Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Acute inhalation toxicity in vitro and ex vivo test battery prior to regulatory OECD 403 studies
Schwarz, Katharina; Hansen, Tanja; Ritter, Detlef; Walter, Dorothee; Knebel, Jan
Abstract
2018Characterization of human precision cut liver slices by various viability andfunctional parameters during 24 hour culture
Elenschneider, Leroy; Knebel, Jan; Braun, Armin; Fangmann, J.; Hansen, Tanja
Abstract
2018A combination of in-vitro and ex-vivo test models as an upstream alternative to regulatory OECD 403 animal studies
Walter, Dorothee; Ritter, Detlef; Knebel, Jan; Schwarz, Katharina; Hansen, Tanja
Abstract
2018Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process
Ritter, Detlef; Bitsch, Annette; Elend, Manfred; Schuchardt, Sven; Hansen, Tanja; Brodbeck, Carsten; Knebel, Jan; Fuchs, Anne; Gronewold, Claas; Fautz, Rolf
Journal Article
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2017Applying CFD for the Design of an Air-Liquid Interface In-Vitro Testing Method for Inhalable Compounds
Brodbeck, Carsten; Knebel, Jan; Ritter, Detlef; Wolf, Klaus
Book Article
2017Evaluation of a human in vitro hepatocyte-NPC co-culture model for the prediction of idiosyncratic drug-induced liver injury: A pilot study
Granitzny, Anne; Knebel, Jan; Müller, Meike; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Journal Article
2017Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound
Granitzny, Anne; Knebel, Jan; Schaudien, Dirk; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Journal Article
2016Expositionsvorrichtung
Brodbeck, Carsten; Ritter, Detlef; Knebel, Jan; Wolf, Klaus
Patent
2016Method for identification of low soluble, biopersistent susts (GBS) - comparison of intratracheal installation and subacute inhalation
Creutzenberg, Otto H.; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Knebel, Jan
Abstract
2015Acute inhalation toxicity of volatile organic compounds - application of an improved cell-based in vitro procedure
Ritter, Detlef; Krakor, E.; Knebel, Jan
Abstract
2015Acute toxicity testing of inhalable/gaseous compounds by cell-based methods in vitro - application to volatile organic compounds
Ritter, Detlef; Knebel, Jan
Abstract
2015Cigarette smoke and cigarette smoke condensate exposure induces cytotoxicity and inflammation in precision-cut lung slices
Obernolte, Helena; Konzok, Sebastian; Ritter, Detlef; Knebel, Jan; Braubach, Peter; Jonigk, Danny; Fieguth, Hans-Gerd; Braun, Armin; Sewald, Katherina
Abstract
2015Expositionsapparat
Ritter, Detlef; Knebel, Jan
Patent
2014Biological effects of inhalable compounds improvements of the in vitro testing method
Ritter, Detlef; Knebel, Jan; Brodbeck, Carsten; Javala, Pasi
Abstract
2014Biological effects of inhalable substances - development of a concept to standardize in vitro studies using aerosols
Ritter, Detlef; Arndt, Hendrik; Knebel, Jan
Journal Article, Conference Paper
2014Building up a co-culture and surfactant model for routine use in ali exposures
Javala, Pasi; Ritter, Detlef; Knebel, Jan
Abstract
2014CEFIC-LRI N1 project: Genotoxicity of a synthetic amorphous silica (SAS) in rats
Knebel, Jan; Ziemann, Christina; Creutzenberg, Otto H.
Abstract
2014Cytochrome P450 monooxygenases expression in human bronchial epithelial calu-3 cells under different culture conditions
Hansen, Tanja; Niehof, Monika; Knebel, Jan
Abstract
2014Fundamental improvements of the air-liquid interface technique for use in in vitro inhalation toxicology
Knebel, Jan; Ritter, Detlef; Brodbeck, Carsten
Abstract
2014Improvements of the ALI in vitro testing method for inhalable compounds
Ritter, Detlef; Knebel, Jan; Brodbeck, Carsten
Abstract
2014Investigations of the biological effects of airborne and inhalable substances by cell-based in vitro methods
Ritter, Detlef; Knebel, Jan
Journal Article
2014Validation requirements for alternative methods in inhalation toxicology - case study of a German two phase prevalidation project
Liebsch, M.; Pirow, R.; Smirnova, L.; Tharmann, J.; Linsel, G.; Troeller, S.; Huettig, N.; Bauer, M.; Graebsch, C.; Berger-Preiß, Edith; Kock, Heiko; Oertel, Antje; Ritter, Detlef; Knebel, Jan
Abstract
2013Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices
Switalla, Simone; Knebel, Jan; Ritter, Detlef; Dasenbrock, Clemens; Krug, Norbert; Braun, Armin; Sewald, Katherina
Journal Article
2012Acute cigarette smoke exposure induces cytotoxicity and inflammation in living tissue of precision-cut lung slices
Lauenstein, Lan; Switalla, Simone; Ritter, Detlef; Knebel, Jan; Dasenbrock, Clemens; Braun, Armin; Sewald, Katherina
Abstract
2012Measurement of diameter of different nanoparticle agglomerates after contact with A549 cells revealed different size behavior
Schaudien, Dirk; Knebel, Jan; Rittinghausen, Susanne; Creutzberg, Otto
Journal Article, Conference Paper
2011Improvement of experimental methods for toxicological characterization of inhalable substances in vitro by in situ analysis of the cellular status based on fluorescence stainings
Ritter, Detlef; Knebel, Jan
Conference Paper, Journal Article
2011Prävalidierungsstudie zur Prüfung der toxischen Wirkung von inhalativ wirksamen Stoffen (Gase)
Knebel, Jan; Ritter, Detlef; Berger-Preiß, Edith; Kock, Heiko; Liebsch, Manfred; Smirnova, Lena; Pirow, Ralph; Linsel, Gunter; Bauer, Mario; Graebsch, Carolin
Study
2011Toxicological characterization of inhalable substances and aerosols in vitro: Enhancement of experimental methods by in situ fluorescence analysis of the cellular status during exposure
Ritter, Detlef; Knebel, Jan
Journal Article, Conference Paper
2011Untersuchungen zum biologischen Effekt inhalierbarer Aerosole in vitro
Lange, Carsten
: Scharfenberg, Klaus (Erstprüfer); Dasenbrock, Clemens (Zweitprüfer); Knebel, Jan (Betreuer); Ritter, Detlef (Betreuer)
Bachelor Thesis