang, X.; Sousa, A.R.; Corfield, J.; Shaw, D.E.; Fowler, S.; Flemming, L.J.; Riley, J.; Jeyasingham, E.; Rowe, A.; Fichtner, K.; Robberts, G.; Bakke, P.; Singer, T.; Geiser, T.; Frey, U.; Horvarth, I.; Polosa, R.; Bonnelykke, K.; Krug, Norbert; Middelveld, R.; Dahlen, S.-E.; Dahlen, B.; Hedlin, G.; Hashimoto, S.; Nordlund, B.; Musial, J.; Woodcock, A.; Murray, C.S.; Pahus, L.; Chanez, P.; Myles, D.; Compton, C.; Higenbottam, T.W.; Montuschi, P.; Vestbo, J.; Larsson, L.; Sandstrom, T.; Bisgaard, H.; Wagers, S.S.; Howarth, P.H.; Bel, E.H.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.
Journal Article, Conference Paper
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Journal Article
2013Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
Janssen, Ole; Schaumann, Frank; Holz, Olaf; Lavae-Mokhtari, Bianca; Welker, Lutz; Winkler, Carla; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2013Safety profile and pharmacokinetics of an inhaled GATA-3-specific DNAzyme in a phase Ib study in patients with stable allergic asthma
Hohlfeld, Jens; Lüer, Katrin; Krug, Norbert; Turowska, Agnieszka; Renz, Harald; Garn, Holger; Homburg, Ursula
Journal Article, Conference Paper
2013U-BIOPRED asthma cohort: Inflammatory markers and corticosteroid use
Gibeon, D.; Wagener, A.H.; Yang, X.; Sousa, A.R.; Corfield, J.; Shaw, D.E.; Fowler, S.; Flemming, L.J.; Jeyasingham, E.; Rowe, A.; Fichtner, K.; Robberts, G.; Bakke, P.; Singer, T.; Geiser, T.; Frey, U.; Horvarth, I.; Polosa, R.; Bonnelykke, K.; Krug, Norbert; Middelveld, R.; Dahlen, S.-E.; Dahlen, B.; Hedlin, G.; Hashimoto, S.; Nordlund, B.; Musial, J.; Woodcock, A.; Murray, C.S.; Pahus, L.; Myles, D.; Compton, C.; Higenbottam, T.W.; Montuschi, P.; Vestbo, J.; Larsson, L.; Sandstrom, T.; Bisgaard, H.; Wagers, S.S.; Howarth, P.H.; Bel, E.H.; Djukanovic, R.; Sterk, P.J.; Chung, K.F.
Journal Article, Conference Paper
2012Acute ozone induced airway inflammation does not effect resting human sympathetic nerve traffic
Tank, J.; Biller, Heike; Heusser, K.; Holz, Olaf; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, Wolfgang; Krug, Norbert; Jordan, J.; Hohlfeld, Jens
Journal Article, Conference Paper
2012Die Bedeutung von Pollen und Starch Granules bei der Allergie der Atemwege
Emmert, Lorenz Samy
: Krug, Norbert (Doktorvater)
Dissertation
2012CRTH2 antagonist, BI 671800 (BI), reduces nasal symptoms and inhibits nasal cytokines and eosinophils in SAR patients exposed to grass pollen in an environmental challenge chamber (ECC)
Krug, Norbert; Gupta, A.; Badorrek, Philipp; Müller, Meike; Casper, Anja; Pivovarova, A.; Hilbert, J.; Koenen, R.; Hohlfeld, Jens M.; Wood, C.
Abstract
2012Depletion of neutrophils from induced sputum using a novel bead and sieve-separation system
Holz, Olaf; Schaumann, Frank; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Krug, Norbert; Heinrich, J. M.; Hohlfeld, Jens M.
Abstract
2012Experience with an allergen challenge chamber for clinical trials in allergic rhinitis
Krug, Norbert; Badorrek, Phillipp; Hohlfeld, Jens Michael
Journal Article, Conference Paper
2012Low-dose endotoxin inhalation in healthy volunteers: A challenge model for early clinical drug development of novel anti-inflammatory compounds
Schaumann, Frank; Holz, Olaf; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Abstract
2012Pollen starch granules in bronchial inflammation
Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2012Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum
Röpcke, S.; Holz, O.; Lauer, G.; Müller, M.; Rittinghausen, S.; Ernst, P.; Lahu, G.; Elmlinger, M.; Krug, N.; Hohlfeld, J.M.
Journal Article
2012Reproducibility of serum biomarkers and relationship to airway inflammation following LPS challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Faulenbach, Cornelia; Müller, Meike; Krug, Norbert; McLeod, Alison; Hohlfeld, Jens M.
Abstract
2012Safety and efficacy of house dust mite allergen challenge in patients with allergic rhinitis using a novel technique for inhalation studies in the Fraunhofer environmental challenge chamber
Lueer, Katrin; Biller, Heike; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, Armin; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Abstract
2012Semi-quantitative assessment of localized pulmonary inflammation by magnetic resonance imaging in patients with mild allergic asthma following segmental allergen challenge
Vogel-Claussen, Jens; Schaumann, Frank; Renne, Julius; Hinrichs, Jan; Schoenfeld, Christian; Gutberlet, Marcel; Hüper, Klaudia; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.
Abstract
2012Stable inflammatory phenotype in smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Krug, Norbert; Ernst, Peter; Lahu, Gezim; Hohlfeld, Jens M.
Abstract
2012Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Schleh, Carsten; Rothen-Rutishauser, Barbara M.; Blank, Fabian; Lauenstein, Hans D.; Nassimi, Matthias; Krug, Norbert; Braun, Armin; Erpenbeck, Veit; Gehr, Peter; Hohlfeld, Jens M.
Journal Article
2011Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael
Journal Article
2011Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Schaumann, F.; Hohlfeld, J.M.; Krug, N.; Sousa, A.R.; Murdoch, R.
Journal Article
2011Breath profiles by electronic nose correlate with systemic markers but not ozone response
Biller, Heike; Holz, Olaf; Windt, Horst; Koch, Wolfgang; Müller, Meike; Jörres, Rudolf A.; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2011Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Winkler, C.; Atochina-Vasserman, E.N.; Holz, O.; Beers, M.F.; Erpenbeck, V.J.; Krug, N.; Roepcke, S.; Lauer, G.; Elmlinger, M.; Hohlfeld, J.M.
Journal Article
2011Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: A randomized, placebo controlled, crossover study
Tank, J.; Biller, H.; Heusser, K.; Holz, O.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2011The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
Nicholson, G.C.; Kariyawasam, H.H.; Tan, A.J.; Hohlfeld, J.M.; Quinn, D.; Walker, C.; Rodman, D.; Westwick, J.; Jurcevic, S.; Kon, O.M.; Barnes, P.J.; Krug, N.; Hansel, T.T.
Journal Article
2011The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function
Rochlitzer, Sabine; Veres, Tibor Z.; Kühne, Kathleen; Prenzler, Frauke; Pilzner, Carolin; Knothe, Saskia; Winkler, Carla; Lauenstein, Hans-Dieter; Willart, M.; Hammad, H.; Müller, Meike; Krug, Norbert; Lambrecht, Bart N.; Braun, Armin
Journal Article
2011Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice
Lauenstein, H.D.; Quarcoo, D.; Plappert, L.; Schleh, C.; Nassimi, M.; Pilzner, C.; Rochlitzer, S.; Brabet, P.; Welte, T.; Hoymann, H.G.; Krug, N.; Müller, M.; Lerner, E.A.; Braun, A.; Groneberg, D.A.
Journal Article
2011Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans
Atochina-Vasserman, E.N.; Winkler, C.; Abramova, H.; Schaumann, F.; Krug, N.; Gow, A.J.; Beers, M.F.; Hohlfeld, J.M.
Journal Article
2010Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
Schleh, C.; Erpenbeck, V.J.; Winkler, C.; Lauenstein, H.D.; Nassimi, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2010Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions
Hohlfeld, J.M.; Holland-Letz, T.; Larbig, M.; Lavae-Mokhtari, M.; Wierenga, E.; Kapsenberg, M.; Ree, R. van; Krug, N.; Bufe, A.
Journal Article
2010Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air-liquid interface (ALI) culture
Switalla, S.; Knebel, J.; Ritter, D.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices
Switalla, S.; Lauenstein, L.; Prenzler, F.; Knothe, S.; Förster, C.; Fieguth, H.-G.; Pfennig, O.; Schaumann, F.; Martin, C.; Guzman, C.A.; Ebensen, T.; Müller, M.; Hohlfeld, J.M.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010Pharmacodynamic effects of the selective PDE4-inhibitor roflumilast in humans
Bethke, T.D.; Hohlfeld, J.M.; Krug, N.; Grootendorst, D.C.; Rabe, K.F.
Abstract
2010Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
Woodruff, P.G.; Wolff, M.; Hohlfelds, J.M.; Krug, N.; Dransfield, M.T.; Sutherland, E.R.; Criner, G.J.; Kim, V.; Prasse, A.; Nivens, M.C.; Tetzlaff, K.; Heilker, R.; Fahy, J.V.
Journal Article
2010Surfactant protein D modulates pulmonary clearance of pollen starch granules
Winkler, C.; Hüper, K.; Wedekind, A-C.; Rochlitzer, S.; Hartwig, C.; Müller, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.; Erpenbeck, V.J.
Journal Article
2010A toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to timothy grass pollen antigens
Fuchs, B.; Knothe, S.; Rochlitzer, S.; Nassimi, M.; Greweling, M.; Lauenstein, H.D.; Nassenstein, C.; Müller, M.; Ebensen, T.; Dittrich, A.M.; Krug, N.; Guzman, C.A.; Braun, A.
Journal Article
2010A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung
Nassimi, M.; Schleh, C.; Lauenstein, H.D.; Hussein, R.; Hoymann, H.G.; Koch, W.; Pohlmann, G.; Krug, N.; Sewald, K.; Rittinghausen, S.; Braun, A.; Müller-Goymann, C.
Journal Article
2009A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis
Badorrek, P.; Dick, M.; Schauerte, A.; Hecker, H.; Murdoch, R.; Luettig, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2009Cytokine production after acute exposure of precision cut lung slices to NO2 and O3
Switalla, S.; Ritter, D.; Krug, N.; Knebel, J.; Braun, A.; Sewald, K.
Abstract
2009Dendritic cell-nerve clusters are sites of T cell proliferation in allergic airway inflammation
Veres, T.Z.; Shevchenko, M.; Krasteva, G.; Spies, E.; Prenzler, F.; Rochlitzer, S.; Tschernig, T.; Krug, N.; Kummer, W.; Braun, A.
Journal Article
2009Development of a three-dimensional quantification method of immune cells in human airway epithelium
Prenzler, F.; Veres, T.; Holz, O.; Welker, L.; Mueller, M.; Krug, N.; Hohlfeld, J.; Braun, A.
Abstract
2009Different cytokine pattern in human precision cut lung slices after treatment with respiratory and contact allergens
Switalla, S.; Wang, L.; Foerster, C.; Hohlfeld, J.; Krug, N.; Braun, A.; Sewald, K.
Abstract
2009The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
Schleh, C.; Mühlfeld, C.; Pulskamp, K.; Schmiedl, S.; Nassimi, M.; Lauenstein, H.D.; Braun, A.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Journal Article
2009Effects of inhibition of dipeptidyl-peptidase on airway hyperresponsiveness and inflammation in sensitized rats
Hoymann, H.G.; Stephan, M.; Suhling, H.; Pabst, R.; Braun, A.; Krug, N.; Hoersten, S. von; Schmiedl, A.
Abstract
2009Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in aspergillus-fumigatus-sensitized mice
Hoymann, H.-G.; Wollin, L.; Müller, M.; Korolewitz, R.; Krug, N.; Braun, A.; Beume, R.
Journal Article
2009Efficacy of a rush immunotherapy with a depigmented polymerised extract of grass pollen assessed in an environmental challenge chamber
Biller, H.; Badorrek, P.; Hohlfeld, J.; Krug, N.; Sager, A.
Abstract
2009Evaluation of the immunomodulating potential of drug candidates in an in vitro model of human allergy
Knothe, S.; Ebensen, T.; Müller, M.; Krug, N.; Guzman, C.; Braun, A.
Abstract
2009Gesundheitliche Effekte der Feinstaubbelastung aktueller wissenschaftlicher Kenntnisstand
Groneberg, D.A.; Morfeld, P.; Kraus, T.; Köhler, D.; Krug, N.; Magnussen, H.; Nowak, D.; Rabe, K.F.; Schultze-Werninghaus, G.; Schulz, H.; Teschler, H.; Vogelmeier, C.; Wagner, U.; Welte, T.; Voshaar, T.; Witt, C.
Journal Article
2009Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models
Nassimi, M.; Schleh, C.; Lauenstein, H.-D.; Hussein, R.; Lübbers, K.; Pohlmann, G.; Switalla, S.; Sewald, K.; Müller, M.; Krug, N.; Müller-Goymann, C.C.; Braun, A.
Journal Article
2009Mechanismen der broncho-alveolären Entzündungsreaktion durch umweltübliche Feinstäube: Beeinflussung oxidativer Vorgänge durch Metalle in Feinstäuben (PM2,5) im Humanmodell
Herbrich, A.
: Krug, N.; Tschernig, T.; Jordan, J.
Dissertation
2009Modulation of dendritic cells by calcitonin-gene related peptide
Rochlitzer, S.; Krug, N.; Braun, A.
Abstract
2009Noninvasive lung function measurements in juvenile rats at an age range between 2 and 50 days
Hoymann, H.G.; Herzog, S.; Ellinghusen, B.; Krug, N.; Braun, A.; Lewin, G.
Abstract
2009Precision cut lung slices (PCLS) as a tool to predict effective LPS concentrations for in vivo use in common marmoset monkeys
Seehase, S.; Switalla, S.; Schlumbohm, C.; Knöchelmann, N.; Krug, N.; Sewald, K.; Kaup, F.-J.; Fuchs, E.; Braun, A.
Abstract
2009Prolonged pro-inflammatory effects of ultrafine particles in the lung of allergic asthmatics
Schaumann, F.; Dijkstra, D.; Froemke, C.; Windt, H.; Karg, E.; Mueller, M.; Braun, A.; Hohlfeld, J.; Koch, W.; Schulz, H.; Krug, N.
Abstract
2009Respiratory toxicology and immunotoxicology in human precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Wang, L.; Pfennig, O.; Förster, C.; Krug, N.; Braun, A.
Abstract
2009Role of pituitary adenylate cyclase-peptide receptor 1 in a murine model of allergic asthma
Lauenstein, H.; Plappert, L.; Rochlitzer, S.; Pilzner, C.; Welte, T.; Krug, N.; Groneberg, D.; Braun, A.
Abstract
2009Therapeutic surfactants modulate the viability of Eosinophils and induce inflammatory mediator release
Erpenbeck, V.J.; Fischer, I.; Wiese, K.; Schaumann, F.; Schmiedl, A.; Nassenstein, C.; Krug, N.; Hohlfeld, J.M.
Journal Article
2009Therapeutic use of surfactant components in allergic asthma
Erpenbeck, V.J.; Krug, N.; Hohlfeld, J.M.
Journal Article
2009Trimellitic anhydride-induced immune responses in murine and human precision-cut lung slices
Wang, L.; Switalla, S.; Förster, C.; Krug, N.; Hohlfeld, J.; Braun, A.; Sewald, K.
Abstract
2008Animal models for human asthma: The perspective of a clinician
Krug, N.; Rabe, K.F.
Journal Article
2008Effects of specific pituitary adenylate cyclase activating peptide receptor 1 agonist maxadilan in a murine model of allergic asthma
Lauenstein, H.; Plappert, L.; Braun, A.; Krug, N.; Welte, T.; Fuchs, B.; Groneberg, D.
Abstract
2008Efficacy of a rush immunotherapy with a depigmented polymerized extract of grass pollen using an enviromental challenge chamber (ECC)
Sager, A.; Braeutigam, M.; Badorrek, P.; Krug, N.
Abstract
2008Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma
Schaumann, F.; Müller, M.; Braun, A.; Luettig, B.; Peden, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2008Engineered nanoparticles induce a pulmonary surfactant dysfunction after surface area cycling in vitro
Schleh, C.; Nassimi, M.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Conference Paper
2008Evaluation of the immunomodulating potential of a toll-like-receptor agonist in vitro
Knothe, S.; Ebensen, T.; Maller, M.; Krug, N.; Guzman, C.; Braun, A.
Abstract
2008Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies
Henjakovic, M.; Martin, C.; Hoymann, H.G.; Sewald, K.; Ressmeyer, A.R.; Dassow, C.; Pohlmann, G.; Krug, N.; Uhlig, S.; Braun, A.
Journal Article
2008Ex vivo testing of immune responses in precision-cut lung slices
Henjakovic, M.; Sewald, K.; Switalla, S.; Kaiser, D.; Müller, M.; Veres, T.Z.; Martin, C.; Uhlig, S.; Krug, N.; Braun, A.
Journal Article
2008Pneumococcal vaccines: Mechanism of action, impact on epidemiology and adaption of the species
Pletz, M.W.; Maus, U.; Krug, N.; Welte, T.; Lode, H.
Journal Article
2008Precision cut lung slices for prediction of sensitizing potential of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Mueller, M.; Veres, T.; Krug, N.; Braun, A.
Abstract
2008Precision cut lung slices for testing of gaseous compounds
Switalla, S.; Sewald, K.; Ritter, D.; Henjakovic, M.; Krug, N.; Knebel, J.; Braun, A.
Conference Paper, Journal Article
2008Respiratory toxicology and immunotoxicology in precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Henjakovic, M.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2008Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial
Hohlfeld, J.M.; Schönfeld, K.; Lavae-Mokhtari, M.; Schaumann, F.; Müller, M.; Bredenbröker, D.; Krug, N.; Hermann, R.
Journal Article
2008The role of pollen starch granules in bronchial inflammation
Badorrek, P.; Larbig, M.; Dick, M.; Koch, W.; Hecker, H.; Hohlfeld, J.; Krug, N.
Abstract
2008Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis following pollen exposure in the Fraunhofer Environmental Challenge Chamber (ECC)
Badorrek, P.; Dick, M.; Hoffmann, M.; Hecker, H.; Hohlfeld, J.; Krug, N.
Abstract
2008The therapeutic effect of a combination of cetirizine and pseudoephedrine compared to placebo is equivalent when tested in an environmental challenge chamber both within and out of the grass pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Murdoch, R.; Sousa, A.; Hohlfeld, J.; Krug, N.
Abstract
2008A toll-like receptor 2/6-agonist prevents allergic airway inflammation in chronic respiratory sensitisation
Fuchs, B.; Knothe, S.; Rochlitzer, S.; Matthias, N.; Greweling, M.; Lauenstein, H.; Nassenstein, C.; Müller, M.; Ebensen, T.; Krug, N.; Dittrich, A.; Guzman, C.; Braun, A.
Abstract
2008Verfahren zur Herstellung einer Inhalationsatmosphaere fuer die Allergenprovokation
Holfeld, J.; Krug, N.; Lödding, H.; Polmann, G.; Windt, H.; Bader, W.; Langer, P.; Stempfle, M.; Dunkhorst, W.; Koch, W.; Schwarz, K.
Patent
2007The combination therapy with cetirizine and pseudoephedrine is more effective than the treatment with single substances in patients with allergic rhinitis
Badorrek, P.; Bennack, M.; Buckow, K.; Schauerte, A.; Hoffmann, M.; Hecker, H.; Murdoch, R.; Hohlfeld, J.; Krug, N.
Conference Paper, Journal Article
2007Comparison of selective TrkA and TrkB receptor decoys on afferent sensory nerve reactivity, reflex bronchospasm, and airway inflammation in allergic asthma
Nassenstein, C.; Dawbarn, D.; Allen, S.; Kutschker, J.; Spies, E.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Effect of nanosized particles on pulmonary surfactant function
Schleh, C.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Conference Paper, Journal Article
2007Effects of keratinocyte growth factor on intra-alveolar surfactant fixed in situ: Quantitative ultrastructural and immunoelectron microscopic analysis
Fehrenbach, H.; Fehrenbach, A.; Dietzel, E.; Tschernig, T.; Krug, N.; Grau, V.; Hohlfeld, J.M.
Journal Article
2007Endotoxin and allergies
Krug, N.
Abstract
2007Function of pulmonary PACl receptor in a murine model of allergic asthma
Lauenstein, H.-D.; Plappert, L.; Quarcoo, D.; Fuchs, B.; Pilzner, C.; Fischer, A.; Krug, N.; Welte, T.; Braun, A.; Groneberg, D.A.
Abstract
2007Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model
Kouznetsova, I.; Chwieralski, C.E.; Bälder, R.; Hinz, M.; Braun, A.; Krug, N.; Hoffmann, W.
Journal Article
2007Neuroimmune crosstalk in asthma: Dual role of the neurotrophin receptor p75NTR
Nassenstein, C.; Kammertoens, T.; Veres, T.Z.; Uckert, W.; Spies, E.; Fuchs, B.; Krug, N.; Braun, A.
Journal Article
2007Precision cut lung slices (PCLS) for respiratory sensitisation potential testing of allergens and irritants
Henjakovic, M.; Sewald, K.; Switalla, S.; Veres, T.; Mätz-Rensing, K.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Precision cut lung slices as tool for assessment of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Veres, T.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2007Safety and tolerability of indacaterol in asthma: A randomized, placebo-controlled 28-day study
Chuchalin, A.G.; Tsoi, A.N.; Richter, K.; Krug, N.; Dahl, R.; Luursema, P.B.; Cameron, R.; Bao, W.; Higgins, M.; Woessner, R.; As, A. van
Journal Article
2007Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation
Veres, T.Z.; Rochlitzer, S.; Shevchenkom, M.; Fuchs, B.; Prenzler, F.; Nassenstein, C.; Fischer, A.; Welker, L.; Holz, O.; Müller, M.; Krug, N.; Braun, A.
Journal Article
2007Toll-like receptor 2 agonist and IFN-alpha modulate asthma parameters in mice chronically sensitised to grass pollen allergens via the respiratory tract
Fuchs, B.; Rochlitzer, S.; Knothe, S.; Müller, M.; Krug, N.; Braun, A.
Conference Paper, Journal Article
2006Allergic responses induced by grass pollen in an environmental challenge chamber (ECC) reflect changes during seasonal high pollen counts in allergic rhinitis patients
Krug, N.; Holland-Letz, T.; Wierenga, E.; Ree, R. van; Hüsing, A.; Larbig, M.; Hohlfeld, J.M.; Bufe, A.
Conference Paper, Journal Article
2006Comparison of non-invasive measures of cholinergic and allergic airway responsiveness in rats
Glaab, T.; Hecker, H.; Stephan, M.; Baelde, R.; Braun, A.; Korolewitz, R.; Krug, N.; Hoymann, H.G.
Journal Article
2006Efficacy of antihistamines
Mösges, R.; Krug, N.
Journal Article
2006Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
Thum, T.; Erpenbeck, V.J.; Moeller, J.; Hohlfeld, J.M.; Krug, N.; Borlak, J.
Journal Article
2006Facial thermography is a sensitive tool to determine antihistaminic activity
Larbig, M.; Burtin, B.; Martin, L.; Stamm, H.; Luettig, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2006Lung fibroblasts from patients with emphysema show markers of senescence in vitro
Müller, K.C.; Welker, L.; Paasch, K.; Feindt, B.; Erpenbeck, V.J.; Hohlfeld, J.M.; Krug, N.; Nakashima, M.; Branscheid, D.; Magnussen, H.; Jörres, R.A.; Holz, O.
Journal Article
2006Nasal nitric oxide (NNO) in patients with allergic rhinitis and healthy volunteers following pollen exposure in an environmental challenge chamber (ECC)
Holhfeld, J.M.; Larbig, M.; Paczkowski, I.; Hecker, H.; Krug, N.
Abstract
2006Pathomechanismen der chronisch-obstruktiven Lungenerkrankung (COPD)
Glaab, T.; Hohlfeld, J.M.; Jörres, R.A.; Krug, N.; Welte, T.
Journal Article
2006Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma
Nassenstein, C.; Dawbarn, D.; Pollock, K.; Allen, S.J.; Erpenbeck, V.J.; Spies, E.; Krug, N.; Braun, A.
Journal Article
2006Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge
Erpenbeck, V.J.; Hagenberg, A.; Krentel, H.; Discher, M.; Braun, A.; Hohlfeld, J.M.; Krug, N.
Journal Article
2006The role of allergen challenge chambers in the evaluation of anti-allergic medication
Day, J.H.; Horak, F.; Briscoe, M.P.; Canonica, G.W.; Fineman, S.M.; Krug, N.; Leynadier, F.; Liebermann, P.; Quirce, S.; Takenaka, H.; Cauwenberge, P. van
Journal Article
2006Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice
Erpenbeck, V.J.; Ziegert, M.; Cavalet-Blanco, D.; Martin, C.; Bälder, R.; Glaab, T.; Braun, A.; Steinhilber, W.; Luettig, B.; Uhlig, S.; Hoymann, H.G.; Krug, N.; Hohlfeld, J.M.
Journal Article
2006Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma
Erpenbeck, V.J.; Schmidt, R.; Gunther, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2006Usefulness of pollen chamber in the evaluation of clinical trials with allergen products
Krug, N.
Conference Paper
2006Utilisation of an environmental challenge chamber (ECC) to explore allergen induced bronchial hyperresponsiveness (BHR) in mild asthmatic patients with co-morbid rhinitis
Krug, N.; Hohlfeld, J.M.; Bruns, H.; Russell, P.; Weeks, A.; Larbig, M.; Murdoch, R.D.
Abstract
2005Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit
Krug, N.; Hohlfeld, J.M.; Geldmacher, H.; Larbig, M.; Heermann, R.; Lavallee, N.; Nguyen, D.T.; Petzold, U.; Hermann, R.
Journal Article
2005Efficacy of macrophage-activating lipopeptide-2 combined with interferon-{gamma} in a murine asthma model
Weigt, H.; Nassenstein, C.; Tscherning, T.; Mühlradt, P.F.; Krug, N.; Braun, A.
Journal Article
2005The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S.
Journal Article
2005The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Lehr, H.A.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S.
Journal Article
2005Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice
Glaab, T.; Ziegert, M.; Bälder, R.; Korolewitz, R.; Braun, A.; Hohlfeld, J.M.; Mitzner, W.; Krug, N.; Hoymann, H.G.
Journal Article
2005Local nitric oxide levels reflect the degree of allergic airway inflammation after segmental allergen challenge in asthmatics
Erpenbeck, V.J.; Jörres, R.A.; Discher, M.; Luettig, B.; Krug, N.; Hohlfeld, J.M.
Journal Article
2005Mechanismen ultrafeiner Partikeln
Krug, N.
Journal Article
2005Partikuläre Luftverunreinigung und ihre Folgen für die menschliche Gesundheit
Voshaar, T.H.; Heyder, J.; Köhler, D.; Krug, N.; Nowak, D.; Scheuch, G.; Schulz, H.; Witt, C.
Journal Article
2005Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation
Bälder, R.; Fuchs, B.; Bautsch, W.; Zwirner, J.; Kohl, J.; Hoymann, H.G.; Glaab, T.; Erpenbeck, V.; Krug, N.; Braun, A.
Journal Article
2005Pulmonale Sicherheitsaspekte bei Patienten mit allergischer Rhinitis während Gräserpollenprovokation in einem kontrollierten Expositionsraum
Badorrek, P.
: Krug, N. (Prüfer)
Dissertation
2005Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
Erpenbeck, V.J.; Malherbe, D.C.; Sommer, S.; Schmiedl, A.; Steinhilber, W.; Ghio, A.J.; Krug, N.; Wright, J.R.; Hohlfeld, J.M.
Journal Article
2005Vorstudie: Mobile Kältelieferung
Dötsch, C.; Beier, C.; Heinz, F.; Krug, N.; Gringel, M.; Hannot, R.; Scheidt, F.; Reuters, H.; Manderfeld, M.; Buchner, P.
Report
2004Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma
Hohlfeld, J.M.; Schmiedl, A.; Erpenbeck, V.J.; Venge, P.; Krug, N.
Journal Article
2004A human dendritic cell-based test system to evaluate the modulatory potential of drugs on allergic immunoreaction
Braun, A.; Krug, N.; Muhlradt, P.F.; Weigt, H.
Journal Article, Conference Paper
2004Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant
Schmiedl, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2004Keratinocyte growth factor transiently alters pulmonary function in rats
Hohlfeld, J.M.; Hoymann, H.G.; Tschernig, T.; Fehrenbach, A.; Krug, N.; Fehrenbach, H.
Journal Article
2004Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects
Schaumann, F.; Borm, P.J.A.; Herbrich, A.; Knoch, J.; Pitz, M.; Schins, R.P.F.; Luettig, B.; Hohlfeld, J.M.; Heinrich, J.; Krug, N.
Journal Article
2004Natural porcine surfactant augments airway inflammation after allergen challenge in patients with asthma
Erpenbeck, V.J.; Hagenberg, A.; Dulkys, Y.; Elsner, J.; Balder, R.; Krentel, H.; Discher, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2004Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice
Glaab, T.; Mitzner, W.; Braun, A.; Ernst, H.; Korolewitz, R.; Hohlfeld, J.M.; Krug, N.; Hoymann, H.G.
Journal Article
2004The toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model
Weigt, H.; Muhlradt, P.F.; Larbig, M.; Krug, N.; Braun, A.
Journal Article
2003Effect of anti-nerve growth factor on early and late airway responses in allergic rats
Glaab, T.; Hoymann, H.-G.; Hecht, M.; Korolewitz, R.; Tschernig, T.; Hohlfeld, J.M.; Krug, N.; Braun, A.
Journal Article
2003Endotoxin in fine (PM2.5) and coarse (PM2.5-10) particle mass of ambient aerosols
Heinrich, J.; Pitz, M.; Bischof, W.; Krug, N.; Borm, P.J.A.
Journal Article
2003Increase of inactive intra-alveolar surfactant subtypes in lungs of asthmatic Brown Norway rats
Schmiedl, A.; Hoymann, H.-G.; Ochs, M.; Menke, A.; Fehrenbach, A.; Krug, N.; Tschernig, T.; Hohlfeld, J.M.
Journal Article
2003Increased expression of interleukin-9 messenger RNA after segmental allergen challenge in allergic asthmatics
Erpenbeck, V.J.; Hohlfeld, J.M.; Discher, M.; Krentel, H.; Hagenberg, A.; Braun, A.; Krug, N.
Journal Article, Conference Paper
2003Local release of eosinophil peroxidase following segmental allergen provocation in asthma
Erpenbeck, V.J.; Hohlfeld, J.M.; Petschallies, J.; Eklund, E.; Peterson, C.G.B.; Fabel, H.; Krug, N.
Journal Article
2003The neurotrophins nerve growth factor, brain-derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 are survival and activation factors for Eosinophils in patients with allergic bronchial asthma
Nassenstein, C.; Braun, A.; Erpenbeck, V.J.; Lommatzsch, M.; Schmidt, S.; Krug, N.; Luttmann, W.; Renz, H.; Virchow, J.C.
Journal Article
2003Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes
Erpenbeck, V.J.; Hohlfeld, J.M.; Volkmann, B.; Hagenberg, A.; Geldmacher, H.; Braun, A.; Krug, N.
Journal Article
2003Surfactant homeostasis is maintained in vivo during Keratinocyte growth factor-induced rat lung type II cell hyperplasia
Fehrenbach, A.; Bube, C.; Hohlfeld, J.M.; Stevens, P.; Tschernig, T.; Hoymann, H.G.; Krug, N.; Fehrenbach, H.
Journal Article
2003Surfactant proteins SP-A and SP-D as modulators of the allergic inflammation in asthma
Hohlfeld, J.M.; Erpenbeck, V.J.; Krug, N.
Conference Paper, Journal Article
2003Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells
Weigt, H.; Mühlradt, P.F.; Emmendörffer, A.; Krug, N.; Braun, A.
Journal Article
2003Validation of a new lung-function method in orally intubated mice using a model for respiratory allergenicity
Braun, A.; Rott, M.; Hecht, M.; Glaab, T.; Hohlfeld, J.M.; Krug, N.; Hoymann, H.G.
Journal Article
2003Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis
Krug, N.; Loedding, H.; Hohlfeld, J.M.; Larbig, M.; Buckendahl, A.; Badorrek, P.; Geldmacher, H.; Behnke, W.; Dunkhorst, W.; Windt, H.; Luettig, B.; Koch, W.
Journal Article
2002Late allergic response in sensitized rats
Hoymann, H.G.; Glaab, T.; Hohlfeld, J.; Korolewitz, R.; Hecht, M.; Krug, N.
Conference Paper
2002Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats
Glaab, T.; Hoymann, H.G.; Hohlfeld, J.M.; Korolewitz, R.; Hecht, M.; Alarie, Y.; Tschernig, T.; Braun, A.; Krug, N.; Fabel, H.
Journal Article
2002A pilot study to assess the efficacy of loteprednol etabonate nasal spray as a treatment for allergic rhinitis in an environmental exposure unit (eeu)
Geldmacher, H.; Buckendahl, A.; Badorrek, P.; Nguyen, D.; Lavallee, N.; Petzold, U.; Hermann, R.; Hohlfeld, J.M.; Krug, N.
Journal Article
2001Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma
Krug, N.; Tschernig, T.; Erpenbeck, V.J.; Hohlfeld, J.M.; Köhl, J.
Journal Article
2001Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gamma delta T cells in people with asthma after segmental allergen challenge
Krug, N.; Erpenbeck, V.J.; Balke, K.; Petschallies, J.; Tschernig, T.; Hohlfeld, J.M.; Fabel, H.
Journal Article
2001Die Expression von T-Zell-Zytokinen bei Patienten mit allergischem Asthma nach segmentaler Allergenprovokation
Erpenbeck, V.J.
: Freihorst, J. (Prüfer); Kleine, P. (Prüfer); Fabel, H. (Prüfer); Krug, N. (Prüfer)
Dissertation
2001Fulminanter Verlauf einer Leptospirose mit multiplen Organmanifestationen
Kirchner, G.I.; Krug, N.; Bleck, J.S.; Fliser, D.; Manns, M.P.; Wagner, S.
Journal Article
2001Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system
Lehmann, C.; Wilkening, A.; Leiber, D.; Markus, A.; Krug, N.; Pabst, R.; Tschernig, T.
Journal Article
2001Testverfahren für inhalative Testung auf allergenes Potenzial
Hoymann, H.G.; Krug, N.
Journal Article
2000Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma
Krug, N.; Cruikshank, W.W.; Tschernig, T.; Erpenbeck, V.J.; Balke, K.; Hohlfeld, J.M.; Center, D.M.; Fabel, H.
Journal Article
2000Lymphocytes migrate from the blood into the bronchoalveolar lavage and lung parenchyma in the asthma model of the brown Norway rat
Schuster, M.; Tschernig, T.; Krug, N.; Pabst, R.
Journal Article
2000Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma
Heeley, E.L.; Hohlfeld, J.M.; Krug, N.; Postle, A.D.
Journal Article
2000Surfactant function affected by airway inflammation and cooling: Possible impact on exercise-induced asthma
Enhorning, G.; Hohlfeld, J.M.; Krug, N.; Lema, G.; Welliver, R.
Journal Article
1999Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Enhorning, G.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.-G.; Fabel, H.; Krug, N.
Journal Article
1998Endobronchial allergen challenge
Frew, A.J.; Carroll, M.P.; Gratziou, C.; Krug, N.
Journal Article
1998Pulmonary surfactant activity is impaired in lung transplant recipients
Hohlfeld, J.M.; Tiryaki, E.; Hamm, H.; Hoymann, H.G.; Krug, N.; Haverich, A.; Fabel, H.
Journal Article
1998Pulmonary surfactant function is impaired in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H.
Journal Article
1998Störung der Surfactantfunktion bei Asthmatikern nach segmentaler Allergenprovokation
Hohlfeld, J.M.; Ahlf, K.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H.
Journal Article
1994Hemmnisse für Techniken zur rationellen Energienutzung und Vorschläge für deren Abbau
Gruber, E.; Jochem, E.; Reichert, J.; Köwener, D.; Krug, N.; Yigit, Z.
Book