Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.
2021AGMO Inhibitor Reduces 3T3-L1 Adipogenesis
Fischer, C.; Wilken-Schmitz, A.; Hernandez-Olmos, V.; Proschak, E.; Stark, H.; Fleming, I.; Weigert, A.; Thurn, M.; Hofmann, M.; Werner, E.R.; Geisslinger, G.; Niederberger, E.; Watschinger, K.; Tegeder, I.
Journal Article
2021Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels - An Exploratory In Vivo Kinetic Study
Nieraad, H.; Bruin, N. de; Arne, O.; Hofmann, M.C.J.; Gurke, R.; Schmidt, D.; Ritter, M.; Parnham, M.J.; Geisslinger, G.
Journal Article
2021Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen
Kuzikov, M.; Costanzi, E.; Reinshagen, J.; Esposito, F.; Vangeel, L.; Wolf, M.; Ellinger, B.; Claussen, C.; Geisslinger, G.; Corona, A.; Iaconis, D.; Talarico, C.; Manelfi, C.; Cannalire, R.; Rossetti, G.; Gossen, J.; Albani, S.; Musiani, F.; Herzog, K.; Ye, Y.; Giabbai, B.; Demitri, N.; Jochmans, D.; Jonghe, S.D.; Rymenants, J.; Summa, V.; Tramontano, E.; Beccari, A.R.; Leyssen, P.; Storici, P.; Neyts, J.; Gribbon, P.; Zaliani, A.
Journal Article
2021The immunomodulatory potential of the arylmethylaminosteroid sc1o
Blum, L.; Ulshöfer, T.; Henke, M.; Krieg, R.; Berneburg, I.; Geisslinger, G.; Becker, K.; Parnham, M.J.; Schiffmann, S.
Journal Article
2021Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
Rappl, P.; Rösser, S.; Maul, P.; Bauer, R.; Huard, A.; Schreiber, Y.; Thomas, D.; Geisslinger, G.; Jakobsson, P.-J.; Weigert, A.; Brüne, B.; Schmid, T.
Journal Article
2021Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides
Hahnefeld, L.; Kornstädt, L.; Kratz, D.; Ferreiros, N.; Geisslinger, G.; Pierre, S.; Scholich, K.
Journal Article
2021A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization
Schultz, B.; Zaliani, A.; Ebeling, C.; Reinshagen, J.; Bojkova, D.; Lage-Rupprecht, V.; Karki, R.; Lukassen, S.; Gadiya, Y.; Ravindra, N.G.; Das, S.; Baksi, S.; Domingo-Fernandez, D.; Lentzen, M.; Strivens, M.; Raschka, T.; Cinatl, J.; DeLong, L.N.; Gribbon, P.; Geisslinger, G.; Ciesek, S.; Dijk, D. van; Gardner, S.; Kodamullil, A.T.; Fröhlich, H.; Peitsch, M.; Jacobs, M.; Hoeng, J.; Eils, R.; Claussen, C.; Hofmann-Apitius, M.
Journal Article
2021Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity
Rimola, V.; Osthues, T.; Königs, V.; Geißlinger, G.; Sisignano, M.
Journal Article
2021Prodromal sensory neuropathy in Pink1-/-SNCAA53T double mutant Parkinson mice
Valek, L.; Tran, B.; Wilken-Schmitz, A.; Trautmann, S.; Heidler, J.; Schmid, T.; Brüne, B.; Thomas, D.; Deller, T.; Geisslinger, G.; Auburger, G.; Tegeder, I.
Journal Article
2021Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
Schmitz, K.; Trautmann, S.; Hahnefeld, L.; Fischer, C.; Schreiber, Y.; Wilken-Schmitz, A.; Gurke, R.; Brunkhorst, R.; Werner, E.R.; Watschinger, K.; Wicker, S.; Thomas, D.; Geisslinger, G.; Tegeder, I.
Journal Article
2021A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection
Ellinger, B.; Bojkova, D.; Zaliani, A.; Cinatl, J.; Claussen, C.; Westhaus, S.; Keminer, O.; Reinshagen, J.; Kuzikov, M.; Wolf, M.; Geisslinger, G.; Gribbon, P.; Ciesek, S.
Journal Article
202012/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation
Sezin, T.; Ferreiros, N.; Jennrich, M.; Ochirbold, K.; Seutter, M.; Attah, C.; Mousavi, S.; Zillikens, D.; Geisslinger, G.; Sadik, C.D.
Journal Article
2020Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis
Queck, A.; Fink, A.F.; Sirait-Fischer, E.; Rüschenbaum, S.; Thomas, D.; Snodgrass, R.G.; Geisslinger, G.; Baba, H.A.; Trebicka, J.; Zeuzem, S.; Weigert, A.; Lange, C.M.; Brüne, B.
Journal Article
2020A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects
Lötsch, J.; Walter, C.; Zunftmeister, M.; Zinn, S.; Wolters, M.; Ferreiros, N.; Rossmanith, T.; Oertel, B.G.; Geisslinger, G.
Journal Article
2020Design, Synthesis, and Structure - Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
Hiesinger, K.; Kramer, J.S.; Beyer, S.; Eckes, T.; Brunst, S.; Flauaus, C.; Wittmann, S.K.; Weizel, L.; Kaiser, A.; Kretschmer, S.B.M.; George, S.; Angioni, C.; Heering, J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Schmidtko, A.; Pogoryelov, D.; Pfeilschifter, J.; Hofmann, B.; Steinhilber, D.; Schwalm, S.; Proschak, E.
Journal Article
2020The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells
Pflüger-Müller, B.; Oo, J.A.; Heering, J.; Warwick, T.; Proschak, E.; Günther, S.; Looso, M.; Rezende, F.; Fork, C.; Geisslinger, G.; Thomas, D.; Gurke, R.; Steinhilber, D.; Schulz, M.; Leisegang, M.S.; Brandes, R.P.
Journal Article
2020Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells
Hahnefeld, L.; Gruber, L.; Schömel, N.; Fischer, C.; Mattjus, P.; Gurke, R.; Beretta, M.; Ferreirós, N.; Geisslinger, G.; Wegner, M.-S.
Journal Article
2020Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers
Wolters, M.C.; Schmetzer, J.; Möser, C.V.; Hahnefeld, L.; Angioni, C.; Thomas, D.; Ferreirós, N.; Geisslinger, G.; Niederberger, E.
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2020Exploring CYP2J2: Lipid mediators, inhibitors and therapeutic implications
Sisignano, M.; Steinhilber, D.; Parnham, M.J.; Geisslinger, G.
Journal Article
2020High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease
Klatt-Schreiner, K.; Valek, L.; Kang, J.-S.; Khlebtovsky, A.; Trautmann, S.; Hahnefeld, L.; Schreiber, Y.; Gurke, R.; Thomas, D.; Wilken-Schmitz, A.; Wicker, S.; Auburger, G.; Geisslinger, G.; Lötsch, J.; Pfeilschifter, W.; Djaldetti, R.; Tegeder, I.
Journal Article
2020Impact of hyperhomocysteinemia and different dietary interventions on cognitive performance in a knock-in mouse model for alzheimer's disease
Nieraad, H.; de Bruin, N.; Arne, O.; Hofmann, M.C.J.; Schmidt, M.; Saito, T.; Saido, T.C.; Gurke, R.; Schmidt, D.; Till, U.; Parnham, M.J.; Geisslinger, G.
Journal Article
2020Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability?
Hahnefeld, L.; Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Trautmann, S.; Snodgrass, I.F.; Kratz, D.; Geisslinger, G.; Ferreiros, N.
Journal Article
2020In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
Blum, L.; Gul, S.; Ulshöfer, T.; Henke, M.; Krieg, R.; Berneburg, I.; Thomas, D.; Trautmann, S.; Kurz, J.; Geyer, J.; Geisslinger, G.; Becker, K.; Parnham, M.J.; Schiffmann, S.
Journal Article
2020Influence of glycosphingolipids on cancer cell energy metabolism
Schömel, N.; Geisslinger, G.; Wegner, M.-S.
Journal Article
2020Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade
Weiss, U.; Möller, M.; Husseini, S.A.; Manderscheid, C.; Häusler, J.; Geisslinger, G.; Niederberger, E.
Journal Article
2020The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain
Osthues, T.; Zimmer, B.; Rimola, V.; Klann, K.; Schilling, K.; Mathoor, P.; Angioni, C.; Weigert, A.; Geisslinger, G.; Münch, C.; Scholich, K.; Sisignano, M.
Journal Article
2020Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain
Rimola, V.; Hahnefeld, L.; Zhao, J.; Jiang, C.; Angioni, C.; Schreiber, Y.; Osthues, T.; Pierre, S.; Geisslinger, G.; Ji, R.-R.; Scholich, K.; Sisignano, M.
Journal Article
2020Machine-learned association of next-generation sequencing-derived variants in thermosensitive ion channels genes with human thermal pain sensitivity phenotypes
Lötsch, J.; Kringel, D.; Geisslinger, G.; Oertel, B.G.; Resch, E.; Malkusch, S.
Journal Article
2020Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells
Blum, L.; Geisslinger, G.; Parnham, M.J.; Grünweller, A.; Schiffmann, S.
Journal Article
2020Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1
Kallenborn-Gerhardt, W.; Metzner, K.; Lu, R.; Petersen, J.; Kuth, M.S.; Heine, S.; Drees, O.; Paul, M.; Becirovic, E.; Kennel, L.; Flauaus, C.; Gross, T.; Wack, G.; Hohmann, S.W.; Nemirovski, D.; Del Turco, D.; Biel, M.; Geisslinger, G.; Michalakis, S.; Schmidtko, A.
Journal Article
2020The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP)
Schäfer, S.M.G.; Sendetski, M.; Angioni, C.; Nüsing, R.; Geisslinger, G.; Scholich, K.; Sisignano, M.
Journal Article
2020Rab27a Contributes to the Processing of Inflammatory Pain in Mice
Gross, T.; Wack, G.; Syhr, K.M.J.; Tolmachova, T.; Seabra, M.C.; Geisslinger, G.; Niederberger, E.; Schmidtko, A.; Kallenborn-Gerhardt, W.
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2020Schmerzmodelle und klinische Schmerzforschung sind kein Widerspruch
Lötsch, J.; Geisslinger, G.; Walter, C.
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2020Tumors provoke inflammation and perineural microlesions at adjacent peripheral nerves
Cohnen, Jennifer; Kornstädt, Lisa; Hahnefeld, Lisa; Ferreiros, Nerea; Pierre, Sandra; Koehl, Ulrike; Deller, Thomas; Geisslinger, Gerd; Scholich, Klaus
Journal Article
2020UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells
Schömel, N.; Gruber, L.; Alexopoulos, S.J.; Trautmann, S.; Olzomer, E.M.; Byrne, F.L.; Hoehn, K.L.; Gurke, R.; Thomas, D.; Ferreiros, N.; Geisslinger, G.; Wegner, M.-S.
Journal Article
2020Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach
Ingelfinger, R.; Henke, M.; Roser, L.; Ulshöfer, T.; Calchera, A.; Singh, G.; Parnham, M.J.; Geisslinger, G.; Fürst, R.; Schmitt, I.; Schiffmann, S.
Journal Article
20194 Ds in health research - working together toward rapid precision medicine
Niederberger, E.; Parnham, M.J.; Maas, J.; Geisslinger, G.
Journal Article
20195-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift
Martin, L.M.; Möller, M.; Weiss, U.; Russe, O.Q.; Scholich, K.; Pierre, S.; Geisslinger, G.; Niederberger, E.
Journal Article
2019Cancer-induced inflammation and inflammation-induced cancer in colon: A role for S1P lyase
Schwiebs, A.; Herrero San Juan, M.; Schmidt, K.G.; Wiercinska, E.; Anlauf, M.; Ottenlinger, F.; Thomas, D.; Elwakeel, E.; Weigert, A.; Farin, H.F.; Bonig, H.; Scholich, K.; Geisslinger, G.; Pfeilschifter, J.M.; Radeke, H.H.
Journal Article
2019Ceramides as Novel Disease Biomarkers
Kurz, J.; Parnham, M.J.; Geisslinger, G.; Schiffmann, S.
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2019Computer-Aided Selective Optimization of Side Activities of Talinolol
Hiesinger, K.; Kramer, J.S.; Achenbach, J.; Moser, D.; Weber, J.; Wittmann, S.K.; Morisseau, C.; Angioni, C.; Geisslinger, G.; Kahnt, A.S.; Kaiser, A.; Proschak, A.; Steinhilber, D.; Pogoryelov, D.; Wagner, K.; Hammock, B.D.; Proschak, E.
Journal Article
2019CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium
Linke, B.; Meyer Dos Santos, S.; Picard-Willems, B.; Keese, M.; Harder, S.; Geisslinger, G.; Scholich, K.
Journal Article
2019Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation
Maric, J.; Ravindran, A.; Mazzurana, L.; Acker, A. van; Rao, A.; Kokkinou, E.; Ekoff, M.; Thomas, D.; Fauland, A.; Nilsson, G.; Wheelock, C.E.; Dahlen, S.-E.; Ferreiros, N.; Geisslinger, G.; Friberg, D.; Heinemann, A.; Konya, V.; Mjösberg, J.
Journal Article
2019A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients with Dementia
Gurke, R.; Etyemez, S.; Prvulovic, D.; Thomas, D.; Fleck, S.C.; Reif, A.; Geisslinger, G.; Lötsch, J.
Journal Article
2019Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics
Gurke, R.; Thomas, D.; Schreiber, Y.; Schäfer, S.M.G.; Fleck, S.C.; Geisslinger, G.; Ferreiros, N.
Journal Article
2019GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells
Wegner, M.-S.; Gruber, L.; Schömel, N.; Trautmann, S.; Brachtendorf, S.; Fuhrmann, D.; Schreiber, Y.; Olesch, C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2019Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab
Mojtahed Poor, S.; Ulshöfer, T.; Gabriel, L.A.; Henke, M.; Köhm, M.; Behrens, F.; Geisslinger, G.; Parnham, M.J.; Burkhardt, H.; Schiffmann, S.
Journal Article
2019Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice
Möser, C.V.; Möller, M.; Fleck, S.C.; Thomas, D.; Geisslinger, G.; Niederberger, E.
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2019Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization
Astakhova, A.; Chistyakov, D.; Thomas, D.; Geisslinger, G.; Brüne, B.; Sergeeva, M.; Namgaladze, D.
Journal Article
2019The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated
Bazarganipour, S.; Hausmann, J.; Oertel, S.; El-Hindi, K.; Brachtendorf, S.; Blumenstein, I.; Kubesch, A.; Sprinzl, K.; Birod, K.; Hahnefeld, L.; Trautmann, S.; Thomas, D.; Herrmann, E.; Geisslinger, G.; Schiffmann, S.; Grösch, S.
Journal Article
2019Novel Approaches to Persistent Pain Therapy
Sisignano, M.; Parnham, M.J.; Geisslinger, G.
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2019Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation
Schwarzkopf, K.M.; Queck, A.; Thomas, D.; Angioni, C.; Cai, C.; Freygang, Y.; Rüschenbaum, S.; Geisslinger, G.; Zeuzem, S.; Welsch, C.; Lange, C.M.
Journal Article
2019Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
Queck, A.; Thomas, D.; Jansen, C.; Schreiber, Y.; Rüschenbaum, S.; Praktiknjo, M.; Schwarzkopf, K.M.; Mücke, M.M.; Schierwagen, R.; Uschner, F.E.; Meyer, C.; Clària, J.; Zeuzem, S.; Geisslinger, G.; Trebicka, J.; Lange, C.M.
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2019Pharmacological plasticity - How do you hit a moving target?
Parnham, M.J.; Geisslinger, G.
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2019Potential biomarkers for persistent and neuropathic pain therapy
Sisignano, M.; Lötsch, J.; Parnham, M.J.; Geisslinger, G.
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2019Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001
Nothnagel, L.; Jung, F.; Rossmanith, T.; Thurn, M.; Ashtikar, M.; Geisslinger, G.; Parnham, M.J.; Wacker, M.G.
Journal Article
2019Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Bode, E.; Heinrich, A.K.; Hirschmann, M.; Abebew, D.; Shi, Y.-N.; Vo, T.D.; Wesche, F.; Shi, Y.-M.; Grün, P.; Simonyi, S.; Keller, N.; Engel, Y.; Wenski, S.; Bennet, R.; Beyer, S.; Bischoff, I.; Buaya, A.; Brandt, S.; Cakmak, I.; Çimen, H.; Eckstein, S.; Frank, D.; Fürst, R.; Gand, M.; Geisslinger, G.; Hazir, S.; Henke, M.; Heermann, R.; Lecaudey, V.; Schäfer, W.; Schiffmann, S.; Schüffler, A.; Schwenk, R.; Skaljac, M.; Thines, E.; Thines, M.; Ulshöfer, T.; Vilcinskas, A.; Wichelhaus, T.A.; Bode, H.B.
Journal Article
2019Reduced neuropathic pain behavior in mice lacking the cyclic nucleotide-gated channel subunit CNGB1
Kallenborn-Gerhardt, W.; Lu, R.; Petersen, J.J.; Metzner, K.; Kuth, M.S.; Heine, S.; Drees, O.; Paul, M.; Becirovic, E.; Kennel, L.; Flauaus, C.; Gross, T.; Wack, G.; Hohmann, S.W.; Turco, D. del; Biel, M.; Geisslinger, G.; Michalakis, S.; Schmidtko, A.
Journal Article
2019Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
Kurz, J.; Barthelmes, J.; Blum, L.; Ulshöfer, T.; Wegner, M.-S.; Ferreiros, N.; Roser, L.; Geisslinger, G.; Grösch, S.; Schiffmann, S.
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2019Selective Inactivation of Cancer Drugs by SAMHD1 Provides a Molecular Rationale for Therapeutic Stratification in AML
Schneider, C.; Oellerich, T.; Knecht, K.M.; Thomas, D.; Buzovetsky, O.; Schliemann, C.; Bohnenberger, H.; Angenendt, L.; Hartmann, W.; Wardelmann, E.; Scheich, S.; Comoglio, F.; Wilke, A.; Ströbel, P.; Serve, H.; Geisslinger, G.; Keppler, O.T.; Xiong, Y.; Cinatl, J.
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2019Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
Oellerich, T.; Schneider, C.; Thomas, D.; Knecht, K.M.; Buzovetsky, O.; Kaderali, L.; Schliemann, C.; Bohnenberger, H.; Angenendt, L.; Hartmann, W.; Wardelmann, E.; Rothenburger, T.; Mohr, S.; Scheich, S.; Comoglio, F.; Wilke, A.; Ströbel, P.; Serve, H.; Michaelis, M.; Ferreiros, N.; Geisslinger, G.; Xiong, Y.; Keppler, O.T.; Cinatl, J.
Journal Article
2019Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder
Brunkhorst-Kanaan, N.; Klatt-Schreiner, K.; Hackel, J.; Schröter, K.; Trautmann, S.; Hahnefeld, L.; Wicker, S.; Reif, A.; Thomas, D.; Geisslinger, G.; Kittel-Schneider, S.; Tegeder, I.
Journal Article
2019Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation
Tarighi, N.; Menger, D.; Pierre, S.; Kornstädt, L.; Thomas, D.; Ferreiros, N.; Nüsing, R.M.; Geisslinger, G.; Scholich, K.
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2019UGCG influences glutamine metabolism of breast cancer cells
Schömel, N.; Hancock, S.E.; Gruber, L.; Olzomer, E.M.; Byrne, F.L.; Shah, D.; Hoehn, K.L.; Turner, N.; Grösch, S.; Geisslinger, G.; Wegner, M.-S.
Journal Article
2019A validated LC-MS/MS method for the determination of homocysteic acid in biological samples
Gurke, R.; Schmidt, D.; Thomas, D.; Fleck, S.C.; Geisslinger, G.; Ferreiros, N.
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2019Wissensgenerierung aus komplexen Datensätzen in der humanexperimentellen Schmerzforschung
Lötsch, J.; Geisslinger, G.; Walter, C.
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2019Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
Göbel, T.; Diehl, O.; Heering, J.; Merk, D.; Angioni, C.; Wittmann, S.K.; Buscato, E. la; Kottke, R.; Weizel, L.; Schader, T.; Maier, T.J.; Geisslinger, G.; Schubert-Zsilavecz, M.; Steinhilber, D.; Proschak, E.; Kahnt, A.S.
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2018Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Pleli, T.; Mondorf, A.; Ferreiros, N.; Thomas, D.; Dvorak, K.; Biondi, R.M.; Heringdorf, D.M.; Zeuzem, S.; Geisslinger, G.; Zimmermann, H.; Waidmann, O.; Piiper, A.
Journal Article
2018Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages
Ringleb, J.; Strack, E.; Angioni, C.; Geisslinger, G.; Steinhilber, D.; Weigert, A.; Brüne, B.
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2018Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigrudsson, T.; Hauser, M.J.; Tenzer, S.; Distler, U.; Aoki, J.; Morris, A.J.; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, H.J.; Radyushkin, K.; Nitsch, R.; Vogt, J.
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2018Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders
Thalman, C.; Horta, G.; Qiao, L.; Endle, H.; Tegeder, I.; Cheng, H.; Laube, G.; Sigrudsson, T.; Hauser, M.J.; Tenzer, S.; Distler, U.; Aoki, J.; Morris, A.J.; Geisslinger, G.; Röper, J.; Kirischuk, S.; Luhmann, H.J.; Radyushkin, K.; Nitsch, R.; Vogt, J.
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2018Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
Schierle, S.; Flauaus, C.; Heitel, P.; Willems, S.; Schmidt, J.; Kaiser, A.; Weizel, L.; Goebel, T.; Kahnt, A.S.; Geisslinger, G.; Steinhilber, D.; Wurglics, M.; Rovati, G.E.; Schmidtko, A.; Proschak, E.; Merk, D.
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2018Bovine embryo elongation is altered due to maternal fatty acid supplementation
Giller, K.; Drews, B.; Berard, J.; Kienberger, H.; Schmicke, M.; Frank, J.; Spanier, B.; Daniel, H.; Geisslinger, G.; Ulbrich, S.E.
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2018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Brachtendorf, S.; Wanger, R.A.; Birod, K.; Thomas, D.; Trautmann, S.; Wegner, M.-S.; Fuhrmann, D.C.; Brüne, B.; Geisslinger, G.; Grösch, S.
Journal Article
2018Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression
Blum, L.; Tafferner, N.; Spring, I.; Kurz, J.; deBruin, N.; Geisslinger, G.; Parnham, M.J.; Schiffmann, S.
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2018Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase
Roos, J.; Peters, M.; Maucher, I.V.; Kühn, B.; Fettel, J.; Hellmuth, N.; Brat, C.; Sommer, B.; Urbschat, A.; Piesche, M.; Vogel, A.; Proschak, E.; Blöcher, R.; Buscató, E.; Häfner, A.-K.; Matrone, C.; Werz, O.; Heidler, J.; Wittig, I.; Angioni, C.; Geisslinger, G.; Parnham, M.J.; Zacharowski, K.; Steinhilber, D.; Maier, T.J.
Journal Article
2018The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue
Kern, K.; Schäfer, S.M.G; Cohnen, J.; Pierre, S.; Osthues, T.; Tarighi, N.; Hohmann, S.; Ferreiros, N.; Brüne, B.; Weigert, A.; Geisslinger, G.; Sisignano, M.; Scholich, K.
Journal Article
2018The histone demethylase Jarid1b mediates angiotensin II‐induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase
Vasconez, A.E.; Janetzko, P.; Oo, J.A.; Pflüger‐Müller, B.; Ratiu, C.; Gu, L.; Helin, K.; Geisslinger, G.; Fleming, I.; Schröder, K.; Fork, C.; Brandes, R.P.; Leisegang, M.S.
Journal Article
2018An in vitro test system for compounds that modulate human inflammatory macrophage polarization
Shiratori, H.; Feinweber, C.; Luckhardt, S.; Wallner, N.; Geisslinger, G.; Weigert, A.; Parnham, M.J.
Journal Article
2018Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin
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2018Oxidized lipids as biomarkers for neuropathic pain
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Hitzel, J.; Lee, E.; Zhang, Y.; Bibli, S.I.; Li, X.; Zukunft, S.; Pflüger, B.; Hu, J.; Schürmann, C.; Vasconez, A.E.; Oo, J.A.; Kratzer, A.; Kumar, S.; Rezende, F.; Josipovic, I.; Thomas, D.; Giral, H.; Schreiber, Y.; Geisslinger, G.; Fork, C.; Yang, X.; Sigala, F.; Romanoski, C.E.; Kroll, J.; Jo, H.; Landmesser, U.; Lusis, A.J.; Namgaladze, D.; Fleming, I.; Leisegang, M.S.; Zhu, J.; Brandes, R.P.
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2018Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity
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Patent
2017Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects
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Patent
2015Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo
Weth, D.; Benetti, C.; Rauch, C.; Gstraunthaler, G.; Schmidt, H.; Geisslinger, G.; Sabbadini, R.; Proia, R.L.; Kress, M.
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2015Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils
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2015In vivo availability of pro-resolving lipid mediators in oxazolone induced dermal inflammation in the mouse
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