Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2019GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells
Wegner, M.-S.; Gruber, L.; Schömel, N.; Trautmann, S.; Brachtendorf, S.; Fuhrmann, D.; Schreiber, Y.; Olesch, C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2019Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
Kurz, J.; Barthelmes, J.; Blum, L.; Ulshöfer, T.; Wegner, M.-S.; Ferreiros, N.; Roser, L.; Geisslinger, G.; Grösch, S.; Schiffmann, S.
Journal Article
2018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Brachtendorf, S.; Wanger, R.A.; Birod, K.; Thomas, D.; Trautmann, S.; Wegner, M.-S.; Fuhrmann, D.C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2018UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells
Wegner, M.-S.; Schömel, N.; Gruber, L.; Örtel, S.B.; Kjellberg, M.A.; Mattjus, P.; Kurz, J.; Trautmann, S.; Peng, B.; Wegner, M.; Kaulich, M.; Ahrends, R.; Geisslinger, G.; Grösch, S.
Journal Article
2018The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)
Wegner, M.-S.; Gruber, L.; Mattjus, P.; Geisslinger, G.; Grösch, S.
Journal Article
2017Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice
Oertel, S.; Scholich, K.; Weigert, A.; Thomas, D.; Schmetzer, J.; Trautmann, S.; Wegner, M.S.; Radeke, H.H.; Filmann, N.; Brüne, B.; Geisslinger, G.; Tegeder, I.; Grösch, S.
Journal Article
2017Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain
Grösch, S.; Niederberger, E.; Geisslinger, G.
Journal Article
2017R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4
Wobst, I.; Ebert, L.; Birod, K.; Wegner, M.-S.; Hoffmann, M.; Thomas, D.; Angioni, C.; Parnham, M.J.; Steinhilber, D.; Tegeder, I.; Geisslinger, G.; Grösch, S.
Journal Article
2016The enigma of ceramide synthase regulation in mammalian cells
Wegner, M.-S.; Schiffmann, S.; Parnham, M.J.; Geisslinger, G.; Grösch, S.
Journal Article
2016Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors
Roos, J.; Grösch, S.; Werz, O.; Schröder, P.; Ziegler, S.; Fulda, S.; Paulus, P.; Urbschat, A.; Kühn, B.; Maucher, I.; Fettel, J.; Vorup-Jensen, T.; Piesche, M.; Matrone, C.; Steinhilber, D.; Parnham, M.J.; Maier, T.J.
Journal Article
2016Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling
Zschiebsch, K.; Fischer, C.; Pickert, G.; Häussler, A.; Radeke, H.; Grösch, S.; Ferreirós, N.; Geisslinger, G.; Werner, E.R.; Tegeder, I.
Journal Article
2015Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils
Eberle, M.; Ebel, P.; Mayer, C.A.; Barthelmes, J.; Tafferner, N.; Ferreiros, N.; Ulshöfer, T.; Henke, M.; Foerch, C.; Männer de Bazo, A.; Grösch, S.; Geisslinger, G.; Willecke, K.; Schiffmann, S.
Journal Article
2015Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils
Barthelmes, J.; Bazo, A.M. de; Pewzner-Jung, Y.; Schmitz, K.; Mayer, C.A.; Foerch, C.; Eberle, M.; Tafferner, N.; Ferreiros, N.; Henke, M.; Geisslinger, G.; Futerman, A.H.; Grösch, S.; Schiffmann, S.
Journal Article
2015MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer
Olesch, C.; Sha, W.; Angioni, C.; Sha, L.K.; Acaf, E.; Patrignani, P.; Jakobsson, P.-J.; Radeke, H.H.; Grösch, S.; Geisslinger, G.; Knethen, A. von; Weigert, A.; Brüne, B.
Journal Article
2014Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells
Wegner, M.S.; Wanger, R.A.; Oertel, S.; Brachtendorf, S.; Hartmann, D.; Schiffmann, S.; Marschalek, R.; Schreiber, Y.; Ferreirós, N.; Geisslinger, G.; Grösch, S.
Journal Article
2014LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR
Russe, O.Q.; Möser, C.V.; Kynast, K.L.; King, T.S.; Olbrich, K.; Grösch, S.; Geisslinger, G.; Niederberger, E.
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2014PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis
Schiffmann, S.; Weigert, A.; Männich, J.; Eberle, M.; Birod, K.; Häussler, A.; Ferreiros, N.; Schreiber, Y.; Kunkel, H.; Grez, M.; Weichand, B.; Brüne, B.; Pfeilschifter, W.; Nüsing, R.; Niederberger, E.; Grösch, S.; Scholich, K.; Geisslinger, G.
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2014Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent
Eberle, M.; Ebel, P.; Wegner, M.S.; Männich, J.; Tafferner, N.; Ferreiros, N.; Birod, K.; Schreiber, Y.; Krishnamoorthy, G.; Willecke, K.; Geisslinger, G.; Grösch, S.; Schiffmann, S.
Journal Article
2013Ceramide metabolism in mouse tissue
Schiffmann, S.; Birod, K.; Männich, J.; Eberle, M.; Wegner, M.-S.; Wanger, R.; Hartmann, D.; Ferreiros, N.; Geisslinger, G.; Grösch, S.
Journal Article
2013Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity
Kahnt, A.S.; Rörsch, F.; Diehl, O.; Hofmann, B.; Lehmann, C.; Steinbrink, S.D.; Angioni, C.; Geisslinger, G.; Grösch, S.; Steinhilber, D.; Maier, T.J.
Journal Article
2013Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1
Hanke, T.; Rörsch, F.; Thieme, T.; Ferreiros, N.; Schneider, G.; Geisslinger, G.; Proschak, E.; Grösch, S.; Schubert-Zsilavecz, M.
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