Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy
Rothbart, N.; Holz, O.; Koczulla, R.; Schmalz, K.; Hübers, H.-W.
Journal Article
2019Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans
Heusser, K.; Tank, J.; Holz, O.; May, M.; Brinkmann, J.; Engeli, S.; Diedrich, A.; Framke, T.; Koch, A.; Großhennig, A.; Danser, A.H.J.; Sweep, F.C.G.J.; Schindler, C.; Schwarz, K.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2018129Xenon-enhanced magnetic resonance imaging to understand particle exhalation from the human lung
Holz, Olaf; Kern, Agilo Luitger; Biller, Heike; Olin, Anna-Carin; Vogel-Claussen, Jens; Hohlfeld, Jens M.
Abstract
2018Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects
Holz, Olaf; Heusser, Karsten; Müller, Meike; Windt, Horst; Schwarz, Katharina; Schindler, Christoph; Tank, Jens; Hohlfeld, Jens M.; Jordan, Jens
Journal Article
2018Breath volatile organic compounds of lung transplant recipients with and without chronic lung allograft dysfunction
Küppers, L.; Holz, Olaf; Schuchardt, Sven; Gottlieb, J.; Fuge, J.; Greer, M.; Hohlfeld, Jens M.
Journal Article
2018A comprehensive way to rate sputum quality in clinical trials
Pedersen, Frauke; Zissler, U.; Watz, Henrik; Rabe, Klaus F.; Hohlfeld, Jens M.; Holz, Olaf
Abstract
2018Hyperpolarized 129Xe functional MR imaging to monitor the response of human lungs after segmental lipopolysaccharide challenge
Kern, Agilo Luitger; Biller, Heike; Klimes, Filip; Voskrebenzev, Andreas; Gutberlet, Marcel; Rotärmel, Alexander; Schönfeld, Christian; Renne, Julius; Holz, Olaf; Wacker, Frank; Vogel-Claussen, Jens; Hohlfeld, Jens M.
Abstract
2018Measurement of volatile organic compounds in exhaled breath of children of the ALL Age Asthma Cohort
Ehrmann, Maximilian; Mutius, Erika von; Hansen, Gesine; Kopp, Matthias; Hohlfeld, Jens M.; Holz, Olaf; Fuchs, Oliver
Abstract
2018Validation of cell analysis by chipcytometry in induced sputum cells
Carstensen, Saskia; Holz, Olaf; Müller, Meike; Hohlfeld, Jens M.
Abstract
2017A European Respiratory Society technical standard: exhaled biomarkers in lung disease
Horvath, I.; Barnes, P.J.; Loukides, S.; Sterk, P.J.; Hogman, M.; Olin, A.C.; Amann, A.; Antus, B.; Baraldi, E.; Bikov, A.; Boots, A.W.; Bos, L.D.; Brinkman, P.; Bucca, C.; Carpagnano, G.E.; Corradi, M.; Cristescu, S.; Jongste, J.C. de; Dinh-Xuan, A.T.; Dompeling, E.; Fens, N.; Fowler, S.; Hohlfeld, J.M.; Holz, O.; Jobsis, Q.; Kant, K.V. van de; Knobel, H.H.; Kostikas, K.; Lehtimaki, L.; Lundberg, J.; Montuschi, P.; Muylem, A. van; Pennazza, G.; Reinhold, P.; Ricciardolo, F.L.M.; Rosias, P.; Santonico, M.; Schee, M.P. van der; Schooten, F.J. van; Spanevello, A.; Tonia, T.; Vink, T.J.
Journal Article
2017Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study
Tank, J.; Heusser, K.; Holz, O.; May, M.; Brinkmann, J.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Sweep, F.C.G.J.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.
Abstract
2017Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function
Waschki, Benjamin; Watz, Henrik; Holz, Olaf; Magnussen, Helgo; Olejnicka, Beata; Welte, Tobias; Rabe, Klaus F.; Janciauskiene, Sabina
Journal Article
2017Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease
Ikari, J.; Nelson, A.J.; Obaid, J.; Giron-Martinez, A.; Ikari, K.; Makino, F.; Iwasawa, S.; Gunji, Y.; Farid, M.; Wang, X.; Basma, H.; Demeo, D.; Feghali-Bostwick, C.; Holz, O.; Rabe, K.; Liu, X.; Rennard, S.I.
Journal Article
2016α1-Antitrypsin (a1at) serum levels as marker of systemic inflammation in non-A1at-deficient patients with COPD
Waschki, B.; Kirsten, A.-M.; Holz, O.; Meyer, T.; Lichtinghagen, R.; Rabe, K.F.; Magnussen, H.; Welte, T.; Watz, H.; Janciauskiene, S.
Abstract
2016Angiopoietin-like protein 4 and cardiovascular function in COPD
Waschki, Benjamin; Kirsten, Anne-Marie; Holz, Olaf; Meyer, T.; Lichtinghagen, R.; Rabe, K.F.; Magnussen, Helgo; Welte, T.; Watz, H.; Janciauskiene, S.
Journal Article
2016Comparison Of COPD related breath VOCs assessed by a compact high-resolution closed-loop GC-IMS and by standard GC-MS
Holz, O.; Allers, M.; Gaida, A.; Schuchardt, S.; Hohlfeld, J.M.; Zimmermann, S.
Abstract
2016A dual center study to compare breath volatile organic compounds from smokers and non-smokers with and without COPD
Gaida, Arne; Holz, Olaf; Nell, Christoph; Schuchardt, Sven; Lavae-Mokhtari, Bianca; Kruse, Lena; Boas, Ursula; Langejuergen, Jens; Allers, Maria; Zimmermann, Stefan
Journal Article
2016Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS
Allers, Maria; Langejuergen, Jens; Gaida, Arne; Holz, Olaf; Schuchardt, Sven; Hohlfeld, Jens M.; Zimmermann, Stefan
Journal Article
2016Rating the value of COPD related breath VOCs in models created by linear discriminant analysis
Holz, O.; Gaida, A.; Nell, C.; Allers, M.; Schuchardt, S.; Zimmermann, S.; Koczulla, R.; Hohlfeld, J.M.
Abstract
2015Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Watz, Henrik; Tegtbur, Uwe; Lahu, Gezim; Hohlfeld, Jens Michael
Journal Article
2015Determination of markers that predict the individual response of perennial allergic subjects to house dust mite allergen in the Fraunhofer Environmental Challenge Chamber (ECC)
Hohlfeld, J.M.; Lüer, K.; Holz, O.; Häfner, D.; Koch, W.; Krug, N.
Abstract
2015Disease progression and changes in physical activity in patients with chronic obstructive pulmonary disease
Waschki, Benjamin; Kirsten, Anne M.; Holz, Olaf; Müller, Kai-Christian; Schaper, Miriam; Sack, Anna-Lena; Meyer, Thorsten; Rabe, Klaus F.; Magnussen, Helgo; Watz, Henrik
Journal Article
2015Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial
Holz, Olaf; Biller, Heike; Müller, Meike; Kane, Katie; Rosano, Molly; Hanrahan, John; Hava, David L.; Hohlfeld, Jens M.
Journal Article
2015Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Schaumann, Frank; Müller, Meike; Scholl, Dorothea; Hidi, R.; McLeod, Alison; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2015Multi-analyte profiling of inflammatory mediators in COPD sputum - The effects of processing
Pedersen, Frauke; Holz, Olaf; Lauer, Gereon; Quintini, Gianluca; Kiwull-Schöne, Heidrun; Kirsten, Anne-Marie; Magnussen, Helgo; Rabe, Klaus F.; Goldmann, Torsten; Watz, Henrik
Journal Article
2015Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients
Pedersen, Frauke; Marwitz, Sebastian; Holz, Olaf; Kirsten, Anne; Bahmer, Thomas; Waschki, Benjamin; Magnussen, Helgo; Rabe, Klaus F.; Goldmann, Torsten; Uddin, Mohib; Watz, Henrik
Journal Article
2014Applications of lp-norms and their smooth approximations for gradient based learning vector quantization
Lange, M.; Zühlke, D.; Holz, O.; Villmann, T.
Conference Paper
2014Diamide does not improve the analysis of IL1b and TNFa in dithiothreitol-treated sputum supernatants
Holz, Olaf; Lavae-Mokhtari, Bianca; Witte, Lena; Hohlfeld, Jens Michael
Abstract
2014The effect of flow rate on the level of volatile organic compounds (voc) in exhaled breath
Holz, Olaf; Gaida, Arne; Schuchardt, Sven; Langejuergen, Jens; Zimmermann, Stefan; Hohlfeld, Jens Michael
Abstract
2014Effect of sample processing on the analysis of IL4, IL5, and IL13 in sputum supernatants
Holz, Olaf; Müller, Meike; Ignatenko, Stanislav; Kappeler, Dominik; Buhl, Roland; Beeh, Kai-Michael; Kornmann, Oliver; Kirsten, Anne; Homburg, Ursula; Garn, Holger; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014Evaluation of small molecule FRET reporter for the diagnosis and monitoring of proteolytic activity in a chronic obstructive lung disease model
Reither, G.; Heath, N.; Holz, Olaf; Kahn, N.; Hohlfeld, Jens Michael; Schulz, C.; Mall, M.A.
Abstract
2014Exercise challenge amplifies differences in metabolomic signals between healthy smokers and smokers with COPD (gold2)
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Elmlinger, Martin; Lahu, Gezim; Hohlfeld, Jens Michael
Abstract
2014Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
Winkler, C.; Witte, L.; Moraw, N.; Faulenbach, C.; Müller, M.; Holz, O.; Schaumann, F.; Hohlfeld, J.M.
Journal Article
2014Longitudinal measurement of airway inflammation over one year in children and adults with intermittent asthma
Holz, Olaf; Pedersen, Frauke; Kanniess, Frank; Zielen, Stefan; Gillissen, Adrian; Berg, Andrea von; Berdel, Dietrich; Schnoor, Maike; Magnussen, Helgo
Abstract
2014Longitudinal measurement of airway inflammation over one year in children and adults with intermittent asthma
Pedersen, F.; Holz, O.; Kanniess, F.; Zielen, S.; Schulze, J.; Gillissen, A.; Berg, A. von; Berdel, D.; Beier, J.; Beeh, K.; Schnoor, M.; Magnussen, H.
Journal Article
2014Optimizing gene-expression analysis for induced sputum
Holz, Olaf; Hansen, Tanja; Homburg, Ursula; Garn, Holger; Hohlfeld, Jens Michael; Niehof, Monika
Abstract
2014Potential prognostic value of biomarkers in lavage, sputum and serum in a five year clinical follow-up of smokers with and without COPD
Holz, Olaf; Waschki, Benjamin; Roepcke, Stefan; Watz, Henrik; Lauer, Gereon; Faulenbach, Cornelia; Hohlfeld, Jens M.
Journal Article
2014Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells (iPSCs)
Basma, H.; Gunji, Y.; Iwasawa, S.; Nelson, A.; Farid, M.; Ikari, J.; Liu, X.; Wang, X.; Michalski, J.; Smith, L.M.; Iqbal, J.; El Behery, R.; West, W.; Yelamanchili, S.; Rennard, D.; Holz, O.; Mueller, K.-C.; Magnussen, H.; Rabe, K.F.; Castaldi, P.J.; Rennard, S.I.
Journal Article
2014Safety and efficacy of Pur118 in the ozone challenge model
Holz, Olaf; Biller, Heike; Müller, Meike; Kane, Katie; Rosano, Molly; Hanrahan, John; Hava, David L.; Hohlfeld, Jens Michael
Abstract
2013The anti-IL-17A antibody secukinumab does not attenuate ozone-induced airway neutrophilia in healthy volunteers
Kirsten, A.; Watz, H.; Pedersen, F.; Holz, O.; Smith, R.; Bruin, G.; Koehne-Voss, S.; Magnussen, H.; Waltz, D.A.
Journal Article
2013Fast escape of hydrogen from gas cavities around corroding magnesium implants
Kuhlmann, Julia; Bartsch, Yvonne; Willbold, Elmar; Schuchardt, Sven; Holz, Olaf; Hort, Norbert; Höche, Daniel; Heineman, William R.; Witte, Frank
Journal Article
2013Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
Janssen, Ole; Schaumann, Frank; Holz, Olaf; Lavae-Mokhtari, Bianca; Welker, Lutz; Winkler, Carla; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2013Oncostatin M modulates fibroblast function via signal transducers and activators of transcription proteins-3
Nagahama, K.Y.; Togo, S.; Holz, O.; Magnussen, H.; Liu, X.; Seyama, K.; Takahashi, K.; Rennard, S.I.
Journal Article
2013Sampling and analysis of exhaled breath particles
Schwarz, Katharina; Holz, Olaf; Koch, Wolfgang; Hohlfeld, Jens M.
Conference Paper, Journal Article
2012Acute ozone induced airway inflammation does not effect resting human sympathetic nerve traffic
Tank, J.; Biller, Heike; Heusser, K.; Holz, Olaf; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, Wolfgang; Krug, Norbert; Jordan, J.; Hohlfeld, Jens
Journal Article, Conference Paper
2012Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4
Michalski, Joel; Kanaji, Nobuhiro; Liu, Xiangde; Nogel, Steve; Wang, Xingqui; Basma, Hesham; Nakanishi, Masanori; Sato, Tadashi; Gunji, Yoko; Fahrid, Maha; Nelson, Amy; Muller, Kai-Christian; Holz, Olaf; Magnussen, Helgo; Rabe, Klaus F.; Toews, Myron L.; Rennard, Stephen I.
Journal Article
2012Depletion of neutrophils from induced sputum using a novel bead and sieve-separation system
Holz, Olaf; Schaumann, Frank; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Krug, Norbert; Heinrich, J.M.; Hohlfeld, Jens M.
Abstract
2012Generation of ips-like cells from COPD lung fibroblasts
Basma, Hesham; Gunji, Yoko; Liu, Xiangde; Nelson, Amy; Farid, Maha; Iwasawa, Shunichiro; Ikari, Jun; Wang, Xingqui; Holz, Olaf; Müller, Kai-Christian; Magnussen, Helgo; Rabe, Klaus; Rennard, Stephen I.
Abstract
2012Low-dose endotoxin inhalation in healthy volunteers: A challenge model for early clinical drug development of novel anti-inflammatory compounds
Schaumann, Frank; Holz, Olaf; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Abstract
2012Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts
Nakanishi, Masanori; Sato, Tadashi; Li, Yingji; Nelson, Amy J.; Farid, Maha; Michalski, Joel; Kanaji, Nobuhiro; Wang, Xingqi; Basma, Hesham; Patil, Amol; Goraya, Jadvinder; Liu, Xiangde; Togo, Shinsaku; Toews, Myron L.; Holz, Olaf; Muller, Kai-Christian; Magnussen, Helgo; Rennard, Stephen I.
Journal Article
2012Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum
Röpcke, S.; Holz, O.; Lauer, G.; Müller, M.; Rittinghausen, S.; Ernst, P.; Lahu, G.; Elmlinger, M.; Krug, N.; Hohlfeld, J.M.
Journal Article
2012Reproducibility of serum biomarkers and relationship to airway inflammation following LPS challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Faulenbach, Cornelia; Müller, Meike; Krug, Norbert; McLeod, Alison; Hohlfeld, Jens M.
Abstract
2012Stable inflammatory phenotype in smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Krug, Norbert; Ernst, Peter; Lahu, Gezim; Hohlfeld, Jens M.
Abstract
2012Systemic biomarkers of neutrophilic inflammation, tissue injury and repair in COPD patients with differing levels of desease severity
Cockayne, Debra A.; Cheng, Donovan T.; Waschki, Benjamin; Sridhar, Sriram; Ravindran, Palanikumar; Hilton, Holly; Kourteva, Galina; Bitter, Hans; Pillai, Sreekumar G.; Visvanathan, Sudha; Müller, Kai-Christian; Holz, Olaf; Magnussen, Helgo; Watz, Henrik; Fine, Jay S.
Journal Article
2011Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael
Journal Article
2011Breath profiles by electronic nose correlate with systemic markers but not ozone response
Biller, Heike; Holz, Olaf; Windt, Horst; Koch, Wolfgang; Müller, Meike; Jörres, Rudolf A.; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2011Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Winkler, C.; Atochina-Vasserman, E.N.; Holz, O.; Beers, M.F.; Erpenbeck, V.J.; Krug, N.; Roepcke, S.; Lauer, G.; Elmlinger, M.; Hohlfeld, J.M.
Journal Article
2011Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: A randomized, placebo controlled, crossover study
Tank, J.; Biller, H.; Heusser, K.; Holz, O.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2009Development of a three-dimensional quantification method of immune cells in human airway epithelium
Prenzler, F.; Veres, T.; Holz, O.; Welker, L.; Mueller, M.; Krug, N.; Hohlfeld, J.; Braun, A.
Abstract
2007Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation
Veres, T.Z.; Rochlitzer, S.; Shevchenkom, M.; Fuchs, B.; Prenzler, F.; Nassenstein, C.; Fischer, A.; Welker, L.; Holz, O.; Müller, M.; Krug, N.; Braun, A.
Journal Article
2006Lung fibroblasts from patients with emphysema show markers of senescence in vitro
Müller, K.C.; Welker, L.; Paasch, K.; Feindt, B.; Erpenbeck, V.J.; Hohlfeld, J.M.; Krug, N.; Nakashima, M.; Branscheid, D.; Magnussen, H.; Jörres, R.A.; Holz, O.
Journal Article

 

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