Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients
Winkler, C.; Hochdörfer, T.; Israelsson, E.; Hasselberg, A.; Cavallin, A.; Thörn, K.; Muthas, D.; Shojaee, S.; Lüer, K.; Müller, M.; Mjösberg, J.; Vaarala, O.; Hohlfeld, J.; Pardali, K.
Journal Article
2019BAL cell gene expression is indicative of outcome and airway basal cell involvement in idiopathic pulmonary fibrosis
Prasse, Antje; Binder, Harald; Schupp, Jonas C.; Kayser, Gian; Bargagli, Elena; Jäger, Benedikt; Hess, Moritz; Rittinghausen, Susanne; Vuga, Louis; Lynn, Heather; Violette, Shelia; Jung, Birgit; Quast, Karsten; Vanaudenaerde, Bart; Xu, Yan; Hohlfeld, Jens M.; Krug, Norbert; Herazo-Maya, Jose D.; Rottoli, Paola; Wuyts, Wim A.; Kaminski, Naftali
Journal Article
2019Effect of Indacaterol/Glycopyrronium on Pulmonary Perfusion and Ventilation in Hyperinflated Patients with Chronic Obstructive Pulmonary Disease (CLAIM)
Vogel-Claussen, J.; Schönfeld, C.-O.; Kaireit, T.F.; Voskrebenzev, A.; Czerner, C.P.; Renne, J.; Tillmann, H.-C.; Berschneider, K.; Hiltl, S.; Bauersachs, J.; Welte, T.; Hohlfeld, J.M.
Journal Article
2019Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
Jevnikar, Z.; Östling, J.; Ax, E.; Calven, J.; Thörn, K.; Israelsson, E.; Öberg, L.; Singhania, A.; Lau, L.C.K.; Wilson, S.J.; Ward, J.A.; Chauhan, A.; Sousa, A.R.; Meulder, B. de; Loza, M.J.; Baribaud, F.; Sterk, P.J.; Chung, K.F.; Sun, K.; Guo, Y.; Adcock, I.M.; Payne, D.; Dahlen, B.; Chanez, P.; Shaw, D.E.; Krug, Norbert; Hohlfeld, Jens M.; Sandström, T.; Djukanovic, R.; James, A.; Hinks, T.S.C.; Howarth, P.H.; Vaarala, O.; Geest, M. van; Olsson, H.; Adcock, I.M.; Ahmed, H.; Auffray, C.; Bakke, P.; Bansal, A.T.; Baribaud, F.; Bates, S.; Bel, E.H.; Bigler, J.; Bisgaard, H.; Boedigheimer, M.J.; Bonnelykke, K.; Brandsma, J.; Brinkman, P.; Bucchioni, E.; Burg, D.; Bush, A.; Caruso, M.; Chaiboonchoe, A.; Chanez, P.; Chung, F.K.; Compton, C.H.; Corfield, J.; D'Amico, A.; Dahlen, S.E.; De Meulder, B.; Djukanovic, R.; Erpenbeck, V.J.; Erzen, D.; Fichtner, K.; Fitch, N.; Fleming, L.J.; Formaggio, E.; Fowler, S.J.; Frey, U.; Gahlemann, M.; Geiser, T.; Goss, V.; Guo, Y.; Hashimoto, S.; Haughney, J.; Hedlin,
Journal Article
2019Mapping of regional lung microstructural parameters using hyperpolarized 129Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease
Kern, A.L.; Gutberlet, M.; Voskrebenzev, A.; Klimes, F.; Rotärmel, A.; Wacker, F.; Hohlfeld, J.M.; Vogel-Claussen, J.
Journal Article
2019Nachbildung des menschlichen Knochens mit Metall - das Testmaterial der Zukunft?
Hannemann, Christian; Uhlig, Mandy; Hohlfeld, Jörg; Oefner, Christoph; Schoenfelder, Stephan; Heyde, Christoph-E.
Conference Paper
2019Randomized immunotherapy trial in dual‐allergic patients using "active allergen placebo" as control
Wagenmann, M.; Worm, M.; Akboga, Y.; Karjalainen, M.; Hohlfeld, J.M.
Journal Article
2019Regional investigation of lung function and microstructure parameters by localized 129Xe chemical shift saturation recovery and dissolved‐phase imaging
Kern, A.L.; Gutberlet, M.; Qing, K.; Voskrebenzev, A.; Klimes, F.; Kaireit, T.F.; Czerner, C.; Biller, H.; Wacker, F.; Ruppert, K.; Hohlfeld, J.M.; Vogel-Claussen, J.
Journal Article
2019Repeatability of Regional Lung Ventilation Quantification Using Fluorinated (19F) Gas Magnetic Resonance Imaging
Gutberlet, M.; Kaireit, T.F.; Voskrebenzev, A.; Kern, A.L.; Obert, A.; Wacker, F.; Hohlfeld, J.M.; Vogel-Claussen, J.
Journal Article
2019Treatable traits in the European U-BIOPRED adult asthma cohorts
Simpson, A.J.; Hekking, P.-P.; Shaw, D.E.; Fleming, L.J.; Roberts, G.; Riley, J.H.; Bates, S.; Sousa, A.R.; Bansal, A.T.; Pandis, I.; Sun, K.; Bakke, P.S.; Caruso, M.; Dahlen, B.; Dahlen, S.-E.; Horvath, I.; Krug, N.; Montuschi, P.; Sandstrom, T.; Singer, F.; Adcock, I.M.; Wagers, S.S.; Djukanovic, R.; Chung, K.F.; Sterk, P.J.; Fowler, S.J.; Hohlfeld, J.M. et al.
Journal Article
2019Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans
Heusser, K.; Tank, J.; Holz, O.; May, M.; Brinkmann, J.; Engeli, S.; Diedrich, A.; Framke, T.; Koch, A.; Großhennig, A.; Danser, A.H.J.; Sweep, F.C.G.J.; Schindler, C.; Schwarz, K.; Krug, N.; Jordan, J.; Hohlfeld, J.M.
Journal Article
2018Airway and systemic inflammatory responses to ultrafine carbon black particles and ozone in older healthy subjects
Holz, Olaf; Heusser, Karsten; Müller, Meike; Windt, Horst; Schwarz, Katharina; Schindler, Christoph; Tank, Jens; Hohlfeld, Jens M.; Jordan, Jens
Journal Article
2018Attenuation of vibrations with particle filled hollow sphere structures
Jehring, Ulrike; Quadbeck, Peter; Hohlfeld, Jörg; Andersen, Olaf; Kieback, Bernd
Presentation
2018Breath volatile organic compounds of lung transplant recipients with and without chronic lung allograft dysfunction
Küppers, L.; Holz, Olaf; Schuchardt, Sven; Gottlieb, J.; Fuge, J.; Greer, M.; Hohlfeld, Jens M.
Journal Article
2018Comparison of quantitative regional ventilation‐weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients
Kaireit, Till F.; Gutberlet, Marcel; Voskrebenzev, Andreas; Freise, Julia; Welte, Tobias; Hohlfeld, Jens M.; Wacker, Frank; Vogel-Claussen, Jens
Journal Article
2018A comprehensive way to rate sputum quality in clinical trials
Pedersen, Frauke; Zissler, U.; Watz, Henrik; Rabe, Klaus F.; Hohlfeld, Jens M.; Holz, Olaf
Abstract
2018A computational framework for complex disease stratification from multiple large-scale datasets
Meulder, Bertrand de; Lefaudeux, Diane; Bansal, Aruna T.; Mazein, Alexander; Chaiboonchoe, Amphun; Ahmed, Hassan; Balaur, Irina; Saqi, Mansoor; Pellet, Johann; Ballereau, Stephane; Lemonnier, Nathanaël; Sun, Kai; Pandis, Ioannis; Yang, Xian; Batuwitage, Manohara; Kretsos, Kosmas; Eyll, Jonathan van; Bedding, Alun; Davison, Timothy; Dodson, Paul; Larminie, Christopher; Postle, Anthony; Corfield, Julie; Djukanović, Ratko; Chung, Kian Fan; Adcock, Ian M.; Guo, Yi-Ke; Sterk, Peter J.; Manta, Alexander; Rowe, Anthony; Baribaud, Frédéric; Auffray, Charles; Badorrek, Philipp; Faulenbach, Cornelia; Braun, Armin; Hohlfeld, Jens; Krug, Norbert
Journal Article
2018Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): A double-blind, randomised, crossover, placebo-controlled, single-centre trial
Hohlfeld, Jens M.; Vogel-Claussen, Jens; Biller, Heike; Berliner, Dominik; Berschneider, Korbinian; Tillmann, Hanns-Christian; Hiltl, Simone; Bauersachs, Johann; Welte, Tobias
Journal Article
2018Extrudierte schäumbare Sandwichverbunde
Hohlfeld, Jörg; Hannemann, Christian; Hipke, Thomas
Journal Article
2018Free-breathing dynamic (19)F gas MR imaging for mapping of regional lung ventilation in patients with COPD
Gutberlet, Marcel; Kaireit, Till F.; Voskrebenzev, Andreas; Lasch, Florian; Freise, Julia; Welte, Tobias; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2018A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: A feasibility randomized clinical trial
Greulich, Timm; Hohlfeld, Jens M.; Neuser, Petra; Lueer, Katrin; Klemmer, Andreas; Schade-Brittinger, Carmen; Harnisch, Susanne; Garn, Holger; Renz, Harald; Homburg, Ursula; Renz, Jonas; Kirsten, Anne; Pedersen, Frauke; Müller, Meike; Vogelmeier, Claus F.; Watz, Henrik
Journal Article
2018Geometrisch bestimmte offenzellige Feingussstrukturen
Hohlfeld, Jörg; Uhlig, Mandy; Hannemann, Christian
Journal Article
2018Hybrider Werkstoff aus Holzschaum und Metallschwamm
Bunzel, Frauke; Kowalik, Thomas; Scholz, S.; Hohlfeld, Jörg
Journal Article
2018International consensus statement on allergy and rhinology: Allergic rhinitis
Wise, Sarah K.; Lin, Sandra Y.; Toskala, Elina; Orlandi, Richard R.; Akdis, Cezmi A.; Alt, Jeremiah A.; Azar, Antoine; Baroody, Fuad M.; Bachert, Claus; Canonica, G. Walter; Chacko, Thomas; Cingi, Cemal; Ciprandi, Giorgio; Corey, Jacquelynne; Cox, Linda S.; Creticos, Peter Socrates; Custovic, Adnan; Damask, Cecelia; DeConde, Adam; DelGaudio, John M.; Ebert, Charles S.; Eloy, Jean Anderson; Flanagan, Carrie E.; Fokkens, Wytske J.; Franzese, Christine; Gosepath, Jan; Halderman, Ashleigh; Hamilton, Robert G.; Hoffman, Hans Jürgen; Hohlfeld, Jens M.; Houser, Steven M.; Hwang, Peter H.; Incorvaia, Cristoforo; Jarvis, Deborah; Khalid, Ayesha N.; Kilpeläinen, Maritta; Kingdom, Todd T.; Krouse, Helene; Larenas-Linnemann, Desiree; Laury, Adrienne M.; Lee, Stella E.; Levy, Joshua M.; Luong, Amber U.; Marple, Bradley F.; McCoul, Edward D.; McMains, K. Christopher; Melén, Erik; Mims, James W.; Moscato, Gianna; Mullol, Joaquim; Nelson, Harold S.; Patadia, Monica; Pawankar, Ruby; Pfaar, Oliver; Platt, Michael P.;
Journal Article
2018Isolated aggregates of lymphoid cells in the inner bronchial wall in asthma patients
Tschernig, Thomas; Pabst, Reinhard; Prenzler, Frauke; Rittinghausen, Susanne; Braun, Armin; Hohlfeld, Jens M.
Journal Article
2018Leichtbau aus der Strangpresse
Hohlfeld, Jörg; Hannemann, Christian
Journal Article
2018Manufacturing of foamable semi-finished products for aluminium foam sandwiches produced by extrusion
Hannemann, Christian; Hohlfeld, Jörg; Hipke, Thomas; Schneider, Frank
Presentation
2018Phase 1 pharmacokinetics and phase 3 efficacy of testosterone nasal gel in subjects with seasonal allergies
Rogol, Alan D.; Tkachenko, Natalia; Badorrek, Philipp; Hohlfeld, Jens M.; Bryson, Nathan
Journal Article
2018Sandwich manufacturing with foam core and aluminum face sheets - a new process without rolling
Hohlfeld, Jörg; Hipke, Martin; Schuller, Friedrich
Conference Paper
2018Wood foam and metal sponge hybrid material
Bunzel, F.; Kowalik, T.; Scholz, S.; Hohlfeld, J.
Journal Article
2017Allergen exposure chambers: harmonizing current concepts and projecting the needs for the future - an EAACI Position Paper
Pfaar, O.; Calderon, M.A.; Andrews, C.P.; Angjeli, E.; Bergmann, K.C.; Bonlokke, J.H.; Blay, F. de; Devillier, P.; Ellis, A.K.; Wijk, R.G. van; Hohlfeld, J.M.; Horak, F.; Jacobs, R.L.; Jacobsen, L.; Jutel, M.; Kaul, S.; Larche, M.; Larenas-Linnemann, D.; Mosges, R.; Nolte, H.; Patel, P.; Peoples, L.; Rabin, R.L.; Rather, C.; Salapatek, A.M.; Sigsgaard, T.; Thaarup, S.; Yang, J.; Zieglmayer, P.; Zuberbier, T.; Demoly, P.
Journal Article
2017Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients
Krug, N.; Hohlfeld, J.M.; Buhl, R.; Renz, J.; Garn, H.; Renz, H.
Journal Article
2017Dose-response relationship of a new Timothy grass pollen allergoid in comparison with a 6-grass pollen allergoid
Pfaar, O.; Hohlfeld, J.M.; Al-Kadah, B.; Hauswald, B.; Homey, B.; Hunzelmann, N.; Schliemann, S.; Velling, P.; Worm, M.; Klimek, L.
Journal Article
2017A European Respiratory Society technical standard: exhaled biomarkers in lung disease
Horvath, I.; Barnes, P.J.; Loukides, S.; Sterk, P.J.; Hogman, M.; Olin, A.C.; Amann, A.; Antus, B.; Baraldi, E.; Bikov, A.; Boots, A.W.; Bos, L.D.; Brinkman, P.; Bucca, C.; Carpagnano, G.E.; Corradi, M.; Cristescu, S.; Jongste, J.C. de; Dinh-Xuan, A.T.; Dompeling, E.; Fens, N.; Fowler, S.; Hohlfeld, J.M.; Holz, O.; Jobsis, Q.; Kant, K.V. van de; Knobel, H.H.; Kostikas, K.; Lehtimaki, L.; Lundberg, J.; Montuschi, P.; Muylem, A. van; Pennazza, G.; Reinhold, P.; Ricciardolo, F.L.M.; Rosias, P.; Santonico, M.; Schee, M.P. van der; Schooten, F.J. van; Spanevello, A.; Tonia, T.; Vink, T.J.
Journal Article
2017Herstellung von Sandwiches mit Aluminiumdeckblechen und Aluminiumschaumkern ohne Walzverdichten
Hohlfeld, Jörg; Hipke, Thomas; Schuller, Friedrich; Holders, Karsten
Journal Article
2017Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome
Engel, M.; Endesfelder, D.; Schloter-Hai, B.; Kublik, S.; Granitsiotis, M.S.; Boschetto, P.; Stendardo, M.; Barta, I.; Dome, B.; Deleuze, J.F.; Boland, A.; Müller-Quernheim, J.; Prasse, A.; Welte, T.; Hohlfeld, J.; Subramanian, D.; Parr, D.; Gut, I.G.; Greulich, T.; Koczulla, A.R.; Nowinski, A.; Gorecka, D.; Singh, D.; Gupta, S.; Brightling, CE.; Hoffmann, H.; Frankenberger, M.; Hofer, TP.; Burggraf, D.; Heiss-Neumann, M.; Ziegler-Heitbrock, L.; Schloter, M.; Castell, W. zu
Journal Article
2017Influences of Experimental Air Pollution on Human Sympathetic Nerve Traffic and Norepinephrine Metabolism: A Double Blind, Randomized, Twofold Crossover Study
Tank, J.; Heusser, K.; Holz, O.; May, M.; Brinkmann, J.; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Sweep, F.C.G.J.; Koch, W.; Krug, N.; Jordan, J.; Hohlfeld, J.
Abstract
2017Metal foams in research and development - new approaches in industrial aluminum foam production
Hipke, Thomas; Vogel, René; Hohlfeld, Jörg; Schuller, Friedrich
Presentation
2017Sandwich manufacturing with foam core and coversheets out of aluminum - a new process without rolling
Schuller, Friedrich; Hohlfeld, Jörg; Hipke, Martin; Vogel, René
Presentation
2017Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure
Badorrek, Philipp; Müller, Meike; Koch, Wolfgang; Hohlfeld, Jens M.; Krug, Norbert
Journal Article
2017Verbundwerkstoffe aus Aluminiumschaum und metallischer Bewehrung für energieabsorbierende Anwendungen
Rybandt, Susi; Hohlfeld, Jörg; Vogel, René; Dani, Ines; Hipke, Thomas
Conference Paper
2016Aluminiumschaum - Herstellung, Eigenschaften und Anwendungen
Hohlfeld, Jörg; Hipke, Thomas
Conference Paper
2016Comparison Of COPD related breath VOCs assessed by a compact high-resolution closed-loop GC-IMS and by standard GC-MS
Holz, O.; Allers, M.; Gaida, A.; Schuchardt, S.; Hohlfeld, J.M.; Zimmermann, S.
Abstract
2016Development of a technology for the production of reinforced aluminum foam absorbers
Rybandt, Susi; Hohlfeld, Jörg; Hipke, Thomas
Poster
2016Double-blind randomized multicenter clinical trial to evaluate the specific and non-specific effects of AIT with a grass and a birch pollen allergoid
Wagenmann, M.; Hohlfeld, J.; Tribanek, M.; Homolla, V.; Karjalainen, M.; Häfner, D.
Abstract
2016Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography
Subramanian, Deepak R.; Gupta, Sumit; Burggraf, Dorothe; Silberberg, Suzan J. vom; Heimbeck, Irene; Heiss-Neumann, Marion S.; Haeussinger, Karl; Newby, Chris; Hargadon, Beverley; Raj, Vimal; Singh, Dave; Kolsum, Umme; Hofer, Thomas P.; Al-Shair, Khaled; Luetzen, Niklas; Prasse, Antje; Müller-Quernheim, Joachim; Benea, Giorgio; Leprotti, Stefano; Boschetto, Piera; Gorecka, Dorota; Nowinski, Adam; Oniszh, Karina; Castell, Wolfgang zu; Hagen, Michael; Barta, Imre; Döme, Balazs; Strausz, Janos; Greulich, Timm; Vogelmeier, Claus; Koczulla, Andreas R.; Gut, Ivo; Hohlfeld, Jens; Welte, Tobias; Lavae-Mokhtari, Mahyar; Ziegler-Heitbrock, Loems; Brightling, Christopher; Parr, David G.
Journal Article
2016HYDRA - Energieabsorption mit Hybridverbunden aus drapierfähigem Material und Aluminiumschaum
Rybandt, Susi; Hohlfeld, Jörg
Poster
2016Measurement of exhaled volatile organic compounds from patients with chronic obstructive pulmonary disease (COPD) using closed gas loop GC-IMS and GC-APCI-MS
Allers, Maria; Langejuergen, Jens; Gaida, Arne; Holz, Olaf; Schuchardt, Sven; Hohlfeld, Jens M.; Zimmermann, Stefan
Journal Article
2016Prevalence of ragweed sensitization at a clinical trial unit in northern Germany
Badorrek, P.; Krug, N.; Hohlfeld, J.M.
Abstract
2016Rating the value of COPD related breath VOCs in models created by linear discriminant analysis
Holz, O.; Gaida, A.; Nell, C.; Allers, M.; Schuchardt, S.; Zimmermann, S.; Koczulla, R.; Hohlfeld, J.M.
Abstract
2016Safety, efficacy and repeatability of a novel house dust mite allergen challenge technique in the Fraunhofer allergen challenge chamber
Lüer, Katrin; Biller, Heike; Casper, Anja; Windt, Horst; Müller, Meike; Badorrek, Philipp; Haefner, Dietrich; Framke, Theodor; Koch, A.; Ziehr, Holger; Krug, Norbert; Koch, Wolfgang; Hohlfeld, Jens M.
Journal Article
2016Sandwich manufacturing with foam core and coversheets out of aluminum - a new process without rolling
Holders, Karsten; Hohlfeld, Jörg; Hipke, Thomas
Presentation
2016Severe asthma exists despite suppressed tissue inflammation: Findings of the U-BIOPRED study
Wilson, Susan J.; Ward, Jonathan A.; Sousa, Ana R.; Corfield, Julie; Bansal, Aruna T.; Meulder, Bertrand de; Lefaudeux, Diane; Auffray, Charles; Loza, Matthew J.; Baribaud, Frédéric; Fitch, Neil; Sterk, Peter J.; Chung, Kian Fan; Gibeon, David; Sun, Kai; Guo, Yi-Ke; Adcock, Ian M.; Djukanovic, Ratko; Dahlén, Barbro; Chanez, Pascal; Shaw, Dominick E.; Krug, Norbert; Hohlfeld, Jens; Sandström, Thomas; Howarth, Peter H.
Journal Article
2016Tiotropium respimat® versus hHndiHaler®: Comparison of bronchodilator efficacy of various doses in clinical trials
Calverley, Peter M.A.; Könen-Bergmann, Michael; Richard, Frank; Bell, Susan; Hohlfeld, Jens M.
Journal Article
2016Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study
Loza, M.J.; Djukanovic, R.; Chung, K.F.; Horowitz, D.; Ma, K.; Branigan, P.; Barnathan, E.S.; Susulic, V.S.; Silkoff, P.E.; Sterk, P.J.; Baribaud, F.; Badorrek, P.; Faulenbach, C.; Braun, A.; Hohlfeld, J.; Krug, N.; et. al.
Journal Article
2016Verfahren zur Herstellung von geschäumten Sandwichelementen
Hohlfeld, Jörg; Hannemann, Christian; Berthold, Patrick
Patent
2015Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme
Krug, Norbert; Hohlfeld, Jens Michael; Kirsten, Anne-Marie; Kornmann, Oliver; Beeh, Kai-Michael; Kappeler, Dominik; Korn, Stephanie; Ignatenko, Stanislav; Timmer, Wolfgang; Rogon, Cordelia; Zeitvogel, Jana; Zhang, Nan; Bille, Joachim; Homburg, Ursula; Turowska, Agnieszka; Bachert, Claus; Werfel, Thomas; Buhl, Roland; Renz, Jonas; Garn, Holger; Renz, Harald
Journal Article
2015Assessing the breathing capability of patients through inhalers
Pohlmann, G.; Hohlfeld, J.; Pankalla, J.
Conference Paper, Journal Article
2015Cardiac safety of tiotropium in patients with COPD: A combined analysis of Holter-ECG data from four randomised clinical trials
Hohlfeld, Jens Michael; Furtwaengler, A.; Könen-Bergmann, M.; Wallenstein, G.; Walter, B.; Bateman, E.D.
Journal Article
2015Characterization of exhaled particles from the human lungs in airway obstruction
Schwarz, Katharina; Biller, Heike; Windt, Horst; Koch, Wolfgang; Hohlfeld, Jens M.
Journal Article
2015Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact
Toncheva, A.A.; Potaczek, D.P.; Schedel, M.; Gersting, S.W.; Michel, S.; Krajnov, N.; Gaertner, V.D.; Klingbeil, J.M.; Illig, T.; Franke, A.; Winkler, Carla; Hohlfeld, Jens M.; Vogelberg, C.; Berg, A. von; Bufe, A.; Heinzmann, A.; Laub, O.; Rietschel, E.; Simma, B.; Genuneit, J.; Muntau, A.C.; Kabesch, Michael
Journal Article
2015Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD
Holz, Olaf; Roepcke, Stefan; Watz, Henrik; Tegtbur, Uwe; Lahu, Gezim; Hohlfeld, Jens Michael
Journal Article
2015Controlled exposure to grass pollen in an environmental challenge chamber induces a worsening of cutaneous symptoms in patients with atopic dermatitis
Heratizadeh, A.; Badorrek, P.; Kapp, A.; Niebuhr, M.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Loesche, C.; Jung, T.; Krug, N.; Hohlfeld, J.M.; Werfel, T.
Abstract
2015Determination of markers that predict the individual response of perennial allergic subjects to house dust mite allergen in the Fraunhofer Environmental Challenge Chamber (ECC)
Hohlfeld, J.M.; Lüer, K.; Holz, O.; Häfner, D.; Koch, W.; Krug, N.
Abstract
2015Efficacy and safety of a novel nasal steroid, S0597, in patients with seasonal allergic rhinitis
Badorrek, Philipp; Hohlfeld, Jens M.; Krug, Norbert; Joshi, Abhijeet; Raut, Atul
Journal Article
2015Efficacy and safety of inhaled calcium lactate PUR118 in the ozone challenge model - a clinical trial
Holz, Olaf; Biller, Heike; Müller, Meike; Kane, Katie; Rosano, Molly; Hanrahan, John; Hava, David L.; Hohlfeld, Jens M.
Journal Article
2015Entwicklung einer Triebkopfkabine aus Aluminiumschaum-Verbund für Hochgeschwindigkeitszüge
Hohlfeld, Jörg; Ketzscher, Richard; Drebenstedt, Claudia; Lies, Carsten
Conference Paper
2015Evaluating cardiac safety of tiotropium in patients with COPD: Combined analysis of Holter-ECG data from four trials
Hohlfeld, Jens M.; Furtwängler, Armin; Könen-Bergmann, Michael; Wallenstein, Gudrun; Walter, Blate; Bateman, Eric D.
Abstract
2015Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T.; Heratizadeh, A.; Niebuhr, M.; Kapp, A.; Roesner, L.M.; Karch, A.; Erpenbeck, V.J.; Lösche, C.; Jung, T.; Krug, N.; Badorrek, P.; Hohlfeld, J.M.
Journal Article
2015Inter- and intrasubject variability of the inflammatory response to segmental endotoxin challenge in healthy volunteers
Holz, Olaf; Tan, Lisa; Schaumann, Frank; Müller, Meike; Scholl, Dorothea; Hidi, R.; McLeod, Alison; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2015Niedrig dosierte inhalative Endotoxin Provokation bei gesunden Probanden als Modell in der klinischen Atemwegsforschung
Janssen, Ole
: Hohlfeld, Jens M. (Betreuer); Braun, Armin (Referent); Dittrich, Anna-Maria (Korreferent)
Dissertation
2015Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging: A proof of concept study
Renne, Julius; Hinrichs, Jan; Schönfeld, Christian; Gutberlet, Marcel; Winkler, Carla; Faulenbach, Cornelia; Jakob, Peter; Schaumann, Frank; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2015A novel universal allergen challenge technique for efficacy testing of immunotherapy
Schwarz, K.; Lueer, K.; Biller, H.; Windt, H.; Badorrek, P.; Hafner, D.; Koch, A.; Krug, N.; Koch, W.; Hohlfeld, J.
Abstract
2015Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma
Homburg, Ursula; Renz, Harald; Timmer, Wolfgang; Hohlfeld, Jens M.; Seitz, Friedeborg; Lüer, Katrin; Mayer, Alexandra; Wacker, Anja; Schmidt, Oliver; Kuhlmann, Jens; Turowska, Agnieszka; Roller, Julia; Kutz, Klaus; Schlüter, Gerhard; Krug, Norbert; Garn, Holger
Journal Article
2015Tiotropium respimat: Comparison of bronchodilator efficacy of 5 and 2.5 µg doses
Hohlfeld, Jens M.; Calverley, P.; Könen-Bergmann, M.; Metzdorf, N.; Bell, S.
Abstract
2014Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets (Callithrix jacchus)
Curths, Christoph; Wichmann, Judy; Dunker, Sarah; Windt, Horst; Hoymann, Heinz-Gerd; Lauenstein, Hans D.; Hohlfeld, Jens M.; Becker, Tamara; Kaup, Franz-Josef; Braun, Armin; Knauf, Sascha
Journal Article
2014Aluminiumsandguss - so leicht wie Wasser
Stephan, Volker; Neubert, Michael C.; Hannemann, Christian; Hohlfeld, Jörg
Journal Article
2014Cell counting in human endobronchial biopsies - disagreement of 2D versus 3D morphometry
Bratu, Vlad A.; Erpenbeck, Veit J.; Fehrenbach, Antonia; Rausch, Tanja; Rittinghausen, Susanne; Krug, Norbert; Hohlfeld, Jens M.; Fehrenbach, Heinz
Journal Article
2014Cellular metals - applications in mining and railway industry
Hipke, Thomas; Ketzscher, Richard; Lies, C.; Vogel, René; Hohlfeld, Jörg
Conference Paper
2014Diamide does not improve the analysis of IL1b and TNFa in dithiothreitol-treated sputum supernatants
Holz, Olaf; Lavae-Mokhtari, Bianca; Witte, Lena; Hohlfeld, Jens Michael
Abstract
2014Dose-range finding of natural birch pollen exposure in patients with seasonal allergic rhinitis in the Fraunhofer Environmental Challenge Chamber
Lüer, Katrin; Windt, Horst; Schwarz, Katharina; Badorrek, Philipp; Sebastian, Ramona; Haefner, Dietrich; Koch, Wolfgang; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014The effect of controlled exposure to grass pollen in an environmental challenge chamber on dermal symptoms in patients with atopic dermatitis
Heratizadeh, Annice; Badorrek, Philipp; Niebuhr, Margarete; Erpenbeck, Veit Johannes; Lösche, C.; Krug, Norbert; Hohlfeld, Jens Michael; Werfel, Thomas
Abstract
2014The effect of flow rate on the level of volatile organic compounds (voc) in exhaled breath
Holz, Olaf; Gaida, Arne; Schuchardt, Sven; Langejuergen, Jens; Zimmermann, Stefan; Hohlfeld, Jens Michael
Abstract
2014Effect of sample processing on the analysis of IL4, IL5, and IL13 in sputum supernatants
Holz, Olaf; Müller, Meike; Ignatenko, Stanislav; Kappeler, Dominik; Buhl, Roland; Beeh, Kai-Michael; Kornmann, Oliver; Kirsten, Anne; Homburg, Ursula; Garn, Holger; Krug, Norbert; Hohlfeld, Jens Michael
Abstract
2014Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study
Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Othmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert
Journal Article
2014Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis
Krug, Norbert; Gupta, Abhy; Badorrek, Philipp; Koennen, Ruediger; Mueller, Meike; Pivovarova, Anna; Hilbert, James; Wetzel, Kristiane; Hohlfeld, Jens M.; Wood, Chester
Journal Article
2014Evaluation of small molecule FRET reporter for the diagnosis and monitoring of proteolytic activity in a chronic obstructive lung disease model
Reither, G.; Heath, N.; Holz, Olaf; Kahn, N.; Hohlfeld, Jens Michael; Schulz, C.; Mall, M.A.
Abstract
2014Exercise challenge amplifies differences in metabolomic signals between healthy smokers and smokers with COPD (gold2)
Holz, Olaf; Roepcke, Stefan; Lauer, Gereon; Elmlinger, Martin; Lahu, Gezim; Hohlfeld, Jens Michael
Abstract
2014Functionally aluminum foam composites for building industry
Hipke, Thomas; Hohlfeld, Jörg; Rybandt, Susi
Journal Article, Conference Paper
2014Identification and quantification of basophils in the airways of asthmatics following segmental allergen challenge
Dijkstra, D.; Hennig, C.; Hansen, G.; Biller, H.; Krug, N.; Hohlfeld, J.M.
Journal Article
2014Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model
Winkler, C.; Bahlmann, O.; Viereck, J.; Knudsen, L.; Wedekind, D.; Hoymann, H.G.; Madsen, J.; Thum, T.; Hohlfeld, J.M.; Ochs, M.
Journal Article
2014Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
Winkler, C.; Witte, L.; Moraw, N.; Faulenbach, C.; Müller, M.; Holz, O.; Schaumann, F.; Hohlfeld, J.M.
Journal Article
2014Lung function assessment in nonhuman primate models of obstructive pulmonary diseases
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz-Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Lung function assessment in the common marmoset (Callithrix jacchus) for the evaluation of translational nonhuman primate models of lung inflammation
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz Josef; Hohlfeld, Jens Michael; Windt, Horst; Dunker, Sarah; Hoymann, Heinz Gerd; Braun, Armin; Knauf, Sascha
Abstract
2014Optimizing gene-expression analysis for induced sputum
Holz, Olaf; Hansen, Tanja; Homburg, Ursula; Garn, Holger; Hohlfeld, Jens Michael; Niehof, Monika
Abstract
2014Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease
Hohlfeld, Jens M.; Sharma, A.; Noord, J.A. van; Cornelissen, P.J.; Derom, E.; Towse, L.; Peterkin, V.; Disse, B.
Journal Article
2014Phase-contrast MRI for detection of mild systemic hemodynamic response after segmental allergen challenge in asthmatic patients
Hinrichs, Jan; Schaumann, Frank; Renne, Julius; Schönfeld, Christian; Faulenbach, Cornelia; Winkler, Carla; Gutberlet, Marcel; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens M.; Vogel-Claussen, Jens
Journal Article
2014Potential prognostic value of biomarkers in lavage, sputum and serum in a five year clinical follow-up of smokers with and without COPD
Holz, Olaf; Waschki, Benjamin; Roepcke, Stefan; Watz, Henrik; Lauer, Gereon; Faulenbach, Cornelia; Hohlfeld, Jens M.
Journal Article
2014Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging
Vogel-Claussen, Jens; Renne, Julius; Hinrichs, Jan; Schönfeld Christian; Gutberlet, Marcel; Schaumann, Frank; Winkler, Carla; Faulenbach, Cornelia; Krug, Norbert; Wacker, Frank; Hohlfeld, Jens Michael
Journal Article
2014Safety and efficacy of Pur118 in the ozone challenge model
Holz, Olaf; Biller, Heike; Müller, Meike; Kane, Katie; Rosano, Molly; Hanrahan, John; Hava, David L.; Hohlfeld, Jens Michael
Abstract
2013Aluminum foam - a material for the building industry?!
Hannemann, Christian; Rybandt, Susi; Hohlfeld, Jörg
Presentation
2013Comparison of the pharmacokinetics and pharmacodynamics of once daily tiotropium Respimat® and tiotropium HandiHaler® in COPD patients
Sharma, Ashish; Hohlfeld, Jens; Cornelissen, Piet; Noord, Jan van; Derom, Eric; Towse, Lesley; Peterkin, Vicky; Disse, Bernd
Journal Article, Conference Paper
2013Functionally aluminum foam composites for building industry
Hipke, Thomas; Hohlfeld, Jörg; Rybandt, Susi
Presentation
2013IL-13-induced cytokine release and hyperresponsiveness in precision cut lung slices of different species - characterization of a model potentially suitable for translational research of asthma cellular events
Jiménez Delgado, Sharon Melissa; Danov, Olga; Braun, Armin; Pfenning, Olaf; Förster, Christine; Hohlbaum, Andreas; Audoly, Laurent; Hohlfeld, Jens; Sewald, Katherina
Journal Article, Conference Paper
2013Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
Janssen, Ole; Schaumann, Frank; Holz, Olaf; Lavae-Mokhtari, Bianca; Welker, Lutz; Winkler, Carla; Biller, Heike; Krug, Norbert; Hohlfeld, Jens M.
Journal Article
2013Multifunktionale Leichtbauelemente aus zellularen Werkstoffen für innovatives Bauen
Rybandt, Susi; Hohlfeld, Jörg; Andersen, O.; Göhler, H.; Kaufmann, G.; Schulze, C.
Journal Article
2013Das Netzwerk zellulare metallische Werkstoffe - Initiierung, Ziele, Projekte
Lies, Carsten; Hohlfeld, Jörg
Presentation
2013Neue Werkstoffe für den Werkzeugmaschinenbau
Meltke, Robert; Hohlfeld, Jörg; Lies, Carsten
Journal Article
2013Safety profile and pharmacokinetics of an inhaled GATA-3-specific DNAzyme in a phase Ib study in patients with stable allergic asthma
Hohlfeld, Jens; Lüer, Katrin; Krug, Norbert; Turowska, Agnieszka; Renz, Harald; Garn, Holger; Homburg, Ursula
Journal Article, Conference Paper
2013Sampling and analysis of exhaled breath particles
Schwarz, Katharina; Holz, Olaf; Koch, Wolfgang; Hohlfeld, Jens M.
Conference Paper, Journal Article
2013Surfactant and allergic airway inflammation
Winkler, C.; Hohlfeld, J.M.
Journal Article
2013A translational non-human primate model for human asthma in the common marmoset (Callithrix Jacchus)
Curths, Christoph; Wichmann, Judy; Becker, Tamara; Kaup, Franz-Josef; Hohlfeld, Jens M.; Sewald, Katherina; Windt, Horst; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales LPS-Modell zur präklinischen Testung anti-inflammatorischer Substanzen im Weißbüschelaffen (Callithrix jacchus)
Seehase, Sophie; Switalla, Simone; Neuhaus, Vanessa; Zöller, Martina; Kaup, Franz Josef; Schlumbohm, Christina; Fuchs, E.; Lauenstein, Hans Dieter; Sewald, Katherina; Hohlfeld, Jens M.; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2013Ein translationales Tiermodell für das allergische Asthma des Menschen im Weißbüschelaffen (Callithrix jacchus)
Curths, Christoph; Becker, T.; Kaup, Franz Josef; Schlumbohm, Christina; Sewald, Katherina; Hohlfeld, Jens M.; Dunker, Sarah; Braun, Armin; Knauf, Sascha
Journal Article, Conference Paper
2012Acute ozone induced airway inflammation does not effect resting human sympathetic nerve traffic
Tank, J.; Biller, Heike; Heusser, K.; Holz, Olaf; Diedrich, A.; Framke, T.; Koch, A.; Grosshennig, A.; Koch, Wolfgang; Krug, Norbert; Jordan, J.; Hohlfeld, Jens
Journal Article, Conference Paper
2012Alternative activation of macrophages during the allergic airway inflammation alters antigen presenting capacities
Winkler, Carla; Carstens, Hauke; Müller, Meike; Schaumann, Frank; Faulenbach, Cornelia; Hohlfeld, Jens M.
Abstract