Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2017Improvement of a fermentation process for the production of two PfAMA1-DiCo-based malaria vaccine candidates in Pichia pastoris
Kastilan, R.; Boes, A.; Spiegel, H.; Voepel, N.; Chudobova, I.; Hellwig, S.; Buyel, J.F.; Reimann, A.; Fischer, R.
Journal Article
2016Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins
Arfi, Z.A.; Hellwig, S.; Drossard, J.; Fischer, R.; Buyel, J.F.
Journal Article
2016Production, quality control, stability and pharmacotoxicity of a malaria vaccine comprising three highly similar PfAMA1 protein molecules to overcome antigenic variation
Faber, B.W.; Hellwig, S.; Houard, S.; Havelange, N.; Drossard, J.; Mertens, H.; Croon, A.; Kastilan, R.; Byrne, R.; Werff, N. van der; Eijk, M. van der; Thomas, A.W.; Kocken, C.H.M.; Remarque, E.J.
Journal Article
2015From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants
Sack, M.; Rademacher, T.; Spiegel, H.; Boes, A.; Hellwig, S.; Drossard, J.; Stoger, E.; Fischer, R.
Journal Article
2013The in-line measurement of plant cell biomass using radio frequency impedance spectroscopy as a component of process analytical technology
Holland, T.; Blessing, D.; Hellwig, S.; Sack, M.
Journal Article
2012GMP issues for recombinant plant-derived pharmaceutical proteins
Fischer, R.; Schillberg, S.; Hellwig, S.; Twyman, R.M.; Drossard, J.
Journal Article
2010Bioreactor production of scFv fragments in pichia pastoris
Hellwig, S.; Melmer, G.
Book Article
2010Lost in translation
Hellwig, S.
Journal Article
2010Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture
Holland, T.; Sack, M.; Rademacher, T.; Schmale, K.; Altmann, F.; Stadlmann, J.; Fischer, R.; Hellwig, S.
Journal Article
2008Autonomous navigation assistant for MRI guided interventions
Friebe, M.; Sachtler, D.; Hellwig, S.; Schlüter, M.; Sakas, Georgios; Jorczyck, U.
Conference Paper
2007Facing the future with pharmaceuticals from plants
Fischer, R.; Twyman, R.M.; Hellwig, S.; Drossard, J.; Schillberg, S.
Conference Paper
2007Increase of calnexin gene dosage boosts the secretion of heterologous proteins by Hansenula polymorpha
Klabunde, J.; Kleebank, S.; Piontek, M.; Hollenberg, C.P.; Hellwig, S.; Degelmann, A.
Journal Article
2006Towards industrial usefulness - cryo-cell-banking of transgenic BY-2 cell cultures
Schmale, K.; Rademacher, T.; Fischer, R.; Hellwig, S.
Journal Article
2005Plant cells
Fischer, R.; Twyman, R.M.; Drossard, J.; Hellwig, S.; Schillberg, S.
Book Article
2004Plant cell cultures for the production of recombinant proteins
Hellwig, S.; Drossard, J.; Twyman, R.M.; Fischer, R.
Journal Article
2003Necessity of a two-stage process for the production of azadirachtin-related limonoids in suspension cultures of Azadirachta indica
Raval, K.N.; Hellwig, S.; Prakash, G.; Ramos-Plasencia, A.; Srivastava, A.; Büchs, J.
Journal Article
2003Using plants as a production system for N-Glycosylated proteins of therapeutic relevance
Hellwig, S.; Sack, M.; Spiegel, H.; Drossard, J.; Fischer, R.
Journal Article
2002Entwicklung neuer Arzneimittel
Barth, S.; Finnern, R.; Fischer, R.; Hellwig, S.; Prüfer, D.
Journal Article
2001Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations
Hellwig, S.; Emde, F.; Raven, N.P.G.; Henke, M.; Logt, P. van der; Fischer, R.
Journal Article
2000Entwicklung von Fermentationsprozessen zur Produktion rekombinanter Antikörperfragmente in Pichia pastoris und Nicotiana tabacum
Hellwig, S.
Dissertation
1999Production of carcinoembryonic antigen (CEA) N-A3 domain in Pichia pastoris by fermentation
Hellwig, S.; Robin, F.; Drossard, J.; Raven, N.P.G.; Vaquero-Martin, C.; Shively, J.E.; Fischer, R.
Journal Article
1999Towards molecular farming in the future: Pichia pastoris-based production of single-chain antibody fragments
Fischer, R.; Drossard, J.; Emans, N.; Commandeur, U.; Hellwig, S.
Journal Article
1999Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors
Fischer, R.; Emans, N.; Schuster, F.; Hellwig, S.; Drossard, J.
Journal Article
1999Transgenic plants as bioreactors for the expression of recombinant antibodies and their downstream processing
Fischer, R.; Hellwig, S.; Drossard, J.; Emans, N.; Schillberg, S.
Conference Paper
1998Transgenic plants as bioreactors for the expression of recombinant antibodies
Fischer, R.; Drossard, J.; Hellwig, S.; Emans, N.; Schillberg, S.
Conference Paper
1997Production of engineered antibodies in tobacco plants and cell suspension cultures
Drossard, J.; Nähring, J.M.; Hellwig, S.; Fischer, R.
Conference Paper