Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated Patients with Chronic Obstructive Pulmonary Disease (CLAIM)
Vogel-Claussen, J.; Schönfeld, C.-O.; Kaireit, T.F.; Voskrebenzev, A.; Czerner, C.P.; Renne, J.; Tillmann, H.-C.; Berschneider, K.; Hiltl, S.; Bauersachs, J.; Welte, T.; Hohlfeld, J.M.
Journal Article
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
Journal Article
2019Mapping of regional lung microstructural parameters using hyperpolarized 129Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease
Kern, A.L.; Gutberlet, M.; Voskrebenzev, A.; Klimes, F.; Rotärmel, A.; Wacker, F.; Hohlfeld, J.M.; Vogel-Claussen, J.
Journal Article
2019Randomized immunotherapy trial in dual‐allergic patients using "active allergen placebo" as control
Wagenmann, M.; Worm, M.; Akboga, Y.; Karjalainen, M.; Hohlfeld, J.M.
Journal Article
2019Regional investigation of lung function and microstructure parameters by localized 129Xe chemical shift saturation recovery and dissolved‐phase imaging
Kern, A.L.; Gutberlet, M.; Qing, K.; Voskrebenzev, A.; Klimes, F.; Kaireit, T.F.; Czerner, C.; Biller, H.; Wacker, F.; Ruppert, K.; Hohlfeld, J.M.; Vogel-Claussen, J.
Journal Article
2019Repeatability of Regional Lung Ventilation Quantification Using Fluorinated (19F) Gas Magnetic Resonance Imaging
Gutberlet, M.; Kaireit, T.F.; Voskrebenzev, A.; Kern, A.L.; Obert, A.; Wacker, F.; Hohlfeld, J.M.; Vogel-Claussen, J.
Journal Article
2019Treatable traits in the European U-BIOPRED adult asthma cohorts
Simpson, A.J.; Hekking, P.-P.; Shaw, D.E.; Fleming, L.J.; Roberts, G.; Riley, J.H.; Bates, S.; Sousa, A.R.; Bansal, A.T.; Pandis, I.; Sun, K.; Bakke, P.S.; Caruso, M.; Dahlen, B.; Dahlen, S.-E.; Horvath, I.; Krug, N.; Montuschi, P.; Sandstrom, T.; Singer, F.; Adcock, I.M.; Wagers, S.S.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.; Fowler, S.J.; Hohlfeld, J.M. et al.
Journal Article
2019Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans
Heusser, K.; Tank, J.; Holz, O.; May, M.; Brinkmann, J.; Engeli, S.; Diedrich, A.; Framke, T.; Koch, A.; Großhennig, A.; Danser, A.H.J.; Sweep, F.C.G.J.; Schindler, C.; Schwarz, K.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2017Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future - an EAACI Position Paper
Pfaar, O.; Calderon, M.A.; Andrews, C.P.; Angjeli, E.; Bergmann, K.C.; Bonlokke, J.H.; Blay, F. de; Devillier, P.; Ellis, A.K.; Wijk, R.G. van; Hohlfeld, J.M.; Horak, F.; Jacobs, R.L.; Jacobsen, L.; Jutel, M.; Kaul, S.; Larche, M.; Larenas-Linnemann, D.; Mosges, R.; Nolte, H.; Patel, P.; Peoples, L.; Rabin, R.L.; Rather, C.; Salapatek, A.M.; Sigsgaard, T.; Thaarup, S.; Yang, J.; Zieglmayer, P.; Zuberbier, T.; Demoly, P.
Journal Article
2017Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients
Krug, N.; Hohlfeld, J.M.; Buhl, R.; Renz, J.; Garn, H.; Renz, H.
Journal Article
2017Dose-response relationship of a new Timothy grass pollen allergoid in comparison with a 6-grass pollen allergoid
Pfaar, O.; Hohlfeld, J.M.; Al-Kadah, B.; Hauswald, B.; Homey, B.; Hunzelmann, N.; Schliemann, S.; Velling, P.; Worm, M.; Klimek, L.
Journal Article
2017A European Respiratory Society technical standard: exhaled biomarkers in lung disease
Horvath, I.; Barnes, P.J.; Loukides, S.; Sterk, P.J.; Hogman, M.; Olin, A.C.; Amann, A.; Antus, B.; Baraldi, E.; Bikov, A.; Boots, A.W.; Bos, L.D.; Brinkman, P.; Bucca, C.; Carpagnano, G.E.; Corradi, M.; Cristescu, S.; Jongste, J.C. de; Dinh-Xuan, A.T.; Dompeling, E.; Fens, N.; Fowler, S.; Hohlfeld, J.M.; Holz, O.; Jobsis, Q.; Kant, K.V. van de; Knobel, H.H.; Kostikas, K.; Lehtimaki, L.; Lundberg, J.; Montuschi, P.; Muylem, A. van; Pennazza, G.; Reinhold, P.; Ricciardolo, F.L.M.; Rosias, P.; Santonico, M.; Schee, M.P. van der; Schooten, F.J. van; Spanevello, A.; Tonia, T.; Vink, T.J.
Journal Article
2016Comparison Of COPD related breath VOCs assessed by a compact high-resolution closed-loop GC-IMS and by standard GC-MS
Holz, O.; Allers, M.; Gaida, A.; Schuchardt, S.; Hohlfeld, J.M.; Zimmermann, S.
Abstract
2016Prevalence of ragweed sensitization at a clinical trial unit in northern Germany
Badorrek, P.; Krug, N.; Hohlfeld, J.M.
Abstract
2016Rating the value of COPD related breath VOCs in models created by linear discriminant analysis
Holz, O.; Gaida, A.; Nell, C.; Allers, M.; Schuchardt, S.; Zimmermann, S.; Koczulla, R.; Hohlfeld, J.M.
Abstract
2015Controlled exposure to grass pollen in an environmental challenge chamber induces a worsening of cutaneous symptoms in patients with atopic dermatitis
Heratizadeh, A.; Badorrek, P.; Kapp, A.; Niebuhr, M.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Loesche, C.; Jung, T.; Krug, N.; Hohlfeld, J.M.; Werfel, T.
Abstract
2015Determination of markers that predict the individual response of perennial allergic subjects to house dust mite allergen in the Fraunhofer Environmental Challenge Chamber (ECC)
Hohlfeld, J.M.; Lüer, K.; Holz, O.; Häfner, D.; Koch, W.; Krug, N.
Abstract
2015Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T.; Heratizadeh, A.; Niebuhr, M.; Kapp, A.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Lösche, C.; Jung, T.; Krug, N.; Badorrek, P.; Hohlfeld, J.M.
Journal Article
2014Identification and quantification of basophils in the airways of asthmatics following segmental allergen challenge
Dijkstra, D.; Hennig, C.; Hansen, G.; Biller, H.; Krug, N.; Hohlfeld, J.M.
Journal Article
2014Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model
Winkler, C.; Bahlmann, O.; Viereck, J.; Knudsen, L.; Wedekind, D.; Hoymann, H.G.; Madsen, J.; Thum, T.; Hohlfeld, J.M.; Ochs, M.
Journal Article
2014Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
Winkler, C.; Witte, L.; Moraw, N.; Faulenbach, C.; Müller, M.; Holz, O.; Schaumann, F.; Hohlfeld, J.M.
Journal Article
2013Surfactant and allergic airway inflammation
Winkler, C.; Hohlfeld, J.M.
Journal Article
2012The EvA study: Aims and strategy
Ziegler-Heitbrock, L.; Frankenberger, M.; Heimbeck, I.; Burggraf, D.; Wjst, M.; Häussinger, K.; Brightling, C.; Gupta, S.; Parr, D.; Subramanian, D.; Singh, D.; Kolsum, U.; Boschetto, P.; Potena, A.; Gorecka, D.; Nowinski, A.; Barta, I.; Döme, B.; Strausz, J.; Greulich, T.; Vogelmeier, C.; Bals, R.; Hohlfeld, J.M.; Welte, T.; Venge, P.; Gut, I.; Boland, A.; Olaso, R.; Hager, J.; Hiemstra, P.; Rabe, K.F.; Unmüßig, M.; Müller-Quernheim, J.; Prasse, A.
Journal Article
2012LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing
Seehase, S.; Lauenstein, H.D.; Schlumbohm, C.; Switalla, S.; Neuhaus, V.; Förster, C.; Fieguth, H.G.; Pfennig, O.; Fuchs, E.; Kaup, F.J.; Bleyer, M.; Hohlfeld, J.M.; Braun, A.; Sewald, K.; Knauf, S.
Journal Article
2012Repeatability of and relationship between potential COPD biomarkers in bronchoalveolar lavage, bronchial biopsies, serum, and induced sputum
Röpcke, S.; Holz, O.; Lauer, G.; Müller, M.; Rittinghausen, S.; Ernst, P.; Lahu, G.; Elmlinger, M.; Krug, N.; Hohlfeld, J.M.
Journal Article
2011Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season
Badorrek, P.; Dick, M.; Hecker, H.; Schaumann, F.; Hohlfeld, J.M.; Krug, N.; Sousa, A.R.; Murdoch, R.
Journal Article
2011Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Winkler, C.; Atochina-Vasserman, E.N.; Holz, O.; Beers, M.F.; Erpenbeck, V.J.; Krug, N.; Roepcke, S.; Lauer, G.; Elmlinger, M.; Hohlfeld, J.M.
Journal Article
2011Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: A randomized, placebo controlled, crossover study
Tank, J.; Biller, H.; Heusser, K.; Holz, O.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2011The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
Nicholson, G.C.; Kariyawasam, H.H.; Tan, A.J.; Hohlfeld, J.M.; Quinn, D.; Walker, C.; Rodman, D.; Westwick, J.; Jurcevic, S.; Kon, O.M.; Barnes, P.J.; Krug, N.; Hansel, T.T.
Journal Article
2011Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice
Bühling, F.; Kouadio, M.; Chwieralski, C.E.; Kern, U.; Hohlfeld, J.M.; Klemm, N.; Friedrichs, N.; Roth, W.; Deussing, J.M.; Peters, C.; Reinheckel, T.
Journal Article
2011Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans
Atochina-Vasserman, E.N.; Winkler, C.; Abramova, H.; Schaumann, F.; Krug, N.; Gow, A.J.; Beers, M.F.; Hohlfeld, J.M.
Journal Article
2010Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
Schleh, C.; Erpenbeck, V.J.; Winkler, C.; Lauenstein, H.D.; Nassimi, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2010Characterization of exhaled particles from the healthy human lung - a systematic analysis in relation to pulmonary function variables
Schwarz, K.; Biller, H.; Windt, H.; Koch, W.; Hohlfeld, J.M.
Journal Article
2010Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions
Hohlfeld, J.M.; Holland-Letz, T.; Larbig, M.; Lavae-Mokhtari, M.; Wierenga, E.; Kapsenberg, M.; Ree, R. van; Krug, N.; Bufe, A.
Journal Article
2010Human eosinophil granulocytes do not express the enzyme arginase
Luckner-Minden, C.; Fischer, I.; Langhans, C.-D.; Schiller, M.; Kropf, P.; Müller, I.; Hohlfeld, J.M.; Ho, A.D.; Munder, M.
Journal Article
2010Independent information of nonspecific biomarkers in exhaled breath condensate
Dressel, H.; Müller, F.; Fischer, R.; Römmelt, H.; Hohlfeld, J.M.; Behr, J.; Huber, R.M.; Nowak, D.; Jörres, R.A.
Journal Article
2010Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices
Switalla, S.; Lauenstein, L.; Prenzler, F.; Knothe, S.; Förster, C.; Fieguth, H.-G.; Pfennig, O.; Schaumann, F.; Martin, C.; Guzman, C.A.; Ebensen, T.; Müller, M.; Hohlfeld, J.M.; Krug, N.; Braun, A.; Sewald, K.
Journal Article
2010Pharmacodynamic effects of the selective PDE4-inhibitor roflumilast in humans
Bethke, T.D.; Hohlfeld, J.M.; Krug, N.; Grootendorst, D.C.; Rabe, K.F.
Abstract
2010Submicron droplet formation in the human lung
Haslbeck, K.; Schwarz, K.; Hohlfeld, J.M.; Seume, J.R.; Koch, W.
Journal Article
2010Surfactant protein D modulates pulmonary clearance of pollen starch granules
Winkler, C.; Hüper, K.; Wedekind, A-C.; Rochlitzer, S.; Hartwig, C.; Müller, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.; Erpenbeck, V.J.
Journal Article
2009A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis
Badorrek, P.; Dick, M.; Schauerte, A.; Hecker, H.; Murdoch, R.; Luettig, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2009Correlation of donor leukocyte chimerism with pulmonary allograft survival after immunosuppressive drug withdrawal in a porcine model
Kruse, B.; Thissen, S.; Warnecke, G.; Avsar, M.; Gottlieb, J.; Hohlfeld, J.M.; Karstens, J.H.; Kaever, V.; Länger, F.; Pabst, B.; Ungefroren, H.; Haverich, A.; Strüber, M.
Journal Article
2009The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
Schleh, C.; Mühlfeld, C.; Pulskamp, K.; Schmiedl, S.; Nassimi, M.; Lauenstein, H.D.; Braun, A.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Journal Article
2009Interaction of nanoparticles with the pulmonary surfactant system
Schleh, C.; Hohlfeld, J.M.
Journal Article
2009On the importance of the use of proper approaches for comparison of analytical methods for serum nitrate and for evaluation of reference concentrations
Tsikas, D.; Hohlfeld, J.M.
Journal Article
2009Therapeutic surfactants modulate the viability of Eosinophils and induce inflammatory mediator release
Erpenbeck, V.J.; Fischer, I.; Wiese, K.; Schaumann, F.; Schmiedl, A.; Nassenstein, C.; Krug, N.; Hohlfeld, J.M.
Journal Article
2009Therapeutic use of surfactant components in allergic asthma
Erpenbeck, V.J.; Krug, N.; Hohlfeld, J.M.
Journal Article
2008Elastase-induced lung emphysema in rats is not reduced by hematopoietic growth factors when applied preventionally
Schmiedl, A.; Lempa, T.; Hoymann, H.G.; Rittinghausen, S.; Popa, D.; Tschernig, T.; Fehrenbach, H.; Pabst, R.; Hoeper, M.M.; Hohlfeld, J.M.
Journal Article
2008Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma
Schaumann, F.; Müller, M.; Braun, A.; Luettig, B.; Peden, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2008Engineered nanoparticles induce a pulmonary surfactant dysfunction after surface area cycling in vitro
Schleh, C.; Nassimi, M.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Conference Paper
2008Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts
Sadovski, J.; Kuchenbuch, T.; Ruppert, C.; Fehrenbach, A.; Hirschburger, M.; Padberg, W.; Günther, A.; Hohlfeld, J.M.; Fehrenbach, H.; Grau, V.
Journal Article
2008Pneumokokkenimpfung: Konjugatimpfstoff induziert Herdenimmunität und reduziert Antibiotikaresistenz
Pletz, M.W.; Maus, U.; Hohlfeld, J.M.; Lode, H.; Welte, T.
Journal Article
2008Die Prävalenz der chronisch obstruktiven Lungenerkrankung (COPD) in Deutschland
Geldmacher, H.; Biller, H.; Herbst, A.; Urbanski, K.; Allison, M.; Buist, A.S.; Hohlfeld, J.M.; Welte, T.
Journal Article
2008Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: A randomized placebo-controlled trial
Hohlfeld, J.M.; Schönfeld, K.; Lavae-Mokhtari, M.; Schaumann, F.; Müller, M.; Bredenbröker, D.; Krug, N.; Hermann, R.
Journal Article
2007Effect of nanosized particles on pulmonary surfactant function
Schleh, C.; Krug, N.; Erpenbeck, V.J.; Hohlfeld, J.M.
Conference Paper, Journal Article
2007Effects of exogenous surfactant instillation in clinical lung transplantation
Strüber, M.; Fischer, S.; Niedermeyer, J.; Warnecke, G.; Gohrbandt, B.; Görler, A.; Simon, A.R.; Haverich, A.; Hohlfeld, J.M.
Journal Article
2007Effects of keratinocyte growth factor on intra-alveolar surfactant fixed in situ: Quantitative ultrastructural and immunoelectron microscopic analysis
Fehrenbach, H.; Fehrenbach, A.; Dietzel, E.; Tschernig, T.; Krug, N.; Grau, V.; Hohlfeld, J.M.
Journal Article
2006Allergic responses induced by grass pollen in an environmental challenge chamber (ECC) reflect changes during seasonal high pollen counts in allergic rhinitis patients
Krug, N.; Holland-Letz, T.; Wierenga, E.; Ree, R. van; Hüsing, A.; Larbig, M.; Hohlfeld, J.M.; Bufe, A.
Conference Paper, Journal Article
2006Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
Thum, T.; Erpenbeck, V.J.; Moeller, J.; Hohlfeld, J.M.; Krug, N.; Borlak, J.
Journal Article
2006Facial thermography is a sensitive tool to determine antihistaminic activity
Larbig, M.; Burtin, B.; Martin, L.; Stamm, H.; Luettig, B.; Hohlfeld, J.M.; Krug, N.
Journal Article
2006Lung fibroblasts from patients with emphysema show markers of senescence in vitro
Müller, K.C.; Welker, L.; Paasch, K.; Feindt, B.; Erpenbeck, V.J.; Hohlfeld, J.M.; Krug, N.; Nakashima, M.; Branscheid, D.; Magnussen, H.; Jörres, R.A.; Holz, O.
Journal Article
2006Pathomechanismen der chronisch-obstruktiven Lungenerkrankung (COPD)
Glaab, T.; Hohlfeld, J.M.; Jörres, R.A.; Krug, N.; Welte, T.
Journal Article
2006Preoperative low-dose irradiation promotes long-term allograft acceptance and induces regulatory T cells in a porcine model of pulmonary transplantation
Warnecke, G.; Avsar, M.; Morancho, M.; Peters, C.; Thissen, S.; Kruse, B.; Baumann, R.; Ungefroren, H.; Simon, A.R.; Hohlfeld, J.M.; Karstens, J.H.; Haverich, A.; Struber, M.
Journal Article
2006Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge
Erpenbeck, V.J.; Hagenberg, A.; Krentel, H.; Discher, M.; Braun, A.; Hohlfeld, J.M.; Krug, N.
Journal Article
2006Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice
Erpenbeck, V.J.; Ziegert, M.; Cavalet-Blanco, D.; Martin, C.; Bälder, R.; Glaab, T.; Braun, A.; Steinhilber, W.; Luettig, B.; Uhlig, S.; Hoymann, H.G.; Krug, N.; Hohlfeld, J.M.
Journal Article
2006Surfactant protein levels in bronchoalveolar lavage after segmental allergen challenge in patients with asthma
Erpenbeck, V.J.; Schmidt, R.; Gunther, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2006Utilisation of an environmental challenge chamber (ECC) to explore allergen induced bronchial hyperresponsiveness (BHR) in mild asthmatic patients with co-morbid rhinitis
Krug, N.; Hohlfeld, J.M.; Bruns, H.; Russell, P.; Weeks, A.; Larbig, M.; Murdoch, R.D.
Abstract
2005Effect of loteprednol etabonate nasal spray suspension on seasonal allergic rhinitis assessed by allergen challenge in an environmental exposure unit
Krug, N.; Hohlfeld, J.M.; Geldmacher, H.; Larbig, M.; Heermann, R.; Lavallee, N.; Nguyen, D.T.; Petzold, U.; Hermann, R.
Journal Article
2005Exhaled breath condensate: Methodological recommendations and unresolved questions
Horváth, I.; Hunt, J.P.; Barnes, J.; Alving, K.; Antczak, A.; Baraldi, E.; Becher, G.; Beurden, W.J. van; Corradi, M.; Dekhuijzen, R.; Dweik, R.A.; Dwyer, T.; Effros, R.; Erzurum, S.; Gaston, B.; Gessner, C.; Greening, A.; Ho, L.P.; Hohlfeld, J.M.; Jöbsis, Q.; Laskowski, D.; Loukides, S.; Marlin, D.; Montuschi, P.; Olin, A.C.; Redington, A.E.; Reinhold, P.; Rensen, E.L. van; Rubinstein, I.; Silkoff, P.; Toren, K.; Vass, G.; Vogelberg, C.; Wirtz, H.
Journal Article
2005Glutathione improves the function of porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution
Sommer, S.P.; Gohrbandt, B.; Fischer, S.; Hohlfeld, J.M.; Warnecke, G.; Avsar, M.; Struber, M.
Journal Article
2005The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S.
Journal Article
2005The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Doganci, A.; Eigenbrod, T.; Krug, N.; Sanctis, G.T. de; Hausding, M.; Erpenbeck, V.J.; Haddad, E.-B.; Lehr, H.A.; Schmitt, E.; Bopp, T.; Kallen, K.-J.; Herz, U.; Schmitt, S.; Luft, C.; Hecht, O.; Hohlfeld, J.M.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Rose-John, S.; Renz, H.; Neurath, M.F.; Galle, P.R.; Finotto, S.
Journal Article
2005Iloprost to improve surfactant function in porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution
Gohrbandt, B.; Sommer, S.P.; Fischer, S.; Hohlfeld, J.M.; Warnecke, G.; Haverich, A.; Strüber, M.
Journal Article
2005Invasive versus noninvasive measurement of allergic and cholinergic airway responsiveness in mice
Glaab, T.; Ziegert, M.; Bälder, R.; Korolewitz, R.; Braun, A.; Hohlfeld, J.M.; Mitzner, W.; Krug, N.; Hoymann, H.G.
Journal Article
2005Local nitric oxide levels reflect the degree of allergic airway inflammation after segmental allergen challenge in asthmatics
Erpenbeck, V.J.; Jörres, R.A.; Discher, M.; Luettig, B.; Krug, N.; Hohlfeld, J.M.
Journal Article
2005Pulmonary surfactant in asthma and allergy
Hohlfeld, J.M.
Book Article
2005Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation
Malherbe, D.C.; Erpenbeck, V.; Abraham, S.N.; Crouch, E.C.; Hohlfeld, J.M.; Wright, J.R.
Journal Article
2005Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules
Erpenbeck, V.J.; Malherbe, D.C.; Sommer, S.; Schmiedl, A.; Steinhilber, W.; Ghio, A.J.; Krug, N.; Wright, J.R.; Hohlfeld, J.M.
Journal Article
2004Asthma bronchiale
Hohlfeld, J.M.
Book Article
2004Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma
Hohlfeld, J.M.; Schmiedl, A.; Erpenbeck, V.J.; Venge, P.; Krug, N.
Journal Article
2004Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant
Schmiedl, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2004Keratinocyte growth factor transiently alters pulmonary function in rats
Hohlfeld, J.M.; Hoymann, H.G.; Tschernig, T.; Fehrenbach, A.; Krug, N.; Fehrenbach, H.
Journal Article
2004Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated choline
Bernhard, W.; Pynn, C.J.; Jaworski, A.; Rau, G.A.; Hohlfeld, J.M.; Freihorst, J.; Poets, C.F.; Stoll, D.; Postle, A.D.
Journal Article
2004Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects
Schaumann, F.; Borm, P.J.A.; Herbrich, A.; Knoch, J.; Pitz, M.; Schins, R.P.F.; Luettig, B.; Hohlfeld, J.M.; Heinrich, J.; Krug, N.
Journal Article
2004Natural porcine surfactant augments airway inflammation after allergen challenge in patients with asthma
Erpenbeck, V.J.; Hagenberg, A.; Dulkys, Y.; Elsner, J.; Balder, R.; Krentel, H.; Discher, M.; Braun, A.; Krug, N.; Hohlfeld, J.M.
Journal Article
2004Pulmonary preservation with LPD and celsior solution in porcine lung transplantation after 24 h of cold ischemia
Sommer, S.P.; Warnecke, G.; Hohlfeld, J.M.; Gohrbandt, B.; Niedermeyer, J.; Kofidis, T.; Haverich, A.; Struber, M.
Journal Article
2004Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice
Glaab, T.; Mitzner, W.; Braun, A.; Ernst, H.; Korolewitz, R.; Hohlfeld, J.M.; Krug, N.; Hoymann, H.G.
Journal Article
2004Warm or cold ischemia in animal models of lung ischemia-reperfusion injury
Warnecke, G.; Sommer, S.P.; Gohrbandt, B.; Fischer, S.; Hohlfeld, J.M.; Niedermeyer, J.; Haverich, A.; Struber, M.
Journal Article
2003Divergence in urinary 8-iso-PGF[2alpha] (iPF[2alpha],-III, 15-F2t-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF[2alpha]
Tsikas, D.; Schwedhelm, E.; Suchy, M.-T.; Niemann, J.; Gutzki, F.-M.; Erpenbeck, V.J.; Hohlfeld, J.M.; Surdacki, A.; Frölich, J.C.
Journal Article
2003Effect of anti-nerve growth factor on early and late airway responses in allergic rats
Glaab, T.; Hoymann, H.-G.; Hecht, M.; Korolewitz, R.; Tschernig, T.; Hohlfeld, J.M.; Krug, N.; Braun, A.
Journal Article
2003In-situ topical cooling of lung grafts
Kutschka, I.; Sommer, S.P.; Hohlfeld, J.M.; Warnecke, G.; Morancho, M.; Fischer, S.; Haverich, A.; Strüber, M.
Journal Article
2003Increase of inactive intra-alveolar surfactant subtypes in lungs of asthmatic Brown Norway rats
Schmiedl, A.; Hoymann, H.-G.; Ochs, M.; Menke, A.; Fehrenbach, A.; Krug, N.; Tschernig, T.; Hohlfeld, J.M.
Journal Article
2003Increased expression of interleukin-9 messenger RNA after segmental allergen challenge in allergic asthmatics
Erpenbeck, V.J.; Hohlfeld, J.M.; Discher, M.; Krentel, H.; Hagenberg, A.; Braun, A.; Krug, N.
Journal Article, Conference Paper
2003Local release of eosinophil peroxidase following segmental allergen provocation in asthma
Erpenbeck, V.J.; Hohlfeld, J.M.; Petschallies, J.; Eklund, E.; Peterson, C.G.B.; Fabel, H.; Krug, N.
Journal Article
2003Pulmonary surfactant and lung fluid balance
Hohlfeld, J.M.
Book Article
2003Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes
Erpenbeck, V.J.; Hohlfeld, J.M.; Volkmann, B.; Hagenberg, A.; Geldmacher, H.; Braun, A.; Krug, N.
Journal Article
2003Surfactant homeostasis is maintained in vivo during Keratinocyte growth factor-induced rat lung type II cell hyperplasia
Fehrenbach, A.; Bube, C.; Hohlfeld, J.M.; Stevens, P.; Tschernig, T.; Hoymann, H.G.; Krug, N.; Fehrenbach, H.
Journal Article
2003Surfactant proteins SP-A and SP-D as modulators of the allergic inflammation in asthma
Hohlfeld, J.M.; Erpenbeck, V.J.; Krug, N.
Conference Paper, Journal Article
2003Validation of a new lung-function method in orally intubated mice using a model for respiratory allergenicity
Braun, A.; Rott, M.; Hecht, M.; Glaab, T.; Hohlfeld, J.M.; Krug, N.; Hoymann, H.G.
Journal Article
2003Validation of an environmental exposure unit for controlled human inhalation studies with grass pollen in patients with seasonal allergic rhinitis
Krug, N.; Loedding, H.; Hohlfeld, J.M.; Larbig, M.; Buckendahl, A.; Badorrek, P.; Geldmacher, H.; Behnke, W.; Dunkhorst, W.; Windt, H.; Luettig, B.; Koch, W.
Journal Article
2002Empfehlungen zum Tuberkulose-Screening und zur Therapie der latenten Tuberkulose bei Anti-TNF[alpha]-Therapie mit Infliximab
Hülsemann, J.L.; Hohlfeld, J.M.; Schnarr, S.; Stoll, M.; Zeidler, H.
Journal Article
2002Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats
Glaab, T.; Hoymann, H.G.; Hohlfeld, J.M.; Korolewitz, R.; Hecht, M.; Alarie, Y.; Tschernig, T.; Braun, A.; Krug, N.; Fabel, H.
Journal Article
2002A pilot study to assess the efficacy of loteprednol etabonate nasal spray as a treatment for allergic rhinitis in an environmental exposure unit (eeu)
Geldmacher, H.; Buckendahl, A.; Badorrek, P.; Nguyen, D.; Lavallee, N.; Petzold, U.; Hermann, R.; Hohlfeld, J.M.; Krug, N.
Journal Article
2002Pulmonary preservation with Bretschneider's HTK and Celsior solution in minipigs
Warnecke, G.; Strüber, M.; Hohlfeld, J.M.; Niedermeyer, J.; Sommer, S.P.; Haverich, A.
Journal Article
2002The role of surfactant in asthma. Review
Hohlfeld, J.M.
Journal Article
2002Surfactant function in lung transplantation after 24 hours of ischemia
Strüber, M.; Hohlfeld, J.M.; Kofidis, T.; Warnecke, G.; Niedermeyer, J.; Sommer, S.P.; Haverich, A.
Journal Article
2001Combined exogenous surfactant and inhaled nitric oxide therapy for lung ischemia-reperfusion injury in minipigs
Warnecke, G.; Strüber, M.; Fraund, S.; Hohlfeld, J.M.; Haverich, A.
Journal Article
2001Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma
Krug, N.; Tschernig, T.; Erpenbeck, V.J.; Hohlfeld, J.M.; Köhl, J.
Journal Article
2001Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gamma delta T cells in people with asthma after segmental allergen challenge
Krug, N.; Erpenbeck, V.J.; Balke, K.; Petschallies, J.; Tschernig, T.; Hohlfeld, J.M.; Fabel, H.
Journal Article
2001The role of surfactant in asthma
Hohlfeld, J.M.
Journal Article
2000Aspiration und "near drowning"
Hohlfeld, J.M.; Fabel, H.
Journal Article
2000Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma
Krug, N.; Cruikshank, W.W.; Tschernig, T.; Erpenbeck, V.J.; Balke, K.; Hohlfeld, J.M.; Center, D.M.; Fabel, H.
Journal Article
2000Low-potassium dextran solution ameliorates reperfusion injury of the lung and protects surfactant function
Strüber, M.; Hohlfeld, J.M.; Fraund, S.; Kim, P.; Warnecke, G.; Haverich, A.
Journal Article
2000Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma
Heeley, E.L.; Hohlfeld, J.M.; Krug, N.; Postle, A.D.
Journal Article
2000Stellenwert des intensivmedizinischen Monitoring mit dem Pulmonararterienkatheter
Hohlfeld, J.M.; Niedermeyer, J.; Fabel, H.
Journal Article
2000Surfactant function affected by airway inflammation and cooling: Possible impact on exercise-induced asthma
Enhorning, G.; Hohlfeld, J.M.; Krug, N.; Lema, G.; Welliver, R.
Journal Article
2000Surfactant in the airways: Composition, function and relevance in asthma
Hohlfeld, J.M.
Journal Article
1999Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Enhorning, G.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.-G.; Fabel, H.; Krug, N.
Journal Article
1998Pulmonary surfactant activity is impaired in lung transplant recipients
Hohlfeld, J.M.; Tiryaki, E.; Hamm, H.; Hoymann, H.G.; Krug, N.; Haverich, A.; Fabel, H.
Journal Article
1998Pulmonary surfactant function is impaired in asthmatics after segmental allergen challenge
Hohlfeld, J.M.; Ahlf, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H.
Journal Article
1998Störung der Surfactantfunktion bei Asthmatikern nach segmentaler Allergenprovokation
Hohlfeld, J.M.; Ahlf, K.; Balke, K.; Erpenbeck, V.J.; Petschallies, J.; Hoymann, H.G.; Krug, N.; Fabel, H.
Journal Article
1997Pulmonary surfactant composition in sensitized guinea pigs challenged by aerosolized ovalbumin
Hohlfeld, J.M.; Hamm, H.; Martin-Carrera, I.; Hoymann, H.G.; Heinrich, U.; Fabel, H.
Journal Article
1996Pulmonary surfactant impairment in lung transplant recipients
Hohlfeld, J.M.; Tiryaki, E.; Hamm, H.; Tschorn, H.; Schöfers, H.J.; Hoymann, H.G.; Wagner, T.O.F.; Fabel, H.
Conference Paper, Journal Article
1996Surfactant activity is decreased in patients after lung transplantation
Hohlfeld, J.M.; Tiryaki, E.; Hamm, H.; Heilmann, M.; Tschorn, H.; Schürmann, W.H.T.; Demertzis, S.; Schäfers, H.J.; Hoymann, H.G.; Wagner, T.O.F.; Fabel, H.
Journal Article
1993An efficient aerosolization method for surfactant and its surface activity prior and after aerosolization
Hohlfeld, J.M.; Molthan, J.; Fabel, H.; Heinrich, U.
Conference Paper, Journal Article