Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020A Computational Approach for Mapping Heme Biology in the Context of Hemolytic Disorders
Humayun, Farah; Domingo-Fernández, Daniel; Abisheck Paul George, Ajay; Hopp, Marie-Thérèse; Syllwasschy, Benjamin; Detzel, Milena; Tapley Hoyt, Charles; Hofmann-Apitius, Martin; Imhof, Diana
Journal Article
2020Data science in neurodegenerative disease
Golriz Khatami, Sepehr; Mubeen, S.; Hofmann-Apitius, Martin
Journal Article
2020Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice
Birkenbihl, Colin; Emon, Mohammad Asif; Vrooman, Henri; Westwood, Sarah; Lovestone, Simon; Hofmann-Apitius, Martin; Fröhlich, Holger
Journal Article
2020GuiltyTargets: Prioritization of Novel Therapeutic Targets with Deep Network Representation Learning
Muslu, Özlem; Hoyt, Charles Tapley; Lacerda, Mauricio Pio de; Hofmann-Apitius, Martin; Fröhlich, Holger
Journal Article
2020PS4DR: A multimodal workflow for identification and prioritization of drugs based on pathway signatures
Emon, Mohammad Asif; Domingo-Fernandez, Daniel; Tapley Hoyt, Charles; Hofmann-Apitius, Martin
Journal Article
2020Variational Autoencoder Modular Bayesian Networks for Simulation of Heterogeneous Clinical Study Data
Gootjes-Dreesbach, Luise; Sood, Meemansa; Sahay, Akrishta; Hofmann-Apitius, Martin; Fröhlich, Holger
Journal Article
2019Deep learning for clustering of multivariate clinical patient trajectories with missing values
Jong, Johann de; Emon, Mohammad Asif; Wu, Ping; Karki, Reagon; Sood, Meemansa; Godard, Patrice; Ahmad, Ashar; Vrooman, Henri; Hofmann-Apitius, Martin; Fröhlich, Holger
Journal Article
2019The Impact of Pathway Database Choice on Statistical Enrichment Analysis and Predictive Modeling
Mubeen, Sarah; Hoyt, Charles Tapley; Gemünd, André; Hofmann-Apitius, Martin; Fröhlich, Holger; Domingo-Fernandez, Daniel
Journal Article
2019PTSD Biomarker Database: Deep Dive Metadatabase for PTSD Biomarkers, Visualizations and Analysis Tools
Domingo-Fernandez, Daniel; Provost, Allison; Kodamullil, Alpha Tom; Marín-Llaó, Josep; Lasseter, Heather; Diaz, Kristophe; Daskalakis, Nikolaos P.; Lancashire, Lee; Hofmann-Apitius, Martin; Haas, Magali
Journal Article
2018BEL Commons: An environment for exploration and analysis of networks encoded in Biological Expression Language
Hoyt, Charles Tapley; Domingo-Fernandez, Daniel; Hofmann-Apitius, Martin
Journal Article
2018BEL2ABM: agent-based simulation of static models in Biological Expression Language
Gündel, Michaela; Hoyt, Charles Tapley; Hofmann-Apitius, Martin
Journal Article
2018Insights into the Folding of Disulfide-Rich μ-Conotoxins
Ajay Abisheck Paul George; Heimer, Pascal; Maaß, Astrid; Hamaekers, Jan; Hofmann-Apitius, Martin; Biswas, Arijit; Imhof, Diana
Journal Article
2018A systematic approach for identifying shared mechanisms in epilepsy and its comorbidities
Hoyt, Charles Tapley; Domingo-Fernandez, Daniel; Balzer, Nora; Güldenpfennig, Anka; Hofmann-Apitius, Martin
Journal Article
2018Using Multi-Scale Genetic, Neuroimaging and Clinical Data for Predicting Alzheimer's Disease and Reconstruction of Relevant Biological Mechanisms
Khanna, Shashank; Domingo-Fernández, Daniel; Iyappan, Anandhi; Emon, Mohammad Asif; Hofmann-Apitius, Martin; Fröhlich, Holger
Journal Article
2017Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): A web server for mechanism enrichment
Domingo-Fernández, Daniel; Kodamullil, Alpha Tom; Iyappan, Anandhi; Naz, Mufassra; Emon, Mohammad Asif; Raschka, Tamara; Karki, Reagon; Springstubbe, Stephan; Ebeling, Christian; Hofmann-Apitius, Martin
Journal Article
2017Systematic Analysis of GWAS Data Reveals Genomic Hotspots for Shared Mechanisms between Neurodegenerative Diseases
Naz, Mufassra; Younesi, Erfan; Hofmann-Apitius, Martin
Journal Article
2017Trial watch: Tracing investment in drug development for Alzheimer disease
Kodamullil, Alpha Tom; Zekri, Firas; Sood, Meemansa; Hengerer, Bastian; Canard, Luc; McHale, Duncan; Hofmann-Apitius, Martin
Journal Article
2016Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases
Naz, Mufassra; Kodamullil, Alpha Tom; Hofmann-Apitius, Martin
Journal Article
2015Bioinformatics mining and modeling methods for the identification of disease mechanisms in neurodegenerative disorders
Hofmann-Apitius, Martin; Ball, Gordon; Gebel, Stephan; Bagewadi, Shweta; Bono, Bernard de; Schneider, Reinhard; Page, Matt; Kodamullil, Alpha Tom; Younesi, Erfan; Ebeling, Christian; Tegnér, Jesper; Canard, Luc
Journal Article
2015Computational modelling approaches on epigenetic factors in neurodegenerative and autoimmune diseases and their mechanistic analysis
Irin, Afroza Khanam; Kodamullil, Alpha Tom; Gündel, Michaela; Hofmann-Apitius, Martin
Journal Article
2015Construction of biological networks from unstructured information based on a semi-automated curation workflow
Szostak, Justyna; Ansari, Sam; Madan, Sumit; Fluck, Juliane; Talikka, Marja; Iskandar, Anita; Leon, Hector de; Hofmann-Apitius, Martin; Peitsch, Manuel C.; Hoeng, Julia
Journal Article
2015NeuroTransDB: Highly curated and structured transcriptomic metadata for neurodegenerative diseases
Bagewadi, Shweta; Adhikari, Subash; Dhrangadhariya, Anjani; Irin, Afroza Khanam; Ebeling, Christian; Namasivayam, Aishwarya Alex; Page, Matthew; Hofmann-Apitius, Martin; Senger, Philipp
Journal Article
2015Systems approach for the selection of micro-RNAs as therapeutic biomarkers of anti-EGFR monoclonal antibody treatment in colorectal cancer
Deyati, Avisek; Bagewadi, Shweta; Senger, Philipp; Hofmann-Apitius, Martin; Novac, Natalia
Journal Article
2015Towards the taxonomy of human disease. Editorial
Hofmann-Apitius, Martin; Alarcon-Riquelme, M.E.; Chamberlain, C.; McHale, D.
Journal Article
2014BELIEF - a semiautomatic workflow for BEL network creation
Fluck, Juliane; Madan, Sumit; Ansari, Sam; Szostak, Justyna; Hoeng, Julia; Zimmermann, Marc; Hofmann-Apitius, Martin; Peitsch, Manuel C
Conference Paper
2014Linking hypothetical knowledge patterns to disease molecular signatures for biomarker discovery in Alzheimer's disease
Malhotra, Ashutosh; Younesi, Erfan; Bagewadi, Shweta; Hofmann-Apitius, Martin
Journal Article
2014NeuroRDF: Semantic data integration strategies for modeling neurodegenerative diseases
Iyappan, Anandhi; Bagewadi, Shweta; Page, Matthew; Hofmann-Apitius, Martin; Senger, Philipp
Conference Paper
2013Challenges and opportunities for oncology biomarker discovery
Younesi, Erfan; Hofmann-Apitius, Martin; Dyati, Avisek; Novac, Natalia
Journal Article
2013From integrative disease modeling to predictive, preventive, personalized and participatory (P4) medicine
Younesi, Erfan; Hofmann-Apitius, Martin
Journal Article
2013HuPSON: The human physiology simulation ontology
Gündel, Michaela; Younesi, Erfan; Malhotra, Ashutosh; Wang, Jiali; Li, Hui; Zhang, Bijun; Bono, Bernard de; Mevissen, Heinz-Theodor; Hofmann-Apitius, Martin
Journal Article
2013SCAI: Extracting drug-drug interactions using a rich feature vector
Bobic, Tamara; Fluck, Juliane; Hofmann-Apitius, Martin
Conference Paper
2012Development of a benchmark corpus to support the automatic extraction of drug-related adverse effects from medical case reports
Gurulingappa, Harsha; Rajput, Abdul-Mateen; Roberts, Angus; Fluck, Juliane; Hofmann-Apitius, Martin; Toldo, Luca
Journal Article
2012Mining biomarker information in biomedical literature
Younesi, Erfan; Toldo, Luca; Müller, Bernd; Friedrich, Christoph M.; Novac, Natalia; Scheer, Alexander; Hofmann-Apitius, Martin; Fluck, Juliane
Journal Article
2011Information retrieval framework for technology survey in biomedical and chemistry literature
Gurulingappa, Harsha; Müller, Bernd; Hofmann-Apitius, Martin; Fluck, Juliane
Conference Paper
2011A semantic platform for information retrieval from e-health records
Gurulingappa, Harsha; Müller, Bernd; Hofmann-Apitius, Martin; Fluck, Juliane
Conference Paper