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| 2013 | Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina | Journal Article |
| 2012 | Acute ozone induced airway inflammation does not effect resting human sympathetic nerve traffic
Tank, J.; Biller, Heike; Heusser, K.; Holz, Olaf; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, Wolfgang; Krug, Norbert; Jordan, J.; Hohlfeld, Jens | Journal Article, Conference Paper |
| 2012 | Die Bedeutung von Pollen und Starch Granules bei der Allergie der Atemwege
Emmert, Lorenz Samy
: Krug, Norbert (Doktorvater) | Dissertation |
| 2012 | CRTH2 antagonist, BI 671800 (BI), reduces nasal symptoms and inhibits nasal cytokines and eosinophils in SAR patients exposed to grass pollen in an environmental challenge chamber (ECC)
Krug, Norbert; Gupta, A.; Badorrek, Philipp; Müller, Meike; Casper, Anja; Pivovarova, A.; Hilbert, J.; Koenen, R.; Hohlfeld, Jens M.; Wood, C. | Abstract, Conference Paper |
| 2012 | Depletion of neutrophils from induced sputum using a novel bead and sieve-separation system
Holz, Olaf; Schaumann, Frank; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Krug, Norbert; Heinrich, J. M.; Hohlfeld, Jens M. | Abstract, Conference Paper |
| 2012 | Experience with an allergen challenge chamber for clinical trials in allergic rhinitis
Krug, Norbert; Badorrek, Phillipp; Hohlfeld, Jens Michael | Journal Article, Conference Paper |
| 2012 | Low-dose endotoxin inhalation in healthy volunteers: A challenge model for early clinical drug development of novel anti-inflammatory compounds
Schaumann, Frank; Holz, Olaf; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M. | Abstract, Conference Paper |
| 2012 | Pollen starch granules in bronchial inflammation
Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert | Journal Article |
| 2012 | Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum
Röpcke, S.; Holz, O.; Lauer, G.; Müller, M.; Rittinghausen, S.; Ernst, P.; Lahu, G.; Elmlinger, M.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2012 | Reproducibility of serum biomarkers and relationship to airway inflammation following LPS challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Faulenbach, Cornelia; Müller, Meike; Krug, Norbert; McLeod, Alison; Hohlfeld, Jens M. | Abstract, Conference Paper |
| 2012 | Safety and efficacy of house dust mite allergen challenge in patients with allergic rhinitis using a novel technique for inhalation studies in the Fraunhofer environmental challenge chamber
Lueer, Katrin; Biller, Heike; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, Armin; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M. | Abstract, Conference Paper |
| 2012 | Semi-quantitative assessment of localized pulmonary inflammation by magnetic resonance imaging in patients with mild allergic asthma following segmental allergen challenge
Vogel-Claussen, Jens; Schaumann, Frank; Renne, Julius; Hinrichs, Jan; Schoenfeld, Christian; Gutberlet, Marcel; Hüper, Klaudia; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M. | Abstract, Conference Paper |
| 2012 | Stable inflammatory phenotype in smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Krug, Norbert; Ernst, Peter; Lahu, Gezim; Hohlfeld, Jens M. | Abstract, Conference Paper |
| 2012 | Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Schleh, Carsten; Rothen-Rutishauser, Barbara M.; Blank, Fabian; Lauenstein, Hans D.; Nassimi, Matthias; Krug, Norbert; Braun, Armin; Erpenbeck, Veit; Gehr, Peter; Hohlfeld, Jens M. | Journal Article |
| 2011 | Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael | Journal Article |
| 2011 | Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Schaumann, F.; Hohlfeld, J.M.; Krug, N.; Sousa, A.R.; Murdoch, R. | Journal Article |
| 2011 | Breath profiles by electronic nose correlate with systemic markers but not ozone response
Biller, Heike; Holz, Olaf; Windt, Horst; Koch, Wolfgang; Müller, Meike; Jörres, Rudolf A.; Krug, Norbert; Hohlfeld, Jens M. | Journal Article |
| 2011 | Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Winkler, C.; Atochina-Vasserman, E.N.; Holz, O.; Beers, M.F.; Erpenbeck, V.J.; Krug, N.; Roepcke, S.; Lauer, G.; Elmlinger, M.; Hohlfeld, J.M. | Journal Article |
| 2011 | Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: A randomized, placebo controlled, crossover study
Tank, J.; Biller, H.; Heusser, K.; Holz, O.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.M. | Journal Article |
| 2011 | The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
Nicholson, G.C.; Kariyawasam, H.H.; Tan, A.J.; Hohlfeld, J.M.; Quinn, D.; Walker, C.; Rodman, D.; Westwick, J.; Jurcevic, S.; Kon, O.M.; Barnes, P.J.; Krug, N.; Hansel, T.T. | Journal Article |
| 2011 | The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function
Rochlitzer, Sabine; Veres, Tibor Z.; Kühne, Kathleen; Prenzler, Frauke; Pilzner, Carolin; Knothe, Saskia; Winkler, Carla; Lauenstein, Hans-Dieter; Willart, M.; Hammad, H.; Müller, Meike; Krug, Norbert; Lambrecht, Bart N.; Braun, Armin | Journal Article |
| 2011 | Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice
Lauenstein, H.D.; Quarcoo, D.; Plappert, L.; Schleh, C.; Nassimi, M.; Pilzner, C.; Rochlitzer, S.; Brabet, P.; Welte, T.; Hoymann, H.G.; Krug, N.; Müller, M.; Lerner, E.A.; Braun, A.; Groneberg, D.A. | Journal Article |
| 2011 | Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans
Atochina-Vasserman, E.N.; Winkler, C.; Abramova, H.; Schaumann, F.; Krug, N.; Gow, A.J.; Beers, M.F.; Hohlfeld, J.M. | Journal Article |
| 2010 | Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
Schleh, C.; Erpenbeck, V.J.; Winkler, C.; Lauenstein, H.D.; Nassimi, M.; Braun, A.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2010 | Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions
Hohlfeld, J.M.; Holland-Letz, T.; Larbig, M.; Lavae-Mokhtari, M.; Wierenga, E.; Kapsenberg, M.; Ree, R. van; Krug, N.; Bufe, A. | Journal Article |
| 2010 | Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air-liquid interface (ALI) culture
Switalla, S.; Knebel, J.; Ritter, D.; Krug, N.; Braun, A.; Sewald, K. | Journal Article |
| 2010 | Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices
Switalla, S.; Lauenstein, L.; Prenzler, F.; Knothe, S.; Förster, C.; Fieguth, H.-G.; Pfennig, O.; Schaumann, F.; Martin, C.; Guzman, C.A.; Ebensen, T.; Müller, M.; Hohlfeld, J.M.; Krug, N.; Braun, A.; Sewald, K. | Journal Article |
| 2010 | Pharmacodynamic effects of the selective PDE4-inhibitor roflumilast in humans
Bethke, T.D.; Hohlfeld, J.M.; Krug, N.; Grootendorst, D.C.; Rabe, K.F. | Abstract, Journal Article |
| 2010 | Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease
Woodruff, P.G.; Wolff, M.; Hohlfelds, J.M.; Krug, N.; Dransfield, M.T.; Sutherland, E.R.; Criner, G.J.; Kim, V.; Prasse, A.; Nivens, M.C.; Tetzlaff, K.; Heilker, R.; Fahy, J.V. | Journal Article |
| 2010 | Surfactant protein D modulates pulmonary clearance of pollen starch granules
Winkler, C.; Hüper, K.; Wedekind, A-C.; Rochlitzer, S.; Hartwig, C.; Müller, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.; Erpenbeck, V.J. | Journal Article |
| 2010 | A toll-like receptor 2/6 agonist reduces allergic airway inflammation in chronic respiratory sensitisation to timothy grass pollen antigens
Fuchs, B.; Knothe, S.; Rochlitzer, S.; Nassimi, M.; Greweling, M.; Lauenstein, H.D.; Nassenstein, C.; Müller, M.; Ebensen, T.; Dittrich, A.M.; Krug, N.; Guzman, C.A.; Braun, A. | Journal Article |
| 2010 | A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung
Nassimi, M.; Schleh, C.; Lauenstein, H.D.; Hussein, R.; Hoymann, H.G.; Koch, W.; Pohlmann, G.; Krug, N.; Sewald, K.; Rittinghausen, S.; Braun, A.; Müller-Goymann, C. | Journal Article |
| 2009 | A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis
Badorrek, P.; Dick, M.; Schauerte, A.; Hecker, H.; Murdoch, R.; Luettig, B.; Hohlfeld, J.M.; Krug, N. | Journal Article |
| 2009 | Cytokine production after acute exposure of precision cut lung slices to NO2 and O3
Switalla, S.; Ritter, D.; Krug, N.; Knebel, J.; Braun, A.; Sewald, K. | Abstract, Journal Article |
| 2009 | Dendritic cell-nerve clusters are sites of T cell proliferation in allergic airway inflammation
Veres, T.Z.; Shevchenko, M.; Krasteva, G.; Spies, E.; Prenzler, F.; Rochlitzer, S.; Tschernig, T.; Krug, N.; Kummer, W.; Braun, A. | Journal Article |
| 2009 | Development of a three-dimensional quantification method of immune cells in human airway epithelium
Prenzler, F.; Veres, T.; Holz, O.; Welker, L.; Mueller, M.; Krug, N.; Hohlfeld, J.; Braun, A. | Abstract, Conference Paper |
| 2009 | Different cytokine pattern in human precision cut lung slices after treatment with respiratory and contact allergens
Switalla, S.; Wang, L.; Foerster, C.; Hohlfeld, J.; Krug, N.; Braun, A.; Sewald, K. | Abstract, Conference Paper |
| 2009 | The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
Schleh, C.; Muhlfeld, C.; Pulskamp, K.; Schmiedl, S.; Nassimi, M.; Lauenstein, H.D.; Braun, A.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M. | Journal Article |
| 2009 | Effects of inhibition of dipeptidyl-peptidase on airway hyperresponsiveness and inflammation in sensitized rats
Hoymann, H.G.; Stephan, M.; Suhling, H.; Pabst, R.; Braun, A.; Krug, N.; Hoersten, S. von; Schmiedl, A. | Abstract, Conference Paper |
| 2009 | Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in aspergillus-fumigatus-sensitized mice
Hoymann, H.-G.; Wollin, L.; Müller, M.; Korolewitz, R.; Krug, N.; Braun, A.; Beume, R. | Journal Article |
| 2009 | Efficacy of a rush immunotherapy with a depigmented polymerised extract of grass pollen assessed in an environmental challenge chamber
Biller, H.; Badorrek, P.; Hohlfeld, J.; Krug, N.; Sager, A. | Abstract, Conference Paper |
| 2009 | Evaluation of the immunomodulating potential of drug candidates in an in vitro model of human allergy
Knothe, S.; Ebensen, T.; Müller, M.; Krug, N.; Guzman, C.; Braun, A. | Abstract, Conference Paper |
| 2009 | Gesundheitliche Effekte der Feinstaubbelastung aktueller wissenschaftlicher Kenntnisstand
Groneberg, D.A.; Morfeld, P.; Kraus, T.; Köhler, D.; Krug, N.; Magnussen, H.; Nowak, D.; Rabe, K.F.; Schultze-Werninghaus, G.; Schulz, H.; Teschler, H.; Vogelmeier, C.; Wagner, U.; Welte, T.; Voshaar, T.; Witt, C. | Journal Article |
| 2009 | Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models
Nassimi, M.; Schleh, C.; Lauenstein, H.-D.; Hussein, R.; Lübbers, K.; Pohlmann, G.; Switalla, S.; Sewald, K.; Müller, M.; Krug, N.; Müller-Goymann, C.C.; Braun, A. | Journal Article |
| 2009 | Mechanismen der broncho-alveolären Entzündungsreaktion durch umweltübliche Feinstäube: Beeinflussung oxidativer Vorgänge durch Metalle in Feinstäuben (PM2,5) im Humanmodell
Herbrich, A.
: Krug, N.; Tschernig, T.; Jordan, J. | Dissertation |
| 2009 | Modulation of dendritic cells by calcitonin-gene related peptide
Rochlitzer, S.; Krug, N.; Braun, A. | Abstract, Journal Article |
| 2009 | Noninvasive lung function measurements in juvenile rats at an age range between 2 and 50 days
Hoymann, H.G.; Herzog, S.; Ellinghusen, B.; Krug, N.; Braun, A.; Lewin, G. | Abstract, Conference Paper |
| 2009 | Precision cut lung slices (PCLS) as a tool to predict effective LPS concentrations for in vivo use in common marmoset monkeys
Seehase, S.; Switalla, S.; Schlumbohm, C.; Knöchelmann, N.; Krug, N.; Sewald, K.; Kaup, F.-J.; Fuchs, E.; Braun, A. | Abstract, Journal Article |
| 2009 | Prolonged pro-inflammatory effects of ultrafine particles in the lung of allergic asthmatics
Schaumann, F.; Dijkstra, D.; Froemke, C.; Windt, H.; Karg, E.; Mueller, M.; Braun, A.; Hohlfeld, J.; Koch, W.; Schulz, H.; Krug, N. | Abstract, Journal Article |
| 2009 | Respiratory toxicology and immunotoxicology in human precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Wang, L.; Pfennig, O.; Förster, C.; Krug, N.; Braun, A. | Abstract, Journal Article |
| 2009 | Role of pituitary adenylate cyclase-peptide receptor 1 in a murine model of allergic asthma
Lauenstein, H.; Plappert, L.; Rochlitzer, S.; Pilzner, C.; Welte, T.; Krug, N.; Groneberg, D.; Braun, A. | Abstract, Journal Article |
| 2009 | Therapeutic surfactants modulate the viability of Eosinophils and induce inflammatory mediator release
Erpenbeck, V.J.; Fischer, I.; Wiese, K.; Schaumann, F.; Schmiedl, A.; Nassenstein, C.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2009 | Therapeutic use of surfactant components in allergic asthma
Erpenbeck, V.J.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2009 | Trimellitic anhydride-induced immune responses in murine and human precision-cut lung slices
Wang, L.; Switalla, S.; Förster, C.; Krug, N.; Hohlfeld, J.; Braun, A.; Sewald, K. | Abstract, Conference Paper |
| 2008 | Animal models for human asthma: The perspective of a clinician
Krug, N.; Rabe, K.F. | Journal Article |
| 2008 | Effects of specific pituitary adenylate cyclase activating peptide receptor 1 agonist maxadilan in a murine model of allergic asthma
Lauenstein, H.; Plappert, L.; Braun, A.; Krug, N.; Welte, T.; Fuchs, B.; Groneberg, D. | Abstract, Journal Article |
| 2008 | Efficacy of a rush immunotherapy with a depigmented polymerized extract of grass pollen using an enviromental challenge chamber (ECC)
Sager, A.; Braeutigam, M.; Badorrek, P.; Krug, N. | Abstract, Conference Paper |
| 2008 | Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma
Schaumann, F.; Müller, M.; Braun, A.; Luettig, B.; Peden, B.; Hohlfeld, J.M.; Krug, N. | Journal Article |
| 2008 | Engineered nanoparticles induce a pulmonary surfactant dysfunction after surface area cycling in vitro
Schleh, C.; Nassimi, M.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M. | Conference Paper |
| 2008 | Evaluation of the immunomodulating potential of a toll-like-receptor agonist in vitro
Knothe, S.; Ebensen, T.; Maller, M.; Krug, N.; Guzman, C.; Braun, A. | Abstract, Journal Article |
| 2008 | Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies
Henjakovic, M.; Martin, C.; Hoymann, H.G.; Sewald, K.; Ressmeyer, A.R.; Dassow, C.; Pohlmann, G.; Krug, N.; Uhlig, S.; Braun, A. | Journal Article |
| 2008 | Ex vivo testing of immune responses in precision-cut lung slices
Henjakovic, M.; Sewald, K.; Switalla, S.; Kaiser, D.; Müller, M.; Veres, T.Z.; Martin, C.; Uhlig, S.; Krug, N.; Braun, A. | Journal Article |
| 2008 | Pneumococcal vaccines: Mechanism of action, impact on epidemiology and adaption of the species
Pletz, M.W.; Maus, U.; Krug, N.; Welte, T.; Lode, H. | Journal Article |
| 2008 | Precision cut lung slices for prediction of sensitizing potential of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Mueller, M.; Veres, T.; Krug, N.; Braun, A. | Abstract, Journal Article |
| 2008 | Precision cut lung slices for testing of gaseous compounds
Switalla, S.; Sewald, K.; Ritter, D.; Henjakovic, M.; Krug, N.; Knebel, J.; Braun, A. | Conference Paper, Journal Article |
| 2008 | Respiratory toxicology and immunotoxicology in precision cut lung slices (PCLS)
Sewald, K.; Switalla, S.; Henjakovic, M.; Krug, N.; Braun, A. | Conference Paper, Journal Article |
| 2008 | Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial
Hohlfeld, J.M.; Schönfeld, K.; Lavae-Mokhtari, M.; Schaumann, F.; Müller, M.; Bredenbröker, D.; Krug, N.; Hermann, R. | Journal Article |
| 2008 | The role of pollen starch granules in bronchial inflammation
Badorrek, P.; Larbig, M.; Dick, M.; Koch, W.; Hecker, H.; Hohlfeld, J.; Krug, N. | Abstract, Conference Paper |
| 2008 | Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis following pollen exposure in the Fraunhofer Environmental Challenge Chamber (ECC)
Badorrek, P.; Dick, M.; Hoffmann, M.; Hecker, H.; Hohlfeld, J.; Krug, N. | Abstract, Conference Paper |
| 2008 | The therapeutic effect of a combination of cetirizine and pseudoephedrine compared to placebo is equivalent when tested in an environmental challenge chamber both within and out of the grass pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Murdoch, R.; Sousa, A.; Hohlfeld, J.; Krug, N. | Abstract, Conference Paper |
| 2008 | A toll-like receptor 2/6-agonist prevents allergic airway inflammation in chronic respiratory sensitisation
Fuchs, B.; Knothe, S.; Rochlitzer, S.; Matthias, N.; Greweling, M.; Lauenstein, H.; Nassenstein, C.; Müller, M.; Ebensen, T.; Krug, N.; Dittrich, A.; Guzman, C.; Braun, A. | Abstract, Conference Paper |
| 2008 | Verfahren zur Herstellung einer Inhalationsatmosphaere fuer die Allergenprovokation
Holfeld, J.; Krug, N.; Lödding, H.; Polmann, G.; Windt, H.; Bader, W.; Langer, P.; Stempfle, M.; Dunkhorst, W.; Koch, W.; Schwarz, K. | Patent |
| 2007 | The combination therapy with cetirizine and pseudoephedrine is more effective than the treatment with single substances in patients with allergic rhinitis
Badorrek, P.; Bennack, M.; Buckow, K.; Schauerte, A.; Hoffmann, M.; Hecker, H.; Murdoch, R.; Hohlfeld, J.; Krug, N. | Conference Paper, Journal Article |
| 2007 | Comparison of selective TrkA and TrkB receptor decoys on afferent sensory nerve reactivity, reflex bronchospasm, and airway inflammation in allergic asthma
Nassenstein, C.; Dawbarn, D.; Allen, S.; Kutschker, J.; Spies, E.; Krug, N.; Braun, A. | Conference Paper, Journal Article |
| 2007 | Effect of nanosized particles on pulmonary surfactant function
Schleh, C.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M. | Conference Paper, Journal Article |
| 2007 | Effects of keratinocyte growth factor on intra-alveolar surfactant fixed in situ: Quantitative ultrastructural and immunoelectron microscopic analysis
Fehrenbach, H.; Fehrenbach, A.; Dietzel, E.; Tschernig, T.; Krug, N.; Grau, V.; Hohlfeld, J.M. | Journal Article |
| 2007 | Endotoxin and allergies
Krug, N. | Journal Article, Abstract |
| 2007 | Function of pulmonary PACl receptor in a murine model of allergic asthma
Lauenstein, H.-D.; Plappert, L.; Quarcoo, D.; Fuchs, B.; Pilzner, C.; Fischer, A.; Krug, N.; Welte, T.; Braun, A.; Groneberg, D.A. | Abstract, Journal Article |
| 2007 | Induced trefoil factor family 1 expression by trans-differentiating Clara cells in a murine asthma model
Kouznetsova, I.; Chwieralski, C.E.; Bälder, R.; Hinz, M.; Braun, A.; Krug, N.; Hoffmann, W. | Journal Article |
| 2007 | Neuroimmune crosstalk in asthma: Dual role of the neurotrophin receptor p75NTR
Nassenstein, C.; Kammertoens, T.; Veres, T.Z.; Uckert, W.; Spies, E.; Fuchs, B.; Krug, N.; Braun, A. | Journal Article |
| 2007 | Precision cut lung slices (PCLS) for respiratory sensitisation potential testing of allergens and irritants
Henjakovic, M.; Sewald, K.; Switalla, S.; Veres, T.; Mätz-Rensing, K.; Krug, N.; Braun, A. | Conference Paper, Journal Article |
| 2007 | Precision cut lung slices as tool for assessment of allergens
Switalla, S.; Sewald, K.; Henjakovic, M.; Veres, T.; Krug, N.; Braun, A. | Conference Paper, Journal Article |
| 2007 | Safety and tolerability of indacaterol in asthma: A randomized, placebo-controlled 28-day study
Chuchalin, A.G.; Tsoi, A.N.; Richter, K.; Krug, N.; Dahl, R.; Luursema, P.B.; Cameron, R.; Bao, W.; Higgins, M.; Woessner, R.; As, A. van | Journal Article |
| 2007 | Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation
Veres, T.Z.; Rochlitzer, S.; Shevchenkom, M.; Fuchs, B.; Prenzler, F.; Nassenstein, C.; Fischer, A.; Welker, L.; Holz, O.; Müller, M.; Krug, N.; Braun, A. | Journal Article |
| 2007 | Toll-like receptor 2 agonist and IFN-alpha modulate asthma parameters in mice chronically sensitised to grass pollen allergens via the respiratory tract
Fuchs, B.; Rochlitzer, S.; Knothe, S.; Müller, M.; Krug, N.; Braun, A. | Conference Paper, Journal Article |
| 2006 | Allergic responses induced by grass pollen in an environmental challenge chamber (ECC) reflect changes during seasonal high pollen counts in allergic rhinitis patients
Krug, N.; Holland-Letz, T.; Wierenga, E.; Ree, R. van; Hüsing, A.; Larbig, M.; Hohlfeld, J.M.; Bufe, A. | Conference Paper, Journal Article |
| 2006 | Comparison of non-invasive measures of cholinergic and allergic airway responsiveness in rats
Glaab, T.; Hecker, H.; Stephan, M.; Baelde, R.; Braun, A.; Korolewitz, R.; Krug, N.; Hoymann, H.G. | Journal Article |
| 2006 | Efficacy of antihistamines
Mösges, R.; Krug, N. | Journal Article |
| 2006 | Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
Thum, T.; Erpenbeck, V.J.; Moeller, J.; Hohlfeld, J.M.; Krug, N.; Borlak, J. | Journal Article |
| 2006 | Facial thermography is a sensitive tool to determine antihistaminic activity
Larbig, M.; Burtin, B.; Martin, L.; Stamm, H.; Luettig, B.; Hohlfeld, J.M.; Krug, N. | Journal Article |
| 2006 | Lung fibroblasts from patients with emphysema show markers of senescence in vitro
Müller, K.C.; Welker, L.; Paasch, K.; Feindt, B.; Erpenbeck, V.J.; Hohlfeld, J.M.; Krug, N.; Nakashima, M.; Branscheid, D.; Magnussen, H.; Jörres, R.A.; Holz, O. | Journal Article |
| 2006 | Nasal nitric oxide (NNO) in patients with allergic rhinitis and healthy volunteers following pollen exposure in an environmental challenge chamber (ECC)
Holhfeld, J.M.; Larbig, M.; Paczkowski, I.; Hecker, H.; Krug, N. | Conference Paper, Abstract |
| 2006 | Pathomechanismen der chronisch-obstruktiven Lungenerkrankung (COPD)
Glaab, T.; Hohlfeld, J.M.; Jörres, R.A.; Krug, N.; Welte, T. | Journal Article |
| 2006 | Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma
Nassenstein, C.; Dawbarn, D.; Pollock, K.; Allen, S.J.; Erpenbeck, V.J.; Spies, E.; Krug, N.; Braun, A. | Journal Article |
| 2006 | Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge
Erpenbeck, V.J.; Hagenberg, A.; Krentel, H.; Discher, M.; Braun, A.; Hohlfeld, J.M.; Krug, N. | Journal Article |
| 2006 | The role of allergen challenge chambers in the evaluation of anti-allergic medication
Day, J.H.; Horak, F.; Briscoe, M.P.; Canonica, G.W.; Fineman, S.M.; Krug, N.; Leynadier, F.; Liebermann, P.; Quirce, S.; Takenaka, H.; Cauwenberge, P. van | Journal Article |
| 2006 | Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice
Erpenbeck, V.J.; Ziegert, M.; Cavalet-Blanco, D.; Martin, C.; Bälder, R.; Glaab, T.; Braun, A.; Steinhilber, W.; Luettig, B.; Uhlig, S.; Hoymann, H.G.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2006 | Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma
Erpenbeck, V.J.; Schmidt, R.; Gunther, A.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2006 | Usefulness of pollen chamber in the evaluation of clinical trials with allergen products
Krug, N. | Conference Paper |
| 2006 | Utilisation of an environmental challenge chamber (ECC) to explore allergen induced bronchial hyperresponsiveness (BHR) in mild asthmatic patients with co-morbid rhinitis
Krug, N.; Hohlfeld, J.M.; Bruns, H.; Russell, P.; Weeks, A.; Larbig, M.; Murdoch, R.D. | Conference Paper, Abstract |
| 2005 | Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit
Krug, N.; Hohlfeld, J.M.; Geldmacher, H.; Larbig, M.; Heermann, R.; Lavallee, N.; Nguyen, D.T.; Petzold, U.; Hermann, R. | Journal Article |
| 2005 | Efficacy of macrophage-activating lipopeptide-2 combined with interferon-{gamma} in a murine asthma model
Weigt, H.; Nassenstein, C.; Tscherning, T.; Mühlradt, P.F.; Krug, N.; Braun, A. | Journal Article |
| 2005 | The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S. | Journal Article |
| 2005 | The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Lehr, H.A.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S. | Corrigendum |
| 2005 | Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice
Glaab, T.; Ziegert, M.; Bälder, R.; Korolewitz, R.; Braun, A.; Hohlfeld, J.M.; Mitzner, W.; Krug, N.; Hoymann, H.G. | Journal Article |
| 2005 | Local nitric oxide levels reflect the degree of allergic airway inflammation after segmental allergen challenge in asthmatics
Erpenbeck, V.J.; Jörres, R.A.; Discher, M.; Luettig, B.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2005 | Mechanismen ultrafeiner Partikeln
Krug, N. | Journal Article |
| 2005 | Partikuläre Luftverunreinigung und ihre Folgen für die menschliche Gesundheit
Voshaar, T.H.; Heyder, J.; Köhler, D.; Krug, N.; Nowak, D.; Scheuch, G.; Schulz, H.; Witt, C. | Journal Article |
| 2005 | Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation
Bälder, R.; Fuchs, B.; Bautsch, W.; Zwirner, J.; Kohl, J.; Hoymann, H.G.; Glaab, T.; Erpenbeck, V.; Krug, N.; Braun, A. | Journal Article |
| 2005 | Pulmonale Sicherheitsaspekte bei Patienten mit allergischer Rhinitis während Gräserpollenprovokation in einem kontrollierten Expositionsraum
Badorrek, P.
: Krug, N. (Prüfer) | Dissertation |
| 2005 | Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
Erpenbeck, V.J.; Malherbe, D.C.; Sommer, S.; Schmiedl, A.; Steinhilber, W.; Ghio, A.J.; Krug, N.; Wright, J.R.; Hohlfeld, J.M. | Journal Article |
| 2005 | Vorstudie: Mobile Kältelieferung
Dötsch, C.; Beier, C.; Heinz, F.; Krug, N.; Gringel, M.; Hannot, R.; Scheidt, F.; Reuters, H.; Manderfeld, M.; Buchner, P. | Research Report |
| 2004 | Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma
Hohlfeld, J.M.; Schmiedl, A.; Erpenbeck, V.J.; Venge, P.; Krug, N. | Journal Article |
| 2004 | A human dendritic cell-based test system to evaluate the modulatory potential of drugs on allergic immunoreaction
Braun, A.; Krug, N.; Muhlradt, P.F.; Weigt, H. | Journal Article, Conference Paper |
| 2004 | Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant
Schmiedl, A.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2004 | Keratinocyte growth factor transiently alters pulmonary function in rats
Hohlfeld, J.M.; Hoymann, H.G.; Tschernig, T.; Fehrenbach, A.; Krug, N.; Fehrenbach, H. | Journal Article |
| 2004 | Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects
Schaumann, F.; Borm, P.J.A.; Herbrich, A.; Knoch, J.; Pitz, M.; Schins, R.P.F.; Luettig, B.; Hohlfeld, J.M.; Heinrich, J.; Krug, N. | Journal Article |
| 2004 | Natural porcine surfactant augments airway inflammation after allergen challenge in patients with asthma
Erpenbeck, V.J.; Hagenberg, A.; Dulkys, Y.; Elsner, J.; Balder, R.; Krentel, H.; Discher, M.; Braun, A.; Krug, N.; Hohlfeld, J.M. | Journal Article |
| 2004 | Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice
Glaab, T.; Mitzner, W.; Braun, A.; Ernst, H.; Korolewitz, R.; Hohlfeld, J.M.; Krug, N.; Hoymann, H.G. | Journal Article |
| 2004 | The toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model
Weigt, H.; Muhlradt, P.F.; Larbig, M.; Krug, N.; Braun, A. | Journal Article |
| 2003 | Effect of anti-nerve growth factor on early and late airway responses in allergic rats
Glaab, T.; Hoymann, H.-G.; Hecht, M.; Korolewitz, R.; Tschernig, T.; Hohlfeld, J.M.; Krug, N.; Braun, A. | Journal Article |
| 2003 | Endotoxin in fine (PM2.5) and coarse (PM2.5-10) particle mass of ambient aerosols
Heinrich, J.; Pitz, M.; Bischof, W.; Krug, N.; Borm, P.J.A. | Journal Article |
| 2003 | Increase of inactive intra-alveolar surfactant subtypes in lungs of asthmatic Brown Norway rats
Schmiedl, A.; Hoymann, H.-G.; Ochs, M.; Menke, A.; Fehrenbach, A.; Krug, N.; Tschernig, T.; Hohlfeld, J.M. | Journal Article |
| 2003 | Increased expression of interleukin-9 messenger RNA after segmental allergen challenge in allergic asthmatics
Erpenbeck, V.J.; Hohlfeld, J.M.; Discher, M.; Krentel, H.; Hagenberg, A.; Braun, A.; Krug, N. | Journal Article, Conference Paper |
| 2003 | Local release of eosinophil peroxidase following segmental allergen provocation in asthma
Erpenbeck, V.J.; Hohlfeld, J.M.; Petschallies, J.; Eklund, E.; Peterson, C.G.B.; Fabel, H.; Krug, N. | Journal Article |
| 2003 | The neurotrophins nerve growth factor, brain-derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 are survival and activation factors for Eosinophils in patients with allergic bronchial asthma
Nassenstein, C.; Braun, A.; Erpenbeck, V.J.; Lommatzsch, M.; Schmidt, S.; Krug, N.; Luttmann, W.; Renz, H.; Virchow, J.C. | Journal Article |
| 2003 | Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes
Erpenbeck, V.J.; Hohlfeld, J.M.; Volkmann, B.; Hagenberg, A.; Geldmacher, H.; Braun, A.; Krug, N. | Journal Article |
| 2003 | Surfactant homeostasis is maintained in vivo during Keratinocyte growth factor-induced rat lung type II cell hyperplasia
Fehrenbach, A.; Bube, C.; Hohlfeld, J.M.; Stevens, P.; Tschernig, T.; Hoymann, H.G.; Krug, N.; Fehrenbach, H. | Journal Article |
| 2003 | Surfactant proteins SP-A and SP-D as modulators of the allergic inflammation in asthma
Hohlfeld, J.M.; Erpenbeck, V.J.; Krug, N. | Conference Paper, Journal Article |
| 2003 | Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells
Weigt, H.; Mühlradt, P.F.; Emmendörffer, A.; Krug, N.; Braun, A. | Journal Article |
| 2003 | Validation of a new lung-function method in orally intubated mice using a model for respiratory allergenicity
Braun, A.; Rott, M.; Hecht, M.; Glaab, T.; Hohlfeld, J.M.; Krug, N.; Hoymann, H.G. | Journal Article |
| 2003 | Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis
Krug, N.; Loedding, H.; Hohlfeld, J.M.; Larbig, M.; Buckendahl, A.; Badorrek, P.; Geldmacher, H.; Behnke, W.; Dunkhorst, W.; Windt, H.; Luettig, B.; Koch, W. | Journal Article |
| 2002 | Late allergic response in sensitized rats
Hoymann, H.G.; Glaab, T.; Hohlfeld, J.; Korolewitz, R.; Hecht, M.; Krug, N. | Conference Paper |
| 2002 | Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats
Glaab, T.; Hoymann, H.G.; Hohlfeld, J.M.; Korolewitz, R.; Hecht, M.; Alarie, Y.; Tschernig, T.; Braun, A.; Krug, N.; Fabel, H. | Journal Article |
| 2002 | A pilot study to assess the efficacy of loteprednol etabonate nasal spray as a treatment for allergic rhinitis in an environmental exposure unit (eeu)
Geldmacher, H.; Buckendahl, A.; Badorrek, P.; Nguyen, D.; Lavallee, N.; Petzold, U.; Hermann, R.; Hohlfeld, J.M.; Krug, N. | Journal Article |
| 2001 | Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma
Krug, N.; Tschernig, T.; Erpenbeck, V.J.; Hohlfeld, J.M.; Köhl, J. | Journal Article |
| 2001 | Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gamma delta T cells in people with asthma after segmental allergen challenge
Krug, N.; Erpenbeck, V.J.; Balke, K.; Petschallies, J.; Tschernig, T.; Hohlfeld, J.M.; Fabel, H. | Journal Article |
| 2001 | Die Expression von T-Zell-Zytokinen bei Patienten mit allergischem Asthma nach segmentaler Allergenprovokation
Erpenbeck, V.J.
: Freihorst, J. (Prüfer); Kleine, P. (Prüfer); Fabel, H. (Prüfer); Krug, N. (Prüfer) | Dissertation |
| 2001 | Fulminanter Verlauf einer Leptospirose mit multiplen Organmanifestationen
Kirchner, G.I.; Krug, N.; Bleck, J.S.; Fliser, D.; Manns, M.P.; Wagner, S. | Journal Article |
| 2001 | Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system
Lehmann, C.; Wilkening, A.; Leiber, D.; Markus, A.; Krug, N.; Pabst, R.; Tschernig, T. | Journal Article |
| 2001 | Testverfahren für inhalative Testung auf allergenes Potenzial
Hoymann, H.G.; Krug, N. | Journal Article |
| 2000 | Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma
Krug, N.; Cruikshank, W.W.; Tschernig, T.; Erpenbeck, V.J.; Balke, K.; Hohlfeld, J.M.; Center, D.M.; Fabel, H. | Journal Article |
| 2000 | Lymphocytes migrate from the blood into the bronchoalveolar lavage and lung parenchyma in the asthma model of the brown Norway rat
Schuster, M.; Tschernig, T.; Krug, N.; Pabst, R. | Journal Article |
| 2000 | Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma
Heeley, E.L.; Hohlfeld, J.M.; Krug, N.; Postle, A.D. | Journal Article |
| 2000 | Surfactant function affected by airway inflammation and cooling: Possible impact on exercise-induced asthma
Enhorning, G.; Hohlfeld, J.M.; Krug, N.; Lema, G.; Welliver, R. | Journal Article |
| 1999 | Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Enhorning, G.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.-G.; Fabel, H.; Krug, N. | Journal Article |
| 1998 | Endobronchial allergen challenge
Frew, A.J.; Carroll, M.P.; Gratziou, C.; Krug, N. | Journal Article |
| 1998 | Pulmonary surfactant activity is impaired in lung transplant recipients
Hohlfeld, J.M.; Tiryaki, E.; Hamm, H.; Hoymann, H.G.; Krug, N.; Haverich, A.; Fabel, H. | Journal Article |
| 1998 | Pulmonary surfactant function is impaired in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H. | Journal Article |
| 1998 | Störung der Surfactantfunktion bei Asthmatikern nach segmentaler Allergenprovokation
Hohlfeld, J.M.; Ahlf, K.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H. | Journal Article |
| 1994 | Hemmnisse für Techniken zur rationellen Energienutzung und Vorschläge für deren Abbau
Gruber, E.; Jochem, E.; Reichert, J.; Köwener, D.; Krug, N.; Yigit, Z. | Book |