Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2018Acute inhalation toxicity in vitro and ex vivo test battery prior to regulatory OECD 403 studies
Schwarz, Katharina; Hansen, Tanja; Ritter, Detlef; Walter, Dorothee; Knebel, Jan
Abstract
2018Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II
Schwotzer, Daniela; Niehof, Monika; Schaudien, Dirk; Kock, Heiko; Hansen, Tanja; Dasenbrock, Clemens; Creutzenberg, Otto H.
Journal Article
2018Characterization of human precision cut liver slices by various viability andfunctional parameters during 24 hour culture
Elenschneider, Leroy; Knebel, Jan; Braun, Armin; Fangmann, J.; Hansen, Tanja
Abstract
2018A combination of in-vitro and ex-vivo test models as an upstream alternative to regulatory OECD 403 animal studies
Walter, Dorothee; Ritter, Detlef; Knebel, Jan; Schwarz, Katharina; Hansen, Tanja
Abstract
2018Cytotoxicity testing of therapeutic nanosystems for pulmonary infection using an air-lifted interphase in-vitro test system
Knebel, Jan W.; Ritter, Detlef; Niehof, Monika; Hansen, Tanja; Strandh, M.; Falciani, C.; Flores, M.; Welscher, Y. te; Nostrum, C. van; Gracia, R.; Marradi, M.; Loinaz, I.
Abstract
2018Development and evaluation of an in vitro test system for toxicity screening of aerosols released from consumer products and first application to aerosols from a hair straightening process
Ritter, Detlef; Bitsch, Annette; Elend, Manfred; Schuchardt, Sven; Hansen, Tanja; Brodbeck, Carsten; Knebel, Jan; Fuchs, Anne; Gronewold, Claas; Fautz, Rolf
Journal Article
2018EXITOX-II: Development of an animal free testing strategy for the risk assessment of inhalable compounds
Escher, Sylvia E.; Tluczkiewicz, Inga; Hansen, Tanja; Niehof, Monika; Knebel, Jan; Ritter, Detlef; Danov, Olga; Obernolte, Helena; Schramm, Sinja-Fee; Koschmann, Jeannette; Kel, Alexander; Wingender, Edgar; Meckbach, Cornelia; Boomgarden, Wolfgang; Sewald, Katherina
Abstract
2018Low dose carbon black nanoparticle exposure does not aggravate allergic airway inflammation in mice irrespective of the presence of surface polycyclic aromatic hydrocarbons
Lindner, Karina; Webering, Sina; Ströbele, Michael; Bockhorn, Henning; Hansen, Tanja; König, Peter; Fehrenbach, Heinz
Journal Article
2017Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons
Lindner, Karina; Ströbele, Michael; Schlick, Sandra; Webering, Sina; Jenckel, André; Kopf, Johannes; Danov, Olga; Sewald, Katherina; Buj, Christian; Creutzenberg, Otto; Tillmann, Thomas; Pohlmann, Gerhard; Ernst, Heinrich; Ziemann, Christina; Hüttmann, Gereon; Heine, Holger; Bockhorn, Henning; Hansen, Tanja; König, Peter
Journal Article
2017Evaluation of a human in vitro hepatocyte-NPC co-culture model for the prediction of idiosyncratic drug-induced liver injury: A pilot study
Granitzny, Anne; Knebel, Jan; Müller, Meike; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Journal Article
2017Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound
Granitzny, Anne; Knebel, Jan; Schaudien, Dirk; Braun, Armin; Steinberg, Pablo; Dasenbrock, Clemens; Hansen, Tanja
Journal Article
2017RNA isolation from precision-cut lung slices (PCLS) from different species
Niehof, Monika; Hildebrandt, Tobias; Danov, Olga; Arndt, Kirsten; Koschmann, Jeannette; Dahlmann, Franziska; Hansen, Tanja; Sewald, Katherina
Journal Article
2016Method for identification of low soluble, biopersistent susts (GBS) - comparison of intratracheal installation and subacute inhalation
Creutzenberg, Otto H.; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Knebel, Jan
Abstract
2016Toxicity of CeO2 nanoparticles estimated in a 90-day nose-only inhalation study
Schwotzer, Daniela; Niehof, Monika; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas; Ernst, Heinrich; Creutzenberg, Otto H.
Abstract
2015Comparison of fibrotic and emphysematous alterations in the lungs of bleomycin-treated rats and hamsters
Hoymann, Heinz-G.; Schaudien, Dirk; Hansen, Tanja; Müller, Meike; Braun, Armin
Abstract
2015Development of a co-culture model for the prediction of idiosyncratic drug-induced liver injury
Granitzny, Anne; Hansen, Tanja; Knebel, Jan W.; Dasenbrock, Clemens; Steinberg, Pablo
Abstract
2015Development of hematological and immunological characteristics in neonatal rats
Sewald, Katherina; Müller, Meike; Buschmann, Jochen; Hansen, Tanja; Lewin, Geertje
Journal Article, Conference Paper
2015In vitro toxicity testing of two multi-walled carbon nanotubes determined for the purpose of targeted drug delivery
Requardt, Hendrik; Hansen, Tanja; Eisenbarth, E.; Hampel, S.; Dasenbrock, Clemens
Abstract
2015Inhalation toxicity of carbon black depends on surface coating with polycyclic aromatic hydrocarbons
Hansen, Tanja; König, P.; Creutzenberg, Otto H.; Weinhold, K.; Schlick, S.; Tillmann, Thomas; Pohlmann, Gerhard; Kolling, Angelika; Ziemann, Christina; Kopf, Johannes; Ströbele, Michael; Bockhorn, H.; Danov, Olga; Sewald, Katherina; Müller, B.; Fehrenbach, Heinz
Abstract
2015Method for identification of low soluble, biopersistent dusts (GBS) at workplaces
Creutzenberg, Otto H.; Hansen, Tanja; Schuchardt, Sven; Tillmann, Thomas
Abstract
2015An overview of the InhalT-90 project - a 90-day inhalation toxicity study with CeO2 nanoparticles
Schwotzer, Daniela; Hansen, Tanja; Niehof, Monika; Creutzenberg, Otto
Abstract
2015The Silicoat project: In vitro and in vivo toxicity screening of quartz varieties from ceramics industry and approaches for an effective quartz surface coating
Creutzenberg, Otto H.; Reamon-Buettner, Stella Marie; Tillmann, Thomas; Hansen, Tanja; Garcia, M.J.; Monfort, Eliseo; Bonvicini, Giuliana; Escrig, Alberto; Ziemann, Christina
Abstract
2014Biological impact of modified inhalable carbon black nanoparticles assessed in cell and tissue culture models
Danov, Olga; Kopf, Johannes; Ströbele, M.; Bockhorn, H.; Fehrenbach, H.; Braun, Armin; Sewald, Katherina; Hansen, Tanja
Abstract
2014CEFIC-LRI N1 Project: Inhalation toxicity of a synthetic amorphous silica (SAS) in rats
Creutzenberg, Otto H.; Pohlmann, Gerhard; Hansen, Tanja; Schuchardt, Sven; Ernst, Heinrich; Tillmann, Thomas; Schaudien, Dirk
Abstract
2014Cytochrome P450 monooxygenases expression in human bronchial epithelial calu-3 cells under different culture conditions
Hansen, Tanja; Niehof, Monika; Knebel, Jan
Abstract
2014Establishment of pathway-specific gene expression analysis using the example of the paraquat action on human lung epithelial cells
Niehof, Monika; Augustin, Christian; Hansen, Tanja
Journal Article, Conference Paper
2014Lung tissue culture model for assessment of cytotoxicity and inflammation induced by inhalable carbon black nanoparticles
Braun, Armin; Danov, Olga; Kopf, Johannes Claudius; Ströbele, Michael; Hansen, Tanja; Fehrenbach, Heinz; Sewald, Katherina
Abstract
2014Optimizing gene-expression analysis for induced sputum
Holz, Olaf; Hansen, Tanja; Homburg, Ursula; Garn, Holger; Hohlfeld, Jens Michael; Niehof, Monika
Abstract
2014The SILICOAT project: In vitro and in vivo toxicity screening of quartz varieties from traditional ceramics industry and approaches for an effective quartz surface coating
Ziemann, Christina; Reamon-Buettner, Stella Marie; Tillmann, Thomas; Hansen, Tanja; Ibañez, Maria Jesus; Monfort, Eliseo; Bonvicini, Giuliana; Escrig, Alberto; Creutzenberg, Otto H.
Journal Article, Conference Paper
2014Toxic effects of various modifications of a nanoparticle following inhalation
Creutzenberg, Otto; Voss, Jens-Uwe; Mangelsdorf, Inge; Tillmann, Thomas; Pohlmann, Gerhard; Hansen, Tanja; Kock, Heiko; Schaudien, Dirk
Journal Article, Conference Paper
2014Toxikologische Untersuchungen von Multiwalled Carbon Nanotubes, mit und ohne Eisenkatalysator, für den Einsatz in der targeted Drug Delivery, durchgeführt an humanen Lungenepithelzellen und Hepatozyten
Requardt, Hendrik
: Eisenbarth, Eva (Erstprüferin); Hennes, Kilian (Zweitprüfer); Dasenbrock, Clemens (Betreuer); Hansen, Tanja (Betreuerin)
Master Thesis
2014Untersuchungen zum Wirkmechanismus von nanostrukturiertem Carbon Black mit unterschiedlicher Oberflächenbeschaffenheit
Tautenhahn, Sven
: Scharfenberg, Klaus (1. Gutachter); Hansen, Tanja (2. Gutachter); Niehof, Monika (Wiss. Betreuung)
Bachelor Thesis
2013CarbonBlack: A joint research project to establish a test system for predicting human-toxicological effects of synthetic carbon black nanoparticles
Fehrenbach, Heinz; Müller, B.; König, P.; Hansen, Tanja; Bockhorn, H.
Journal Article, Conference Paper
2013Cytochrome P450 monooxygenases expression in human epithelial lung cell lines
Niehof, Monika; Hansen, Tanja
Journal Article, Conference Paper
2013Effects of carbon black nanoparticles on human pulmonary cell lines and precision cut lung slices
Hansen, Tanja; Kopf, Johannes Claudius; Danov, Olga; Ströbele, M.; Braun, Armin; Sewald, Katherina; Steinberg, P.; Fehrenbach, H.
Journal Article, Conference Paper
2013In vitro and ex vivo toxicity screening for predicting toxicological effects of synthetic carbon black nanoparticles in humans
Hansen, Tanja; Kopf, Johannes; Danov, Olga; Ströbele, Michael; Braun, Armin; Sewald, Katherina; Bockhorn, H.; Fehrenbach, Heinz
Journal Article, Conference Paper
2013Pulmonary toxicity of printer toner following inhalation and intratracheal instillation
Morimoto, Yasuo; Oyabu, Takako; Horie, Masanori; Kambara, Tatsunori; Izumi, Hiroto; Kuroda, Etsushi; Creuzenberg, Otto; Bellmann, Bernd; Pohlmann, Gerhard; Schuhardt, Sven; Hansen, Tanja; Ernst, Heinrich
Journal Article
2013Relative oral bioavailability of glycidol from glycidyl fatty acid esters in rats
Appel, Klaus E.; Abraham, Klaus; Berger-Preiss, Edith; Hansen, Tanja; Apel, Elisabeth; Schuchardt, Sven; Vogt, Carla; Bakhiya, Nadiya; Creutzenberg, Otto; Lampen, Alfonso
Journal Article
2013Studies on the mode of action of Multi-Walled Carbon Nanotubes onto human bronchial epithelial cells
Walter, Dorothee; Niehof, Monika; Hackbarth, Anja; Hansen, Tanja
Abstract
2013Untersuchungen zum Wirkmechanismus von Multi-Walled Carbon Nanotubes an Bronchialepithelzellen
Walter, Dorothee
: Steinberg, Pablo (Erstprüfer); Hansen, Tanja (Zweitprüfer); Niehof, Monika (Betreuer)
Master Thesis
2012Subacute and subchronic inhalation toxicity and dermal absorption of the nanoscaled zinc oxide Z-COTE HP1 in the rat
Creutzenberg, Otto H.; Ziemann, Christina; Hansen, Tanja; Ernst, Heinrich; Schaudien, Dirk; Schuchardt, Sven; Wiench, Karin; Bellmann, Bernd
Journal Article