Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Challenging the dose-response-time data approach
Andersson, R.; Jirstrand, M.; Almquist, J.; Gabrielsson, J.
Journal Article
2019Dose-Response-Time Data Analysis: An Underexploited Trinity
Gabrielsson, J.; Andersson, R.; Jirstrand, M.; Hjorth, S.
Journal Article
2019Modelling of oscillatory cortisol response in horses using a Bayesian population approach for evaluation of dexamethasone suppression test protocols
Held, F.; Ekstrand, C.; Cvijovic, M.; Gabrielsson, J.; Jirstrand, M.
Journal Article
2019Three novel approaches to structural identifiability analysis in mixed-effects models
Janzen, D.L.I.; Jirstrand, M.; Chappell, M.J.; Evans, N.D.
Journal Article
2018Contraction clustering (raster): A big data algorithm for density-based clustering in constant memory and linear time
Ulm, G.; Gustavsson, E.; Jirstrand, M.
Conference Paper
2018Evaluation and translation of combination therapies in oncology
Cardilin, T.; Almquist, J.; Jirstrand, M.; Gabrielsson, J.
Journal Article
2018Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics
Olafsdottir, H.K.; Leander, J.; Almquist, J.; Jirstrand, M.
Journal Article
2018Extending existing structural identifiability analysis methods to mixed-effects models
Janzén, D.L.I.; Jirstrand, M.; Chappell, M.J.; Evans, N.D.
Journal Article
2018Reinforcement learning in real-time geometry assurance
Jorge, E.; Brynte, L.; Cronrath, C.; Wigström, O.; Bengtsson, K.; Gustavsson, E.; Lennartson, B.; Jirstrand, M.
Journal Article, Conference Paper
2018Root cause analysis of failures and quality deviations in manufacturing using machine learning
Lokrantz, A.; Gustavsson, E.; Jirstrand, M.
Journal Article, Conference Paper
2017Design analytics is the answer, but what questions would product developers like to have answered?
Arnarsson, I.Ö.; Gustavsson, E.; Malmqvist, J.; Jirstrand, M.
Conference Paper
2017Modeling of free fatty acid dynamics: Insulin and nicotinic acid resistance under acute and chronic treatments
Andersson, R.; Kroon, T.; Almquist, J.; Jirstrand, M.; Oakes, N.D.; Evans, N.D.; Chappel, M.J.; Gabrielsson, J.
Journal Article
2017Tumor static concentration curves in combination therapy
Cardilin, T.; Almquist, J.; Jirstrand, M.; Sostelly, A.; Amendt, C.; El Bawab, S.; Gabrielsson, J.
Journal Article
2016Dose-response-time modelling
Andersson, R.; Jirstrand, M.; Peletier, L.; Chappell, M.J.; Evans, N.D.; Gabrielsson, J.
Journal Article
2016Parameter identifiability of fundamental pharmacodynamic models
Janzén, D.L.I.; Bergenholm, L.; Jirstrand, M.; Parkinson, J.; Yates, J.; Evans, N.D.; Chappell, M.J.
Journal Article
2016Towards big-data analysis of deviation and error reports in product development projects
Arnarsson, I.Ö.; Malmqvist, J.; Gustavsson, E.; Jirstrand, M.
Conference Paper
2015Bile canalicular dynamics in hepatocyte sandwich cultures
Reif, R.; Karlsson, J.; Gunther, G.; Beattie, L.; Wrangborg, D.; Hammad, S.; Begher-Tibbe, B.; Vartak, A.; Melega, S.; Kaye, P.M.; Hengstler, J.G.; Jirstrand, M.
Journal Article
2015Mixed effects modeling using stochastic differential equations: Illustrated by pharmacokinetic data of nicotinic acid in obese zucker rats
Leander, J.; Almquist, J.; Ahlström, C.; Gabrielsson, J.; Jirstrand, M.
Journal Article
2015A nonlinear mixed effects approach for modeling the cell-to-cell variability of Mig1 dynamics in yeast
Almquist, J.; Bendrioua, L.; Adiels, C.B.; Goksör, M.; Hohmann, S.; Jirstrand, M.
Journal Article
2015Structural identifiability in mixed-effects models: Two different approaches
Janzen, D.; Jirstrand, M.; Evans, N.D.; Chappell, M.
Journal Article, Conference Paper
2015Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood
Almquist, J.; Leander, J.; Jirstrand, M.
Journal Article
2014Bridging the gaps in systems biology
Cvijovic, M.; Almquist, J.; Hagmar, J.; Hohmann, S.; Kaltenbach, H.-M.; Klipp, E.; Krantz, M.; Mendes, P.; Nelander, S.; Nielsen, J.; Pagnani, A.; Przulj, N.; Raue, A.; Stelling, J.; Stoma, S.; Tobin, F.; Wodke, J.A.H.; Zecchina, R.; Jirstrand, M.
Journal Article
2014Comparison of approaches for parameter identifiability analysis of biological systems
Raue, A.; Karlsson, J.; Saccomani, M.P.; Jirstrand, M.; Timmer, J.
Journal Article
2014Joint feedback analysis modeling of nonesterified fatty acids in obese zucker rats and normal sprague-dawley rats after different routes of administration of nicotinic acid
Tapani, S.; Almquist, J.; Leander, J.; Ahlström, C.; Peletier, L.A.; Jirstrand, M.; Gabrielsson, J.
Journal Article
2014Kinetic models in industrial biotechnology - improving cell factory performance
Almquist, J.; Cvijovic, M.; Hatzimanikatis, V.; Nielsen, J.; Jirstrand, M.
Journal Article
2014Maxsim2 - Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics
Gabrielsson, J.; Andersson, K.; Tobin, G.; Ingvast-Larsson, C.; Jirstrand, M.
Journal Article
2014Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements
Leander, J.; Lundh, T.; Jirstrand, M.
Journal Article
2014Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
Bendrioua, L.; Smedh, M.; Almquist, J.; Cvijovic, M.; Jirstrand, M.; Goksör, M.; Adiels, C.B.; Hohmann, S.
Journal Article
2013A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model
Krengel, A.; Hauth, J.; Taskinen, M.-R.; Adiels, M.; Jirstrand, M.
Journal Article
2013Toward quantifying the thymic dysfunctional state in mouse models of inflammatory bowel disease. Review
Jansson, A.; Pernestig, A.K.; Nilsson, P.; Jirstrand, M.; Hornquist, E.H.
Journal Article
2012An efficient method for structural identifiability analysis of large dynamic systems
Karlsson, J.; Anguelova, M.; Jirstrand, M.
Conference Paper
2012Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration
Meyer, R.; D'Alessandro, L.A.; Kar, S.; Kramer, B.; She, B.; Kaschek, D.; Hahn, B.; Wrangborg, D.; Karlsson, J.; Kvarnström, M.; Jirstrand, M.; Lehmann, W.-D.; Timmer, J.; Höfer, T.; Klingmüller, U.
Journal Article
2012Investigations of a compartmental model for leucine kinetics using non-linear mixed effects models with ordinary and stochastic differential equations
Berglund, M.; Sunnaker, M.; Adiels, M.; Jirstrand, M.; Wennberg, B.
Journal Article
2012Minimal output sets for identifiability
Anguelova, M.; Karlsson, J.; Jirstrand, M.
Journal Article
2012Optimal posterior density approximation for bearings-only tracking
Morelande, M.R.; Svensson, L.; Hagmar, J.; Jirstrand, M.
Conference Paper
2011A method for zooming of nonlinear models of biochemical systems
Sunnaker, M.; Cedersund, G.; Jirstrand, M.
Journal Article
2011Optimal parameterization of posterior densities using homotopy
Hagmar, J.; Jirstrand, M.; Svensson, L.; Morelande, M.
Conference Paper
2010Biochemical modeling with Systems Biology Graphical Notation. Review
Jansson, A.; Jirstrand, M.
Journal Article
2010A kinetic model of the monocarboxylate transporter MCT1 and its interaction with carbonic anhydrase II
Almquist, J.; Lang, P.; Prätzel-Wolters, D.; Deitmer, J.; Jirstrand, M.; Becker, H.
Journal Article
2010Modeling the effect of Kv1.5 block on the canine action potential
Almquist, J.; Wallman, M.; Jacobson, I.; Jirstrand, M.
Journal Article
2010Zooming of states and parameters using a lumping approach including back-translation
Sunnaker, M.; Schmidt, H.; Jirstrand, M.; Cedersund, G.
Journal Article
2008Determination of interaction between MCT1 and CAII via a mathematical and physiological approach
Almquist, J.; Schmidt, H.; Lang, P.; Deitmer, J.; Jirstrand, M.; Prätzel-Wolters, D.; Becker, H.
Report
2007Evolutionary search for improved path diagrams
Laurio, K.; Svensson, T.; Jirstrand, M.; Nilsson, P.; Gamalielsson, J.; Olsson, B.
Conference Paper
2007Systembiologin kan förändra sjukvården radikalt: Ger underlag för individualiserad prediktion, prevention och behandling
Benson, M.; Cardell, L.O.; Hohmann, S.; Jirstrand, M.; Langston, M.; Mobini, R.; Nerman, O.
Journal Article
2006Systems Biology Toolbox for MATLAB: A computational platform for research in systems biology
Schmidt, H.; Jirstrand, M.
Journal Article