Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis
Prasse, Antje; Binder, Harald; Schupp, Jonas C.; Kayser, Gian; Bargagli, Elena; Jäger, Benedikt; Hess, Moritz; Rittinghausen, Susanne; Vuga, Louis; Lynn, Heather; Violette, Shelia; Jung, Birgit; Quast, Karsten; Vanaudenaerde, Bart; Xu, Yan; Hohlfeld, Jens M.; Krug, Norbert; Herazo-Maya, Jose D.; Rottoli, Paola; Wuyts, Wim A.; Kaminski, Naftali
Journal Article
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
Journal Article
2018Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects
Holz, Olaf; Heusser, Karsten; Müller, Meike; Windt, Horst; Schwarz, Katharina; Schindler, Christoph; Tank, Jens; Hohlfeld, Jens M.; Jordan, Jens
Journal Article
2018Breath volatile organic compounds of lung transplant recipients with and without chronic lung allograft dysfunction
Küppers, L.; Holz, Olaf; Schuchardt, Sven; Gottlieb, J.; Fuge, J.; Greer, M.; Hohlfeld, Jens M.
Journal Article
2018Comparison of quantitative regional ventilation‐weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients
Kaireit, Till F.; Gutberlet, Marcel; Voskrebenzev, Andreas; Freise, Julia; Welte, Tobias; Hohlfeld, Jens M.; Wacker, Frank; Vogel-Claussen, Jens
Journal Article
2018A comprehensive way to rate sputum quality in clinical trials
Pedersen, Frauke; Zissler, U.; Watz, Henrik; Rabe, Klaus F.; Hohlfeld, Jens M.; Holz, Olaf
Abstract
2018Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): A double-blind, randomised, crossover, placebo-controlled, single-centre trial
Hohlfeld, Jens M.; Vogel-Claussen, Jens; Biller, Heike; Berliner, Dominik; Berschneider, Korbinian; Tillmann, Hanns-Christian; Hiltl, Simone; Bauersachs, Johann; Welte, Tobias
Journal Article
2018Free-breathing dynamic (19)F gas MR imaging for mapping of regional lung ventilation in patients with COPD
Gutberlet, Marcel; Kaireit, Till F.; Voskrebenzev, Andreas; Lasch, Florian; Freise, Julia; Welte, Tobias; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2018A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: A feasibility randomized clinical trial
Greulich, Timm; Hohlfeld, Jens M.; Neuser, Petra; Lueer, Katrin; Klemmer, Andreas; Schade-Brittinger, Carmen; Harnisch, Susanne; Garn, Holger; Renz, Harald; Homburg, Ursula; Renz, Jonas; Kirsten, Anne; Pedersen, Frauke; Müller, Meike; Vogelmeier, Claus F.; Watz, Henrik
Journal Article
2018International consensus statement on allergy and rhinology: Allergic rhinitis
Wise, Sarah K.; Lin, Sandra Y.; Toskala, Elina; Orlandi, Richard R.; Akdis, Cezmi A.; Alt, Jeremiah A.; Azar, Antoine; Baroody, Fuad M.; Bachert, Claus; Canonica, G. Walter; Chacko, Thomas; Cingi, Cemal; Ciprandi, Giorgio; Corey, Jacquelynne; Cox, Linda S.; Creticos, Peter Socrates; Custovic, Adnan; Damask, Cecelia; DeConde, Adam; DelGaudio, John M.; Ebert, Charles S.; Eloy, Jean Anderson; Flanagan, Carrie E.; Fokkens, Wytske J.; Franzese, Christine; Gosepath, Jan; Halderman, Ashleigh; Hamilton, Robert G.; Hoffman, Hans Jürgen; Hohlfeld, Jens M.; Houser, Steven M.; Hwang, Peter H.; Incorvaia, Cristoforo; Jarvis, Deborah; Khalid, Ayesha N.; Kilpeläinen, Maritta; Kingdom, Todd T.; Krouse, Helene; Larenas-Linnemann, Desiree; Laury, Adrienne M.; Lee, Stella E.; Levy, Joshua M.; Luong, Amber U.; Marple, Bradley F.; McCoul, Edward D.; McMains, K. Christopher; Melén, Erik; Mims, James W.; Moscato, Gianna; Mullol, Joaquim; Nelson, Harold S.; Patadia, Monica; Pawankar, Ruby; Pfaar, Oliver; Platt, Michael P.;
Journal Article
2018Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients
Tschernig, Thomas; Pabst, Reinhard; Prenzler, Frauke; Rittinghausen, Susanne; Braun, Armin; Hohlfeld, Jens M.
Journal Article
2018Phase 1 pharmacokinetics and phase 3 efficacy of testosterone nasal gel in subjects with seasonal allergies
Rogol, Alan D.; Tkachenko, Natalia; Badorrek, Philipp; Hohlfeld, Jens M.; Bryson, Nathan
Journal Article
2017Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure
Badorrek, Philipp; Müller, Meike; Koch, Wolfgang; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2016Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS
Allers, Maria; Langejuergen, Jens; Gaida, Arne; Holz, Olaf; Schuchardt, Sven; Hohlfeld, Jens M.; Zimmermann, Stefan
Journal Article
2016Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber
Lüer, Katrin; Biller, Heike; Casper, Anja; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, A.; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Journal Article
2016Tiotropium respimat® versus hHndiHaler®: Comparison of bronchodilator efficacy of various doses in clinical trials
Calverley, Peter M.A.; Könen-Bergmann, Michael; Richard, Frank; Bell, Susan; Hohlfeld, Jens M.
Journal Article
2015Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
Krug, Norbert; Hohlfeld, Jens Michael; Kirsten, Anne-Marie; Kornmann, Oliver; Beeh, Kai-Michael; Kappeler, Dominik; Korn, Stephanie; Ignatenko, Stanislav; Timmer, Wolfgang; Rogon, Cordelia; Zeitvogel, Jana; Zhang, Nan; Bille, Joachim; Homburg, Ursula; Turowska, Agnieszka; Bachert, Claus; Werfel, Thomas; Buhl, Roland; Renz, Jonas; Garn, Holger; Renz, Harald
Journal Article
2015Cardiac safety of tiotropium in patients with COPD: A combined analysis of Holter-ECG data from four randomised clinical trials
Hohlfeld, Jens Michael; Furtwaengler, A.; Könen-Bergmann, M.; Wallenstein, G.; Walter, B.; Bateman, E.D.
Journal Article
2015Characterization of exhaled particles from the human lungs in airway obstruction
Schwarz, Katharina; Biller, Heike; Windt, Horst; Koch, Wolfgang; Hohlfeld, Jens M.
Journal Article
2015Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact
Toncheva, A.A.; Potaczek, D.P.; Schedel, M.; Gersting, S.W.; Michel, S.; Krajnov, N.; Gaertner, V.D.; Klingbeil, J.M.; Illig, T.; Franke, A.; Winkler, Carla; Hohlfeld, Jens M.; Vogelberg, C.; Berg, A. von; Bufe, A.; Heinzmann, A.; Laub, O.; Rietschel, E.; Simma, B.; Genuneit, J.; Muntau, A.C.; Kabesch, Michael
Journal Article
2015Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Watz, Henrik; Tegtbur, Uwe; Lahu, Gezim; Hohlfeld, Jens Michael
Journal Article
2015Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis
Badorrek, Philipp; Hohlfeld, Jens M.; Krug, Norbert; Joshi, Abhijeet; Raut, Atul
Journal Article
2015Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial
Holz, Olaf; Biller, Heike; Müller, Meike; Kane, Katie; Rosano, Molly; Hanrahan, John; Hava, David L.; Hohlfeld, Jens M.
Journal Article
2015Evaluating cardiac safety of tiotropium in patients with COPD: Combined analysis of Holter-ECG data from four trials
Hohlfeld, Jens M.; Furtwängler, Armin; Könen-Bergmann, Michael; Wallenstein, Gudrun; Walter, Blate; Bateman, Eric D.
Abstract
2015Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Schaumann, Frank; Müller, Meike; Scholl, Dorothea; Hidi, R.; McLeod, Alison; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2015Niedrig dosierte inhalative Endotoxin Provokation bei gesunden Probanden als Modell in der klinischen Atemwegsforschung
Janssen, Ole
: Hohlfeld, Jens M. (Betreuer); Braun, Armin (Referent); Dittrich, Anna-Maria (Korreferent)
Dissertation
2015Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: A proof of concept study
Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Winkler, Carla; Faulenbach, Cornelia; Jakob, Peter; Schaumann, Frank; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2015Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
Homburg, Ursula; Renz, Harald; Timmer, Wolfgang; Hohlfeld, Jens M.; Seitz, Friedeborg; Lüer, Katrin; Mayer, Alexandra; Wacker, Anja; Schmidt, Oliver; Kuhlmann, Jens; Turowska, Agnieszka; Roller, Julia; Kutz, Klaus; Schlüter, Gerhard; Krug, Norbert; Garn, Holger
Journal Article
2015Tiotropium respimat: Comparison of bronchodilator efficacy of 5 and 2.5 µg doses
Hohlfeld, Jens M.; Calverley, P.; Könen-Bergmann, M.; Metzdorf, N.; Bell, S.
Abstract
2014Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets (Callithrix jacchus)
Curths, Christoph; Wichmann, Judy; Dunker, Sarah; Windt, Horst; Hoymann, Heinz-Gerd; Lauenstein, Hans D.; Hohlfeld, Jens M.; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Journal Article
2014Cell counting in human endobronchial biopsies - disagreement of 2D versus 3D morphometry
Bratu, Vlad A.; Erpenbeck, Veit J.; Fehrenbach, Antonia; Rausch, Tanja; Rittinghausen, Susanne; Krug, Norbert; Hohlfeld, Jens M.; Fehrenbach, Heinz
Journal Article
2014Diamide does not improve the analysis of IL1b and TNFa in dithiothreitol-treated sputum supernatants
Holz, Olaf; Lavae-Mokhtari, Bianca; Witte, Lena; Hohlfeld, Jens Michael
Abstract
2014Dose-range finding of natural birch pollen exposure in patients with seasonal allergic rhinitis in the Fraunhofer Environmental Challenge Chamber
Lüer, Katrin; Windt, Horst; Schwarz, Katharina; Badorrek, Philipp; Sebastian, Ramona; Haefner, Dietrich; Koch, Wolfgang; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014The effect of controlled exposure to grass pollen in an environmental challenge chamber on dermal symptoms in patients with atopic dermatitis
Heratizadeh, Annice; Badorrek, Philipp; Niebuhr, Margarete; Erpenbeck, Veit Johannes; Lösche, C.; Krug, Norbert; Hohlfeld, Jens Michael; Werfel, Thomas
Abstract
2014The effect of flow rate on the level of volatile organic compounds (voc) in exhaled breath
Holz, Olaf; Gaida, Arne; Schuchardt, Sven; Langejuergen, Jens; Zimmermann, Stefan; Hohlfeld, Jens Michael
Abstract
2014Effect of sample processing on the analysis of IL4, IL5, and IL13 in sputum supernatants
Holz, Olaf; Müller, Meike; Ignatenko, Stanislav; Kappeler, Dominik; Buhl, Roland; Beeh, Kai-Michael; Kornmann, Oliver; Kirsten, Anne; Homburg, Ursula; Garn, Holger; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Othmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Journal Article
2014Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis
Krug, Norbert; Gupta, Abhy; Badorrek, Philipp; Koennen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M.; Wood, Chester
Journal Article
2014Evaluation of small molecule FRET reporter for the diagnosis and monitoring of proteolytic activity in a chronic obstructive lung disease model
Reither, G.; Heath, N.; Holz, Olaf; Kahn, N.; Hohlfeld, Jens Michael; Schulz, C.; Mall, M.A.
Abstract
2014Exercise challenge amplifies differences in metabolomic signals between healthy smokers and smokers with COPD (gold2)
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Elmlinger, Martin; Lahu, Gezim; Hohlfeld, Jens Michael
Abstract
2014Lung function assessment in nonhuman primate models of obstructive pulmonary diseases
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz-Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Lung function assessment in the common marmoset (Callithrix jacchus) for the evaluation of translational nonhuman primate models of lung inflammation
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Optimizing gene-expression analysis for induced sputum
Holz, Olaf; Hansen, Tanja; Homburg, Ursula; Garn, Holger; Hohlfeld, Jens Michael; Niehof, Monika
Abstract
2014Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease
Hohlfeld, Jens M.; Sharma, A.; Noord, J.A. van; Cornelissen, P.J.; Derom, E.; Towse, L.; Peterkin, V.; Disse, B.
Journal Article
2014Phase-contrast MRI for detection of mild systemic hemodynamic response after segmental allergen challenge in asthmatic patients
Hinrichs, Jan; Schaumann, Frank; Renne, Julius; Schönfeld, Christian; Faulenbach, Cornelia; Winkler, Carla; Gutberlet, Marcel; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2014Potential prognostic value of biomarkers in lavage, sputum and serum in a five year clinical follow-up of smokers with and without COPD
Holz, Olaf; Waschki, Benjamin; Roepcke, Stefan; Watz, Henrik; Lauer, Gereon; Faulenbach, Cornelia; Hohlfeld, Jens M.
Journal Article
2014Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging
Vogel-Claussen, Jens; Renne, Julius; Hinrichs, Jan; Schönfeld Christian; Gutberlet, Marcel; Schaumann, Frank; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens Michael
Journal Article
2014Safety and efficacy of Pur118 in the ozone challenge model
Holz, Olaf; Biller, Heike; Müller, Meike; Kane, Katie; Rosano, Molly; Hanrahan, John; Hava, David L.; Hohlfeld, Jens Michael
Abstract
2013Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
Janssen, Ole; Schaumann, Frank; Holz, Olaf; Lavae-Mokhtari, Bianca; Welker, Lutz; Winkler, Carla; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2013Sampling and analysis of exhaled breath particles
Schwarz, Katharina; Holz, Olaf; Koch, Wolfgang; Hohlfeld, Jens M.
Conference Paper, Journal Article
2013A translational non-human primate model for human asthma in the common marmoset (Callithrix Jacchus)
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens M.; Sewald, Katherina; Windt, Horst; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales LPS-Modell zur präklinischen Testung anti-inflammatorischer Substanzen im Weißbüschelaffen (Callithrix jacchus)
Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz Josef; Schlumbohm, Christina; Fuchs, E.; Lauenstein, Hans Dieter; Sewald, Katherina; Hohlfeld, Jens M.; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales Tiermodell für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Becker, T.; Kaup, Franz Josef; Schlumbohm, Christina; Sewald, Katherina; Hohlfeld, Jens M.; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2012Alternative activation of macrophages during the allergic airway inflammation alters antigen presenting capacities
Winkler, Carla; Carstens, Hauke; Müller, Meike; Schaumann, Frank; Faulenbach, Cornelia; Hohlfeld, Jens M.
Abstract
2012Characterization of exhaled particles from the human lung in airway obstruction
Biller, Heike; Schwarz, Katharina; Windt, Horst; Koch, Wolfgang; Hohlfeld, Jens M.
Abstract
2012CRTH2 antagonist, BI 671800 (BI), reduces nasal symptoms and inhibits nasal cytokines and eosinophils in SAR patients exposed to grass pollen in an environmental challenge chamber (ECC)
Krug, Norbert; Gupta, A.; Badorrek, Philipp; Müller, Meike; Casper, Anja; Pivovarova, A.; Hilbert, J.; Koenen, R.; Hohlfeld, Jens M.; Wood, C.
Abstract
2012Depletion of neutrophils from induced sputum using a novel bead and sieve-separation system
Holz, Olaf; Schaumann, Frank; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Krug, Norbert; Heinrich, J. M.; Hohlfeld, Jens M.
Abstract
2012Detection of air trapping in chronic obstructive pulmonary disease by low frequency ultrasound
Morenz, Katrin; Biller, Heike; Wolfram, Frank; Leonhardt, Steffen; Ruter, Dirk; Glaab, Thomas; Uhlig, Stefan; Hohlfeld, Jens M.
Journal Article
2012Ex vivo lung culture models of marmoset monkeys and humans for anti-inflammatory drug testing
Seehase, Sophie; Neuhaus, Vanessa; Kaup, Franz-Josef; Pfennig, O.; Förster, Christine; Hohlfeld, Jens Michael; Knauf, Sascha; Braun, Armin; Sewald, Katherina
Abstract
2012Experience with an allergen challenge chamber for clinical trials in allergic rhinitis
Krug, Norbert; Badorrek, Phillipp; Hohlfeld, Jens Michael
Journal Article, Conference Paper
2012Low-dose endotoxin inhalation in healthy volunteers: A challenge model for early clinical drug development of novel anti-inflammatory compounds
Schaumann, Frank; Holz, Olaf; Janben, Ole; Lavae-Mokhtari, Bianca; Witte, Lena; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Abstract
2012A new model for testing human specific anti-inflammatory drugs: LPS-induced lung inflammation in the common marmoset
Knauf, Sascha; Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz-Josef; Schlumbohm, Christina; Fuchs, Eberhard; Lauenstein, Hand D.; Sewald, Katherina; Hohlfeld, Jens Michael; Braun, Armin
Abstract
2012Pollen starch granules in bronchial inflammation
Badorrek, Philipp; Dick, Melanie; Emmert, Lorenz; Schaumann, Frank; Koch, Wolfgang; Hecker, Hartmut; Murdoch, Robert; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2012Reproducibility of serum biomarkers and relationship to airway inflammation following LPS challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Faulenbach, Cornelia; Müller, Meike; Krug, Norbert; McLeod, Alison; Hohlfeld, Jens M.
Abstract
2012Safety and efficacy of house dust mite allergen challenge in patients with allergic rhinitis using a novel technique for inhalation studies in the Fraunhofer environmental challenge chamber
Lueer, Katrin; Biller, Heike; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, Armin; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Abstract
2012Semi-quantitative assessment of localized pulmonary inflammation by magnetic resonance imaging in patients with mild allergic asthma following segmental allergen challenge
Vogel-Claussen, Jens; Schaumann, Frank; Renne, Julius; Hinrichs, Jan; Schoenfeld, Christian; Gutberlet, Marcel; Hüper, Klaudia; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.
Abstract
2012Single breath particle characterization to detect small airway alterations
Schwarz, Katharina; Hohlfeld, Jens M.; Biller, Heike; Koch, Wolfgang
Abstract
2012Stable inflammatory phenotype in smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Krug, Norbert; Ernst, Peter; Lahu, Gezim; Hohlfeld, Jens M.
Abstract
2012Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model
Schleh, Carsten; Rothen-Rutishauser, Barbara M.; Blank, Fabian; Lauenstein, Hans D.; Nassimi, Matthias; Krug, Norbert; Braun, Armin; Erpenbeck, Veit; Gehr, Peter; Hohlfeld, Jens M.
Journal Article
2011Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
Zoerner, A.A.; Stichtenoth, D.O.; Engeli, S.; Batkai, S.; Winkler, Carla; Schaumann, Frank; Janke, J.; Holz, Olaf; Krug, Norbert; Tsikas, D.; Jordan, J.; Hohlfeld, Jens Michael
Journal Article
2011Breath profiles by electronic nose correlate with systemic markers but not ozone response
Biller, Heike; Holz, Olaf; Windt, Horst; Koch, Wolfgang; Müller, Meike; Jörres, Rudolf A.; Krug, Norbert; Hohlfeld, Jens M.
Journal Article