Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2020Bone Marrow Mononuclear Cells Activate Angiogenesis via Gap Junction-Mediated Cell-Cell Interaction
Kikuchi-Taura, A.; Okinaka, Y.; Takeuchi, Y.; Ogawa, Y.; Maeda, M.; Kataoka, Y.; Yasui, T.; Kimura, T.; Gul, S.; Claussen, C.; Boltze, J.; Taguchi, A.
Journal Article
2020Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
Runfola, M.; Sestito, S.; Gul, S.; Chiellini, G.; Rapposelli, S.
Journal Article
2020Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis
Runfola, M.; Sestito, S.; Bellusci, L.; Pietra, V. la; D'Amore, V.M.; Kowalik, M.A.; Chiellini, G.; Gul, S.; Perra, A.; Columbano, A.; Marinelli, L.; Novellino, E.; Rapposelli, S.
Journal Article
2020Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
Linciano, P.; Cullia, G.; Borsari, C.; Santucci, M.; Ferrari, S.; Witt, G.; Gul, S.; Kuzikov, M.; Ellinger, B.; Santarem, N.; Cordeiro da Silva, A.; Conti, P.; Bolognesi, M.L.; Roberti, M.; Prati, F.; Bartoccini, F.; Retini, M.; Piersanti, G.; Cavalli, A.; Goldoni, L.; Bertozzi, S.M.; Bertozzi, F.; Brambilla, E.; Rizzo, V.; Piomelli, D.; Pinto, A.; Bandiera, T.; Costi, M.P.
Journal Article
2020In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
Blum, L.; Gul, S.; Ulshöfer, T.; Henke, M.; Krieg, R.; Berneburg, I.; Thomas, D.; Trautmann, S.; Kurz, J.; Geyer, J.; Geisslinger, G.; Becker, K.; Parnham, M.J.; Schiffmann, S.
Journal Article
2020Intravenous Bone Marrow Mononuclear Cells Transplantation in Aged Mice Increases Transcription of Glucose Transporter 1 and Na+/K+-ATPase at Hippocampus Followed by Restored Neurological Functions
Takeuchi, Y.; Okinaka, Y.; Ogawa, Y.; Kikuchi-Taura, A.; Kataoka, Y.; Gul, S.; Claussen, C.; Boltze, J.; Taguchi, A.
Journal Article
2020Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds
Salado, I.G.; Singh, A.K.; Moreno-Cinos, C.; Sakaine, G.; Siderius, M.; Veken, P. Van Der; Matheeussen, A.; Meer, T. Van Der; Sadek, P.; Gul, S.; Maes, L.; Sterk, G.-J.; Leurs, R.; Brown, D.; Augustyns, K.
Journal Article
2019Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Moraes, C.B.; Witt, G.; Kuzikov, M.; Ellinper, B.; Calogeropoulou, T.; Prousis, K.C.; Mangani, S.; Pisa, F. di; Landi, G.; Dello Lacono, L.; Pozzi, C.; Freitas, L.H.; Pascoalino, B.D.; Bertolacini, C.P.; Behrens, B.; Keminer, O.; Leu, J.; Wolf, M.; Reinshagen, J.; Cordeiro-da-Silva, A.; Santarem, N.; Venturelli, A.; Wrigley, S.; Karunakaran, D.; Kebede, B.; Pohner, I.; Muller, W.; Panecka-Hofman, J.; Wade, R.C.; Fenske, M.; Clos, J.; Alunda, J.M.; Corral, M.J.; Uliassi, E.; Bolognesi, M.L.; Linciano, P.; Quotadamo, A.; Ferrari, S.; Santucci, M.; Borsari, C.; Costi, M.P.; Gul, S.
Journal Article
2019Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
Ehrnhoefer, D.E.; Skotte, N.H.; Reinshagen, J.; Qiu, X.; Windshügel, B.; Jaishankar, P.; Ladha, S.; Petina, O.; Khankischpur, M.; Nguyen, Y.T.N.; Caron, N.S.; Razeto, A.; Meyer zu Rheda, M.; Deng, Y.; Huynh, K.T.; Wittig, I.; Gribbon, P.; Renslo, A.R.; Geffken, D.; Gul, S.; Hayden, M.R.
Journal Article
2019Clot derived contaminants in transplanted cells enhance inflammation at peri-stroke area after bone marrow mononuclear cell transplantation in murine stroke model
Taura, A.; Ogawa, Y.; Okinaka, Y.; Takeuchi, Y.; Boltze, J.; Gul, S.; Claussen, C.; Taguchi, A.
Abstract
2019Clot-Derived Contaminants in Transplanted Bone Marrow Mononuclear Cells Impair the Therapeutic Effect in Stroke
Okinaka, Y.; Kikuchi-Taura, A.; Takeuchi, Y.; Ogawa, Y.; Boltze, J.; Gul, S.; Claussen, C.; Taguchi, A.
Journal Article
2019Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics
Borsari, C.; Jiménez-Antón, M.D.; Eick, J.; Bifeld, E.; Torrado, J.J.; Olías-Molero, A.I.; Corral, M.J.; Santarem, N.; Baptista, C.; Severi, L.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Reinshagen, J.; Witt, G.; Linciano, P.; Tait, A.; Costantino, L.; Luciani, R.; Tejera Nevado, P.; Zander-Dinse, D.; Franco, C.H.; Ferrari, S.; Moraes, C.B.; Cordeiro-da-Silva, A.; Ponterini, G.; Clos, J.; Alunda, J.M.; Costi, M.P.
Journal Article
2019Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections
Linciano, P.; Pozzi, C.; Iacono, L. dello; Pisa, F. di; Landi, G.; Bonucci, A.; Gul, S.; Kuzikov, M.; Ellinger, B.; Witt, G.; Santarem, N.; Baptista, C.; Franco, C.; Moraes, C.B.; Müller, W.; Wittig, U.; Luciani, R.; Sesenna, A.; Quotadamo, A.; Ferrari, S.; Pöhner, I.; Cordeiro-da-Silva, A.; Mangani, S.; Costantino, L.; Costi, M.P.
Journal Article
2019SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti- Trypanosoma brucei Agent
Borsari, C.; Santarem, N.; Macedo, S.; Jiménez-Antón, M.D.; Torrado, J.J.; Olías-Molero, A.I.; Corral, M.J.; Tait, A.; Ferrari, S.; Costantino, L.; Luciani, R.; Ponterini, G.; Gul, S.; Kuzikov, M.; Ellinger, B.; Behrens, B.; Reinshagen, J.; Alunda, J.M.; Cordeiro-Da-Silva, A.; Costi, M.P.
Journal Article
2019Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors
Landi, G.; Linciano, P.; Borsari, C.; Bertolacini, C.P.; Moraes, C.B.; Cordeiro-da-Silva, A.; Gul, S.; Witt, G.; Kuzikov, M.; Costi, M.P.; Pozzi, C.; Mangani, S.
Journal Article
2018Aryl thiosemicarbazones for the treatment of trypanosomatidic infections
Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; Santarem, N.; Cordeiro-da-Silva, A.; Gul, S.; Witt, G.; Kuzikov, M.; Ellinger, B.; Ferrari, S.; Luciani, R.; Quotadamo, A.; Costantino, L.; Costi, M.P.
Journal Article
2018Development of a Focused Library of Triazole‐Linked Privileged‐Structure‐Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections
Uliassi, E.; Piazzi, L.; Belluti, F.; Mazzanti, A.; Kaiser, M.; Brun, R.; Moraes, C.B.; Freitas-Junior, L.H.; Gul, S.; Kuzikov, M.; Ellinger, B.; Borsari, C.; Costi, M.P.; Bolognesi, M.L.
Journal Article
2018In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
Witte, W.E.A. de; Versfelt, J.W.; Kuzikov, M.; Rolland, S.; Georgi, V.; Gribbon, P.; Gul, S.; Huntjens, D.; Graaf, P.H. van der; Danhof, M.; Fernández‐Montalván, A.; Witt, G.; Lange, E.C.M. de
Journal Article
2018Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
Spry, C.; Sewell, A.L.; Hering, Y.; Villa, M.V.J.; Weber, J.; Hobson, S.J.; Harnor, S.J.; Gul, S.; Marquez, R.; Salib, K.J.
Journal Article
2018Therapeutics discovery: From bench to first in-human trials
Al-Hujaily, E.M.; Khatlani, T.; Alehaideb, Z.; Ali, R.; Almuzaini, B.; Alrfaei, B.M.; Iqbal, J.; Islam, I.; Malik, S.; Marwani, B.A.; Massadeh, S.; Muzaini, B.; Nehdi, A.; Alsomaie, B.; Debasi, B.; Bushnak, I.; Noibi, S.; Hussain, S.; Wajid, W.A.; Armand, J.-P.; Gul, S.; Oyarzabal, J.; Rais, R.; Bountra, C.; Alaskar, A.; Al Knawy, B.; Boudjelal, M.
Journal Article
2017Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
Pisa, F. di; Landi, G.; Iacono, L. dello; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; Santarem, N.; Cordeiro-da-Silva, A.; Moraes, C.B.; Alcantara, L.M.; Fontana, V.; Freitas, L.H.; Gul, S.; Kuzikov, M.; Behrens, B.; Pöhner, I.; Wade, R.C.; Costi, M.P.; Mangani, S.
Journal Article
2017Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
Uliassi, E.; Fiorani, G.; Krauth-Siegel, R.L.; Bergamini, C.; Fato, R.; Bianchini, G.; Carlos Menéndez, J.; Molina, M.T.; López-Montero, E.; Falchi, F.; Cavalli, A.; Gul, S.; Kuzikov, M.; Ellinger, B.; Witt, G.; Moraes, C.B.; Freitas-Junior, L.H.; Borsari, C.; Costi, M.P.; Bolognesi, M.L.
Journal Article
2017Enforced polarization of melanoma cells towards a JARID1B-high phenotype exhausts tumour fitness
Chauvistre, H.; Shannan, B.; Vogel, F.; Krepler, C.; Picard, D.; Remke, M.; Haass, N.; Daignault, S.; Keminer, O.; Gul, S.; Sechi, A.; Lorberg, N.; Zarschler, D.; Höwner, A.; Becher, C.; Liu, Q.; Herlyn, M.; Schadendorf, D.; Roesch, A.
Abstract
2017Epigenetic assays for chemical biology and drug discovery
Gul, S.
Journal Article
2017Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
Linciano, P.; Dawson, A.; Pöhner, I.; Costa, D.M.; Sá, M.S.; Cordeiro-da-Silva, A.; Luciani, R.; Gul, S.; Witt, G.; Ellinger, B.; Kuzikov, M.; Gribbon, P.; Reinshagen, J.; Wolf, M.; Behrens, B.; Hannaert, V.; Michels, P.A.M.; Nerini, E.; Pozzi, C.; Pisa, F. di; Landi, G.; Santarem, N.; Ferrari, S.; Saxena, P.; Lazzari, S.; Cannazza, G.; Freitas-Junior, L.H.; Moraes, C.B.; Pascoalino, B.S.; Alcântara, L.M.; Bertolacini, C.P.; Fontana, V.; Wittig, U.; Müller, W.; Wade, R.C.; Hunter, W.N.; Mangani, S.; Costantino, L.; Costi, M.P.
Journal Article
2017From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action
Nederpelt, I.; Kuzikov, M.; Witte, W.E.A. de; Schnider, P.; Tuijt, B.; Gul, S.; IJzerman, A.P.; Lange, E.C.M. de; Heitman, L.H.
Journal Article
2017Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Borsari, C.; Santarem, N.; Torrado, J.; Olías, A.I.; Corral, M.J.; Baptista, C.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Witt, G.; Gribbon, P.; Reinshagen, J.; Linciano, P.; Tait, A.; Costantino, L.; Freitas-Junior, L.H.; Moraes, C.B.; Bruno dos Santos, P.; Alcântara, L.M.; Franco, C.H.; Bertolacini, C.D.; Fontana, V.; Tejera Nevado, P.; Clos, J.; Alunda, J.M.; Cordeiro-da-Silva, A.; Ferrari, S.; Costi, M.P.
Journal Article
2017The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C
Loers, G.; Astafiev, S.; Hapiak, Y.; Saini, V.; Mishra, B.; Gul, S.; Kaur, G.; Schachner, M.; Theis, T.
Journal Article
2017Synthesis and Biological Activity of Octaketides from the Cytosporone Family
Delius, M. von; Le, C.M.; Ellinger, B.; Kuzikov, M.; Gul, S.; Dong, V.M.
Journal Article
2017The target residence time of antihistamines determines their antagonism of the G protein-coupled histamine H1 receptor
Bosma, R.; Witt, G.; Vaas, L.A.I.; Josimovic, I.; Gribbon, P.; Vischer, H.F.; Gul, S.; Leurs, R.
Journal Article
2016Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction
Brenke, J.K.; Salmina, E.S.; Ringelstetter, L.; Dornauer, S.; Kuzikov, M.; Rothenaigner, I.; Schorpp, K.; Giehler, F.; Gopalakrishnan, J.; Kieser, A.; Gul, S.; Tetko, I.V.; Hadian, K.
Journal Article
2016On the robustness of action recognition methods in compressed and pixel domain
Srinivasan, V.; Gul, S.; Bosse, S.; Meyer, J.T.; Schierl, T.; Hellge, C.; Samek, W.
Conference Paper
2016Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
Borsari, C.; Lucian, R.; Pozz, C.; Poehner, I.; Henrich, S.; Trande, M.; Cordeiro-Da-silva, A.; Santarem, N.; Baptista, C.; Tait, A.; Di Pisa, F.; Iacono, L.D.; Landi, G.; Gul, S.; Wolf, M.; Kuzikov, M.; Ellinger, B.; Reinshagen, J.; Witt, G.; Gribbon, P.; Kohler, M.; Keminer, O.; Behrens, B.; Costantino, L.; Nevado, P.T.; Bifeld, E.; Eick, J.; Clos, J.; Torrado, J.; Jiménez-Antón, M.D.; Corral, M.J.; Alunda, J.Ma.; Pellati, F.; Wade, R.C.; Ferrari, S.; Mangani, S.; Costi, M.P.
Journal Article
2016Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions
Loers, G.; Saini, V.; Mishra, B.; Gul, S.; Chaudhury, S.; Wallqvist, A.; Kaur, G.; Schachner, M.
Journal Article
2015Cell-based assays for screening: A practical workshop
Gul, S.
Journal Article, Conference Paper
2015Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and derivatives are potent inducers of Oct3/4
Cheng, X.; Yoshida, H.; Raoofi, D.; Saleh, S.; Alborzinia, H.; Wenke, F.; Göhring, A.; Reuter, S.; Mah, N.; Fuchs, H.; Andrade-Navarro, M.A.; Adjaye, J.; Gul, S.; Utikal, J.; Mrowka, R.; Wölfl, S.
Journal Article
2015Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers
Cheng, X.; Dimou, E.; Alborzinia, H.; Wenke, F.; Göhring, A.; Reuter, S.; Mah, N.; Fuchs, H.; Andrade-Navarro, M.A.; Adjaye, J.; Gul, S.; Harms, C.; Utikal, J.; Klipp, E.; Mrowka, R.; Wölfl, S.
Journal Article
2014Protein-protein interaction modulator drug discovery
Gul, S.; Hadian, K.
Journal Article